{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:11:55Z","timestamp":1778904715480,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012503","name":"Dream Project of Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2023YFC2508402"],"award-info":[{"award-number":["2023YFC2508402"]}],"id":[{"id":"10.13039\/501100012503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["shslczdzk00801"],"award-info":[{"award-number":["shslczdzk00801"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2022XD059"],"award-info":[{"award-number":["2022XD059"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20MC1920200"],"award-info":[{"award-number":["20MC1920200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192862"],"award-info":[{"award-number":["82192862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371146"],"award-info":[{"award-number":["82371146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.isci.2025.112840","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T19:21:14Z","timestamp":1749496874000},"page":"112840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Randomized controlled trial of prednisone in treating acute subjective tinnitus patients with normal pure-tone thresholds"],"prefix":"10.1016","volume":"28","author":[{"given":"Peifan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhao","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dantong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-4307","authenticated-orcid":false,"given":"Shan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.112840_bib1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaneurol.2022.2189","article-title":"Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis","volume":"79","author":"Jarach","year":"2022","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.isci.2025.112840_bib2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/jamaoto.2019.0566","article-title":"Sex-Specific Association of Tinnitus With Suicide Attempts","volume":"145","author":"Lugo","year":"2019","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2025.112840_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7438461","article-title":"Auditory Neural Plasticity in Tinnitus Mechanisms and Management","volume":"2020","author":"Wang","year":"2020","journal-title":"Neural Plast."},{"key":"10.1016\/j.isci.2025.112840_bib4","first-page":"278","article-title":"Chronic tinnitus: an interdisciplinary challenge","volume":"110","author":"Kreuzer","year":"2013","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.isci.2025.112840_bib5","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(13)60142-7","article-title":"Tinnitus","volume":"382","author":"Baguley","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2025.112840_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2024.111879","article-title":"Association between hospital-diagnosed tinnitus and suicide: A Nationwide Danish longitudinal study","volume":"185","author":"M\u00f8lhave","year":"2024","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.isci.2025.112840_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00106-019-0633-7","article-title":"A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment","volume":"67","author":"Cima","year":"2019","journal-title":"Hno"},{"key":"10.1016\/j.isci.2025.112840_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5152\/iao.2016.2632","article-title":"Comparison of Long-Term Outcome of Intratympanic Dexamethasone Therapy between Acute Noise-Induced Tinnitus and Acute Idiopathic Tinnitus","volume":"13","author":"Shim","year":"2017","journal-title":"J. Int. Adv. Otol."},{"key":"10.1016\/j.isci.2025.112840_bib9","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/lary.25074","article-title":"Successful treatment of sudden sensorineural hearing loss assures improvement of accompanying tinnitus","volume":"125","author":"Rah","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2025.112840_bib10","article-title":"High-Dose Glucocorticoids for the Treatment of Sudden Hearing Loss","volume":"3","author":"Plontke","year":"2024","journal-title":"NEJM Evid."},{"key":"10.1016\/j.isci.2025.112840_bib11","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.1002\/lary.25345","article-title":"Dexamethasone prevents hearing loss by restoring glucocorticoid receptor expression in the guinea pig cochlea","volume":"126","author":"Heinrich","year":"2016","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2025.112840_bib12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/lary.30811","article-title":"Physiologic Effects of Microneedle-Mediated Intracochlear Dexamethasone Injection in the Guinea Pig","volume":"134","author":"Feng","year":"2024","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2025.112840_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00106-016-0266-z","article-title":"Reduction of permanent hearing loss by local glucocorticoid application : Guinea pigs with acute acoustic trauma","volume":"65","author":"M\u00fcller","year":"2017","journal-title":"Hno"},{"key":"10.1016\/j.isci.2025.112840_bib14","article-title":"Intratympanic corticosteroids for sudden sensorineural hearing loss","volume":"7","author":"Plontke","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.isci.2025.112840_bib15","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1152\/physrev.00029.2020","article-title":"What's the buzz? The neuroscience and the treatment of tinnitus","volume":"101","author":"Henton","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2025.112840_bib16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3389\/fneur.2017.00605","article-title":"Transition from Acute to Chronic Tinnitus: Predictors for the Development of Chronic Distressing Tinnitus","volume":"8","author":"Wallh\u00e4usser-Franke","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.isci.2025.112840_bib17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1288\/00005537-199308000-00007","article-title":"Localization of glucocorticoid receptors and glucocorticoid receptor mRNAs in the rat cochlea","volume":"103","author":"ten Cate","year":"1993","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2025.112840_bib18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/lary.26541","article-title":"Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo-controlled, multicenter study","volume":"128","author":"Lee","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2025.112840_bib19","article-title":"Objective Verification of Acute Tinnitus and Validation of Efficacy of Systemic Steroids in Rats","volume":"35","author":"Kim","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.isci.2025.112840_bib20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.otohns.2004.09.138","article-title":"Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss","volume":"132","author":"Herr","year":"2005","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2025.112840_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0194-5998(96)70133-X","article-title":"Receptors for glucocorticoids in the human inner ear","volume":"115","author":"Rarey","year":"1996","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2025.112840_bib22","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/jnr.20795","article-title":"NF-kappaB mediated glucocorticoid response in the inner ear after acoustic trauma","volume":"83","author":"Tahera","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.isci.2025.112840_bib23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.heares.2009.05.003","article-title":"Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K\/Akt and NFkappaB signaling","volume":"255","author":"Haake","year":"2009","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2025.112840_bib24","first-page":"S1","article-title":"Clinical Practice Guideline: Sudden Hearing Loss (Update)","volume":"161","author":"Chandrasekhar","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2025.112840_bib25","first-page":"S1","article-title":"Clinical practice guideline: tinnitus","volume":"151","author":"Tunkel","year":"2014","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2025.112840_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.21053\/ceo.2021.01459","article-title":"Effectiveness of Intratympanic Dexamethasone Injection for Tinnitus Treatment: A Systematic Review and Meta-Analysis","volume":"15","author":"Chung","year":"2022","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"10.1016\/j.isci.2025.112840_bib27","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/lary.22350","article-title":"Comparison of various treatment modalities for acute tinnitus","volume":"121","author":"Shim","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2025.112840_bib28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5152\/iao.2020.8205","article-title":"Predictive Factors for the Success of Intratympanic Dexamethasone Treatment of Acute Subjective Tinnitus","volume":"16","author":"Oh","year":"2020","journal-title":"J. Int. Adv. Otol."},{"key":"10.1016\/j.isci.2025.112840_bib29","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/MAO.0b013e31819bda66","article-title":"Individual differences in the permeability of the round window: evaluating the movement of intratympanic gadolinium into the inner ear","volume":"30","author":"Yoshioka","year":"2009","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.isci.2025.112840_bib30","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/MAO.0000000000003189","article-title":"Evidence of Cochlear Synaptopathy and the Effect of Systemic Steroid in Acute Idiopathic Tinnitus With Normal Hearing","volume":"42","author":"Park","year":"2021","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.isci.2025.112840_bib31","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-041290","article-title":"Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis","volume":"10","author":"Dawes","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.isci.2025.112840_bib32","article-title":"Ginkgo biloba for tinnitus","volume":"11","author":"Sereda","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.isci.2025.112840_bib33","article-title":"Pharmacotherapy options for the management of subjective tinnitus: a systematic review and network meta-analysis","volume":"15","author":"Li","year":"2025","journal-title":"BMJ Open"},{"key":"10.1016\/j.isci.2025.112840_bib34","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s11096-018-0654-4","article-title":"Ginkgo biloba extract EGb 761(\u00ae) versus pentoxifylline in chronic tinnitus: a randomized, double-blind clinical trial","volume":"40","author":"Proch\u00e1zkov\u00e1","year":"2018","journal-title":"Int. J. Clin. Pharm."},{"key":"10.1016\/j.isci.2025.112840_bib35","first-page":"CD013514","article-title":"Ginkgo biloba for tinnitus","volume":"2019","author":"Sereda","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.isci.2025.112840_bib36","article-title":"Clinical characteristics and prognosis of acute low-frequency hearing loss and ascending sensorineural sudden sensorineural hearing loss","volume":"16","author":"Diao","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2025.112840_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/0036554021000028074","article-title":"Immunological responses in acute low-tone sensorineural hearing loss and M\u00e9ni\u00e8re's disease","volume":"123","author":"Fuse","year":"2003","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.isci.2025.112840_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8815990","article-title":"Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss","volume":"2020","author":"Wei","year":"2020","journal-title":"Neural Plast."},{"key":"10.1016\/j.isci.2025.112840_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2024.108967","article-title":"Hidden hearing loss: Fifteen years at a glance","volume":"443","author":"Liu","year":"2024","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2025.112840_bib40","doi-asserted-by":"crossref","first-page":"522","DOI":"10.5152\/iao.2022.21503","article-title":"Reliability and Validity of the Tinnitus Handicap Inventory: A Clinical Study of Questionnaires","volume":"18","author":"Zhang","year":"2022","journal-title":"J. Int. Adv. Otol."},{"key":"10.1016\/j.isci.2025.112840_bib41","first-page":"153","article-title":"Psychometric adequacy of the Tinnitus Handicap Inventory (THI) for evaluating treatment outcome","volume":"9","author":"Newman","year":"1998","journal-title":"J. Am. Acad. Audiol."},{"key":"10.1016\/j.isci.2025.112840_bib42","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/0194599811403882","article-title":"Tinnitus handicap inventory for evaluating treatment effects: which changes are clinically relevant?","volume":"145","author":"Zeman","year":"2011","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2025.112840_bib43","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/AUD.0b013e3181cdb2a2","article-title":"Incidence, Persistence, and Progression of Tinnitus Symptoms in Older Adults: The Blue Mountains Hearing Study","volume":"31","author":"Gopinath","year":"2010","journal-title":"Ear Hear."},{"key":"10.1016\/j.isci.2025.112840_bib44","first-page":"389","article-title":"A triage guide for tinnitus","volume":"59","author":"Henry","year":"2010","journal-title":"J. Fam. Pract."},{"key":"10.1016\/j.isci.2025.112840_bib45","series-title":"World Report on Hearing","author":"Organization","year":"2021"},{"key":"10.1016\/j.isci.2025.112840_bib46","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1808-8694(15)30835-1","article-title":"Correlation analysis of the visual-analogue scale and the Tinnitus Handicap Inventory in tinnitus patients","volume":"75","author":"Figueiredo","year":"2009","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"10.1016\/j.isci.2025.112840_bib47","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1081-1206(10)61756-5","article-title":"Assessment of mood states in patients receiving long-term corticosteroid therapy and in controls with patient-rated and clinician-rated scales","volume":"92","author":"Bolanos","year":"2004","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.isci.2025.112840_bib48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3342\/ceo.2012.5.1.10","article-title":"Reliability and validity of the chinese (mandarin) tinnitus handicap inventory","volume":"5","author":"Meng","year":"2012","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"10.1016\/j.isci.2025.112840_bib49","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000494021","article-title":"Visual Analogue Scales as a Tool for Initial Assessment of Tinnitus Severity: Psychometric Evaluation in a Clinical Population","volume":"23","author":"Raj-Koziak","year":"2018","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.isci.2025.112840_bib50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0022-3999(02)00604-9","article-title":"The diagnostic validity of the Athens Insomnia Scale","volume":"55","author":"Soldatos","year":"2003","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.isci.2025.112840_bib51","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.5811\/westjem.2017.8.35985","article-title":"Understanding the Intention-to-treat Principle in Randomized Controlled Trials","volume":"18","author":"McCoy","year":"2017","journal-title":"West. J. Emerg. Med."},{"key":"10.1016\/j.isci.2025.112840_bib52","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/0194599820986571","article-title":"Clinical Profile of Patients With Unilateral Sudden Sensorineural Hearing Loss: Correlation With Hearing Prognosis","volume":"165","author":"Perez Ferreira Neto","year":"2021","journal-title":"Otolaryngol. Head Neck Surg."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225011010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225011010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:26:01Z","timestamp":1778901961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225011010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2589004225011010"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.112840","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized controlled trial of prednisone in treating acute subjective tinnitus patients with normal pure-tone thresholds","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.112840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112840"}}