{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:49:51Z","timestamp":1790423391391,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA029176"],"award-info":[{"award-number":["AA029176"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA029409"],"award-info":[{"award-number":["AA029409"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA007462"],"award-info":[{"award-number":["AA007462"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.isci.2025.112920","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T14:09:11Z","timestamp":1750169351000},"page":"112920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-0863","authenticated-orcid":false,"given":"Kathleen G.","family":"Bryant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Swygart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith R.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell D.","family":"Morningstar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Timme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen E.","family":"McGonigle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Engleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"Sheets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Lapish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.112920_bib1","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1111\/acer.14463","article-title":"Ethanol alters variability, but not rate, of firing in medial prefrontal cortex neurons of awake-behaving rats","volume":"44","author":"Morningstar","year":"2020","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib2","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1523\/JNEUROSCI.5378-06.2007","article-title":"Ethanol inhibits persistent activity in prefrontal cortical neurons","volume":"27","author":"Tu","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0077-20.2020","article-title":"Distinct region- and time-dependent functional cortical adaptations in C57BL\/6J mice after short and prolonged alcohol drinking","volume":"7","author":"Cannady","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.isci.2025.112920_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.alcohol.2019.03.006","article-title":"Acute alcohol and cognition: remembering what it causes us to forget","volume":"79","author":"Van Skike","year":"2019","journal-title":"Alcohol"},{"key":"10.1016\/j.isci.2025.112920_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108780","article-title":"Understanding ethanols acute effects on medial prefrontal cortex neural activity using state-space approaches","volume":"198","author":"Morningstar","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2025.112920_bib6","doi-asserted-by":"crossref","first-page":"15218","DOI":"10.1073\/pnas.2435171100","article-title":"Ethanol enhances \u03b14\u03b23\u03b4 and \u03b16\u03b23\u03b4 \u03b3-aminobutyric acid type A receptors at low concentrations known to affect humans","volume":"100","author":"Wallner","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.112920_bib7","doi-asserted-by":"crossref","first-page":"33052","DOI":"10.1074\/jbc.M707233200","article-title":"Protein kinase C\u03b5 regulates \u03b3-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of \u03b32 subunits","volume":"282","author":"Qi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.112920_bib8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00008877-199408000-00003","article-title":"Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels","volume":"5","author":"Grant","year":"1994","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.isci.2025.112920_bib9","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1073\/pnas.1137276100","article-title":"Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons","volume":"100","author":"Carta","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.112920_bib10","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1111\/bph.13487","article-title":"Intersubunit interactions at putative sites of ethanol action in the M3 and M4 domains of the NMDA receptor GluN1 and GluN2B subunits","volume":"173","author":"Zhao","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2025.112920_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0197-0186(00)00094-2","article-title":"Ethanol sensitivity of recombinant human N-methyl-d-aspartate receptors","volume":"38","author":"Sm","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.isci.2025.112920_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuropharm.2017.04.007","article-title":"Effects of acute alcohol on excitability in the CNS","volume":"122","author":"Harrison","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2025.112920_bib13","series-title":"Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol","author":"Cui","year":"2017"},{"key":"10.1016\/j.isci.2025.112920_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pbb.2014.03.006","article-title":"Stimulant and motivational effects of alcohol: lessons from rodent and primate models","volume":"122","author":"Brabant","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.isci.2025.112920_bib15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ejim.2007.06.033","article-title":"Acute alcohol intoxication","volume":"19","author":"Vonghia","year":"2008","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.isci.2025.112920_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00432377","article-title":"Biphasic action of ethanol on single units of the dorsal hippocampus and the relationship to the cortical EEG","volume":"70","author":"Grupp","year":"1980","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.isci.2025.112920_bib17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0091-3057(78)90087-4","article-title":"Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats","volume":"8","author":"Penn","year":"1978","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.isci.2025.112920_bib18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1369-1600.2005.00029.x","article-title":"The alcohol-preferring P rat and animal models of excessive alcohol drinking","volume":"11","author":"Bell","year":"2006","journal-title":"Addict. Biol."},{"key":"10.1016\/j.isci.2025.112920_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.alcohol.2014.12.002","article-title":"The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats","volume":"49","author":"Ornelas","year":"2015","journal-title":"Alcohol"},{"key":"10.1016\/j.isci.2025.112920_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","article-title":"An integrative theory of prefrontal cortex function","volume":"24","author":"Miller","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tins.2021.03.006","article-title":"Circuit organization of the rodent medial prefrontal cortex","volume":"44","author":"Anastasiades","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1523\/ENEURO.0315-18.2018","article-title":"What, if anything, is rodent prefrontal cortex?","volume":"5","author":"Laubach","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.isci.2025.112920_bib23","doi-asserted-by":"crossref","first-page":"30728","DOI":"10.1073\/pnas.2019077117","article-title":"Evidence accumulation for value computation in the prefrontal cortex during decision making","volume":"117","author":"Lin","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.112920_bib24","article-title":"Differential processing of decision information in subregions of rodent medial prefrontal cortex","author":"Diehl","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2025.112920_bib25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0074-7742(10)91009-X","article-title":"Alcohol and the prefrontal cortex","volume":"91","author":"Abernathy","year":"2010","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.isci.2025.112920_bib26","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0028-3932(00)00136-6","article-title":"Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers","volume":"39","author":"Bechara","year":"2001","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.isci.2025.112920_bib27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00213-009-1562-z","article-title":"The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progress","volume":"205","author":"Kumar","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.isci.2025.112920_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2022.936911","article-title":"Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder","volume":"14","author":"Fish","year":"2022","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib29","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1530-0277.2008.00625.x","article-title":"Ethanol selectively attenuates NMDAR-mediated synaptic transmission in the prefrontal cortex","volume":"32","author":"Weitlauf","year":"2008","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib30","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1111\/j.1530-0277.2009.01059.x","article-title":"Effects of ethanol on persistent activity and up-states in excitatory and inhibitory neurons in prefrontal cortex","volume":"33","author":"Woodward","year":"2009","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1523\/JNEUROSCI.17-02-00625.1997","article-title":"Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor","volume":"17","author":"Ueno","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.clinph.2007.10.021","article-title":"Acute and chronic effects of ethanol on cortical excitability","volume":"119","author":"Conte","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.isci.2025.112920_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0163-7258(99)00040-6","article-title":"The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol","volume":"84","author":"Little","year":"1999","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.isci.2025.112920_bib34","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1530-0277.1998.tb03880.x","article-title":"Quantitative microdialysis of ethanol in rat striatum","volume":"22","author":"Gonzales","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib35","doi-asserted-by":"crossref","first-page":"649","DOI":"10.15288\/jsad.2007.68.649","article-title":"Uneven distribution of ethanol in rat brain following acute administration, with the highest level in the striatum","volume":"68","author":"Chen","year":"2007","journal-title":"J. Stud. Alcohol Drugs"},{"key":"10.1016\/j.isci.2025.112920_bib36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1530-0277.2007.00587.x","article-title":"In vivo time-course changes in ethanol levels sampled with subcutaneous microdialysis","volume":"32","author":"Engleman","year":"2008","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib37","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1530-0277.2010.01193.x","article-title":"Acute ethanol effects on brain activation in low- and high-level responders to alcohol","volume":"34","author":"Trim","year":"2010","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037541","article-title":"Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex","volume":"7","author":"Kroener","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.112920_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.addicn.2023.100105","article-title":"Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats","volume":"7","author":"Lee","year":"2023","journal-title":"Addict. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pbb.2016.08.001","article-title":"Sex, strain, and estrous cycle influences on alcohol drinking in rats","volume":"152","author":"Priddy","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.isci.2025.112920_bib41","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s10519-010-9394-5","article-title":"Derivation and characterization of replicate high- and low-alcohol preferring lines of mice and a high-drinking crossed HAP line","volume":"41","author":"Oberlin","year":"2011","journal-title":"Behav. Genet."},{"key":"10.1016\/j.isci.2025.112920_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pbb.2015.07.011","article-title":"Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning","volume":"137","author":"de la Torre","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.isci.2025.112920_bib43","first-page":"163","article-title":"Differences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence","volume":"11","author":"Li","year":"2019","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.isci.2025.112920_bib44","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/acer.14384","article-title":"Increased responding for alcohol and resistance to aversion in female mice","volume":"44","author":"Sneddon","year":"2020","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13434","article-title":"Sex differences in neural networks recruited by frontloaded binge alcohol drinking","volume":"29","author":"Ardinger","year":"2024","journal-title":"Addict. Biol."},{"key":"10.1016\/j.isci.2025.112920_bib46","doi-asserted-by":"crossref","DOI":"10.1186\/s13293-021-00395-y","article-title":"Shortening time for access to alcohol drives up front-loading behavior, bringing consumption in male rats to the level of females","volume":"12","author":"Flores-Bonilla","year":"2021","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.isci.2025.112920_bib47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.conb.2018.01.007","article-title":"Sex differences in behavioral strategies: avoiding interpretational pitfalls","volume":"49","author":"Shansky","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.isci.2025.112920_bib48","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/pr.115.011163","article-title":"Sex differences in animal models: focus on addiction","volume":"68","author":"Becker","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.isci.2025.112920_bib49","series-title":"Recent developments in alcoholism","first-page":"231","article-title":"Sex differences in mesolimbic dopamine responses to ethanol and relationship to ethanol intake in rats","author":"Blanchard","year":"2002"},{"key":"10.1016\/j.isci.2025.112920_bib50","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1038\/sj.npp.1301023","article-title":"In vivo quantification of ethanol kinetics in rat brain","volume":"31","author":"Adalsteinsson","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2025.112920_bib51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0741-8329(03)00025-9","article-title":"Blood ethanol concentration profiles: a comparison between rats and mice","volume":"29","author":"Livy","year":"2003","journal-title":"Alcohol"},{"key":"10.1016\/j.isci.2025.112920_bib52","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/acer.12709","article-title":"The \u201cfirst hit\u201d toward alcohol reinforcement: role of ethanol metabolites","volume":"39","author":"Israel","year":"2015","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib53","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.neuron.2017.10.032","article-title":"Alcohol and the brain: neuronal molecular targets, synapses, and circuits","volume":"96","author":"Abrahao","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.112920_bib54","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.alcohol.2015.09.001","article-title":"Alcohol-induced alterations in dopamine modulation of prefrontal activity","volume":"49","author":"Trantham-Davidson","year":"2015","journal-title":"Alcohol"},{"key":"10.1016\/j.isci.2025.112920_bib55","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/adb.12424","article-title":"Acute effect of intravenously applied alcohol in the human striatal and extrastriatal D2\/D3 dopamine system","volume":"22","author":"Pfeifer","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.isci.2025.112920_bib56","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0074-7742(10)91008-8","article-title":"Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs","volume":"91","author":"Morikawa","year":"2010","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.isci.2025.112920_bib57","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.neuron.2008.01.022","article-title":"Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system","volume":"57","author":"Lammel","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.112920_bib58","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.91136.3","article-title":"Functional diversity of dopamine axons in prefrontal cortex during classical conditioning","volume":"12","author":"Abe","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.isci.2025.112920_bib59","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1530-0277.1999.tb04082.x","article-title":"Ethanol directly excites dopaminergic ventral tegmental area reward neurons","volume":"23","author":"Brodie","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib60","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neuroscience.2014.12.081","article-title":"A subset of ventral tegmental area dopamine neurons responds to acute ethanol","volume":"290","author":"Mrejeru","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2025.112920_bib61","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1152\/jn.00069.2006","article-title":"Ventral hippocampal neurons project axons simultaneously to the medial prefrontal cortex and amygdala in the rat","volume":"96","author":"Ishikawa","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.isci.2025.112920_bib62","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.celrep.2017.12.097","article-title":"Organization of valence-encoding and projection-defined neurons in the basolateral amygdala","volume":"22","author":"Beyeler","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.112920_bib63","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.alcohol.2007.04.007","article-title":"Ethanol effects on GABA-gated current in a model of increased \u03b14\u03b2\u03b4 GABAA receptor expression depend on time course and preexposure to low concentrations of the drug","volume":"41","author":"Smith","year":"2007","journal-title":"Alcohol"},{"key":"10.1016\/j.isci.2025.112920_bib64","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1523\/JNEUROSCI.2040-04.2004","article-title":"Low ethanol concentrations selectively augment the tonic inhibition mediated by \u03b4 subunit-containing GABAA receptors in hippocampal neurons","volume":"24","author":"Wei","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib65","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0006-8993(94)91352-8","article-title":"Guanosine phosphate analogs modulate ethanol potentiation of GABAA-mediated synaptic currents in hippocampal CA1 neurons","volume":"665","author":"Weiner","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2025.112920_bib66","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1523\/JNEUROSCI.2490-12.2013","article-title":"Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice","volume":"33","author":"Herman","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib67","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1073\/pnas.0437926100","article-title":"Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons","volume":"100","author":"Roberto","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.112920_bib68","doi-asserted-by":"crossref","first-page":"265","DOI":"10.12717\/DR.2012.16.4.265","article-title":"Modulation of neural circuit activity by ethanol in basolateral amygdala","volume":"16","author":"Chung","year":"2012","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.isci.2025.112920_bib69","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1111\/j.1530-0277.2009.01059.x","article-title":"Effects of ethanol on persistent activity and up-States in excitatory and inhibitory neurons in prefrontal cortex","volume":"33","author":"Woodward","year":"2009","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.isci.2025.112920_bib70","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00429-021-02327-3","article-title":"Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net","author":"Bucher","year":"2021","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.isci.2025.112920_bib71","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1016\/j.neuron.2024.05.015","article-title":"Dynamic assemblies of parvalbumin interneurons in brain oscillations","volume":"112","author":"Huang","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.112920_bib72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2013.10.031","article-title":"Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition","volume":"81","author":"Lee","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.112920_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108501","article-title":"Alcohol reduces the activity of somatostatin interneurons in the mouse prefrontal cortex: a neural basis for its disinhibitory effect?","volume":"188","author":"Li","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2025.112920_bib74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0022-5193(84)80021-1","article-title":"Analysis of the effects of cesium ions on potassium channel currents in biological membranes","volume":"107","author":"Clay","year":"1984","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.isci.2025.112920_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00161","article-title":"Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala","volume":"9","author":"Ferreira","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib76","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1523\/JNEUROSCI.2731-17.2018","article-title":"Altered excitability and local connectivity of mPFC-PAG neurons in a mouse model of neuropathic pain","volume":"38","author":"Cheriyan","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib77","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nn.2538","article-title":"Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex","volume":"13","author":"Anderson","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib78","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fncir.2010.00100","article-title":"Ephus: Multipurpose data acquisition software for neuroscience experiments","volume":"4","author":"Suter","year":"2010","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.isci.2025.112920_bib79","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1523\/JNEUROSCI.21-10-03580.2001","article-title":"Layer-specific intracolumnar and transcolumnar functional connectivity of layer V pyramidal cells in rat barrel cortex","volume":"21","author":"Schubert","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.112920_bib80","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/aa5eea","article-title":"Open Ephys: an open-source, plugin-based platform for multichannel electrophysiology","volume":"14","author":"Siegle","year":"2017","journal-title":"J. Neural. Eng."},{"key":"10.1016\/j.isci.2025.112920_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05894-y","article-title":"Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons","volume":"9","author":"Sakaguchi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.112920_bib82","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61834","article-title":"Spikeinterface, a unified framework for spike sorting","volume":"9","author":"Buccino","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.isci.2025.112920_bib83","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41592-024-02232-7","article-title":"Spike sorting with Kilosort4","author":"Pachitariu","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2025.112920_bib84","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1038\/s41467-022-31731-4","article-title":"Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex","volume":"13","author":"Timme","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.112920_bib85","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/adb.12018","article-title":"Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats","volume":"18","author":"Ding","year":"2013","journal-title":"Addict. Biol."},{"key":"10.1016\/j.isci.2025.112920_bib86","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.alcohol.2006.03.001","article-title":"Extracellular dopamine levels are lower in the medial prefrontal cortex of alcohol-preferring rats compared to Wistar rats","volume":"38","author":"Engleman","year":"2006","journal-title":"Alcohol"},{"key":"10.1016\/j.isci.2025.112920_bib87","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.forsciint.2013.05.007","article-title":"Comparison of SPME and static headspace analysis of blood alcohol concentration utilizing two novel chromatographic stationary phases","volume":"231","author":"Westland","year":"2013","journal-title":"Forensic Sci. Int."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225011812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225011812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:32:28Z","timestamp":1777948348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225011812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":87,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2589004225011812"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.112920","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.112920","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112920"}}