{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:50:45Z","timestamp":1785235845561,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","award":["218218"],"award-info":[{"award-number":["218218"]}],"id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH NIGMS","doi-asserted-by":"publisher","award":["3P20GM103434-21S2"],"award-info":[{"award-number":["3P20GM103434-21S2"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.isci.2025.112143","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T18:31:41Z","timestamp":1740853901000},"page":"112143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dual targeting of CXCR4 and EZH2 in endometriosis"],"prefix":"10.1016","volume":"28","author":[{"given":"Sarah","family":"Brunty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassey","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Fleshman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Ruley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-6081","authenticated-orcid":false,"given":"Nalini","family":"Santanam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.112143_bib1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/1471-0528.16447","article-title":"Prevalence and incidence of endometriosis in Australian women: a data linkage cohort study","volume":"128","author":"Rowlands","year":"2021","journal-title":"BJOG"},{"key":"10.1016\/j.isci.2025.112143_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41591-024-02795-0","article-title":"Surge in endometriosis research after decades of underfunding could herald new era for women's health","volume":"30","author":"Watson","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2025.112143_bib3","first-page":"28","article-title":"Endometriosis: From Identification to Management Clinician Reviews","volume":"27","author":"Curtis","year":"2017","journal-title":"Clin. Rev."},{"key":"10.1016\/j.isci.2025.112143_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10815-010-9436-1","article-title":"Endometriosis and infertility","volume":"27","author":"Bulletti","year":"2010","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"key":"10.1016\/j.isci.2025.112143_bib5","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-9378(15)30003-X","article-title":"Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity","volume":"14","author":"Sampson","year":"1927","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.isci.2025.112143_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000052855","article-title":"Coelomic metaplasia theory of endometriosis: evidence from in\u00a0vivo studies and an in\u00a0vitro experimental model","volume":"47","author":"Matsuura","year":"1999","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.isci.2025.112143_bib7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/cge.12897","article-title":"Recent insights on the genetics and epigenetics of endometriosis","volume":"91","author":"Borghese","year":"2017","journal-title":"Clin. Genet."},{"key":"10.1016\/j.isci.2025.112143_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/795976","article-title":"Pathophysiology and Immune Dysfunction in Endometriosis","volume":"2015","author":"Ahn","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.isci.2025.112143_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1196\/annals.1434.014","article-title":"Stem cells and the pathogenesis of endometriosis","volume":"1127","author":"Sasson","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib10","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/01.j.pain.0000460321.72396.88","article-title":"Oxidation-sensitive nociception involved in endometriosis-associated pain","volume":"156","author":"Ray","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.isci.2025.112143_bib11","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.redox.2017.04.037","article-title":"Redox regulation of microRNAs in endometriosis-associated pain","volume":"12","author":"Wright","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2025.112143_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-2007-1016286","article-title":"Endometriosis: a disease of oxidative stress?","volume":"16","author":"Murphy","year":"1998","journal-title":"Semin. Reprod. Endocrinol."},{"key":"10.1016\/j.isci.2025.112143_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2002.tb02779.x","article-title":"Macrophages, oxidation, and endometriosis","volume":"955","author":"Santanam","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.trsl.2012.05.001","article-title":"Antioxidant supplementation reduces endometriosis-related pelvic pain in humans","volume":"161","author":"Santanam","year":"2013","journal-title":"Transl. Res."},{"key":"10.1016\/j.isci.2025.112143_bib15","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1080\/1071576021000049908","article-title":"Atherosclerosis, oxidation and endometriosis","volume":"36","author":"Santanam","year":"2002","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.isci.2025.112143_bib16","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0015-0282(99)00145-4","article-title":"Autoantibodies to markers of oxidative stress are elevated in women with endometriosis","volume":"71","author":"Shanti","year":"1999","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2025.112143_bib17","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.molmed.2018.07.004","article-title":"The Immunopathophysiology of Endometriosis","volume":"24","author":"Symons","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.isci.2025.112143_bib18","first-page":"1287","article-title":"Inflammatory cytokine profile of cocultivated primary cells from the endometrium of women with and without endometriosis","volume":"18","author":"Luckow Invitti","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.isci.2025.112143_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics13050868","article-title":"Similarities in Pathogenetic Mechanisms Underlying the Bidirectional Relationship between Endometriosis and Pelvic Inflammatory Disease","volume":"13","author":"Kobayashi","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.isci.2025.112143_bib20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/HUMREP\/11.2.380","article-title":"Peritoneal fluid cytokines and the relationship with endometriosis and pain","volume":"11","author":"Overton","year":"1996","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2025.112143_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103515","article-title":"Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes","volume":"21","author":"Zhou","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031518","article-title":"Endometriosis: An Inflammatory Disease That Requires New Therapeutic Options","volume":"23","author":"Donnez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib23","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.fertnstert.2004.02.133","article-title":"Effects of oxidants and antioxidants on proliferation of endometrial stromal cells","volume":"82","author":"Foyouzi","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2025.112143_bib24","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3389\/fimmu.2020.02109","article-title":"The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration","volume":"11","author":"Bianchi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.112143_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12958-018-0333-2","article-title":"Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7","volume":"16","author":"Zheng","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.isci.2025.112143_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.574667","article-title":"The Role of the CXCL12\/CXCR4\/CXCR7 Chemokine Axis in Cancer","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2025.112143_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jri.2013.12.121","article-title":"Role of the CXCL12-CXCR4 axis in the development of deep rectal endometriosis","volume":"103","author":"Leconte","year":"2014","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.isci.2025.112143_bib28","doi-asserted-by":"crossref","first-page":"FDD77","DOI":"10.4155\/fdd-2022-0007","article-title":"CXCR4 as a novel target in immunology: moving away from typical antagonists","volume":"4","author":"Caspar","year":"2022","journal-title":"Future Drug Discov."},{"key":"10.1016\/j.isci.2025.112143_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012499","article-title":"Targeting CXCR4 and CD47 Receptors: An Overview of New and Old Molecules for a Biological Personalized Anticancer Therapy","volume":"23","author":"Leo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-5793(02)03143-5","article-title":"Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4","volume":"527","author":"Hatse","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2025.112143_bib31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/biolre\/iox152","article-title":"Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion","volume":"98","author":"Ruiz","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112143_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073492","article-title":"Peritoneal Modulators of EZH2-miR-155 Cross-Talk in Endometriosis","volume":"22","author":"Brunty","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib33","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1021\/acs.biochem.5b01191","article-title":"PRC2 and SWI\/SNF Chromatin Remodeling Complexes in Health and Disease","volume":"55","author":"Kadoch","year":"2016","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2025.112143_bib34","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1038\/s41467-018-05728-x","article-title":"Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms","volume":"9","author":"Chan","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.112143_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrfmmm.2008.07.010","article-title":"Roles of the EZH2 histone methyltransferase in cancer epigenetics","volume":"647","author":"Simon","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.isci.2025.112143_bib36","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1016\/j.celrep.2018.11.035","article-title":"Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator","volume":"25","author":"Kim","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.112143_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4036","article-title":"Targeting EZH2 in cancer","volume":"22","author":"Kim","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2025.112143_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4143\/crt.2014.46.3.209","article-title":"Regulation and Role of EZH2 in Cancer","volume":"46","author":"Yamaguchi","year":"2014","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.isci.2025.112143_bib39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/jb\/mvu054","article-title":"Targeting histone methyltransferase EZH2 as cancer treatment","volume":"156","author":"Kondo","year":"2014","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.isci.2025.112143_bib40","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1080\/10428194.2018.1430795","article-title":"Enhancer of zeste homolog 2 (EZH2) inhibitors","volume":"59","author":"Gulati","year":"2018","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.isci.2025.112143_bib41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/biolre\/ioy030","article-title":"Effects of histone methyltransferase inhibition in endometriosis","volume":"99","author":"Colon-Caraballo","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112143_bib42","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1038\/s41598-017-06920-7","article-title":"Enhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.112143_bib43","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature11606","article-title":"EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations","volume":"492","author":"McCabe","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.112143_bib44","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1007\/s43032-020-00257-9","article-title":"Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis","volume":"27","author":"Seguinot-Tarafa","year":"2020","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib45","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1038\/ncomms9494","article-title":"EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma","volume":"6","author":"Liu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.112143_bib46","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.4049\/jimmunol.0804272","article-title":"CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells","volume":"182","author":"Caron","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2025.112143_bib47","first-page":"27","article-title":"Morphoproteomics Identifies SIRT1, EZH2 and CXCR4 Pathways in Diffuse Large B-Cell Lymphoma: Therapeutic Implications","volume":"52","author":"Brown","year":"2022","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40164-023-00405-2","article-title":"EZH2 in hepatocellular carcinoma: progression, immunity, and potential targeting therapies","volume":"12","author":"Wang","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.isci.2025.112143_bib49","doi-asserted-by":"crossref","first-page":"61775","DOI":"10.18632\/oncotarget.11240","article-title":"A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma","volume":"7","author":"Krook","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2025.112143_bib50","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.fertnstert.2016.07.1075","article-title":"Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis","volume":"106","author":"Donnez","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2025.112143_bib51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2002.tb02779.x","article-title":"Macrophages, oxidation, and endometriosis","volume":"955","author":"Santanam","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib52","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.redox.2017.04.037","article-title":"Redox regulation of microRNAs in endometriosis-associated pain","volume":"12","author":"Wright","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2025.112143_bib53","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1096\/fasebj.31.1_supplement.1058.1","article-title":"Dissecting the role of EZH2 and H3K27me3 in endometriosis","volume":"31","author":"Colon-Caraballo","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.isci.2025.112143_bib54","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3727\/096504015X14343704124430","article-title":"CXCL12-CXCR4 Axis Promotes Proliferation, Migration, Invasion, and Metastasis of Ovarian Cancer","volume":"22","author":"Guo","year":"2014","journal-title":"Oncol. Res."},{"key":"10.1016\/j.isci.2025.112143_bib55","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1111\/jcmm.14933","article-title":"CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking","volume":"24","author":"Pluchino","year":"2020","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.isci.2025.112143_bib56","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1084\/jem.20180801","article-title":"Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities","volume":"215","author":"Serresi","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2025.112143_bib57","article-title":"CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.112143_bib58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2019.03.011","article-title":"Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation","volume":"74","author":"Laugesen","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2025.112143_bib59","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1016\/j.fertnstert.2009.04.042","article-title":"Treatment of endometriosis with a VEGF-targeted conditionally replicative adenovirus","volume":"93","author":"Rein","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2025.112143_bib60","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI118815","article-title":"Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids","volume":"98","author":"McLaren","year":"1996","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.isci.2025.112143_bib61","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1097\/JTO.0b013e31818dda9d","article-title":"The CXCR4\/SDF-1 chemokine receptor axis: a new target therapeutic for non-small cell lung cancer","volume":"3","author":"Otsuka","year":"2008","journal-title":"J.\u00a0Thorac. Oncol."},{"key":"10.1016\/j.isci.2025.112143_bib62","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/humrep\/der043","article-title":"Expression of CXCL12 and CXCR4 in human endometrium; effects of CXCL12 on MMP production by human endometrial cells","volume":"26","author":"Laird","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2025.112143_bib63","article-title":"Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis\/adenomyosis","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.112143_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/srep30155","article-title":"Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists","volume":"6","author":"Mishra","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.112143_bib65","doi-asserted-by":"crossref","first-page":"40402","DOI":"10.18632\/oncotarget.16316","article-title":"Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer","volume":"8","author":"Oki","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2025.112143_bib66","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225004031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225004031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T20:16:18Z","timestamp":1753733778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225004031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S2589004225004031"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.112143","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual targeting of CXCR4 and EZH2 in endometriosis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.112143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112143"}}