{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:17:32Z","timestamp":1793593052041,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007927","name":"University of Oklahoma Health Sciences Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R21AI168929"],"award-info":[{"award-number":["R21AI168929"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.isci.2025.112459","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:44:35Z","timestamp":1744872275000},"page":"112459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Monoclonal antibodies targeting Candida disrupt biofilms and inhibit growth across global clinical isolates"],"prefix":"10.1016","volume":"28","author":[{"given":"Jonothan","family":"Rosario-Colon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Eberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9709-9267","authenticated-orcid":false,"given":"Hong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.112459_bib1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3201\/eid1910.130393","article-title":"New clonal strain of Candida auris, Delhi, India","volume":"19","author":"Chowdhary","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3201\/eid2301.161497","article-title":"Invasive Infections with Multidrug-Resistant Yeast Candida auris, Colombia","volume":"23","author":"Morales-Lopez","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib3","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3201\/eid2507.180491","article-title":"Hospital-associated multicenter outbreak of emerging fungus Candida auris, Colombia, 2016","volume":"25","author":"Armstrong","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijid.2018.01.034","article-title":"First report of sporadic cases of Candida auris in Colombia","volume":"69","author":"Parra-Giraldo","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib6","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/myc.12781","article-title":"An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital","volume":"61","author":"Ruiz-Gaitan","year":"2018","journal-title":"Mycoses"},{"key":"10.1016\/j.isci.2025.112459_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijid.2018.02.005","article-title":"Persistent candidemia despite appropriate fungal therapy: First case of Candida auris from the United Arab Emirates","volume":"70","author":"Alatoom","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib8","series-title":"WHO fungal priority pathogens list to guide research, development and public health action","year":"2022"},{"key":"10.1016\/j.isci.2025.112459_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10096-013-2027-1","article-title":"Multidrug-resistant endemic clonal strain of Candida auris in India","volume":"33","author":"Chowdhary","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib10","article-title":"Candida auris: A systematic review and meta-analysis of current updates on an emerging multidrug-resistant pathogen","volume":"7","author":"Osei Sekyere","year":"2018","journal-title":"Microbiology (Road Town, V. I. (Br.))"},{"key":"10.1016\/j.isci.2025.112459_bib11","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/cid\/cix460","article-title":"Donor-Derived Transmission of Candida auris During Lung Transplantation","volume":"65","author":"Azar","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01625-19","article-title":"Impact of Candida auris infection in a neutropenic murine model","volume":"64","author":"Torres","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.isci.2025.112459_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007460","article-title":"The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection","volume":"15","author":"Singh","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2025.112459_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/myc.12754","article-title":"Comparative virulence of Candida auris with Candida haemulonii, Candida glabrata and Candida albicans in a murine model","volume":"61","author":"Fakhim","year":"2018","journal-title":"Mycoses"},{"key":"10.1016\/j.isci.2025.112459_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02319-17","article-title":"In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A\/APX001 against Candida auris","volume":"62","author":"Hager","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.isci.2025.112459_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mmy\/myy054","article-title":"Candida auris: the recent emergence of a multidrug-resistant fungal pathogen","volume":"57","author":"Forsberg","year":"2019","journal-title":"Med. Mycol."},{"key":"10.1016\/j.isci.2025.112459_bib17","doi-asserted-by":"crossref","first-page":"e01503","DOI":"10.1128\/JCM.01503-19","article-title":"Laboratory analysis of an outbreak of Candida auris in New York from 2016 to 2018: impact and lessons learned","volume":"58","author":"Zhu","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.isci.2025.112459_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.15585\/mmwr.mm7002e3","article-title":"Candida auris Outbreak in a COVID-19 Specialty Care Unit - Florida, July-August 2020","volume":"70","author":"Prestel","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.isci.2025.112459_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/jof7020140","article-title":"Molecular Epidemiological Investigation of a Nosocomial Cluster of C. auris: Evidence of Recent Emergence in Italy and Ease of Transmission during the COVID-19 Pandemic","volume":"7","author":"Di Pilato","year":"2021","journal-title":"J. Fungi"},{"key":"10.1016\/j.isci.2025.112459_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/jof7030220","article-title":"Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit","volume":"7","author":"de Almeida","year":"2021","journal-title":"J. Fungi"},{"key":"10.1016\/j.isci.2025.112459_bib21","article-title":"Molecular Characterization of Candida auris Isolates at a Major Tertiary Care Center in Lebanon","volume":"12","author":"Reslan","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.isci.2025.112459_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03364-19","article-title":"Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses","volume":"11","author":"Chow","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.isci.2025.112459_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01624-18","article-title":"Candida auris Clinical Isolates from South Korea: Identification, Antifungal Susceptibility, and Genotyping","volume":"57","author":"Kwon","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.isci.2025.112459_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01872-17","article-title":"Fluconazole-Resistant Candida auris Is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses","volume":"62","author":"Pathirana","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.isci.2025.112459_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008921","article-title":"Candida auris: Epidemiology, biology, antifungal resistance, and virulence","volume":"16","author":"Du","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2025.112459_bib26","series-title":"Standardized Case Definition for Candida auris clinical and colonization\/screening cases and National Notification of C. auris case, clinical","author":"Kainer","year":"2018"},{"key":"10.1016\/j.isci.2025.112459_bib27","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/s41598-017-01400-4","article-title":"Tumor necrosis factor prevents Candida albicans biofilm formation","volume":"7","author":"Rocha","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.112459_bib28","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1128\/iai.62.7.2761-2772.1994","article-title":"Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis","volume":"62","author":"Louie","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.112459_bib30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1172\/JCI115050","article-title":"Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro","volume":"87","author":"Diamond","year":"1991","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.112459_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01403-18","article-title":"Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack","volume":"9","author":"Johnson","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.isci.2025.112459_bib32","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/IDR.S197531","article-title":"Differential recognition of Candida tropicalis, Candida guilliermondii, Candida krusei, and Candida auris by human innate immune cells","volume":"12","author":"Navarro-Arias","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.isci.2025.112459_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112522","article-title":"Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response","volume":"42","author":"Weerasinghe","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.112459_bib34","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1128\/AAC.47.7.2208-2216.2003","article-title":"Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90","volume":"47","author":"Matthews","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.isci.2025.112459_bib35","doi-asserted-by":"crossref","first-page":"9206","DOI":"10.1038\/s41598-020-65859-4","article-title":"The monoclonal antibody Ca37, developed against Candida albicans alcohol dehydrogenase, inhibits the yeast in vitro and in vivo","volume":"10","author":"Antoran","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.112459_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116162","article-title":"Candida Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Candida auris Invasive Infection","volume":"22","author":"Rosario-Colon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.112459_bib37","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri3897","article-title":"Immune defence against Candida fungal infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.112459_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics9040155","article-title":"Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens","volume":"9","author":"Zurawski","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.isci.2025.112459_bib39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/QCO.0000000000000539","article-title":"Monoclonal antibody-based therapies for bacterial infections","volume":"32","author":"Motley","year":"2019","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.isci.2025.112459_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41541-017-0019-3","article-title":"Antibody therapies for the prevention and treatment of viral infections","volume":"2","author":"Salazar","year":"2017","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.isci.2025.112459_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-019-0592-z","article-title":"Development of therapeutic antibodies for the treatment of diseases","volume":"27","author":"Lu","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.isci.2025.112459_bib42","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/s41467-018-07738-1","article-title":"Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis","volume":"9","author":"Rudkin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.112459_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/jof9010103","article-title":"Protective Efficacy of Anti-Hyr1p Monoclonal Antibody against Systemic Candidiasis Due to Multi-Drug-Resistant Candida auris","volume":"9","author":"Singh","year":"2023","journal-title":"J. Fungi"},{"key":"10.1016\/j.isci.2025.112459_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98659-5","article-title":"A new humanized antibody is effective against pathogenic fungi in vitro","volume":"11","author":"Di Mambro","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.112459_bib45","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1099\/00221287-143-2-321","article-title":"3-phosphoglycerate kinase: a glycolytic enzyme protein present in the cell wall of Candida albicans","volume":"143","author":"Alloush","year":"1997","journal-title":"Microbiology (Read.)"},{"key":"10.1016\/j.isci.2025.112459_bib46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.micpath.2015.10.001","article-title":"Moonlight-like proteins of the cell wall protect sessile cells of Candida from oxidative stress","volume":"90","author":"Serrano-Fujarte","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.isci.2025.112459_bib47","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1128\/iai.58.11.3537-3544.1990","article-title":"Immunoreactivity of neoglycolipids constructed from oligomannosidic residues of the Candida albicans cell wall","volume":"58","author":"Faille","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib49","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1128\/iai.63.7.2714-2719.1995","article-title":"Antibody response that protects against disseminated candidiasis","volume":"63","author":"Han","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib50","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1128\/IAI.68.3.1649-1654.2000","article-title":"Protection against candidiasis by an immunoglobulin G3 (IgG3) monoclonal antibody specific for the same mannotriose as an IgM protective antibody","volume":"68","author":"Han","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00281-014-0466-0","article-title":"The protective role of immunoglobulins in fungal infections and inflammation","volume":"37","author":"Elluru","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.isci.2025.112459_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9101159","article-title":"The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis","volume":"9","author":"Shukla","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.isci.2025.112459_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110550","article-title":"Immune defence to invasive fungal infections: A comprehensive review","volume":"130","author":"Pathakumari","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.isci.2025.112459_bib54","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S1369-5274(02)00337-5","article-title":"Induced humoral immunity and vaccination against major human fungal pathogens","volume":"5","author":"Casadevall","year":"2002","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.isci.2025.112459_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168947","article-title":"The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies","volume":"22","author":"Gogesch","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.112459_bib56","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/glycob\/cwv037","article-title":"Antibody recognition of carbohydrate epitopesdagger","volume":"25","author":"Haji-Ghassemi","year":"2015","journal-title":"Glycobiology"},{"key":"10.1016\/j.isci.2025.112459_bib57","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1074\/jbc.271.3.1527","article-title":"Analysis by surface plasmon resonance of the influence of valence on the ligand binding affinity and kinetics of an anti-carbohydrate antibody","volume":"271","author":"MacKenzie","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.112459_bib58","series-title":"Janeway's Immunobiology","author":"Murphy","year":"2017"},{"key":"10.1016\/j.isci.2025.112459_bib59","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/CMR.9.1.34","article-title":"Activation of the complement system by pathogenic fungi","volume":"9","author":"Kozel","year":"1996","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.isci.2025.112459_bib60","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1189\/jlb.3MR0214-109R","article-title":"Complement modulation of T cell immune responses during homeostasis and disease","volume":"96","author":"Clarke","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.isci.2025.112459_bib61","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/eji.201142057","article-title":"Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs","volume":"42","author":"Cheng","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2025.112459_bib62","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1128\/IAI.72.10.5868-5876.2004","article-title":"Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain","volume":"72","author":"Mullick","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib63","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.4049\/jimmunol.167.3.1550","article-title":"Complement Is Essential for Protection by an IgM and an IgG3 Monoclonal Antibody Against Experimental, Hematogenously Disseminated Candidiasis","volume":"167","author":"Han","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.112459_bib64","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1128\/IAI.00234-06","article-title":"Hybridoma passage in vitro may result in reduced ability of antimannan antibody to protect against disseminated candidiasis","volume":"74","author":"Xin","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib65","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1016\/j.vaccine.2021.06.001","article-title":"Synthetic conjugate peptide Fba-Met6 (MP12) induces complement-mediated resistance against disseminated Candida albicans","volume":"39","author":"Adams","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.isci.2025.112459_bib66","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1128\/IAI.01840-06","article-title":"Fungicidal monoclonal antibody C7 binds to Candida albicans Als3","volume":"75","author":"Brena","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib67","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.1128\/IAI.73.10.6350-6362.2005","article-title":"Specific antibody can prevent fungal biofilm formation and this effect correlates with protective efficacy","volume":"73","author":"Martinez","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib68","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1128\/IAI.71.9.5273-5279.2003","article-title":"A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities","volume":"71","author":"Moragues","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib69","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00844-19","article-title":"The Other Side of the Coin: Anti-inflammatory Antibody Therapy for Infectious Diseases","volume":"88","author":"Goldman","year":"2020","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.112459_bib70","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.3389\/fimmu.2019.02846","article-title":"An Inflammatory Story: Antibodies in Tuberculosis Comorbidities","volume":"10","author":"McLean","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.112459_bib71","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1471-4906(03)00228-X","article-title":"Antibody-mediated regulation of cellular immunity and the inflammatory response","volume":"24","author":"Casadevall","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2025.112459_bib72","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4049\/jimmunol.0902752","article-title":"Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors","volume":"184","author":"Saylor","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.112459_bib73","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02396-16","article-title":"The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation","volume":"61","author":"Larkin","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.isci.2025.112459_bib74","doi-asserted-by":"crossref","DOI":"10.1128\/mSphereDirect.00680-18","article-title":"Conserved Role for Biofilm Matrix Polysaccharides in Candida auris Drug Resistance","volume":"4","author":"Dominguez","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.isci.2025.112459_bib75","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00334-18","article-title":"Transcriptome Assembly and Profiling of Candida auris Reveals Novel Insights into Biofilm-Mediated Resistance","volume":"3","author":"Kean","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.isci.2025.112459_bib76","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00339-19","article-title":"Experimental Mouse Models of Disseminated Candida auris Infection","volume":"4","author":"Xin","year":"2019","journal-title":"mSphere"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225007205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225007205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:05:21Z","timestamp":1776906321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225007205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2589004225007205"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.112459","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monoclonal antibodies targeting Candida disrupt biofilms and inhibit growth across global clinical isolates","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.112459","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112459"}}