{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:26:31Z","timestamp":1793409991061,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital, Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974064"],"award-info":[{"award-number":["81974064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.isci.2024.111255","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T03:58:17Z","timestamp":1730260697000},"page":"111255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Helicobacter pylori activates SLFN4+MDSCs to accelerate gastric intestinal metaplasia"],"prefix":"10.1016","volume":"27","author":[{"given":"Zhihong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.111255_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.isci.2024.111255_bib2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5009\/gnl19418","article-title":"Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication","volume":"15","author":"Ito","year":"2021","journal-title":"Gut Liver"},{"key":"10.1016\/j.isci.2024.111255_bib3","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.2015238","article-title":"Autophagy mediates ER stress and inflammation in Helicobacter pylori-related gastric cancer","volume":"14","author":"Mommersteeg","year":"2022","journal-title":"Gut Microb."},{"key":"10.1016\/j.isci.2024.111255_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00407-21","article-title":"Plasmacytoid Dendritic Cell-Derived Type I Interferon Is Involved in Helicobacter pylori Infection-Induced Differentiation of Schlafen 4-Expressing Myeloid-Derived Suppressor Cells","volume":"89","author":"Xiang","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2024.111255_bib5","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1136\/ard-2022-222605","article-title":"Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-\u03b1-mediated ERK1\/2 and JAK-STAT1 pathways","volume":"81","author":"Qin","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.isci.2024.111255_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13646","article-title":"TNF-\u03b1\/IFN-\u03b3 synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK\/STAT1","volume":"21","author":"Kandhaya-Pillai","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2024.111255_bib7","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1111\/jcmm.12629","article-title":"Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-\u03b1-induced Jak\/Stat1 pathway","volume":"19","author":"Wang","year":"2015","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.isci.2024.111255_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1053\/j.gastro.2003.11.048","article-title":"Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection","volume":"126","author":"Monteleone","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2024.111255_bib9","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1038\/s41388-020-1197-4","article-title":"Cancer-associated fibroblasts-derived VCAM1 induced by H. pylori infection facilitates tumor invasion in gastric cancer","volume":"39","author":"Shen","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2024.111255_bib10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/jcmm.13338","article-title":"LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1","volume":"22","author":"Hu","year":"2018","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.isci.2024.111255_bib11","first-page":"425","article-title":"Modern Methods for Assessment of microRNAs","volume":"87","author":"Bodulev","year":"2022","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2024.111255_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molcel.2021.11.026","article-title":"Life of RISC: Formation, action, and degradation of RNA-induced silencing complex","volume":"82","author":"Iwakawa","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2024.111255_bib13","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1136\/gutjnl-2019-318817","article-title":"MiR130b from Schlafen4 MDSCs stimulates epithelial proliferation and correlates with preneoplastic changes prior to gastric cancer","volume":"69","author":"Ding","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.isci.2024.111255_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278844","article-title":"MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma","volume":"18","author":"Danielson","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.111255_bib15","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/jso.23585","article-title":"Prognostic implication of TSC1 and mTOR expression in gastric carcinoma","volume":"109","author":"Byeon","year":"2014","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.isci.2024.111255_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030758","article-title":"Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments","volume":"21","author":"Jeng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111255_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007468","article-title":"Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection","volume":"15","author":"Holokai","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2024.111255_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.coph.2016.09.003","article-title":"Hedgehog signaling in the stomach","volume":"31","author":"Konstantinou","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2024.111255_bib19","first-page":"25","article-title":"The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies","volume":"63","author":"Stasikowska-Kanicka","year":"2012","journal-title":"Pol. J. Pathol."},{"key":"10.1016\/j.isci.2024.111255_bib20","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/ijc.22835","article-title":"Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia","volume":"121","author":"Shiotani","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.isci.2024.111255_bib21","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1053\/j.gastro.2020.01.012","article-title":"Spotlight: Gastric Intestinal Metaplasia","volume":"158","author":"Shah","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2024.111255_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12957-023-03137-z","article-title":"The value of lymph nodes ratios in the prognosis of resectable remnant gastric cancer through the retrospective propensity score matching analysis","volume":"21","author":"Yang","year":"2023","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.isci.2024.111255_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11306-023-02037-3","article-title":"Plasma metabolome identifies potential biomarkers of gastric precancerous lesions and gastric cancer risk","volume":"19","author":"Li","year":"2023","journal-title":"Metabolomics"},{"key":"10.1016\/j.isci.2024.111255_bib24","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2024.111255_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.bbagrm.2014.06.009","article-title":"CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells","volume":"1839","author":"Cobler","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2024.111255_bib26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/bjc.1994.382","article-title":"Double modulation of 5-fluorouracil with interferon alpha 2a and high-dose leucovorin: a phase I and II study","volume":"70","author":"Seymour","year":"1994","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.isci.2024.111255_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2023.199190","article-title":"African Swine Fever Virus pF778R Attenuates Type I Interferon Response by Impeding STAT1 Nuclear Translocation","volume":"335","author":"Chen","year":"2023","journal-title":"Virus Res."},{"key":"10.1016\/j.isci.2024.111255_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13314","article-title":"Aicardi-Gouti\u00e8res syndrome: A monogenic type I interferonopathy","volume":"98","author":"Liu","year":"2023","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.isci.2024.111255_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg0033","article-title":"Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques","volume":"8","author":"Viox","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2024.111255_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103064","article-title":"Helicobacter suisThe TLR4-TRIF-type 1 IFN-IFN-\u03b3 pathway is crucial for gastric MALT lymphoma formation after infection","volume":"24","author":"Yamamoto","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.isci.2024.111255_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1197293","article-title":"Evidence for increased interferon type I activity in CD8+ T\u00a0cells in giant cell arteritis patients","volume":"14","author":"van Nieuwland","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.111255_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41556-022-01085-6","article-title":"STAM and Hrs interact sequentially with IFN-\u03b1 Receptor to control spatiotemporal JAK-STAT endosomal activation","volume":"25","author":"Zanin","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2024.111255_bib33","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.7150\/thno.43640","article-title":"Dysregulated Sp1\/miR-130b-3p\/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma","volume":"10","author":"Liao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.isci.2024.111255_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.693360","article-title":"Identification of Key Circulating Exosomal microRNAs in Gastric Cancer","volume":"11","author":"Qian","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2024.111255_bib35","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/acn3.51868","article-title":"Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor","volume":"10","author":"Dhamne","year":"2023","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.isci.2024.111255_bib36","article-title":"Tuberous Sclerosis Complex","author":"Wataya-Kaneda","year":"2023","journal-title":"Keio J. Med."},{"key":"10.1016\/j.isci.2024.111255_bib37","first-page":"63","article-title":"Genetic alterations in MED12 promote castration-resistant prostate cancer through modulation of GLI3 signaling","volume":"12","author":"Duong","year":"2023","journal-title":"Mol. Biol. Res. Commun."},{"key":"10.1016\/j.isci.2024.111255_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells12030358","article-title":"Hedgehog Signaling in Gonadal Development and Function","volume":"12","author":"Dilower","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.isci.2024.111255_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cells11193016","article-title":"Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma","volume":"11","author":"Tam","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.isci.2024.111255_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110811","article-title":"The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling","volume":"39","author":"Schembs","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.111255_bib41","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1172\/JCI82529","article-title":"Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia","volume":"126","author":"Ding","year":"2016","journal-title":"J.\u00a0Clin. Invest."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224024805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224024805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:57:28Z","timestamp":1783371448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224024805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2589004224024805"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.111255","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter pylori activates SLFN4+MDSCs to accelerate gastric intestinal metaplasia","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.111255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111255"}}