{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:16:23Z","timestamp":1783462583346,"version":"3.55.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["003100G221-Chelikani"],"award-info":[{"award-number":["003100G221-Chelikani"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["003100G221"],"award-info":[{"award-number":["003100G221"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.isci.2024.111286","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T15:44:54Z","timestamp":1730389494000},"page":"111286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bitter taste receptor T2R14-G\u03b1i coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis"],"prefix":"10.1016","volume":"27","author":[{"given":"Nisha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan H.","family":"Cunnington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Bhagirath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Vaishampayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Wasif","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejas","family":"Gupte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangmin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelilah S.","family":"Gounni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamala","family":"Dakshisnamurti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Hanrahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-7957","authenticated-orcid":false,"given":"Prashen","family":"Chelikani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.111286_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrg3849","article-title":"Cystic fibrosis genetics: from molecular understanding to clinical application","volume":"16","author":"Cutting","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.isci.2024.111286_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12890-016-0339-5","article-title":"Cystic fibrosis lung environment and Pseudomonas aeruginosa infection","volume":"16","author":"Bhagirath","year":"2016","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.isci.2024.111286_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s11046-021-00574-w","article-title":"Emerging Fungal Threats in Cystic Fibrosis","volume":"186","author":"Schwarz","year":"2021","journal-title":"Mycopathologia"},{"key":"10.1016\/j.isci.2024.111286_bib4","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1007\/s00253-022-12150-3","article-title":"Biofilm formation and inhibition mediated by bacterial quorum sensing","volume":"106","author":"Wang","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.isci.2024.111286_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24101950","article-title":"Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review","volume":"24","author":"Mehmood","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.isci.2024.111286_bib6","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1096\/fj.02-0616fje","article-title":"Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2","volume":"17","author":"Wang","year":"2003","journal-title":"Faseb. J."},{"key":"10.1016\/j.isci.2024.111286_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001393","article-title":"Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival","volume":"3","author":"Shaykhiev","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.111286_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1165\/rcmb.2015-0108OC","article-title":"Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes","volume":"54","author":"Szul","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2024.111286_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2023.100786","article-title":"Bronchial epithelial cells release inflammatory markers linked to airway inflammation and remodeling in response to TLR5 ligand flagellin","volume":"16","author":"Losol","year":"2023","journal-title":"World Allergy Organ. J."},{"key":"10.1016\/j.isci.2024.111286_bib10","article-title":"Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity","volume":"9","author":"Crossen","year":"2022","journal-title":"J.\u00a0Fungi"},{"key":"10.1016\/j.isci.2024.111286_bib11","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202000208R","article-title":"Bitter taste receptor T2R14 detects quorum sensing molecules from cariogenic Streptococcus mutans and mediates innate immune responses in gingival epithelial cells","volume":"35","author":"Medapati","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.isci.2024.111286_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1096242","article-title":"Loss of CFTR function is associated with reduced bitter taste receptor-stimulated nitric oxide innate immune responses in nasal epithelial cells and macrophages","volume":"14","author":"Carey","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.111286_bib13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00018-014-1736-7","article-title":"Taste receptors in innate immunity","volume":"72","author":"Lee","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.isci.2024.111286_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11010-016-2902-z","article-title":"Analysis of the expression of human bitter taste receptors in extraoral tissues","volume":"426","author":"Jaggupilli","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2024.111286_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/164_2021_435","article-title":"Pharmacology of T2R Mediated Host-Microbe Interactions","volume":"275","author":"Medapati","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.isci.2024.111286_bib16","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1128\/AEM.68.11.5459-5463.2002","article-title":"Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule","volume":"68","author":"Ramage","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.isci.2024.111286_bib17","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/EC.00219-06","article-title":"Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development","volume":"5","author":"Alem","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.isci.2024.111286_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10863-019-09817-4","article-title":"Farnesol contributes to intestinal epithelial barrier function by enhancing tight junctions via the JAK\/STAT3 signaling pathway in differentiated Caco-2 cells","volume":"51","author":"Fang","year":"2019","journal-title":"J.\u00a0Bioenerg. Biomembr."},{"key":"10.1016\/j.isci.2024.111286_bib19","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/jam.13070","article-title":"Activity of tyrosol against single and mixed-species oral biofilms","volume":"120","author":"Arias","year":"2016","journal-title":"J.\u00a0Appl. Microbiol."},{"key":"10.1016\/j.isci.2024.111286_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00143-15","article-title":"The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity","volume":"6","author":"Leonhardt","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.isci.2024.111286_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80706-0","article-title":"T2Rs function as bitter taste receptors","volume":"100","author":"Chandrashekar","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.111286_bib22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/376080a0","article-title":"Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells","volume":"376","author":"Ruiz-Avila","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.111286_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/BJ20061744","article-title":"Functional characterization of human bitter taste receptors","volume":"403","author":"Sainz","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.isci.2024.111286_bib24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1165\/rcmb.2016-0373OC","article-title":"Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G(alphai1,2,3)","volume":"56","author":"Kim","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2024.111286_bib25","doi-asserted-by":"crossref","first-page":"9824","DOI":"10.1074\/jbc.RA117.001005","article-title":"Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling","volume":"293","author":"Freund","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.111286_bib26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1126\/science.1173869","article-title":"Motile cilia of human airway epithelia are chemosensory","volume":"325","author":"Shah","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.111286_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/164_2021_436","article-title":"Bitter Taste Receptors in the Airway Cells Functions","volume":"275","author":"Sharma","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.isci.2024.111286_bib28","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1016\/j.bmc.2014.04.035","article-title":"Development of inhibitors of heterotrimeric Galphai subunits","volume":"22","author":"Appleton","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.isci.2024.111286_bib29","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1194\/jlr.M700388-JLR200","article-title":"Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism","volume":"49","author":"Andersson","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.isci.2024.111286_bib30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/mol.107.041780","article-title":"Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation","volume":"73","author":"Lehmann","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.isci.2024.111286_bib31","first-page":"590","article-title":"Inhibition of phospholipase C dependent processes by U-73, 122","volume":"19","author":"Bleasdale","year":"1989","journal-title":"Adv. Prostaglandin Thromboxane Leukot. Res."},{"key":"10.1016\/j.isci.2024.111286_bib32","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1091\/mbc.e13-05-0240","article-title":"VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1","volume":"24","author":"Ren","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.isci.2024.111286_bib33","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1242\/jcs.177907","article-title":"Correctors of mutant CFTR enhance subcortical cAMP-PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization","volume":"129","author":"Abbattiscianni","year":"2016","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.isci.2024.111286_bib34","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI72094","article-title":"Bitter and sweet taste receptors regulate human upper respiratory innate immunity","volume":"124","author":"Lee","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2024.111286_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1183\/09031936.00077712","article-title":"Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics","volume":"42","author":"Orsmark-Pietras","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.isci.2024.111286_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000443796","article-title":"Association between Polymorphisms in Bitter Taste Receptor Genes and Clinical Features in Korean Asthmatics","volume":"91","author":"Yoon","year":"2016","journal-title":"Respiration"},{"key":"10.1016\/j.isci.2024.111286_bib37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11010-019-03679-5","article-title":"Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells","volume":"465","author":"Singh","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2024.111286_bib38","doi-asserted-by":"crossref","first-page":"9947","DOI":"10.1523\/JNEUROSCI.23-30-09947.2003","article-title":"Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli","volume":"23","author":"Caicedo","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2024.111286_bib39","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.4049\/jimmunol.167.9.4805","article-title":"Activation of betagamma subunits of G(i2) and G(i3) proteins by basic secretagogues induces exocytosis through phospholipase Cbeta and arachidonate release through phospholipase Cgamma in mast cells","volume":"167","author":"Ferry","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.111286_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115932","article-title":"Cardiac human bitter taste receptors contain naturally occurring variants that alter function","volume":"219","author":"Bloxham","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2024.111286_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13578-023-00975-y","article-title":"Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells","volume":"13","author":"Santos","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.isci.2024.111286_bib42","first-page":"H1865","article-title":"Differential regulation of G protein expression in rat hearts exposed to chronic hypoxia","volume":"269","author":"Kacimi","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.isci.2024.111286_bib43","article-title":"Fenretinide favorably affects mucins (MUC5AC\/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction","volume":"1865","author":"Gari\u0107","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.isci.2024.111286_bib44","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1203\/00006450-199308000-00010","article-title":"Interleukin-8 concentrations are elevated in bronchoalveolar lavage, sputum, and sera of children with cystic fibrosis","volume":"34","author":"Dean","year":"1993","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.isci.2024.111286_bib45","doi-asserted-by":"crossref","first-page":"64030","DOI":"10.18632\/oncotarget.11747","article-title":"Defective CFTR- beta-catenin interaction promotes NF-kappaB nuclear translocation and intestinal inflammation in cystic fibrosis","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2024.111286_bib46","doi-asserted-by":"crossref","first-page":"14250","DOI":"10.1074\/jbc.RA120.013703","article-title":"AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals","volume":"295","author":"Arora","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.111286_bib47","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1074\/jbc.M116.771949","article-title":"Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor","volume":"292","author":"Hariri","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.111286_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/cells11152411","article-title":"Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca(2+)","volume":"11","author":"Hollenhorst","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.isci.2024.111286_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310538","article-title":"It Takes Two to Tango! Protein-Protein Interactions behind cAMP-Mediated CFTR Regulation","volume":"24","author":"Murabito","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111286_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189920","article-title":"Bitter Taste Receptor T2R14 Modulates Gram-Positive Bacterial Internalization and Survival in Gingival Epithelial Cells","volume":"22","author":"Medapati","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111286_bib51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-pathol-042420-094031","article-title":"Cystic Fibrosis and the Cells of the Airway Epithelium: What Are Ionocytes and What Do They Do?","volume":"17","author":"Shah","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.isci.2024.111286_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02420-x","article-title":"Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium","volume":"11","author":"Sato","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.111286_bib53","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12964-023-01233-x","article-title":"Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H(2)O(2)-dependent manner","volume":"21","author":"Klabunde","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2024.111286_bib54","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1021\/acsinfecdis.8b00094","article-title":"Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs)","volume":"4","author":"Jaggupilli","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.isci.2024.111286_bib55","doi-asserted-by":"crossref","first-page":"L1053","DOI":"10.1152\/ajplung.00368.2015","article-title":"Lipoxin A4 prevents tight junction disruption and delays the colonization of cystic fibrosis bronchial epithelial cells by Pseudomonas aeruginosa","volume":"310","author":"Higgins","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.isci.2024.111286_bib56","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/10717540500177009","article-title":"Air-liquid interface culture of serially passaged human nasal epithelial cell monolayer for in\u00a0vitro drug transport studies","volume":"12","author":"Lee","year":"2005","journal-title":"Drug Deliv."},{"key":"10.1016\/j.isci.2024.111286_bib57","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz137","article-title":"Compartment and hub definitions tune metabolic networks for metabolomic interpretations","volume":"9","author":"Waller","year":"2020","journal-title":"GigaScience"},{"key":"10.1016\/j.isci.2024.111286_bib58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nbt.3081","article-title":"Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in\u00a0vitro and in\u00a0vivo","volume":"33","author":"Zuris","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2024.111286_bib59","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00950-2019","article-title":"Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface","volume":"55","author":"Rapiteanu","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.isci.2024.111286_bib60","doi-asserted-by":"crossref","first-page":"25054","DOI":"10.1074\/jbc.M114.576975","article-title":"Amino acid derivatives as bitter taste receptor (T2R) blockers","volume":"289","author":"Pydi","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.111286_bib61","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.3390\/ijms15022554","article-title":"G Protein-Coupled Receptor Signaling Analysis Using Homogenous Time-Resolved F\u00f6rster Resonance Energy Transfer (HTRF\u00ae) Technology","volume":"15","author":"N\u00f8rskov-Lauritsen","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111286_bib62","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.cell.2019.10.010","article-title":"Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors","volume":"179","author":"Foster","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.111286_bib63","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/416878a","article-title":"Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits","volume":"416","author":"Kimple","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.111286_bib64","doi-asserted-by":"crossref","first-page":"33193","DOI":"10.1074\/jbc.C000509200","article-title":"Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3","volume":"275","author":"Peterson","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.111286_bib65","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1021\/jacs.6b13317","article-title":"Rapid and Efficient Genome Editing in Staphylococcus aureus by Using an Engineered CRISPR\/Cas9 System","volume":"139","author":"Chen","year":"2017","journal-title":"J.\u00a0Am. Chem. Soc."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224025112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224025112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:23:56Z","timestamp":1783459436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224025112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":65,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2589004224025112"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.111286","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bitter taste receptor T2R14-G\u03b1i coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.111286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111286"}}