{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:55:35Z","timestamp":1789520135976,"version":"build-2803163510"},"reference-count":130,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.isci.2024.111477","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T17:40:29Z","timestamp":1732642829000},"page":"111477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions"],"prefix":"10.1016","volume":"27","author":[{"given":"Olexandr","family":"Kuryata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-3695","authenticated-orcid":false,"given":"Oleh","family":"Akimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykola","family":"Riabushko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heorhii","family":"Kostenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriia","family":"Kostenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Mishchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Nazarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Solovyova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitalii","family":"Kostenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.111477_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.841443","article-title":"Natural 5-Aminolevulinic Acid: Sources, Biosynthesis, Detection and Applications","volume":"10","author":"Jiang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.isci.2024.111477_bib2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.biotechadv.2012.04.003","article-title":"Recent advances in microbial production of \u03b4-aminolevulinic acid and vitamin B12","volume":"30","author":"Kang","year":"2012","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.isci.2024.111477_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jcis.2020.01.020","article-title":"Enhancing selective photosensitizer accumulation and oxygen supply for high-efficacy photodynamic therapy toward glioma by 5-aminolevulinic acid loaded nanoplatform","volume":"565","author":"Wang","year":"2020","journal-title":"J.\u00a0Colloid Interface Sci."},{"key":"10.1016\/j.isci.2024.111477_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2023.112771","article-title":"Unleashing the potential of 5-Aminolevulinic acid: Unveiling a promising target for cancer diagnosis and treatment beyond photodynamic therapy","volume":"247","author":"Sansaloni-Pastor","year":"2023","journal-title":"J.\u00a0Photochem. Photobiol., B"},{"key":"10.1016\/j.isci.2024.111477_bib5","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/jdv.12950","article-title":"An update on photodynamic therapies in the treatment of onychomycosis","volume":"29","author":"Simmons","year":"2015","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.isci.2024.111477_bib6","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3171\/2015.12.JNS151513","article-title":"Analysis of the surgical benefits of 5-ALA-induced fluorescence in intracranial meningiomas: experience in 204 meningiomas","volume":"125","author":"Millesi","year":"2016","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.isci.2024.111477_bib7","doi-asserted-by":"crossref","first-page":"E529","DOI":"10.1093\/neuros\/nyaa037","article-title":"5-Aminolevulinic Acid and Contrast-Enhanced Ultrasound: The Combination of the Two Techniques to Optimize the Extent of Resection in Glioblastoma Surgery","volume":"86","author":"Della Pepa","year":"2020","journal-title":"Neurosurgery"},{"key":"10.1016\/j.isci.2024.111477_bib8","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/neuros\/nyab361","article-title":"5-Aminolevulinic Acid-Induced Porphyrin Contents in Various Brain Tumors: Implications Regarding Imaging Device Design and Their Validation","volume":"89","author":"Suero Molina","year":"2021","journal-title":"Neurosurgery"},{"key":"10.1016\/j.isci.2024.111477_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102599","article-title":"Quantitative intracellular oxygen availability before and after 5-aminolevulinic acid skin photodynamic therapy","volume":"36","author":"Ubbink","year":"2021","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.isci.2024.111477_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.21856\/j-PEP.2022.4.10","article-title":"The use of 5-aminolevulinic acid gel in the treatment of diabetic foot syndrome","volume":"79","author":"Ivanova","year":"2022","journal-title":"Probl Endocrin Pathol"},{"key":"10.1016\/j.isci.2024.111477_bib11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3892\/etm.2023.12059","article-title":"5-aminiolevulinic acid induces a radiodynamic effect with enhanced delayed reactive oxygen species production under hypoxic conditions in lymphoma cells: An in\u00a0vitro study","volume":"26","author":"Suzuki","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.isci.2024.111477_bib12","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.intimp.2014.02.003","article-title":"5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1","volume":"19","author":"Nishio","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.isci.2024.111477_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.intimp.2015.11.034","article-title":"5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction","volume":"37","author":"Fujino","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.isci.2024.111477_bib14","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1752-8062.2012.00421.x","article-title":"Use of the dietary supplement 5-aminiolevulinic acid (5-ALA) and its relationship with glucose levels and hemoglobin A1C among individuals with prediabetes","volume":"5","author":"Rodriguez","year":"2012","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib15","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.nut.2013.02.008","article-title":"5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects","volume":"29","author":"Higashikawa","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.isci.2024.111477_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.31989\/ffhd.v4i9.151","article-title":"Safety test of a supplement, 5-aminolevulinic acid phosphate with sodium ferrous citrate, in diabetic patients treated with oral hypoglycemic agents","volume":"4","author":"Yamashita","year":"2014","journal-title":"Functional Foods in Health and Disease"},{"key":"10.1016\/j.isci.2024.111477_bib17","article-title":"The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain","volume":"2016","author":"Al-Saber","year":"2016","journal-title":"J.\u00a0Diabetes Res."},{"key":"10.1016\/j.isci.2024.111477_bib18","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000025100","article-title":"A single-arm, open-label, intervention study to investigate the improvement of glucose tolerance after administration of 5-aminolevulinic acid (5-ALA) in patients with mitochondrial diabetes mellitus","volume":"100","author":"Nakamura","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.isci.2024.111477_bib19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s13300-022-01335-8","article-title":"Pilot Trial on the Effect of 5-Aminolevulinic Acid on Glucose Tolerance in Patients with Maternally Inherited Diabetes and Deafness","volume":"14","author":"Nakamura","year":"2023","journal-title":"Diabetes Ther."},{"key":"10.1016\/j.isci.2024.111477_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3164\/jcbn.18-35","article-title":"5-Aminolevulinic acid with ferrous iron improves early renal damage and hepatic steatosis in high fat diet-induced obese mice","volume":"64","author":"Kamiya","year":"2019","journal-title":"J.\u00a0Clin. Biochem. Nutr."},{"key":"10.1016\/j.isci.2024.111477_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1253\/circrep.CR-19-0089","article-title":"5-Aminolevulinic Acid Attenuates Atherosclerotic Plaque Progression in Low-Density Lipoprotein Receptor-Deficient Mice by Heme Oxygenase-1 Induction","volume":"2","author":"Hagisawa","year":"2019","journal-title":"Circ. Rep."},{"key":"10.1016\/j.isci.2024.111477_bib22","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1016\/j.atherosclerosis.2020.10.408","article-title":"Subcellular anti-atherosclerotic therapy: 5-aminolevulinic acid as a potential drug affecting dysfunctional mitochondria","volume":"315","author":"Orekhov","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.isci.2024.111477_bib23","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3382\/ps.2010-01201","article-title":"Dietary supplementation with 5-aminolevulinic acid modulates growth performance and inflammatory responses in broiler chickens","volume":"91","author":"Sato","year":"2012","journal-title":"Poult. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib24","doi-asserted-by":"crossref","first-page":"11009","DOI":"10.3168\/jds.2018-15982","article-title":"Effects of 5-aminolevulinic acid supplementation on milk production, iron status, and immune response of dairy cows","volume":"102","author":"Hendawy","year":"2019","journal-title":"J.\u00a0Dairy Sci."},{"key":"10.1016\/j.isci.2024.111477_bib25","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3390\/ani10081352","article-title":"Effects of 5-Aminolevulinic Acid as a Supplement on Animal Performance, Iron Status, and Immune Response in Farm Animals: A Review","volume":"10","author":"Hendawy","year":"2020","journal-title":"Animals."},{"key":"10.1016\/j.isci.2024.111477_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3147\/jsfp.55.125","article-title":"5-aminolevulinic Acid\u2019s Effects on Immune-related Gene Expression and Acute Hepatopancreatic Necrosis Disease (AHPND) Protection in Pacific White Shrimp Litopenaeus vannamei","volume":"55","author":"Direkbusarakom","year":"2021","journal-title":"Fish Pathol."},{"key":"10.1016\/j.isci.2024.111477_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2022.100575","article-title":"Effects of 5-aminolevulinic acid on the inflammatory responses and antioxidative capacity in broiler chickens challenged with lipopolysaccharide","volume":"16","author":"Chen","year":"2022","journal-title":"Animal"},{"key":"10.1016\/j.isci.2024.111477_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00253-001-0858-7","article-title":"Biosynthesis, biotechnological production and applications of 5-aminolevulinic acid","volume":"58","author":"Sasaki","year":"2002","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.isci.2024.111477_bib29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ymgme.2019.01.015","article-title":"Regulation and tissue-specific expression of \u03b4-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias","volume":"128","author":"Peoc'h","year":"2019","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.isci.2024.111477_bib30","doi-asserted-by":"crossref","first-page":"26424","DOI":"10.1074\/jbc.M110.215772","article-title":"Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells","volume":"286","author":"Tian","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.111477_bib31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2005.06.040","article-title":"Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha","volume":"122","author":"Handschin","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.111477_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13068-020-01685-0","article-title":"Efficient bioproduction of 5-aminolevulinic acid, a promising biostimulant and nutrient, from renewable bioresources by engineered Corynebacterium glutamicum","volume":"13","author":"Chen","year":"2020","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.isci.2024.111477_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-4165(02)00482-8","article-title":"Phenobarbital induction of drug\/steroid-metabolizing enzymes and nuclear receptor CAR","volume":"1619","author":"Kakizaki","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2024.111477_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lfs.2007.04.020","article-title":"Induction of 5-aminolevulinate synthase by activators of steroid biosynthesis","volume":"81","author":"Martini","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.isci.2024.111477_bib35","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1021\/bi101585c","article-title":"Hypoxic induction of human erythroid-specific \u03b4-aminolevulinate synthase mediated by hypoxia-inducible factor 1","volume":"50","author":"Zhang","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2024.111477_bib36","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1182\/blood-2005-05-1809","article-title":"Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis","volume":"107","author":"Schranzhofer","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.isci.2024.111477_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fgene.2014.00079","article-title":"Trans-regulation of RNA-binding protein motifs by microRNA","volume":"5","author":"Doyle","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.111477_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.895521","article-title":"Regulation of Heme Synthesis by Mitochondrial Homeostasis Proteins","volume":"10","author":"Yien","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2024.111477_bib39","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1139\/o05-045","article-title":"Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition","volume":"83","author":"Abu-Farha","year":"2005","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.isci.2024.111477_bib40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/BJ20040570","article-title":"Examination of mitochondrial protein targeting of haem synthetic enzymes: in\u00a0vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase","volume":"386","author":"Dailey","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.isci.2024.111477_bib41","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.3390\/ijms23137467","article-title":"New Avenues of Heme Synthesis Regulation","volume":"23","author":"Medlock","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100886","article-title":"5-Aminolevulinic acid for fluorescence-guided surgery in pancreatic cancer: Cellular transport and fluorescence quantification studies","volume":"14","author":"Labib","year":"2021","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.isci.2024.111477_bib43","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41419-022-04718-8","article-title":"SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma","volume":"13","author":"Fan","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2024.111477_bib44","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.113.301552","article-title":"ATP-binding cassette B10 regulates early steps of heme synthesis","volume":"113","author":"Bayeva","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2024.111477_bib45","doi-asserted-by":"crossref","first-page":"16284","DOI":"10.1074\/jbc.M117.797415","article-title":"Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes","volume":"292","author":"Seguin","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.111477_bib46","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.biocel.2006.03.002","article-title":"Study of the mechanisms of uptake of 5-aminolevulinic acid derivatives by PEPT1 and PEPT2 transporters as a tool to improve photodynamic therapy of tumours","volume":"38","author":"Rodriguez","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.isci.2024.111477_bib47","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1111\/j.1471-4159.2007.04905.x","article-title":"Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity","volume":"103","author":"Hu","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.isci.2024.111477_bib48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/bph.13356","article-title":"The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acid","volume":"173","author":"Xie","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2024.111477_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk3259","article-title":"Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes","volume":"7","author":"Killer","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2024.111477_bib50","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2007.10.026","article-title":"PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation","volume":"134","author":"Dalmasso","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2024.111477_bib51","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.bbagen.2012.07.007","article-title":"The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation","volume":"1820","author":"Kovacs-Nolan","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2024.111477_bib52","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pharmthera.2005.10.017","article-title":"Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects","volume":"111","author":"Tsiftsoglou","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.isci.2024.111477_bib53","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1172\/JCI62422","article-title":"The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation","volume":"122","author":"Chiabrando","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2024.111477_bib54","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3390\/antiox11030555","article-title":"Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders","volume":"11","author":"Ryter","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.isci.2024.111477_bib55","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3389\/fphar.2019.00825","article-title":"Heme Catabolic Pathway in Inflammation and Immune Disorders","volume":"10","author":"Wu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2024.111477_bib56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bcp.2018.02.010","article-title":"The macrophage heme-heme oxygenase-1 system and its role in inflammation","volume":"153","author":"Vijayan","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2024.111477_bib57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/jnc.15969","article-title":"Heme oxygenase-1: The roles of both good and evil in neurodegenerative diseases","volume":"167","author":"Liu","year":"2023","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.isci.2024.111477_bib58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejphar.2018.05.009","article-title":"Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron","volume":"833","author":"Ito","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.isci.2024.111477_bib59","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1089\/ars.2019.7991","article-title":"Regulation of the Expression of Heme Oxygenase-1: Signal Transduction, Gene Promoter Activation, and Beyond","volume":"32","author":"Medina","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.isci.2024.111477_bib60","doi-asserted-by":"crossref","first-page":"22621","DOI":"10.3390\/ijms160922621","article-title":"Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney","volume":"16","author":"Hu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib61","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1002\/anie.201602525","article-title":"Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy","volume":"55","author":"Lee","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.isci.2024.111477_bib62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/ijms20010039","article-title":"A Dual Role of Heme Oxygenase-1 in Cancer Cells","volume":"20","author":"Chiang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib63","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12012-019-09517-w","article-title":"Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus","volume":"19","author":"Zhang","year":"2019","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.isci.2024.111477_bib64","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/pro.405","article-title":"Structure and function of enzymes in heme biosynthesis","volume":"19","author":"Layer","year":"2010","journal-title":"Protein Sci."},{"key":"10.1016\/j.isci.2024.111477_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131793","article-title":"The Effect of 5-Aminolevulinic Acid on Cytochrome P450-Mediated Prodrug Activation","volume":"10","author":"Miura","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.111477_bib66","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.3390\/cimb45060330","article-title":"Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies","volume":"45","author":"Tsiftsoglou","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.isci.2024.111477_bib67","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/2666958702101010052","article-title":"Case reports: safety, tolerability and efficacy of 5-aminolevulinic acid phosphate, an inducer of heme oxygenase 1, in combination with sodium ferrous citrate for the treatment of COVID-19 patients","volume":"1","author":"Kaketani","year":"2021","journal-title":"The Open COVID Journal"},{"key":"10.1016\/j.isci.2024.111477_bib68","first-page":"17","article-title":"Safety and immune-supportive potential of the food supplement 5-aminolevulinic acid phosphate for patients with COVID-19: An open-label, non-randomized pilot study","volume":"7","author":"Darwish","year":"2024","journal-title":"Bioact. Compd. Health Dis."},{"key":"10.1016\/j.isci.2024.111477_bib69","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.livsci.2011.02.017","article-title":"Effects of dietary supplementation with delta-aminolevulinic acid on growth performance, hematological status, and immune responses of weanling pigs","volume":"140","author":"Wang","year":"2011","journal-title":"Livest. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib70","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.anifeedsci.2012.08.011","article-title":"Effects of iron injection at birth on neonatal iron status in young pigs from first-parity sows fed delta-aminolevulinic acid","volume":"178","author":"Wang","year":"2012","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.isci.2024.111477_bib71","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.livsci.2007.04.015","article-title":"Effect of \u03b4-aminolevulinic acid on growth performance, nutrient digestibility, blood parameters, and the immune response of weanling pigs challenged with Escherichia coli lipopolysaccharide","volume":"114","author":"Chen","year":"2008","journal-title":"Livest. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5713\/ajas.2006.97","article-title":"Use of \u03b4-Aminolevulinic Acid in Swine Diet: Effect on Growth Performance, Behavioral Characteristics, and Hematological\/Immune Status in Nursery Pigs","volume":"19","author":"Mateo","year":"2005","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib73","doi-asserted-by":"crossref","first-page":"215","DOI":"10.22358\/jafs\/66601\/2008","article-title":"Utilization of \u03b4-aminolevulinic acid for livestock: Blood characteristics and immune organ weight in broilers","volume":"17","author":"Chen","year":"2008","journal-title":"J.\u00a0Anim. Feed Sci."},{"key":"10.1016\/j.isci.2024.111477_bib74","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.livsci.2010.06.161","article-title":"Effects of dietary delta-aminolevulinic acid and vitamin C on growth performance, immune organ weight, and iron status in broiler chicks","volume":"135","author":"Wang","year":"2011","journal-title":"Livest. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib75","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/2211-5463.12729","article-title":"5-ALA\/SFC enhances HO-1 expression through the MAPK\/Nrf2 antioxidant pathway and attenuates murine tubular epithelial cell apoptosis","volume":"9","author":"Liu","year":"2019","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.isci.2024.111477_bib76","article-title":"Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)","volume":"2019","author":"Rehani","year":"2019","journal-title":"J.\u00a0Diabetes Res."},{"key":"10.1016\/j.isci.2024.111477_bib77","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.7150\/thno.83163","article-title":"5-aminolevulinate and CHIL3\/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury","volume":"13","author":"Jin","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.isci.2024.111477_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112984","article-title":"Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling","volume":"42","author":"Chen","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.111477_bib79","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.bbrc.2016.01.136","article-title":"5-Aminolevulinic acid combined with ferrous iron ameliorate ischemia-reperfusion injury in the mouse fatty liver model","volume":"470","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2024.111477_bib80","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.3390\/ijms24108653","article-title":"5-ALA\/SFC Ameliorates Endotoxin-Induced Ocular Inflammation in Rats by Inhibiting the NF-\u03baB Signaling Pathway and Activating the HO-1\/Nrf2 Signaling Pathway","volume":"24","author":"Otaka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib81","first-page":"207","article-title":"Effects of Oral 5-Aminolevulinic Acid on Lipopolysaccharide-Induced Ocular Inflammation in Rats","volume":"10","author":"Otaka","year":"2023","journal-title":"Vet. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib82","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1740-0929.2011.00942.x","article-title":"The effects of replacement of antibiotics with by-products of oriental medicinal plants on growth performance and meat qualities in fattening pigs","volume":"83","author":"Kang","year":"2012","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.isci.2024.111477_bib83","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/ijms25020988","article-title":"The Impact of 5-Aminolevulinic Acid Supplementation on Redox Balance and Aerobic Capacity","volume":"25","author":"Saga","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib84","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1152\/japplphysiol.00582.2015","article-title":"Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women","volume":"120","author":"Masuki","year":"2016","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.isci.2024.111477_bib85","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1038\/s41598-018-25452-2","article-title":"Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study","volume":"8","author":"Suzuki","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.111477_bib86","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cbpc.2006.07.004","article-title":"The dual face of endogenous alpha-aminoketones: pro-oxidizing metabolic weapons","volume":"146","author":"Bechara","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.isci.2024.111477_bib87","first-page":"194","article-title":"Nrf2 Induction Alleviates Metabolic Disorder and Systemic Inflammatory Response in Rats under a Round-the-Clock Lighting and High-Carbohydrate\u2013Lipid Diet","volume":"29","author":"Frenkel","year":"2022","journal-title":"Romanian Journal of Diabetes Nutrition and Metabolic Diseases"},{"key":"10.1016\/j.isci.2024.111477_bib88","doi-asserted-by":"crossref","first-page":"685","DOI":"10.36740\/WLek202203121","article-title":"Bioflavonoids as agents for correcting nitro-oxidative stress and salivary gland functions in rats exposed to alcohol during modeled lipopolysaccharide-induced systemic inflammatory response","volume":"75","author":"Kozaeva","year":"2022","journal-title":"Wiad. Lek."},{"key":"10.1016\/j.isci.2024.111477_bib89","doi-asserted-by":"crossref","first-page":"11","DOI":"10.15407\/fz69.02.011","article-title":"Effect of NF-\u03baB and Nrf2 Transcription Factor Modulators on Indicators of Oxidative\u2013Nitrosative Stress in Skeletal Muscles of Rats under Chronic Hypomelatoninemia and Carbohydrate-Lipid Diet","volume":"69","author":"Frenkel\u2019","year":"2023","journal-title":"Fiziol. Zh."},{"key":"10.1016\/j.isci.2024.111477_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e15551","article-title":"Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response","volume":"9","author":"Kostenko","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.isci.2024.111477_bib91","doi-asserted-by":"crossref","first-page":"33","DOI":"10.15407\/fz70.04.033","article-title":"Effect of quercetin on oxidative and nitrosative stress in kidney tissues of rats during acute desynchronosis and lipopolysaccharide-induced inflammation","volume":"70","author":"Gutnik","year":"2024","journal-title":"Fiziol. Zh."},{"key":"10.1016\/j.isci.2024.111477_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e25058","article-title":"Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy","volume":"10","author":"Opryshko","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.isci.2024.111477_bib93","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.237917","article-title":"Mitochondrial-nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites","volume":"133","author":"Martinez-Guzman","year":"2020","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.isci.2024.111477_bib94","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1093\/hmg\/ddad092","article-title":"5-Aminolevulinic acid bypasses mitochondrial complex I deficiency and corrects physiological dysfunctions in Drosophila","volume":"32","author":"Nozawa","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2024.111477_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46772-x","article-title":"Effects of 5-aminolevulinic acid and sodium ferrous citrate on fibroblasts from individuals with mitochondrial diseases","volume":"9","author":"Shimura","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.111477_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189593","article-title":"5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice","volume":"13","author":"Saitoh","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.111477_bib97","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1038\/s41598-017-03917-0","article-title":"Treatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid","volume":"7","author":"Fujii","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.111477_bib98","doi-asserted-by":"crossref","first-page":"234","DOI":"10.33160\/yam.2020.08.006","article-title":"Improvement Effect of 5-Aminolevulinic Acid on Hyperlipidemia in Miniature Schnauzer Dogs: An Open Study in 5 Cases of One Pedigree","volume":"63","author":"Sakai","year":"2020","journal-title":"Yonago Acta Med."},{"key":"10.1016\/j.isci.2024.111477_bib99","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/2211-5463.12048","article-title":"Combination of 5-aminolevulinic acid and ferrous ion reduces plasma glucose and hemoglobin A1c levels in Zucker diabetic fatty rats","volume":"6","author":"Hara","year":"2016","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.isci.2024.111477_bib100","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/nsmb1344","article-title":"Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta","volume":"14","author":"Raghuram","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.isci.2024.111477_bib101","doi-asserted-by":"crossref","DOI":"10.1621\/nrs.08001","article-title":"Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism","volume":"8","author":"Yin","year":"2010","journal-title":"Nucl. Recept. Signal."},{"key":"10.1016\/j.isci.2024.111477_bib102","first-page":"8227","article-title":"The chronic effects of 5-aminolevulinic acid plus sodium ferrous citrate on pre-diabetic Wistar rats","volume":"12","author":"Xu","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.isci.2024.111477_bib103","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1530\/JME-16-0260","article-title":"5-ALA ameliorates hepatic steatosis through AMPK signaling pathway","volume":"59","author":"Yu","year":"2017","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.isci.2024.111477_bib104","doi-asserted-by":"crossref","first-page":"8964","DOI":"10.3390\/ijms24108964","article-title":"Reactive Oxygen Species Produced by 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Cancer","volume":"24","author":"Pignatelli","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib105","doi-asserted-by":"crossref","first-page":"709","DOI":"10.4236\/health.2020.127052","article-title":"5-Aminolevulinic Acid Improves Skin Hydration and Reduces Wrinkles","volume":"12","author":"Naraoka","year":"2020","journal-title":"Health"},{"key":"10.1016\/j.isci.2024.111477_bib106","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/1028415X.2016.1199114","article-title":"Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease","volume":"20","author":"Omori","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.isci.2024.111477_bib107","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1038\/s41598-017-06406-6","article-title":"Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells","volume":"7","author":"Takase","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.111477_bib108","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbrc.2021.01.091","article-title":"5-amino levulinic acid inhibits SARS-CoV-2 infection in\u00a0vitro","volume":"545","author":"Sakurai","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2024.111477_bib109","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s41182-021-00397-x","article-title":"Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2","volume":"50","author":"Ngwe Tun","year":"2022","journal-title":"Trop. Med. Health"},{"key":"10.1016\/j.isci.2024.111477_bib110","first-page":"15","article-title":"Phase 2 randomized clinical trial of 5-Aminolevulinic acid plus sodium citrate chloride vs placebo for Covid-19 infected patients recovered with sequelae","volume":"10","author":"Imamura","year":"2021","journal-title":"ALA-Porphyrin Science"},{"key":"10.1016\/j.isci.2024.111477_bib111","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.nutres.2014.04.013","article-title":"Type 2 diabetic conditions in Otsuka Long-Evans Tokushima Fatty rats are ameliorated by 5-aminolevulinic acid","volume":"34","author":"Sato","year":"2014","journal-title":"Nutr. Res."},{"key":"10.1016\/j.isci.2024.111477_bib112","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/oby.23705","article-title":"Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health","volume":"31","author":"Kitamura","year":"2023","journal-title":"Obesity"},{"key":"10.1016\/j.isci.2024.111477_bib113","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3892\/etm.2021.10889","article-title":"5-Aminolevulinic acid combined with ferrous iron improves glucose tolerance in high-fat diet-fed mice via upregulation of glucose transporter 1","volume":"22","author":"Kuroda","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.isci.2024.111477_bib114","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbrc.2016.09.156","article-title":"5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through MAPK-Nrf-2-HO-1 signaling cascade","volume":"479","author":"Zhao","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2024.111477_bib115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000489751","article-title":"5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Alleviates Atherosclerosis via Enhancing Efferocytosis and Facilitating a Shift in the Th1\/Th2 Balance Toward Th2 Polarization","volume":"47","author":"Yang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.isci.2024.111477_bib116","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1536\/ihj.21-233","article-title":"Sonodynamic Therapy Promotes Efferocytosis via CD47 Down-Regulation in Advanced Atherosclerotic Plaque","volume":"63","author":"Cao","year":"2022","journal-title":"Int. Heart J."},{"key":"10.1016\/j.isci.2024.111477_bib117","doi-asserted-by":"crossref","first-page":"483","DOI":"10.24976\/Discov.Med.202335177.49","article-title":"Low Dose of 5-Aminolevulinic Acid Hydrochloride Alleviates the Damage in Cardiomyocytes Induced by Lenvatinib via PI3K\/AKT Signaling Pathway","volume":"35","author":"Shi","year":"2023","journal-title":"Discov. Med."},{"key":"10.1016\/j.isci.2024.111477_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165838","article-title":"Mitochondrial dysfunction in metabolic syndrome","volume":"1866","author":"Prasun","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.isci.2024.111477_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.focha.2023.100335","article-title":"Metabolic syndrome: risk factors, diagnosis, pathogenesis, and management with natural approaches","volume":"3","author":"Mohamed","year":"2023","journal-title":"Food Chem. Adv."},{"key":"10.1016\/j.isci.2024.111477_bib120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.15407\/fz68.01.020","article-title":"Effect of epigallocatechin-3-gallate and quercetin on the production of reactive oxygen and nitrogen species in liver of rats exposed to round-the-clock light and kept on carbohydrate-lipid diet","volume":"68","author":"Frenkel\u2019","year":"2022","journal-title":"Fiziol. Zh."},{"key":"10.1016\/j.isci.2024.111477_bib121","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/pathophysiology30010005","article-title":"Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting","volume":"30","author":"Frenkel","year":"2023","journal-title":"Pathophysiology"},{"key":"10.1016\/j.isci.2024.111477_bib122","first-page":"48","article-title":"Resveratrol attenuates the development of nitro-oxidative stress in the liver of rats under a round-the-clock lighting and high-carbohydrate-lipid diet","volume":"30","author":"Frenkel","year":"2023","journal-title":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases"},{"key":"10.1016\/j.isci.2024.111477_bib123","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of Type 2 Diabetes Mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib124","series-title":"Endotext [Internet]","first-page":"1","article-title":"Pathogenesis of Type 2 Diabetes Mellitus","author":"Solis-Herrera","year":"2000"},{"key":"10.1016\/j.isci.2024.111477_bib125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260400","article-title":"Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells","volume":"16","author":"Kaur","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.111477_bib126","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210151","article-title":"Five-Aminolevulinic Acid (5-ALA) Induces Heme Oxygenase-1 and Ameliorates Palmitic Acid-Induced Endoplasmic Reticulum Stress in Renal Tubules","volume":"24","author":"Hamada","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111477_bib127","article-title":"Safety and efficacy of 5-aminolevulinic acid phosphate\/iron in mild-to-moderate coronavirus disease 2019: A randomized exploratory phase II trial","volume":"102","author":"Tanaka","year":"2023","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.isci.2024.111477_bib128","doi-asserted-by":"crossref","DOI":"10.3390\/nu15132866","article-title":"Efficacy and Safety of 5-Aminolevulinic Acid Combined with Iron on Skeletal Muscle Mass Index and Physical Performance of Patients with Sarcopenia: A Multicenter, Double-Blinded, Randomized-Controlled Trial (ALADDIN Study)","volume":"15","author":"Tamura","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2024.111477_bib129","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/geriatrics3020017","article-title":"The Relationship of 5-Aminolevulinic Acid on Mood and Coping Ability in Prediabetic Middle Aged and Older Adults","volume":"3","author":"Aquino","year":"2018","journal-title":"Geriatrics"},{"key":"10.1016\/j.isci.2024.111477_bib130","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72763-4","article-title":"Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study","volume":"10","author":"Higashikawa","year":"2020","journal-title":"Sci. Rep."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224027044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224027044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:22:56Z","timestamp":1783459376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224027044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":130,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2589004224027044"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.111477","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.111477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111477"}}