{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:55:54Z","timestamp":1792454154296,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["501875662"],"award-info":[{"award-number":["501875662"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.isci.2025.113068","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:20:34Z","timestamp":1751887234000},"page":"113068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["B- and T cell receptor sequencing elucidates characteristics of lymphocyte depletion by ocrelizumab"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-5176","authenticated-orcid":false,"given":"Tilman","family":"Schneider-Hohendorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"W\u00fcnsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schulte-Mecklenbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Revie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Raposo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Strauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Tackenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan D.","family":"L\u00fcnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina C.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Wiendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-9885","authenticated-orcid":false,"given":"Nicholas","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.113068_bib1","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1093\/brain\/awy151","article-title":"The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells","volume":"141","author":"Machado-Santos","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.isci.2025.113068_bib2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/ana.410130410","article-title":"Oligoclonal IgG bands in cerebrospinal fluid in various neurological diseases","volume":"13","author":"Chu","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib3","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1093\/brain\/awab147","article-title":"Classification of neurological diseases using multi-dimensional CSF analysis","volume":"144","author":"Gross","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.isci.2025.113068_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41582-021-00498-5","article-title":"B cells in multiple sclerosis - from targeted depletion to immune reconstitution therapies","volume":"17","author":"Cencioni","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib5","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s10072-022-06582-y","article-title":"Systematic literature review of immunoglobulin trends for anti-CD20 monoclonal antibodies in multiple sclerosis","volume":"44","author":"Saidha","year":"2023","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.isci.2025.113068_bib6","doi-asserted-by":"crossref","first-page":"7864","DOI":"10.1073\/pnas.1522730113","article-title":"Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins","volume":"113","author":"Br\u00e4ndle","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113068_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41586-022-04432-7","article-title":"Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM","volume":"603","author":"Lanz","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.113068_bib8","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/brain\/awad031","article-title":"Cerebrospinal fluid immunoglobulins in primary progressive multiple sclerosis are pathogenic","volume":"146","author":"Wong","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.isci.2025.113068_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00401-023-02537-5","article-title":"Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS","volume":"145","author":"Agrafiotis","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.isci.2025.113068_bib10","doi-asserted-by":"crossref","unstructured":"Roostaei, T., Diaconu, C., Touil, H., Harbison, C., Zhang, Y., Epstein, S., Tuddenham, J., Thakur, K., Bryois, J., Wiendl, H., et al. (2021). Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases. Preprint, https:\/\/doi.org\/10.1101\/2021.11.01.466797.","DOI":"10.1101\/2021.11.01.466797"},{"key":"10.1016\/j.isci.2025.113068_bib11","article-title":"Ocrelizumab associates with reduced cerebrospinal fluid B and CD20dim CD4+ T cells in primary progressive multiple sclerosis","volume":"6","author":"van Puijfelik","year":"2024","journal-title":"Brain Commun."},{"key":"10.1016\/j.isci.2025.113068_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/JCI182790","article-title":"Transcriptomic profiling after B-cell depletion reveals central and peripheral immune cell changes in multiple sclerosis","volume":"135","author":"Wei","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.113068_bib13","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1182\/blood-2010-01-266536","article-title":"Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab","volume":"116","author":"Mei","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.isci.2025.113068_bib14","first-page":"394","article-title":"P657 - Reduction of Intrathecal Immunoglobulin Levels With Ocrelizumab Treatment in Relapsing and Primary Progressive Multiple Sclerosis","volume":"29","author":"Weber","year":"2023","journal-title":"Mult. Scler."},{"key":"10.1016\/j.isci.2025.113068_bib15","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jamaneurol.2020.1568","article-title":"Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials","volume":"77","author":"Kappos","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib16","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/jamaneurol.2023.3331","article-title":"Harmonizing Definitions for Progression Independent of Relapse Activity in Multiple Sclerosis: A Systematic Review","volume":"80","author":"M\u00fcller","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib17","first-page":"125","article-title":"P764 - Circulating B-Cell and Serum Neurofilament Light Chain Levels Associated With Progressive Disease Outcomes in Phase III Trials of Ocrelizumab in People With Relapsing or Progressive Multiple Sclerosis","volume":"30","author":"Hauser","year":"2024","journal-title":"Mult. Scler."},{"key":"10.1016\/j.isci.2025.113068_bib18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/jnnp-2022-330793","article-title":"Ocrelizumab concentration and antidrug antibodies are associated with B-cell count in multiple sclerosis","volume":"94","author":"Toorop","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.isci.2025.113068_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105851","article-title":"A personalized approach for anti-CD20 therapies in multiple sclerosis","volume":"91","author":"Hogenboom","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.isci.2025.113068_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2018.08.011","article-title":"Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis","volume":"175","author":"Jelcic","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113068_bib21","doi-asserted-by":"crossref","first-page":"580","DOI":"10.4049\/jimmunol.1400118","article-title":"Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients","volume":"193","author":"Palanichamy","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.113068_bib22","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2207291120","article-title":"Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity","volume":"120","author":"Shinoda","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113068_bib23","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/eji.202048665","article-title":"White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells","volume":"51","author":"Hsiao","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2025.113068_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105785","article-title":"Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis","volume":"26","author":"Hsiao","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.isci.2025.113068_bib25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/brain\/awy301","article-title":"Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis","volume":"142","author":"von Essen","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.isci.2025.113068_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abi4632","article-title":"Proinflammatory CD20+ T cells contribute to CNS-directed autoimmunity","volume":"14","author":"Ochs","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2025.113068_bib27","article-title":"Intrathecal CD8+CD20+ T Cells in Primary Progressive Multiple Sclerosis","volume":"10","author":"Essen","year":"2023","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.isci.2025.113068_bib28","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200091","article-title":"Immune Profiling Reveals the T-Cell Effect of Ocrelizumab in Early Relapsing-Remitting Multiple Sclerosis","volume":"10","author":"Garcia","year":"2023","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.isci.2025.113068_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adc9778","article-title":"A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis","volume":"14","author":"Ostkamp","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2025.113068_bib30","doi-asserted-by":"crossref","first-page":"22932","DOI":"10.1073\/pnas.2008523117","article-title":"A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis","volume":"117","author":"Ramesh","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113068_bib31","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000732","article-title":"Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation","volume":"7","author":"Esaulova","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.isci.2025.113068_bib32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.immuni.2020.12.011","article-title":"Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid","volume":"54","author":"Heming","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2025.113068_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41467-019-14118-w","article-title":"Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis","volume":"11","author":"Schafflick","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113068_bib34","author":"10x Genomics"},{"key":"10.1016\/j.isci.2025.113068_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2018.01071","article-title":"Real-World Lab Data in Natalizumab Treated Multiple Sclerosis Patients Up to 6 Years Long-Term Follow Up","volume":"9","author":"Kaufmann","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib36","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000292","article-title":"Natalizumab treatment leads to an increase in circulating CXCR3-expressing B cells","volume":"3","author":"Saraste","year":"2016","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.isci.2025.113068_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.102987","article-title":"Natalizumab differentially affects plasmablasts and B cells in multiple sclerosis","volume":"52","author":"Cuculiza Henriksen","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.isci.2025.113068_bib38","doi-asserted-by":"crossref","first-page":"25690","DOI":"10.1073\/pnas.2012249117","article-title":"B cells reappear less mature and more activated after their anti-CD20\u2013mediated depletion in multiple sclerosis","volume":"117","author":"Nissimov","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113068_bib39","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI58743","article-title":"Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity","volume":"122","author":"Maurer","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.113068_bib40","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00011-022-01622-x","article-title":"CD20+ T cells: an emerging T cell subset in human pathology","volume":"71","author":"Lee","year":"2022","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.isci.2025.113068_bib41","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/cyto.990140212","article-title":"CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes","volume":"14","author":"Hultin","year":"1993","journal-title":"Cytometry"},{"key":"10.1016\/j.isci.2025.113068_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abb8786","article-title":"Transcriptomic and clonal characterization of T cells in the human central nervous system","volume":"5","author":"Pappalardo","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2025.113068_bib43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ana.25927","article-title":"Role of B Cells in Multiple Sclerosis and Related Disorders","volume":"89","author":"Comi","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib44","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000940","article-title":"Effect of Ocrelizumab in Blood Leukocytes of Patients With Primary Progressive MS","volume":"8","author":"Fern\u00e1ndez-Velasco","year":"2021","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.isci.2025.113068_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12974-023-02900-z","article-title":"Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis","volume":"20","author":"Rodriguez-Mogeda","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.isci.2025.113068_bib46","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200118","article-title":"Effect of Ocrelizumab on B- and T-Cell Receptor Repertoire Diversity in Patients With Relapsing Multiple Sclerosis From the Randomized Phase III OPERA Trial","volume":"10","author":"Laurent","year":"2023","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.isci.2025.113068_bib47","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/acn3.52009","article-title":"CD11c+ B cells in relapsing\u2013remitting multiple sclerosis and effects of anti-CD20 therapy","volume":"11","author":"El Mahdaoui","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/acn3.51965","article-title":"Repeated iv anti-CD20 treatment in multiple sclerosis: Long-term effects on peripheral immune cell subsets","volume":"11","author":"Feige","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib49","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41590-025-02198-4","article-title":"Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia","volume":"26","author":"Mason","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.113068_bib50","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1093\/brain\/awab307","article-title":"Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity","volume":"144","author":"Liebmann","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.isci.2025.113068_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.109894","article-title":"Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab","volume":"259","author":"Beckers","year":"2024","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.isci.2025.113068_bib52","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1002\/acn3.52182","article-title":"Longitudinal analysis of peripheral immune cells in patients with multiple sclerosis treated with anti-CD20 therapy","volume":"11","author":"Waede","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.isci.2025.113068_bib53","article-title":"CD20+ natural killer cells are polyfunctional, memory-like cells that are enriched in inflammatory disorders","author":"Albayrak","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2025.113068_bib55","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/bioinformatics\/btu138","article-title":"pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires","volume":"30","author":"Vander Heiden","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2025.113068_bib56","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/bioinformatics\/btv359","article-title":"Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data","volume":"31","author":"Gupta","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2025.113068_bib57","doi-asserted-by":"crossref","first-page":"i341","DOI":"10.1093\/bioinformatics\/bty235","article-title":"A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data","volume":"34","author":"Nouri","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2025.113068_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009885","article-title":"Phylogenetic analysis of migration, differentiation, and class switching in B cells","volume":"18","author":"Hoehn","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.isci.2025.113068_bib58","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1093\/brain\/awz301","article-title":"Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis","volume":"142","author":"Herich","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.isci.2025.113068_bib54","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201541119","article-title":"Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19","volume":"119","author":"Joseph","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113068_bib60","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/s41375-023-01952-7","article-title":"Clonotype definitions for immunogenetic studies: proposals from the EuroClonality NGS Working Group","volume":"37","author":"Sofou","year":"2023","journal-title":"Leukemia"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422501329X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422501329X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:18:14Z","timestamp":1777634294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422501329X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S258900422501329X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.113068","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"B- and T cell receptor sequencing elucidates characteristics of lymphocyte depletion by ocrelizumab","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.113068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113068"}}