{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:55:06Z","timestamp":1776387306988,"version":"3.51.2"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007388","name":"St Paul Foundation","doi-asserted-by":"publisher","award":["S1921_EX-POST-21_01"],"award-info":[{"award-number":["S1921_EX-POST-21_01"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"St Paul Foundation","doi-asserted-by":"publisher","award":["375-2019"],"award-info":[{"award-number":["375-2019"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.isci.2025.113529","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T16:11:55Z","timestamp":1757347915000},"page":"113529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multicomponent-based analyses of ACS-patient-derived extracellular vesicles as likely tools for tailored interventional approaches"],"prefix":"10.1016","volume":"28","author":[{"given":"Saveria","family":"Femmin\u00f2","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sarcinella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Mensitieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidio","family":"De Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albino","family":"Coglianese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tapparo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Pace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad","family":"Kholia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Ciullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Buffolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Camussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano Maria","family":"De Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Dal Piaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Felice","family":"Brizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.113529_bib1","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2025.113529_bib2","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics\u20142020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2025.113529_bib3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1001\/jamacardio.2016.2049","article-title":"Updates on Acute Coronary Syndrome: A Review","volume":"1","author":"Eisen","year":"2016","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.isci.2025.113529_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105715","article-title":"Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury","volume":"170","author":"D\u2019Ascenzo","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.isci.2025.113529_bib5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.14348\/molcells.2022.0110","article-title":"Extracellular Vesicles as an Endocrine Mechanism Connecting Distant Cells","volume":"45","author":"Kita","year":"2022","journal-title":"Mol. Cells"},{"key":"10.1016\/j.isci.2025.113529_bib6","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/cvr\/cvz302","article-title":"Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease","volume":"116","author":"Kaur","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2025.113529_bib7","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1586\/14737159.2015.1109450","article-title":"The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease","volume":"15","author":"Bank","year":"2015","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.isci.2025.113529_bib8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12964-023-01089-1","article-title":"Protein corona and exosomes: new challenges and prospects","volume":"21","author":"Heidarzadeh","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2025.113529_bib9","first-page":"143","article-title":"ESC working group position paper on myocardial infarction with non-obstructive coronary arteries","volume":"38","author":"Agewall","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2025.113529_bib10","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"Peduzzi","year":"1996","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.isci.2025.113529_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/cvr\/cvx211","article-title":"Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology","volume":"114","author":"Sluijter","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2025.113529_bib12","first-page":"653","article-title":"Diagnostic value of circulating microRNAs compared to high-sensitivity troponin T for the detection of non-ST-segment elevation myocardial infarction","volume":"10","author":"Biener","year":"2021","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.isci.2025.113529_bib13","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.21037\/jtd.2018.05.141","article-title":"Sensitive miRNA markers for the detection and management of NSTEMI acute myocardial infarction patients","volume":"10","author":"Liu","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.isci.2025.113529_bib14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3390\/biom11070962","article-title":"Circulating extracellular mirna analysis in patients with stable cad and acute coronary syndromes","volume":"11","author":"Zhelankin","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.isci.2025.113529_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800247","article-title":"Application of Extracellular Vesicles Proteomics to Cardiovascular Disease: Guidelines, Data Analysis, and Future Perspectives","volume":"19","author":"Barrachina","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.isci.2025.113529_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.omtn.2018.11.017","article-title":"Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia","volume":"14","author":"Downie Ruiz Velasco","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.isci.2025.113529_bib17","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/jamacardio.2019.3780","article-title":"Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review","volume":"4","author":"Sniderman","year":"2019","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.isci.2025.113529_bib18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.21873\/invivo.11803","article-title":"Quantitative Comparative Proteomics Reveals Candidate Biomarkers for the Early Prediction of Gestational Diabetes Mellitus: A Preliminary Study","volume":"34","author":"Mavreli","year":"2020","journal-title":"In Vivo (Athens)"},{"key":"10.1016\/j.isci.2025.113529_bib19","doi-asserted-by":"crossref","first-page":"71922","DOI":"10.18632\/oncotarget.12431","article-title":"MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K\/Akt\/eNOS signaling pathway","volume":"7","author":"Song","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2025.113529_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/jamacardio.2023.0031","article-title":"Performance of the European Society of Cardiology 0\/1-Hour Algorithm With High-Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease","volume":"8","author":"Ashburn","year":"2023","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.isci.2025.113529_bib21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/MCA.0000000000001169","article-title":"Prevalence of obstructive coronary artery disease in patients with unstable angina","volume":"33","author":"Bean-Thompson","year":"2022","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.isci.2025.113529_bib22","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/heartjnl-2018-314305","article-title":"Incidence and outcomes of unstable angina compared with non-ST-elevation myocardial infarction","volume":"105","author":"Puelacher","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.isci.2025.113529_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007965","article-title":"Clinical Characteristics, Sex Differences, and Outcomes in Patients With Normal or Near-Normal Coronary Arteries, Non-Obstructive or Obstructive Coronary Artery Disease","volume":"7","author":"Ouellette","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.isci.2025.113529_bib24","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/eurheartj\/ehq478","article-title":"Circulating CD31+\/Annexin V+ microparticles correlate with cardiovascular outcomes","volume":"32","author":"Sinning","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2025.113529_bib25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jmb.2015.09.019","article-title":"ExoCarta: A Web-Based Compendium of Exosomal Cargo","volume":"428","author":"Keerthikumar","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.isci.2025.113529_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.isci.2025.113529_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.arcmed.2012.01.006","article-title":"Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation","volume":"43","author":"St\u0119pie\u0144","year":"2012","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.isci.2025.113529_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.thromres.2017.06.003","article-title":"Microparticles in acute coronary syndrome","volume":"156","author":"Mavroudis","year":"2017","journal-title":"Thromb. Res."},{"key":"10.1016\/j.isci.2025.113529_bib29","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1182\/blood.V94.11.3791","article-title":"Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules","volume":"94","author":"Heijnen","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.isci.2025.113529_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11010-016-2756-4","article-title":"Enhanced P-selectin expression on platelet-a marker of platelet activation, in young patients with angiographically proven coronary artery disease","volume":"419","author":"George","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2025.113529_bib31","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1111\/jcmm.15594","article-title":"An extracellular vesicle epitope profile is associated with acute myocardial infarction","volume":"24","author":"Burrello","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.isci.2025.113529_bib32","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0002-9149(96)00861-2","article-title":"Levels of expression of P-selectin, E-selectin, and intercellular adhesion molecule-1 in coronary atherectomy specimens from patients with stable and unstable angina pectoris","volume":"79","author":"Tenaglia","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.isci.2025.113529_bib33","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s11239-020-02302-5","article-title":"Platelet microvesicles are associated with the severity of coronary artery disease: comparison between peripheral and coronary circulation","volume":"51","author":"Gkaliagkousi","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.isci.2025.113529_bib34","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.trsl.2022.02.005","article-title":"Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature","volume":"244","author":"Burrello","year":"2022","journal-title":"Transl. Res."},{"key":"10.1016\/j.isci.2025.113529_bib35","doi-asserted-by":"crossref","first-page":"879351","DOI":"10.3389\/fcvm.2022.879351","article-title":"Insights Into Platelet-Derived MicroRNAs in Cardiovascular and Oncologic Diseases: Potential Predictor and Therapeutic Target","volume":"9","author":"Leng","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.isci.2025.113529_bib36","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3390\/jpm11060508","article-title":"MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty","volume":"11","author":"Hromadka","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.isci.2025.113529_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/09537104.2016.1268255","article-title":"Extracellular vesicles from activated platelets: a semiquantitative cryo-electron microscopy and immuno-gold labeling study","volume":"28","author":"Brisson","year":"2017","journal-title":"Platelets"},{"key":"10.1016\/j.isci.2025.113529_bib38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/cvr\/cvs007","article-title":"Microparticles: major transport vehicles for distinct microRNAs in circulation","volume":"93","author":"Diehl","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2025.113529_bib39","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1159\/000478071","article-title":"Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China","volume":"42","author":"Jia","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.isci.2025.113529_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.909","article-title":"Circulating miR-130 and its target PPAR-\u03b3 may be potential biomarkers in patients of coronary artery disease with type 2 diabetes mellitus","volume":"7","author":"Yuan","year":"2019","journal-title":"Mol. Genet. Genomic Med."},{"key":"10.1016\/j.isci.2025.113529_bib41","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.21037\/jtd-20-3207","article-title":"Circulating miR-130 is a potential bio signature for early prognosis of acute myocardial infarction","volume":"12","author":"Pan","year":"2020","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.isci.2025.113529_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10741-024-10443-5","article-title":"Potential of plasma biomarkers for heart failure prediction, management, and prognosis: A multiomics perspective","volume":"30","author":"Zou","year":"2025","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.isci.2025.113529_bib43","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1021\/acs.jproteome.4c00586","article-title":"The Circulating Proteome\u2500Technological Developments, Current Challenges, and Future Trends","volume":"23","author":"Geyer","year":"2024","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.isci.2025.113529_bib44","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/eurheartj\/ehac055","article-title":"Targeted proteomics improves cardiovascular risk prediction in secondary prevention","volume":"43","author":"Nurmohamed","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2025.113529_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102152","article-title":"Proteomic and metabolomic profiles of plasma-derived Extracellular Vesicles differentiate melanoma patients from healthy controls","volume":"50","author":"Bollard","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.isci.2025.113529_bib46","article-title":"Differential proteomic patterns of plasma extracellular vesicles show potential to discriminate \u03b2-thalassemia subtypes","volume":"26","author":"Li","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.isci.2025.113529_bib47","doi-asserted-by":"crossref","first-page":"C29","DOI":"10.1152\/ajpcell.00280.2019","article-title":"Extracellular vesicles as biomarkers and therapeutic targets for cancer","volume":"318","author":"Urabe","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.isci.2025.113529_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12943-023-01741-x","article-title":"Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis","volume":"22","author":"Lee","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.isci.2025.113529_bib49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCULATIONAHA.124.068885","article-title":"Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice","volume":"150","author":"De Oliveira-Gomes","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2025.113529_bib50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11883-021-00907-6","article-title":"The Role of Phospholipid Transfer Protein in the Development of Atherosclerosis","volume":"23","author":"Jiang","year":"2021","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.isci.2025.113529_bib51","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1161\/01.ATV.0000094433.98445.7F","article-title":"High plasma phospholipid transfer protein levels as a risk factor for coronary artery disease","volume":"23","author":"Schlitt","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2025.113529_bib52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.atherosclerosis.2009.04.011","article-title":"Relation of baseline plasma phospholipid transfer protein (PLTP) activity to left ventricular systolic dysfunction in patients referred for coronary angiography","volume":"207","author":"Cavusoglu","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.isci.2025.113529_bib53","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.atherosclerosis.2015.02.017","article-title":"Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease","volume":"239","author":"Cavusoglu","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.isci.2025.113529_bib54","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1016\/j.jacl.2024.03.007","article-title":"The role of genetically-influenced phospholipid transfer protein activity in lipoprotein metabolism and coronary artery disease","volume":"18","author":"Ao","year":"2024","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.isci.2025.113529_bib55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archinte.160.1.25","article-title":"Unstable Angina: Current Concepts of Pathogenesis and Treatment","volume":"160","author":"Ambrose","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.isci.2025.113529_bib56","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.biomaterials.2006.09.006","article-title":"Volumetric interpretation of protein adsorption: Competition from mixtures and the Vroman effect","volume":"28","author":"Noh","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.isci.2025.113529_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymgme.2021.03.010","article-title":"MTP deficiency caused by HADHB mutations: Pathophysiology and clinical manifestations","volume":"133","author":"Dagher","year":"2021","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.isci.2025.113529_bib58","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.gde.2011.04.010","article-title":"Control of microRNA biogenesis and transcription by cell signaling pathways","volume":"21","author":"Saj","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.isci.2025.113529_bib59","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature08199","article-title":"Modulation of microRNA processing by p53","volume":"460","author":"Suzuki","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.113529_bib60","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature07086","article-title":"SMAD proteins control DROSHA-mediated microRNA maturation","volume":"454","author":"Davis","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.113529_bib61","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2025.113529_bib62","doi-asserted-by":"crossref","first-page":"e00099-20","DOI":"10.1128\/MCB.00099-20","article-title":"The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway","volume":"40","author":"Baird","year":"2020","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.113529_bib63","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/eurheartj\/ehy462","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"40","author":"Thygesen","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2025.113529_bib64","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3892\/ijmm.2016.2759","article-title":"Charge-based precipitation of extracellular vesicles","volume":"38","author":"Deregibus Chiara","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.isci.2025.113529_bib65","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3390\/polym10020211","article-title":"\u03b1-Cyclodextrin and \u03b1-Cyclodextrin Polymers as Oxygen Nanocarriers to Limit Hypoxia\/Reoxygenation Injury: Implications from an In Vitro Model","volume":"10","author":"Femmin\u00f2","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.isci.2025.113529_bib66","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3389\/fimmu.2018.01326","article-title":"Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures","volume":"9","author":"Wiklander","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113529_bib67","doi-asserted-by":"crossref","first-page":"8732","DOI":"10.3390\/ijms22168732","article-title":"Outer Membrane Vesicles Derived from Klebsiella pneumoniae Are a Driving Force for Horizontal Gene Transfer","volume":"22","author":"Dell\u2019Annunziata","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2025.113529_bib68","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: an informative resource for experimentally validated miRNA\u2013target interactions","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2025.113529_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.90","article-title":"Gene Set Knowledge Discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225017900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225017900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:47:31Z","timestamp":1771609651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225017900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2589004225017900"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.113529","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multicomponent-based analyses of ACS-patient-derived extracellular vesicles as likely tools for tailored interventional approaches","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.113529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113529"}}