{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:40:07Z","timestamp":1789800007998,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.isci.2025.112392","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T16:17:27Z","timestamp":1744129047000},"page":"112392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of esketamine on the EC50 of remifentanil for suppression of choking cough during extubation"],"prefix":"10.1016","volume":"28","author":[{"given":"Shouyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liurong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.112392_bib1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bja.2019.11.033","article-title":"Intravenous lidocaine to prevent postoperative airway complications in adults: a systematic review and meta-analysis","volume":"124","author":"Yang","year":"2020","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.isci.2025.112392_bib2","doi-asserted-by":"crossref","first-page":"54S","DOI":"10.1378\/chest.129.1_suppl.54S","article-title":"Complications of cough: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Irwin","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.isci.2025.112392_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1055\/s-0038-1666825","article-title":"Thyroid Disorders and Hemostasis","volume":"44","author":"Elbers","year":"2018","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.isci.2025.112392_bib4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4097\/kjae.2011.61.4.292","article-title":"The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia","volume":"61","author":"Lee","year":"2011","journal-title":"Korean J. Anesthesiol."},{"key":"10.1016\/j.isci.2025.112392_bib5","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1213\/ANE.0000000000002647","article-title":"Alkalinized Lidocaine Preloaded Endotracheal Tube Cuffs Reduce Emergence Cough After Brief Surgery: A Prospective Randomized Trial","volume":"126","author":"Nath","year":"2018","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.isci.2025.112392_bib6","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1213\/ANE.0000000000003699","article-title":"Intravenous Lidocaine for the Prevention of Cough: Systematic Review and Meta-analysis of Randomized Controlled Trials","volume":"129","author":"Clivio","year":"2019","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.isci.2025.112392_bib7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s12630-014-0295-6","article-title":"Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial","volume":"62","author":"Lee","year":"2015","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.isci.2025.112392_bib8","first-page":"53","article-title":"Comparison of the effects of intravenous propofol and propofol with low-dose ketamine on preventing postextubation cough and laryngospasm among patients awakening from general anaesthesia: A prospective randomised clinical trial","volume":"32","author":"Chungsamarnyart","year":"2022","journal-title":"J. Perioper. Pract."},{"key":"10.1016\/j.isci.2025.112392_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108687","article-title":"Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders","volume":"196","author":"Dogra","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2025.112392_bib10","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1111\/anae.15125","article-title":"Comparison of predicted and real propofol and remifentanil concentrations in plasma and brain tissue during target-controlled infusion: a prospective observational study","volume":"75","author":"van Hese","year":"2020","journal-title":"Anaesthesia"},{"key":"10.1016\/j.isci.2025.112392_bib11","first-page":"CD009293","article-title":"Ketamine for management of acute exacerbations of asthma in children","volume":"11","author":"Jat","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.isci.2025.112392_bib12","first-page":"1069","article-title":"The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial","volume":"82","author":"Bornemann-Cimenti","year":"2016","journal-title":"Minerva Anestesiol."},{"key":"10.1016\/j.isci.2025.112392_bib13","first-page":"E1389","article-title":"Intraoperative Intravenous Infusion of Esmketamine Has Opioid-Sparing Effect and Improves the Quality of Recovery in Patients Undergoing Thoracic Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"25","author":"Yuan","year":"2022","journal-title":"Pain Physician"},{"key":"10.1016\/j.isci.2025.112392_bib14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3349\/ymj.2014.55.3.807","article-title":"Sex differences in remifentanil requirements for preventing cough during anesthetic emergence","volume":"55","author":"Soh","year":"2014","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.isci.2025.112392_bib15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/pulp.1996.0046","article-title":"Role of opioidergic and serotonergic mechanisms in cough and antitussives","volume":"9","author":"Kamei","year":"1996","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.isci.2025.112392_bib16","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/BRS.0000000000002512","article-title":"Sex Differences for Anterior Cervical Fusion: Complications and Length of Stay","volume":"43","author":"Basques","year":"2018","journal-title":"Spine"},{"key":"10.1016\/j.isci.2025.112392_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.coph.2015.03.002","article-title":"NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome","volume":"22","author":"Chung","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2025.112392_bib18","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2147\/DDDT.S401161","article-title":"Effect of Subanesthetic Dose of Esketamine on Perioperative Neurocognitive Disorders in Elderly Undergoing Gastrointestinal Surgery: A Randomized Controlled Trial","volume":"17","author":"Han","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.isci.2025.112392_bib19","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2165\/00023210-200418150-00004","article-title":"Remifentanil update: clinical science and utility","volume":"18","author":"Beers","year":"2004","journal-title":"CNS Drugs"},{"key":"10.1016\/j.isci.2025.112392_bib20","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00266-018-1103-4","article-title":"Prevention of Emergence Agitation with Ketamine in Rhinoplasty","volume":"42","author":"Demir","year":"2018","journal-title":"Aesthetic Plast. Surg."},{"key":"10.1016\/j.isci.2025.112392_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jpainsymman.2015.06.002","article-title":"Ketamine","volume":"50","author":"Quibell","year":"2015","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.isci.2025.112392_bib22","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.2147\/DDDT.S224553","article-title":"Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.isci.2025.112392_bib23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.isci.2025.112392_bib24","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.bja.2019.12.041","article-title":"Medications to reduce emergence coughing after general anaesthesia with tracheal intubation: a systematic review and network meta-analysis","volume":"124","author":"Tung","year":"2020","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.isci.2025.112392_bib25","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1002\/lary.24199","article-title":"Effect-site concentration of remifentanil to prevent cough after laryngomicrosurgery","volume":"123","author":"Chang","year":"2013","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2025.112392_bib26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1177\/147323001204000118","article-title":"Comparison of the optimal effect-site concentrations of remifentanil for preventing cough during emergence from desflurane or sevoflurane anaesthesia","volume":"40","author":"Cho","year":"2012","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.isci.2025.112392_bib27","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2147\/CIA.S108705","article-title":"Effect-site concentration of remifentanil for preventing cough during emergence in elderly patients undergoing nasal surgery: a comparison with adult patients","volume":"11","author":"Yoo","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.isci.2025.112392_bib28","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1365-2044.2012.07136.x","article-title":"Comparison of the antitussive effect of remifentanil during recovery from propofol and sevoflurane anaesthesia","volume":"67","author":"Kim","year":"2012","journal-title":"Anaesthesia"},{"key":"10.1016\/j.isci.2025.112392_bib29","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/bja\/aep090","article-title":"Targeting smooth emergence: the effect site concentration of remifentanil for preventing cough during emergence during propofol-remifentanil anaesthesia for thyroid surgery","volume":"102","author":"Lee","year":"2009","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.isci.2025.112392_bib30","article-title":"Predicting effective remifentanil concentration in 95% of patients to prevent emergence cough after laryngomicroscopic surgery","volume":"97","author":"Kim","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.isci.2025.112392_bib31","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.2147\/DDDT.S430077","article-title":"Effect of Esketamine Gargle on Postoperative Sore Throat in Patients Undergoing Double-Lumen Endobronchial Intubation: A Randomised Controlled Trial","volume":"17","author":"Liang","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.isci.2025.112392_bib32","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.biopsych.2015.08.018","article-title":"Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype","volume":"79","author":"Patrizi","year":"2016","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.isci.2025.112392_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.eplepsyres.2017.08.005","article-title":"The effect of atomoxetine, a selective norepinephrine reuptake inhibitor, on respiratory arrest and cardiorespiratory function in the DBA\/1 mouse model of SUDEP","volume":"137","author":"Zhao","year":"2017","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.isci.2025.112392_bib34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nn.3295","article-title":"Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl\u2212 homeostasis","volume":"16","author":"Ferrini","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.112392_bib35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00000542-200507000-00022","article-title":"Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine","volume":"103","author":"Joly","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.isci.2025.112392_bib36","article-title":"The effect of low-dose esketamine on pain and post-partum depression after cesarean section: A prospective, randomized, double-blind clinical trial","volume":"13","author":"Shen","year":"2022","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.isci.2025.112392_bib37","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.biopsych.2012.05.003","article-title":"Ketamine for depression: where do we go from here?","volume":"72","author":"Aan Het Rot","year":"2012","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.isci.2025.112392_bib38","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1176\/appi.ajp.2016.16010037","article-title":"A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression","volume":"173","author":"Singh","year":"2016","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.isci.2025.112392_bib39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00000542-200501000-00030","article-title":"Ketamine for perioperative pain management","volume":"102","author":"Himmelseher","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.isci.2025.112392_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2021.110437","article-title":"Impact of opioid-free anaesthesia on postoperative nausea, vomiting and pain after gynaecological laparoscopy - A randomised controlled trial","volume":"75","author":"Massoth","year":"2021","journal-title":"J. Clin. Anesth."},{"key":"10.1016\/j.isci.2025.112392_bib41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/01.anes.0000267514.42592.2a","article-title":"Advances in and limitations of up-and-down methodology: a pr\u00e9cis of clinical use, study design, and dose estimation in anesthesia research","volume":"107","author":"Pace","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.isci.2025.112392_bib42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1673\/031.003.3401","article-title":"Overlapping confidence intervals or standard error intervals: what do they mean in terms of statistical significance?","volume":"3","author":"Payton","year":"2003","journal-title":"J. Insect Sci."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225006534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225006534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:56:11Z","timestamp":1776905771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225006534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2589004225006534"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.112392","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of esketamine on the EC50 of remifentanil for suppression of choking cough during extubation","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.112392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112392"}}