{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:02:36Z","timestamp":1781784156234,"version":"3.54.5"},"reference-count":69,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["21ZR1436200"],"award-info":[{"award-number":["21ZR1436200"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020737","name":"Renji Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270642"],"award-info":[{"award-number":["82270642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170609"],"award-info":[{"award-number":["32170609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.isci.2025.113067","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:20:28Z","timestamp":1751887228000},"page":"113067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL"],"prefix":"10.1016","volume":"28","author":[{"given":"Xinyuan","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieting","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-538X","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.113067_bib1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1478-3231.2006.01327.x","article-title":"Role of neutrophils in acute inflammatory liver injury","volume":"26","author":"Jaeschke","year":"2006","journal-title":"Liver Int."},{"key":"10.1016\/j.isci.2025.113067_bib2","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1097\/HEP.0000000000000458","article-title":"Future directions in acute liver failure","volume":"78","author":"Stravitz","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2025.113067_bib3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/HEP.0000000000000868","article-title":"NK-cell-elicited gasdermin-D-dependent hepatocyte pyroptosis induces neutrophil extracellular traps that facilitate HBV-related acute-on-chronic liver failure","volume":"81","author":"Zhao","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2025.113067_bib4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: a matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2025.113067_bib5","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s11010-024-05147-1","article-title":"Unveiling the nexus: pyroptosis and its crucial implications in liver diseases","volume":"480","author":"Miao","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2025.113067_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2013.12.026","article-title":"Biomarkers of liver cell death","volume":"60","author":"Eguchi","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2025.113067_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2025.113067_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102691","article-title":"STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome","volume":"62","author":"Xiao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2025.113067_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","article-title":"Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis","volume":"74","author":"Gaul","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2025.113067_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41419-020-03317-9","article-title":"Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2025.113067_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12929-024-01003-y","article-title":"Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells","volume":"31","author":"Huang","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.isci.2025.113067_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116898","article-title":"The role and mechanism of SUMO modification in liver disease","volume":"177","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.isci.2025.113067_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0092-8674(03)00159-4","article-title":"The polycomb protein Pc2 is a SUMO E3","volume":"113","author":"Kagey","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113067_bib14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1097-2765(01)00349-5","article-title":"Involvement of PIAS1 in the sumoylation of tumor suppressor p53","volume":"8","author":"Kahyo","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2025.113067_bib15","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nrn2276","article-title":"Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction","volume":"8","author":"Martin","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.113067_bib16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tibs.2007.05.002","article-title":"Modification in reverse: the SUMO proteases","volume":"32","author":"Mukhopadhyay","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2025.113067_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0092-8674(01)00633-X","article-title":"The nucleoporin RanBP2 has SUMO1 E3 ligase activity","volume":"108","author":"Pichler","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113067_bib18","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1152\/physrev.00025.2019","article-title":"SUMO: From Bench to Bedside","volume":"100","author":"Chang","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2025.113067_bib19","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1128\/MCB.22.18.6498-6508.2002","article-title":"Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113067_bib20","doi-asserted-by":"crossref","first-page":"12906","DOI":"10.1074\/jbc.M109.071431","article-title":"SENP3-mediated de-conjugation of SUMO2\/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress","volume":"285","author":"Han","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113067_bib21","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1128\/MCB.00801-14","article-title":"mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3","volume":"34","author":"Raman","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113067_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/embor.2008.3","article-title":"The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing","volume":"9","author":"Haindl","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.isci.2025.113067_bib23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4161\/nucl.2.6.17604","article-title":"SUMO routes ribosome maturation","volume":"2","author":"Finkbeiner","year":"2011","journal-title":"Nucleus"},{"key":"10.1016\/j.isci.2025.113067_bib24","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/15548627.2019.1647944","article-title":"A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3","volume":"16","author":"Liu","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.isci.2025.113067_bib25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1091\/mbc.e08-05-0511","article-title":"RanBP2 and SENP3 function in a mitotic SUMO2\/3 conjugation-deconjugation cycle on Borealin","volume":"20","author":"Klein","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.isci.2025.113067_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0014-5793(97)01480-4","article-title":"Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53","volume":"420","author":"Honda","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2025.113067_bib27","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1158\/0008-5472.CAN-17-2288","article-title":"Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability","volume":"78","author":"Wei","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2025.113067_bib28","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.celrep.2020.01.036","article-title":"SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2\/3 from IRF8 in Bone Marrow-Derived Monocytes","volume":"30","author":"Zhang","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.113067_bib29","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1038\/emboj.2009.210","article-title":"SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation","volume":"28","author":"Huang","year":"2009","journal-title":"Embo J."},{"key":"10.1016\/j.isci.2025.113067_bib30","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1038\/s41467-018-04957-4","article-title":"Site-specific characterization of endogenous SUMOylation across species and organs","volume":"9","author":"Hendriks","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113067_bib31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.bbamcr.2007.03.017","article-title":"SUMO on the road to neurodegeneration","volume":"1773","author":"Dorval","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2025.113067_bib32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s12017-013-8259-5","article-title":"SUMO and Parkinson's disease","volume":"15","author":"Eckermann","year":"2013","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.isci.2025.113067_bib33","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1136\/gutjnl-2018-317856","article-title":"SUMO pathway inhibition targets an aggressive pancreatic cancer subtype","volume":"69","author":"Biederst\u00e4dt","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.isci.2025.113067_bib34","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1007\/s12035-016-0176-9","article-title":"Targeting SUMO-1ylation Contrasts Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease","volume":"54","author":"Marcelli","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.isci.2025.113067_bib35","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107187119","article-title":"Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease","volume":"119","author":"Ram\u00edrez-Jarqu\u00edn","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113067_bib36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41416-020-01119-6","article-title":"The SUMO pathway in pancreatic cancer: insights and inhibition","volume":"124","author":"Schneeweis","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.isci.2025.113067_bib37","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.trecan.2020.11.009","article-title":"Targeting SUMO Signaling to Wrestle Cancer","volume":"7","author":"Kroonen","year":"2021","journal-title":"Trends Cancer"},{"key":"10.1016\/j.isci.2025.113067_bib38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.chembiol.2020.12.010","article-title":"A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits \u03b1-Synuclein Aggregation","volume":"28","author":"Liang","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.isci.2025.113067_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112825","article-title":"SUMO Interacting Motifs: Structure and Function","volume":"10","author":"Yau","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.isci.2025.113067_bib40","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.molcel.2004.11.007","article-title":"A mechanism for inhibiting the SUMO pathway","volume":"16","author":"Boggio","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2025.113067_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.chembiol.2009.01.009","article-title":"Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate","volume":"16","author":"Fukuda","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.isci.2025.113067_bib42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4161\/rna.7.1.10402","article-title":"HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition","volume":"7","author":"Heiner","year":"2010","journal-title":"RNA Biol."},{"key":"10.1016\/j.isci.2025.113067_bib43","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1074\/jbc.275.9.6252","article-title":"Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2\/3","volume":"275","author":"Saitoh","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113067_bib44","doi-asserted-by":"crossref","first-page":"11349","DOI":"10.1074\/jbc.273.18.11349","article-title":"Characterization of a second member of the sentrin family of ubiquitin-like proteins","volume":"273","author":"Kamitani","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113067_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biochi.2013.06.007","article-title":"Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences","volume":"96","author":"Hijmans","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.isci.2025.113067_bib46","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-pathmechdis-031521-024831","article-title":"Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology","volume":"18","author":"Martini","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.isci.2025.113067_bib47","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/hep.26924","article-title":"T-cell factor 4 and \u03b2-catenin chromatin occupancies pattern zonal liver metabolism in mice","volume":"59","author":"Gougelet","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2025.113067_bib48","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41575-019-0134-x","article-title":"Spatial heterogeneity in the mammalian liver","volume":"16","author":"Ben-Moshe","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2025.113067_bib49","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1177\/1947601910382555","article-title":"SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression","volume":"1","author":"Bawa-Khalfe","year":"2010","journal-title":"Genes Cancer"},{"key":"10.1016\/j.isci.2025.113067_bib50","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0023677215571192","article-title":"The carbon tetrachloride model in mice","volume":"49","author":"Scholten","year":"2015","journal-title":"Lab. Anim."},{"key":"10.1016\/j.isci.2025.113067_bib51","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1038\/s41467-018-05321-2","article-title":"SUMO-mediated regulation of NLRP3 modulates inflammasome activity","volume":"9","author":"Barry","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113067_bib52","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1096\/fj.201901653R","article-title":"SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation","volume":"34","author":"Shao","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.isci.2025.113067_bib53","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/abbs\/gmab096","article-title":"Assessment of SENP3-interacting proteins in hepatocytes treated with diethylnitrosamine by BioID assay","volume":"53","author":"Chen","year":"2021","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.isci.2025.113067_bib54","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1093\/nar\/gks221","article-title":"HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing","volume":"40","author":"Preussner","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2025.113067_bib55","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molcel.2009.12.027","article-title":"Context-dependent regulatory mechanism of the splicing factor hnRNP L","volume":"37","author":"Motta-Mena","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2025.113067_bib56","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1038\/s44319-024-00152-3","article-title":"Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation","volume":"25","author":"Subramani","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.isci.2025.113067_bib57","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1261\/rna.5660803","article-title":"Novel functional role of CA repeats and hnRNP L in RNA stability","volume":"9","author":"Hui","year":"2003","journal-title":"RNA"},{"key":"10.1016\/j.isci.2025.113067_bib58","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1074\/jbc.274.3.1359","article-title":"Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L","volume":"274","author":"Shih","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113067_bib59","doi-asserted-by":"crossref","first-page":"22636","DOI":"10.1074\/jbc.M113.463901","article-title":"Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation","volume":"288","author":"Zhang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113067_bib60","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/s41467-019-09482-6","article-title":"The lncRNA Neat1 promotes activation of inflammasomes in macrophages","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113067_bib61","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41419-021-04040-9","article-title":"FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer","volume":"12","author":"Ji","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2025.113067_bib62","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/BJ20130432","article-title":"Minimal functional domains of paralogues hnRNP L and hnRNP LL exhibit mechanistic differences in exonic splicing repression","volume":"453","author":"Shankarling","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.isci.2025.113067_bib63","article-title":"SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.113067_bib64","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41418-024-01437-9","article-title":"SENP3 inhibition suppresses hepatocellular carcinoma progression and improves the efficacy of anti-PD-1 immunotherapy","volume":"32","author":"Wang","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2025.113067_bib65","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13045-024-01599-6","article-title":"METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma","volume":"17","author":"Wang","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.isci.2025.113067_bib66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s13238-015-0216-7","article-title":"SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2\/3-targeted ubiquitination and degradation","volume":"7","author":"Wang","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.isci.2025.113067_bib67","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1038\/onc.2016.124","article-title":"SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer","volume":"35","author":"Zhou","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2025.113067_bib68","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.3748\/wjg.v26.i41.6346","article-title":"Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis","volume":"26","author":"Cheng","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2025.113067_bib69","article-title":"Stem Cells From Human Exfoliated Deciduous Teeth Alleviate Liver Cirrhosis via Inhibition of Gasdermin D-Executed Hepatocyte Pyroptosis","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225013288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225013288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:17:13Z","timestamp":1771381033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225013288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2589004225013288"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.113067","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.113067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113067"}}