{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:06:00Z","timestamp":1792757160139,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DT.4\/12\/15"],"award-info":[{"award-number":["DT.4\/12\/15"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["EMR\/2014\/000875"],"award-info":[{"award-number":["EMR\/2014\/000875"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007780","name":"Indian Institute of Science","doi-asserted-by":"publisher","award":["BT\/PR27952\/INF\/22\/212\/2018"],"award-info":[{"award-number":["BT\/PR27952\/INF\/22\/212\/2018"]}],"id":[{"id":"10.13039\/100007780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005116","name":"Jawaharlal Nehru Centre for Advanced Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR47843\/MED\/29\/1631\/2023"],"award-info":[{"award-number":["BT\/PR47843\/MED\/29\/1631\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR13522\/COE\/34\/27\/2015"],"award-info":[{"award-number":["BT\/PR13522\/COE\/34\/27\/2015"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR41341\/MED\/29\/1535\/2020"],"award-info":[{"award-number":["BT\/PR41341\/MED\/29\/1535\/2020"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SB\/S2\/JCB-025\/2016"],"award-info":[{"award-number":["SB\/S2\/JCB-025\/2016"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["JBR\/2021\/000011"],"award-info":[{"award-number":["JBR\/2021\/000011"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SP\/DSTO-19-0176"],"award-info":[{"award-number":["SP\/DSTO-19-0176"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["DT.06\/02\/2020"],"award-info":[{"award-number":["DT.06\/02\/2020"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["IRPHA-IPA\/2021\/000180 DT.25\/03\/2022"],"award-info":[{"award-number":["IRPHA-IPA\/2021\/000180 DT.25\/03\/2022"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.isci.2025.113405","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T03:54:55Z","timestamp":1755748495000},"page":"113405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histone demethylase LSD1 regulates lipid homeostasis during Cryptococcus neoformans infection"],"prefix":"10.1016","volume":"28","author":[{"given":"Gaurav Kumar","family":"Lohia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awantika","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kithiganahalli Narayanaswamy","family":"Balaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.113405_bib1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S1473-3099(22)00499-6","article-title":"The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis","volume":"22","author":"Rajasingham","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.isci.2025.113405_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s12257-018-0477-0","article-title":"Invasive Fungal Infections and Their Epidemiology: Measures in the Clinical Scenario","volume":"24","author":"Bajpai","year":"2019","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"10.1016\/j.isci.2025.113405_bib3","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI42949","article-title":"Cryptococci at the brain gate: Break and enter or use a Trojan horse?","volume":"120","author":"Casadevall","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.113405_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006669","article-title":"Pathogen manipulation of host metabolism: A common strategy for immune evasion","volume":"13","author":"Freyberg","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2025.113405_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage Immunometabolism: Where Are We (Going)?","volume":"38","author":"Van den Bossche","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib6","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.it.2019.10.002","article-title":"Foam Cells: One Size Doesn\u2019t Fit All","volume":"40","author":"Guerrini","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00564-17","article-title":"Lipids Affect the Cryptococcus neoformans-Macrophage Interaction and Promote Nonlytic Exocytosis. Infect Immun 85","volume":"85","author":"Nolan","year":"2017","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.113405_bib8","doi-asserted-by":"crossref","DOI":"10.3791\/52432-v","article-title":"Macrophage cholesterol depletion and its effect on the phagocytosis of Cryptococcus neoformans","author":"Bryan","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.isci.2025.113405_bib9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3852\/08-110","article-title":"Cryptococcus neoformans causes lipid peroxidation; therefore it is a potential inducer of atherogenesis","volume":"102","author":"Hall","year":"2010","journal-title":"Mycologia"},{"key":"10.1016\/j.isci.2025.113405_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/mmy.38.6.443.449","article-title":"Lipid peroxidation by alveolar macrophages challenged with Cryptococcus neoformans, Candida albicans or Aspergillus fumigatus","volume":"38","author":"Gross","year":"2000","journal-title":"Med. Mycol."},{"key":"10.1016\/j.isci.2025.113405_bib11","article-title":"Heterogeneity of foam cell biogenesis across diseases","author":"Guerrini","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2025.113405_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113405_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2012.63","article-title":"Regulation of lipid stores and metabolism by lipophagy","volume":"20","author":"Liu","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2025.113405_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fcell.2019.00185","article-title":"Emerging roles of lipophagy in health and disease","volume":"7","author":"Kounakis","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2025.113405_bib15","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.113405_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/15548627.2021.1936355","article-title":"Epigenetic reader BRD4 supports mycobacterial pathogenesis by co-modulating host lipophagy and angiogenesis","volume":"18","author":"Mukherjee","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.isci.2025.113405_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0022034510378683","article-title":"Epigenetic mechanisms in inflammation","volume":"90","author":"Bayarsaihan","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.isci.2025.113405_bib18","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.3390\/ijms21134573","article-title":"Host Epigenetics in Intracellular Pathogen Infections","volume":"21","author":"Fol","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.113405_bib19","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010272","article-title":"Epigenetics and bacterial infections","volume":"2","author":"Bierne","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.isci.2025.113405_bib20","doi-asserted-by":"crossref","first-page":"e1005814","DOI":"10.1371\/journal.ppat.1005814","article-title":"MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection","volume":"12","author":"Holla","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2025.113405_bib21","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","article-title":"Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes","volume":"34","author":"Bekkering","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2025.113405_bib22","doi-asserted-by":"crossref","first-page":"30034","DOI":"10.1074\/jbc.M110.151209","article-title":"Histone demethylase LSD1 regulates adipogenesis","volume":"285","author":"Musri","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113405_bib23","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ncomms1755","article-title":"FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure","volume":"3","author":"Hino","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113405_bib24","doi-asserted-by":"crossref","DOI":"10.3892\/or.2021.8184","article-title":"Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment","volume":"46","author":"Li","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.isci.2025.113405_bib25","doi-asserted-by":"crossref","first-page":"29937","DOI":"10.1074\/jbc.M114.573659","article-title":"Regulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1)","volume":"289","author":"Abdulla","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113405_bib26","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1128\/JVI.02515-08","article-title":"Engagement of the Lysine-Specific Demethylase\/HDAC1\/CoREST\/REST Complex by Herpes Simplex Virus 1","volume":"83","author":"Gu","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.isci.2025.113405_bib27","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2217\/epi-2016-0009","article-title":"LSD1: Biologic roles and therapeutic targeting","volume":"8","author":"Maiques-Diaz","year":"2016","journal-title":"Epigenomics"},{"key":"10.1016\/j.isci.2025.113405_bib28","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1172\/JCI26130","article-title":"You are right too!","volume":"115","author":"Witztum","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.113405_bib29","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/nsmb1337","article-title":"Covalent modifications of histones during development and disease pathogenesis","volume":"14","author":"Bhaumik","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.isci.2025.113405_bib30","article-title":"The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw082","article-title":"Role of epigenetics in modulation of immune response at the junction of host-pathogen interaction and danger molecule signaling","volume":"74","author":"Morandini","year":"2016","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.isci.2025.113405_bib32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41419-023-05656-9","article-title":"Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2025.113405_bib33","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1128\/MCB.00521-10","article-title":"Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability","volume":"30","author":"Foster","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113405_bib34","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/bjc.2013.364","article-title":"LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer","volume":"109","author":"Ding","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.isci.2025.113405_bib35","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1038\/onc.2017.267","article-title":"Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway","volume":"36","author":"Ambrosio","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2025.113405_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-021-00455-7","article-title":"Lysine-specific demethylase 1 inhibition enhances autophagy and attenuates early-stage post-spinal cord injury apoptosis","volume":"7","author":"Gu","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.isci.2025.113405_bib37","doi-asserted-by":"crossref","first-page":"e13102","DOI":"10.1111\/acel.13102","article-title":"LSD1 contributes to programmed oocyte death by regulating the transcription of autophagy adaptor SQSTM1\/p62","volume":"19","author":"He","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2025.113405_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121656","article-title":"Epigenetic Control of Autophagy in Cancer Cells: A Key Process for Cancer-Related Phenotypes","volume":"8","author":"Peixoto","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.isci.2025.113405_bib39","doi-asserted-by":"crossref","first-page":"74434","DOI":"10.18632\/oncotarget.20158","article-title":"Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies","volume":"8","author":"Chao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2025.113405_bib40","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrm3150","article-title":"Chaperone-mediated autophagy: Dice\u2019s \u201cwild\u201d idea about lysosomal selectivity","volume":"12","author":"Cuervo","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113405_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens5020034","article-title":"The Role of Autophagy-Related Proteins in Candida albicans Infections","volume":"5","author":"Tam","year":"2016","journal-title":"Pathogens"},{"key":"10.1016\/j.isci.2025.113405_bib42","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/ncb3192","article-title":"Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins","volume":"17","author":"Martinez","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2025.113405_bib43","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1002\/hep.27667","article-title":"The small GTPase Rab7 as a central regulator of hepatocellular lipophagy","volume":"61","author":"Schroeder","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2025.113405_bib44","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.isci.2025.113405_bib45","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02824-21","article-title":"Wnt-\u03b2-Catenin Signaling in Human Dendritic Cells Mediates Regulatory T-Cell Responses to Fungi via the PD-L1 Pathway","volume":"12","author":"Karnam","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.isci.2025.113405_bib46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.61.6.32","article-title":"Transcriptome Analysis of the Gene Expression Profiles Associated with Fungal Keratitis in Mice Based on RNA-Seq","volume":"61","author":"Zhang","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2025.113405_bib47","doi-asserted-by":"crossref","first-page":"741","DOI":"10.15252\/embr.201540081","article-title":"Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis","volume":"16","author":"Scott","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.isci.2025.113405_bib48","doi-asserted-by":"crossref","first-page":"e1011731","DOI":"10.1371\/journal.ppat.1011731","article-title":"G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival","volume":"19","author":"Prakhar","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2025.113405_bib49","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-pathol-012513-104653","article-title":"The Intracellular Life of Cryptococcus neoformans","volume":"9","author":"Coelho","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.isci.2025.113405_bib50","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.taap.2013.05.036","article-title":"NADPH oxidase\/ROS-dependent PYK2 activation is involved in TNF-\u03b1-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells","volume":"272","author":"Yang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.isci.2025.113405_bib51","doi-asserted-by":"crossref","first-page":"31174","DOI":"10.1074\/jbc.M110.118265","article-title":"Regulation of the Tyrosine Kinase Pyk2 by Calcium Is through Production of Reactive Oxygen Species in Cytotoxic T Lymphocytes","volume":"285","author":"Lysechko","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113405_bib52","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1128\/MCB.16.3.1027","article-title":"Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation","volume":"16","author":"Jelinek","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113405_bib53","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2025.113405_bib55","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.isci.2025.113405_bib56","article-title":"Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113405_bib57","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni.1781","article-title":"Foamy macrophages and the progression of the human tuberculosis granuloma","volume":"10","author":"Russell","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib58","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/IAI.01386-06","article-title":"Chlamydia pneumoniae-Induced Macrophage Foam Cell Formation Is Mediated by Toll-Like Receptor 2","volume":"75","author":"Cao","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2025.113405_bib59","first-page":"207","article-title":"The roles of lipid droplets in human infectious disease","volume":"13","author":"Meester","year":"2011","journal-title":"Med. Univ."},{"key":"10.1016\/j.isci.2025.113405_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01022","article-title":"Lipid Droplet, a Key Player in Host-Parasite Interactions","volume":"9","author":"Vallochi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11121821","article-title":"LSD1\/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target","volume":"11","author":"Karakaidos","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.isci.2025.113405_bib62","article-title":"LSD1 facilitates pro-inflammatory polarization of macrophages by repressing catalase","volume":"10","author":"Sobczak","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113405_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01351","article-title":"Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer","volume":"10","author":"Tan","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006773","article-title":"Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation","volume":"13","author":"Shan","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2025.113405_bib65","article-title":"Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content","author":"Guerrini","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2025.113405_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00081","article-title":"Modulation of host autophagy during bacterial infection: Sabotaging host munitions for pathogen nutrition","volume":"7","author":"Escoll","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib67","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chom.2012.04.012","article-title":"Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program","volume":"11","author":"Tattoli","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.isci.2025.113405_bib68","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.1106036","article-title":"Escape of intracellular Shigella from autophagy","volume":"307","author":"Ogawa","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.113405_bib69","doi-asserted-by":"crossref","first-page":"20800","DOI":"10.1073\/pnas.1218674109","article-title":"Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection","volume":"109","author":"Niu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113405_bib70","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1462-5822.2010.01456.x","article-title":"Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages","volume":"12","author":"Moreau","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.isci.2025.113405_bib71","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1462-5822.2005.00527.x","article-title":"Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles","volume":"7","author":"Gutierrez","year":"2005","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.isci.2025.113405_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2015.00051","article-title":"The role of autophagy in intracellular pathogen nutrient acquisition","volume":"5","author":"Steele","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.isci.2025.113405_bib73","doi-asserted-by":"crossref","DOI":"10.2217\/clp.09.63","article-title":"Lipid droplets in host-pathogen interactions","author":"Bozza","year":"2009","journal-title":"Clin. Lipidol."},{"key":"10.1016\/j.isci.2025.113405_bib74","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.bbrc.2019.11.182","article-title":"LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation","volume":"522","author":"Shi","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2025.113405_bib75","first-page":"817","article-title":"ROS and innate immunity","volume":"29","author":"Kohchi","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.isci.2025.113405_bib76","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00705-016-3130-2","article-title":"Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections","volume":"162","author":"Li","year":"2017","journal-title":"Arch. Virol."},{"key":"10.1016\/j.isci.2025.113405_bib77","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.4049\/jimmunol.1402350","article-title":"Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans","volume":"194","author":"Coelho","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.113405_bib78","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1128\/MCB.00641-14","article-title":"The WNT Signaling Pathway Contributes to Dectin-1-Dependent Inhibition of Toll-Like Receptor-Induced Inflammatory Signature","volume":"34","author":"Trinath","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113405_bib79","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrd.2017.162","article-title":"Host-directed therapies for bacterial and viral infections","volume":"17","author":"Kaufmann","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.isci.2025.113405_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00329","article-title":"Bromodomain Inhibitors as Therapeutics for Herpesvirus-Related Disease: All BETs Are Off?","volume":"10","author":"Groves","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.isci.2025.113405_bib81","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41419-021-04431-y","article-title":"Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy","volume":"12","author":"Mao","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2025.113405_bib82","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4036","article-title":"Targeting EZH2 in cancer","volume":"22","author":"Kim","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2025.113405_bib83","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.21037\/tlcr-23-40","article-title":"LSD1-targeted therapy\u2014a multi-purpose key to unlock immunotherapy in small cell lung cancer","volume":"12","author":"Sattler","year":"2023","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.isci.2025.113405_bib84","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.4155\/fmc-2018-0065","article-title":"Trends of LSD1 inhibitors in viral infections","volume":"10","author":"Zwergel","year":"2018","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.isci.2025.113405_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1120911","article-title":"LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials","volume":"14","author":"Noce","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2025.113405_bib86","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41375-020-0892-z","article-title":"A proof of concept phase I\/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory\/relapsed AML patients not eligible for intensive therapy","volume":"35","author":"Wass","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2025.113405_bib87","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-59745-396-7_9","article-title":"The expression of exogenous genes in macrophages: obstacles and opportunities","volume":"531","author":"Zhang","year":"2009","journal-title":"Methods Mol. Biol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225016669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225016669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:30:20Z","timestamp":1778902220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225016669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":86,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2589004225016669"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.113405","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone demethylase LSD1 regulates lipid homeostasis during Cryptococcus neoformans infection","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.113405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113405"}}