{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:25:32Z","timestamp":1792693532834,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["860960"],"award-info":[{"award-number":["860960"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["BOF22\/ITN\/036"],"award-info":[{"award-number":["BOF22\/ITN\/036"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C1-C14\/22\/125"],"award-info":[{"award-number":["C1-C14\/22\/125"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["I001818N"],"award-info":[{"award-number":["I001818N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0C6120N"],"award-info":[{"award-number":["G0C6120N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G088621N"],"award-info":[{"award-number":["G088621N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["813707"],"award-info":[{"award-number":["813707"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.isci.2025.112337","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:53:11Z","timestamp":1743641591000},"page":"112337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Origin and development of uniparental and polyploid blastomeres"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-705X","authenticated-orcid":false,"given":"Yan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fern\u00e1ndez-Montoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greet","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Jatsenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"De Coster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Angel-Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lefevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Voet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"T\u0161uiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ants","family":"Kurg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Van Soom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris Robert","family":"Vermeesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.112337_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nm.1924","article-title":"Chromosome instability is common in human cleavage-stage embryos","volume":"15","author":"Vanneste","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2025.112337_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1469-1809.1980.tb00955.x","article-title":"A cytogenetic study of 1000 spontaneous abortions","volume":"44","author":"Hassold","year":"1980","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/pd.5895","article-title":"Genome-wide abnormalities in embryos: Origins and clinical consequences","volume":"41","author":"Masset","year":"2021","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.isci.2025.112337_bib5","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1086\/302951","article-title":"Parental origin and phenotype of triploidy in spontaneous abortions: Predominance of diandry and association with the partial hydatidiform mole","volume":"66","author":"Zaragoza","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ajmg.1320250216","article-title":"Long survival in a 69,XXY triploid male","volume":"25","author":"Sherard","year":"1986","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2025.112337_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2020.103971","article-title":"Natural human chimeras: A review","volume":"63","author":"Madan","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib9","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/humrep\/dex286","article-title":"Genome stability of bovine in vivo-conceived cleavage-stage embryos is higher compared to in vitro-produced embryos","volume":"32","author":"T\u0161uiko","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0897.2010.00900.x","article-title":"Medawar redux - an overview on the use of farm animal models to elucidate principles of reproductive immunology","volume":"64","author":"Hansen","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.isci.2025.112337_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1477-7827-12-117","article-title":"Usefulness of bovine and porcine IVM\/IVF models for reproductive toxicology","volume":"12","author":"Santos","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.isci.2025.112337_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000130095","article-title":"Diploid-triploid chimerism in a bovine true hermaphrodite","volume":"9","author":"Dunn","year":"1970","journal-title":"Cytogenetics (Basel)"},{"key":"10.1016\/j.isci.2025.112337_bib13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1101\/gr.200527.115","article-title":"Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage-stage chimerism and mixoploidy","volume":"26","author":"Destouni","year":"2016","journal-title":"Genome Res."},{"key":"10.1016\/j.isci.2025.112337_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/plac.2002.0872","article-title":"A Mola Hydatidosa Coexistent with a Foetus in a Bovine Freemartin Pregnancy","volume":"24","author":"Meinecke","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.isci.2025.112337_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-022-02763-2","article-title":"Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts","volume":"23","author":"De Coster","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2025.112337_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1101\/gr.239830.118","article-title":"Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion","volume":"29","author":"Daughtry","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.isci.2025.112337_bib17","doi-asserted-by":"crossref","first-page":"9744","DOI":"10.1038\/s41598-017-09693-1","article-title":"Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro","volume":"7","author":"Ottolini","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.112337_bib18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00439-013-1309-0","article-title":"The origin and impact of embryonic aneuploidy","volume":"132","author":"Fragouli","year":"2013","journal-title":"Hum. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib19","article-title":"A multi-omics genome-and-transcriptome single-cell atlas of human preimplantation embryogenesis reveals the cellular and molecular impact of chromosome instability","author":"Gallardo","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2025.112337_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41525-021-00246-0","article-title":"Haplotyping-based preimplantation genetic testing reveals parent-of-origin specific mechanisms of aneuploidy formation","volume":"6","author":"T\u0161uiko","year":"2021","journal-title":"NPJ Genom. Med."},{"key":"10.1016\/j.isci.2025.112337_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/vr.137.1.15","article-title":"Production of four identical calves by the separation of blastomeres from an in vitro derived four-cell embryo","volume":"137","author":"Johnson","year":"1995","journal-title":"Vet. Rec."},{"key":"10.1016\/j.isci.2025.112337_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1530\/jrf.0.0590357","article-title":"The viability of early cleavage stages containing half the normal number of blastomeres in the sheep","volume":"59","author":"Willadsen","year":"1980","journal-title":"Reproduction"},{"key":"10.1016\/j.isci.2025.112337_bib23","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1093\/nar\/gkac134","article-title":"Single-cell genome-wide concurrent haplotyping and copy-number profiling through genotyping-by-sequencing","volume":"50","author":"Masset","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2025.112337_bib24","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ajhg.2015.04.011","article-title":"Concurrent Whole-Genome Haplotyping and Copy-Number Profiling of Single Cells","volume":"96","author":"Zamani Esteki","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib25","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1038\/s41467-022-34294-6","article-title":"The first mitotic division of human embryos is highly error prone","volume":"13","author":"Currie","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.112337_bib26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1095\/biolreprod37.2.395","article-title":"Tripronuclear human oocytes: altered cleavage patterns and subsequent karyotypic analysis of embryos","volume":"37","author":"Kola","year":"1987","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166398","article-title":"Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome","volume":"11","author":"Zhan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.112337_bib28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/humrep\/deh652","article-title":"Spindle abnormalities in normally developing and arrested human preimplantation embryos in vitro identified by confocal laser scanning microscopy","volume":"20","author":"Chatzimeletiou","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.theriogenology.2012.01.021","article-title":"Porcine androgenetic embryos develop to fetal stage in recipient mothers","volume":"78","author":"Sembon","year":"2012","journal-title":"Theriogenology"},{"key":"10.1016\/j.isci.2025.112337_bib30","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1095\/biolreprod67.2.386","article-title":"Comparison of gene expression during preimplantation development between diploid and haploid mouse embryos","volume":"67","author":"Latham","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/mrd.20736","article-title":"Quantitative analysis of mitochondrial RNA in goat\u2013sheep cloned embryos","volume":"75","author":"Ma","year":"2008","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.isci.2025.112337_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-3-65","article-title":"Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors","volume":"3","author":"May-Panloup","year":"2005","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.isci.2025.112337_bib33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/mrd.20260","article-title":"Molecular control of mitochondrial function in preimplantation mouse embryos","volume":"71","author":"Thundathil","year":"2005","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.isci.2025.112337_bib34","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.stem.2019.09.004","article-title":"Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development","volume":"25","author":"Leng","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2025.112337_bib35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ydbio.2012.12.008","article-title":"Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse","volume":"375","author":"Niakan","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2025.112337_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2023.107229","article-title":"Species-specific molecular differentiation of embryonic inner cell mass and trophectoderm: A systematic review","volume":"252","author":"Marsico","year":"2023","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.isci.2025.112337_bib37","first-page":"876","article-title":"Genetic redundancy of GATA factors in the extraembryonic trophoblast lineage ensures the progression of preimplantation and postimplantation mammalian development","volume":"144","author":"Home","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.isci.2025.112337_bib38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-020-2759-x","article-title":"Initiation of a conserved trophectoderm program in human, cow and mouse embryos","volume":"587","author":"Gerri","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.112337_bib39","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1095\/biolreprod.113.108993","article-title":"Transcriptional Wiring for Establishing Cell Lineage Specification at the Blastocyst Stage in Cattle1","volume":"88","author":"Nagatomo","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1530\/REP-17-0345","article-title":"Single-cell gene expression of the bovine blastocyst","volume":"154","author":"Negr\u00f3n-P\u00e9rez","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.isci.2025.112337_bib41","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1038\/sj.onc.1207615","article-title":"PRDM5 is silenced in human cancers and has growth suppressive activities","volume":"23","author":"Deng","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2025.112337_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027346","article-title":"The Epigenetic Modifier PRDM5 Functions as a Tumor Suppressor through Modulating WNT\/\u03b2-Catenin Signaling and Is Frequently Silenced in Multiple Tumors","volume":"6","author":"Shu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.112337_bib43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1095\/biolreprod.106.051722","article-title":"Bovine SNRPN Methylation Imprint in Oocytes and Day 17 In Vitro-Produced and Somatic Cell Nuclear Transfer Embryos","volume":"75","author":"Lucifero","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrg2398","article-title":"Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation","volume":"9","author":"L\u00f3pez-Maury","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib45","doi-asserted-by":"crossref","first-page":"21602","DOI":"10.1038\/srep21602","article-title":"Smad2 and Smad3 have differential sensitivity in relaying TGF\u03b2 signaling and inversely regulate early lineage specification","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.112337_bib46","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrc2439","article-title":"MYB function in normal and cancer cells","volume":"8","author":"Ramsay","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2025.112337_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skae103","article-title":"Pleomorphic adenoma gene1 in reproduction and implication for embryonic survival in cattle: a review","volume":"102","author":"D\u2019Occhio","year":"2024","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.isci.2025.112337_bib48","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/hmg\/ddr017","article-title":"Rex1\/Zfp42 as an epigenetic regulator for genomic imprinting","volume":"20","author":"Kim","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib49","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202010106","article-title":"Dual spindles assemble in bovine zygotes despite the presence of paternal centrosomes","volume":"220","author":"Schneider","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.isci.2025.112337_bib50","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1038\/sj.onc.1203131","article-title":"Regulation of translation initiation following stress","volume":"18","author":"Sheikh","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2025.112337_bib51","doi-asserted-by":"crossref","first-page":"860","DOI":"10.18632\/oncotarget.1784","article-title":"Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability","volume":"5","author":"Kim","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2025.112337_bib52","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.molonc.2011.07.007","article-title":"p53: guardian of ploidy","volume":"5","author":"Aylon","year":"2011","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.isci.2025.112337_bib53","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41418-022-00996-z","article-title":"Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?","volume":"29","author":"Thomas","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2025.112337_bib54","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10815-010-9407-6","article-title":"Genome-wide microarray evidence that 8-Cell human blastomeres over-express cell cycle drivers and under-express checkpoints","volume":"27","author":"Kiessling","year":"2010","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.isci.2025.112337_bib55","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.devcel.2017.05.022","article-title":"Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System","volume":"41","author":"Santaguida","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2025.112337_bib56","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1073\/pnas.74.12.5657","article-title":"Microsurgically produced homozygous-diploid uniparental mice","volume":"74","author":"Hoppe","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.112337_bib57","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1101\/gr.273318.120","article-title":"Parental methylome reprogramming in human uniparental blastocysts reveals germline memory transition","volume":"31","author":"Xu","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.isci.2025.112337_bib58","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1095\/biolreprod.103.026005","article-title":"Apoptosis in Parthenogenetic Preimplantation Porcine Embryos","volume":"70","author":"Hao","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ani10040622","article-title":"Developmental and Degenerative Characterization of Porcine Parthenogenetic Fetuses during Early Pregnancy","volume":"10","author":"Hwang","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.isci.2025.112337_bib60","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jez.1402570206","article-title":"Fate of haploid parthenogenetic cells in mouse chimeras during development","volume":"257","author":"Ito","year":"1991","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.isci.2025.112337_bib61","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1095\/biolreprod66.1.204","article-title":"Haploidy but Not Parthenogenetic Activation Leads to Increased Incidence of Apoptosis in Mouse Embryos","volume":"66","author":"Liu","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib62","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1242\/dev.107.3.597","article-title":"The human blastocyst: cell number, death and allocation during late preimplantation development in vitro","volume":"107","author":"Hardy","year":"1989","journal-title":"Development"},{"key":"10.1016\/j.isci.2025.112337_bib63","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1242\/dev.38.1.187","article-title":"In vitro development of haploid mouse embryos produced by bisection of one-cell fertilized eggs","volume":"38","author":"Tarkowski","year":"1977","journal-title":"Development"},{"key":"10.1016\/j.isci.2025.112337_bib64","doi-asserted-by":"crossref","DOI":"10.1242\/dev.198341","article-title":"Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions ofmammalian development","volume":"149","author":"Brooks","year":"2022","journal-title":"Development"},{"key":"10.1016\/j.isci.2025.112337_bib65","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1530\/jrf.0.0980549","article-title":"Binucleate blastomeres in preimplantation human embryos in vitro: failure of cytokinesis during early cleavage","volume":"98","author":"Hardy","year":"1993","journal-title":"Reproduction"},{"key":"10.1016\/j.isci.2025.112337_bib66","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1242\/jcs.022897","article-title":"Cytokinetic furrowing in toroidal, binucleate and anucleate cells in C. elegans embryos","volume":"121","author":"Baruni","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.isci.2025.112337_bib67","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1016\/j.cell.2023.09.010","article-title":"Cytoplasmic division cycles without the nucleus and mitotic CDK\/cyclin complexes","volume":"186","author":"Bakshi","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.112337_bib68","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/humrep\/der037","article-title":"The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting","volume":"26","author":"Balaban","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib69","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1262\/jrd.2017-041","article-title":"Selection of viable in vitro-fertilized bovine embryos using time-lapse monitoring in microwell culture dishes","volume":"63","author":"Sugimura","year":"2017","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.isci.2025.112337_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036627","article-title":"Promising System for Selecting Healthy In Vitro\u2013Fertilized Embryos in Cattle","volume":"7","author":"Sugimura","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.112337_bib71","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00404-016-4196-5","article-title":"Novel embryo selection techniques to increase embryo implantation in IVF attempts","volume":"294","author":"Sigalos","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.isci.2025.112337_bib72","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoaa017","article-title":"ESHRE PGT Consortium good practice recommendations for the detection of structural and numerical chromosomal aberrations","volume":"2020","author":"Coonen","year":"2020","journal-title":"Hum. Reprod. Open"},{"key":"10.1016\/j.isci.2025.112337_bib73","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/humrep\/dead033","article-title":"Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses","volume":"38","author":"Caroselli","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib74","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.fertnstert.2012.07.1135","article-title":"Limited implantation success of direct-cleaved human zygotes: a time-lapse study","volume":"98","author":"Rubio","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2025.112337_bib75","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.115.135483","article-title":"Next generation sequencing-based comprehensive chromosome screening in mouse polar bodies, oocytes, and embryos","volume":"94","author":"Treff","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2025.112337_bib78","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2025.112337_bib79","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"10.1016\/j.isci.2025.112337_bib82","article-title":"Haplotype-based variant detection from short-read sequencing","author":"Garrison","year":"2012","journal-title":"arXiv"},{"key":"10.1016\/j.isci.2025.112337_bib84","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2025.112337_bib85","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2025.112337_bib87","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable SCENIC workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2025.112337_bib76","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1530\/REP-14-0213","article-title":"Individual commitment to a group effect: strengths and weaknesses of bovine embryo group culture","volume":"148","author":"Wydooghe","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.isci.2025.112337_bib77","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/nprot.2016.138","article-title":"Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T-seq","volume":"11","author":"Macaulay","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2025.112337_bib80","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM","author":"Li","year":"2013","journal-title":"arXiv"},{"key":"10.1016\/j.isci.2025.112337_bib81","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8275","article-title":"Algorithms for efficiently collapsing reads with Unique Molecular Identifiers","volume":"7","author":"Liu","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.isci.2025.112337_bib83","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2025.112337_bib86","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1073\/pnas.1321569111","article-title":"Fine mapping of genome activation in bovine embryos by RNA sequencing","volume":"111","author":"Graf","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422500598X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422500598X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:47:00Z","timestamp":1776905220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422500598X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":87,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S258900422500598X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.112337","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.07.30.605883","asserted-by":"object"}]},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Origin and development of uniparental and polyploid blastomeres","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.112337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112337"}}