{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:27:51Z","timestamp":1786415271670,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01KI2013"],"award-info":[{"award-number":["01KI2013"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021372","name":"HW & J. Hector Foundation","doi-asserted-by":"publisher","award":["M2102"],"award-info":[{"award-number":["M2102"]}],"id":[{"id":"10.13039\/501100021372","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.isci.2025.111949","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T19:15:46Z","timestamp":1738610146000},"page":"111949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Coronavirus replicase epitopes induce cross-reactive CD8 T\u00a0cell responses in SARS-CoV-2-naive people with HIV-1"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-6933","authenticated-orcid":false,"given":"Katja G.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Gei\u00dfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2469-9501","authenticated-orcid":false,"given":"Ev-Marie","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sch\u00fclein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen G.","family":"Harrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Sch\u00f6nau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Luber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Spriewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Steininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Ensser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Schober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystelle","family":"Nganou-Makamdop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-3241","authenticated-orcid":false,"given":"Thomas","family":"Harrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.111949_bib1","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2025.111949_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N.\u00a0Engl. J. Med. Overseas. Ed."},{"key":"10.1016\/j.isci.2025.111949_bib3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41586-020-2814-7","article-title":"Synergistic Effect Enables Aqueous Zinc-Ion Batteries to Operate at High Temperatures","volume":"586","author":"Sahin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.111949_bib4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJMoa2117608","article-title":"Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S","volume":"386","author":"Sadoff","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2025.111949_bib5","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1016\/j.vaccine.2023.04.058","article-title":"Efficacy of primary series AZD1222 (ChAdOx1 nCoV-19) vaccination against SARS-CoV-2 variants of concern: Final analysis of a randomized, placebo-controlled, phase 1b\/2 study in South African adults (COV005)","volume":"41","author":"Koen","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.isci.2025.111949_bib6","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa2119451","article-title":"Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant","volume":"386","author":"Andrews","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2025.111949_bib7","author":"Kirsebom","year":"2023","journal-title":"medRxiv"},{"key":"10.1016\/j.isci.2025.111949_bib8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41590-021-01122-w","article-title":"The T\u00a0cell immune response against SARS-CoV-2","volume":"23","author":"Moss","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41590-021-01084-z","article-title":"An immunodominant NP105\u2013113-B\u2217 07: 02 cytotoxic T\u00a0cell response controls viral replication and is associated with less severe COVID-19 disease","volume":"23","author":"Peng","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41586-021-04186-8","article-title":"Pre-existing polymerase-specific T\u00a0cells expand in abortive seronegative SARS-CoV-2","volume":"601","author":"Swadling","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.111949_bib11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41467-021-27674-x","article-title":"Cross-reactive memory T\u00a0cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts","volume":"13","author":"Kundu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.111949_bib12","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cell.2020.05.015","article-title":"Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals","volume":"181","author":"Grifoni","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.111949_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.abd3871","article-title":"Selective and cross-reactive SARS-CoV-2 T\u00a0cell epitopes in unexposed humans","volume":"370","author":"Mateus","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.111949_bib14","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.immuni.2021.04.006","article-title":"CD8+ T\u00a0cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses","volume":"54","author":"Lineburg","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2025.111949_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.627568","article-title":"SARS-CoV-2-Seronegative Subjects Target CTL Epitopes in the SARS-CoV-2 Nucleoprotein Cross-Reactive to Common Cold Coronaviruses","volume":"12","author":"Schmidt","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib16","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.immuni.2021.04.009","article-title":"CD8+ T\u00a0cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity","volume":"54","author":"Nguyen","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2025.111949_bib17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2598-9","article-title":"SARS-CoV-2-reactive T\u00a0cells in healthy donors and patients with COVID-19","volume":"587","author":"Braun","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.111949_bib18","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1086\/597093","article-title":"Incomplete Peripheral CD4+ Cell Count Restoration in HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment","volume":"48","author":"Kelley","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2025.111949_bib19","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.4161\/hv.21827","article-title":"Immune reconstitution and vaccination outcome in HIV-1 infected children","volume":"8","author":"Cagigi","year":"2012","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.isci.2025.111949_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00005792-200205000-00005","article-title":"Immune Reconstitution Inflammatory Syndrome: Emergence of a Unique Syndrome During Highly Active Antiretroviral Therapy","volume":"81","author":"Shelburne","year":"2002","journal-title":"Medicine"},{"key":"10.1016\/j.isci.2025.111949_bib21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/COH.0000000000000088","article-title":"Coinhibitory receptors and CD8 T\u00a0cell exhaustion in chronic infections","volume":"9","author":"Kuchroo","year":"2014","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.isci.2025.111949_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.634489","article-title":"Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment","volume":"12","author":"Turner","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib23","first-page":"644","article-title":"Dynamic Perturbations of the T-Cell Receptor Repertoire in Chronic HIV Infection and following Antiretroviral Therapy","volume":"6","author":"Heather","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib24","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1089\/08892220050195838","article-title":"Longitudinal changes in CD4+ T\u00a0cell antigen receptor diversity and naive\/memory cell phenotype during 9 to 26\u00a0months of antiretroviral therapy of HIV-infected patients","volume":"16","author":"Gea-Banacloche","year":"2000","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.isci.2025.111949_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s002510050595","article-title":"SYFPEITHI: database for MHC ligands and peptide motifs","volume":"50","author":"Rammensee","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/j.isci.2025.111949_bib26","doi-asserted-by":"crossref","first-page":"D339","DOI":"10.1093\/nar\/gky1006","article-title":"The Immune Epitope Database (IEDB): 2018 update","volume":"47","author":"Vita","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2025.111949_bib27","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.4049\/jimmunol.1401689","article-title":"Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule","volume":"193","author":"Rasmussen","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib28","article-title":"Quality of vaccination-induced T\u00a0cell responses is conveyed by polyclonality and high, but not maximum, antigen receptor avidity","author":"Kocher","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2025.111949_bib29","first-page":"757","article-title":"CoVariants: SARS-CoV-2 Mutations and Variants of Interest","volume":"22","author":"Hodcroft","year":"2021","journal-title":"Nature Rev. Genet."},{"key":"10.1016\/j.isci.2025.111949_bib30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41591-020-01143-2","article-title":"Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T\u00a0cells","volume":"27","author":"Schulien","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2025.111949_bib31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41590-020-00808-x","article-title":"SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T\u00a0cell recognition","volume":"22","author":"Nelde","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-020-2550-z","article-title":"SARS-CoV-2-specific T\u00a0cell immunity in cases of COVID-19 and SARS, and uninfected controls","volume":"584","author":"Le Bert","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.111949_bib33","article-title":"Systematic Review and Meta-Analyses of The Interaction Between HIV Infection And COVID-19: Two Years' Evidence Summary","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib34","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1038\/s41467-024-46673-2","article-title":"Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation","volume":"15","author":"Karim","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.111949_bib35","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1038\/s41467-021-26137-7","article-title":"Characterization of humoral and SARS-CoV-2 specific T\u00a0cell responses in people living with HIV","volume":"12","author":"Alrubayyi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.111949_bib36","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/joim.13419","article-title":"Humoral response to two doses of BNT162b2 vaccination in people with HIV","volume":"291","author":"Heftdal","year":"2022","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.isci.2025.111949_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/v14030651","article-title":"Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 Infection","volume":"14","author":"Schmidt","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.isci.2025.111949_bib38","doi-asserted-by":"crossref","first-page":"e552","DOI":"10.1093\/cid\/ciac238","volume":"75","author":"Antinori","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2025.111949_bib39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41423-023-01087-w","article-title":"The immune response to SARS-CoV-2 in people with HIV","volume":"21","author":"H\u00f6ft","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib40","article-title":"Humoral and cell-mediated immune responses in HIV-vertically infected young patients after three doses of the BNT162b2 mRNA SARS-CoV-2 vaccine","volume":"14","author":"Vanetti","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib41","article-title":"T cell receptor \u03b2 repertoires in patients with COVID-19 reveal disease severity signatures","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110952","article-title":"Broadly recognized, cross-reactive SARS-CoV-2 CD4 T\u00a0cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles","volume":"39","author":"Becerra-Artiles","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.111949_bib43","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.4049\/jimmunol.1600582","article-title":"Pan-Specific Prediction of Peptide\u2013MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity","volume":"197","author":"Rasmussen","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib44","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/eji.201141774","article-title":"Peptide-MHC class I stability is a better predictor than peptide affinity of CTL immunogenicity","volume":"42","author":"Harndahl","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109378","article-title":"HLA class-I-peptide stability mediates CD8+ T\u00a0cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV","volume":"36","author":"Kaseke","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.111949_bib46","article-title":"Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2","volume":"2","author":"Wilson","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.isci.2025.111949_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2378","article-title":"The association of human leucocyte antigen (HLA) alleles with COVID-19 severity: A systematic review and meta-analysis","volume":"33","author":"Dobrijevi\u0107","year":"2023","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.isci.2025.111949_bib48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s43042-023-00390-5","article-title":"HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review","volume":"24","author":"Fakhkhari","year":"2023","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"10.1016\/j.isci.2025.111949_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0285712","article-title":"HLA class I associations with the severity of COVID-19 disease in the United Arab Emirates","volume":"18","author":"Tay","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.111949_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.769900","article-title":"HLA-C\u221704:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 Severity","volume":"13","author":"Hovhannisyan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101099","article-title":"Increased risk of severe clinical course of COVID-19 in carriers of HLA-C\u221704:01","volume":"40","author":"Weiner","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.isci.2025.111949_bib52","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1002\/jmv.27003","article-title":"Association between the HLA genotype and the severity of COVID-19 infection among South Asians","volume":"93","author":"Naemi","year":"2021","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.isci.2025.111949_bib53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s40001-021-00560-4","article-title":"Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19","volume":"26","author":"Fischer","year":"2021","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.isci.2025.111949_bib54","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1126\/science.1195271","article-title":"The major genetic determinants of HIV-1 control affect HLA class I peptide presentation","volume":"330","author":"Pereyra","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.111949_bib55","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.4049\/jimmunol.181.7.4874","article-title":"Large scale mass spectrometric profiling of peptides eluted from HLA molecules reveals N-terminal-extended peptide motifs","volume":"181","author":"Escobar","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib56","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41423-023-01116-8","article-title":"In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms","volume":"21","author":"Cankat","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.isci.2025.111949_bib61","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41551-019-0409-0","article-title":"Orthotopic replacement of T-cell receptor \u03b1- and \u03b2-chains with preservation of near-physiological T-cell function","volume":"3","author":"Schober","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.isci.2025.111949_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2020.104468","article-title":"Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies","volume":"129","author":"Beavis","year":"2020","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.isci.2025.111949_bib58","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1515\/cclm-2021-0023","article-title":"Evaluation of the automated LIAISON\u00ae SARS-CoV-2 TrimericS IgG assay for the detection of circulating antibodies","volume":"59","author":"Bonelli","year":"2021","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.isci.2025.111949_bib59","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cca.2020.09.002","article-title":"Evaluation of Abbott anti-SARS-CoV-2 CMIA IgG and Euroimmun ELISA IgG\/IgA assays in a clinical lab","volume":"510","author":"Manalac","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.isci.2025.111949_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.101031","article-title":"Orthotopic T-cell receptor replacement in primary human T\u00a0cells using CRISPR-Cas9-mediated homology-directed repair","volume":"3","author":"Moosmann","year":"2022","journal-title":"STAR Protoc."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225002093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225002093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T01:31:46Z","timestamp":1786411906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225002093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2589004225002093"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.111949","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coronavirus replicase epitopes induce cross-reactive CD8 T\u00a0cell responses in SARS-CoV-2-naive people with HIV-1","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.111949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111949"}}