{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:31:39Z","timestamp":1793388699403,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570053"],"award-info":[{"award-number":["82570053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370042"],"award-info":[{"award-number":["82370042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300045"],"award-info":[{"award-number":["82300045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["24B0016"],"award-info":[{"award-number":["24B0016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ6658"],"award-info":[{"award-number":["2024JJ6658"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ10085"],"award-info":[{"award-number":["2023JJ10085"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ50626"],"award-info":[{"award-number":["2025JJ50626"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ30726"],"award-info":[{"award-number":["2023JJ30726"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ40803"],"award-info":[{"award-number":["2023JJ40803"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.isci.2025.113928","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:57:16Z","timestamp":1762315036000},"page":"113928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury"],"prefix":"10.1016","volume":"28","author":[{"given":"Xinyu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-9576","authenticated-orcid":false,"given":"Chi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.113928_bib1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1165\/rcmb.2021-0531ST","article-title":"Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report","volume":"66","author":"Kulkarni","year":"2022","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2025.113928_bib2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/CS20210879","article-title":"Pathogenesis of pneumonia and acute lung injury","volume":"136","author":"Long","year":"2022","journal-title":"Clin. Sci."},{"key":"10.1016\/j.isci.2025.113928_bib3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","article-title":"Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes","volume":"400","author":"Bos","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2025.113928_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pccm.2024.04.002","article-title":"Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome","volume":"2","author":"Su","year":"2024","journal-title":"Chin. Med. J. Pulm. Crit. Care Med."},{"key":"10.1016\/j.isci.2025.113928_bib5","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI61303","article-title":"Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury","volume":"122","author":"Caudrillier","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.113928_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ccc.2021.05.001","article-title":"The Epidemiology of Acute Respiratory Distress Syndrome Before and After Coronavirus Disease 2019","volume":"37","author":"Hendrickson","year":"2021","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.isci.2025.113928_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109289","article-title":"Targeting immunometabolism against acute lung injury","volume":"249","author":"Ning","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pathol-020712-164023","article-title":"The multifaceted functions of neutrophils","volume":"9","author":"Mayadas","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.isci.2025.113928_bib9","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.113928_bib69","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pccm.2023.10.004","article-title":"A crucial role of neutrophil extracellular traps in pumonary infectious diseases","volume":"2","author":"Pan","year":"2024","journal-title":"Chin. Med. J. Pulm. Crit. Care Med."},{"key":"10.1016\/j.isci.2025.113928_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s13054-018-2290-8","article-title":"Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia","volume":"22","author":"Mikacenic","year":"2018","journal-title":"Crit. Care"},{"key":"10.1016\/j.isci.2025.113928_bib11","doi-asserted-by":"crossref","first-page":"8972","DOI":"10.1038\/s41598-017-09337-4","article-title":"CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock","volume":"7","author":"Pan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.113928_bib12","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1182\/blood-2012-01-405183","article-title":"Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice","volume":"119","author":"Thomas","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.isci.2025.113928_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.157342","article-title":"Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection","volume":"7","author":"Adrover","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2025.113928_bib14","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200652","article-title":"Targeting potential drivers of COVID-19: Neutrophil extracellular traps","volume":"217","author":"Barnes","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2025.113928_bib15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1172\/JCI0213462","article-title":"Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis","volume":"109","author":"Adkison","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.113928_bib16","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.4049\/jimmunol.1103179","article-title":"Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice","volume":"189","author":"Liu","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib17","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1096\/fj.201802016RR","article-title":"Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection","volume":"33","author":"Liu","year":"2019","journal-title":"Faseb j"},{"key":"10.1016\/j.isci.2025.113928_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biochi.2023.09.018","article-title":"Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders","volume":"216","author":"Aghdassi","year":"2024","journal-title":"Biochimie"},{"key":"10.1016\/j.isci.2025.113928_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3389\/fimmu.2016.00325","article-title":"Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype","volume":"7","author":"Akk","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ccell.2021.01.009","article-title":"Neutrophils create a fertile soil for metastasis","volume":"39","author":"Kos","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2025.113928_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ccell.2020.12.012","article-title":"Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation","volume":"39","author":"Xiao","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2025.113928_bib22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1239151","article-title":"Dipeptidyl peptidase 1 inhibition as a potential therapeutic approach in neutrophil-mediated inflammatory disease","volume":"14","author":"Chalmers","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib24","article-title":"Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-\u03b1-accelerated lupus nephritis in mice","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12931-023-02444-z","article-title":"Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial","volume":"24","author":"Cipolla","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.isci.2025.113928_bib26","doi-asserted-by":"crossref","first-page":"9457","DOI":"10.1021\/acs.jmedchem.6b01127","article-title":"Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)","volume":"59","author":"Doyle","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.isci.2025.113928_bib27","doi-asserted-by":"crossref","first-page":"12415","DOI":"10.1074\/jbc.RA118.001922","article-title":"Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis","volume":"293","author":"Seren","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113928_bib28","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1172\/JCI78182","article-title":"Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis","volume":"125","author":"Millet","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2025.113928_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1681\/ASN.2011030298","article-title":"Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles","volume":"23","author":"Hong","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2025.113928_bib30","doi-asserted-by":"crossref","first-page":"10476","DOI":"10.1074\/jbc.M115.698639","article-title":"Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles","volume":"291","author":"Martin","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2025.113928_bib31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.2010080892","article-title":"Neutrophil serine proteases promote IL-1\u03b2 generation and injury in necrotizing crescentic glomerulonephritis","volume":"23","author":"Schreiber","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2025.113928_bib32","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.isci.2025.113928_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4143\/crt.2019.145","article-title":"Cathepsin C Interacts with TNF-\u03b1\/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma","volume":"52","author":"Zhang","year":"2020","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.isci.2025.113928_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jaut.2019.01.003","article-title":"Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37","volume":"98","author":"Ribon","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.isci.2025.113928_bib35","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1096\/fj.201800752R","article-title":"Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases","volume":"33","author":"Hahn","year":"2019","journal-title":"Faseb j"},{"key":"10.1016\/j.isci.2025.113928_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138999","article-title":"Neutrophil extracellular traps in COVID-19","volume":"5","author":"Zuo","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2025.113928_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76781-0","article-title":"The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)","volume":"10","author":"Arcanjo","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.113928_bib38","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.7150\/ijbs.69141","article-title":"Neutrophil extracellular traps mediate m(6)A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2025.113928_bib39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12929-023-00957-9","article-title":"Exosomal PGE2 from M2 macrophages inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis","volume":"30","author":"Jiao","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.isci.2025.113928_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajpath.2011.03.013","article-title":"Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis","volume":"179","author":"Narasaraju","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2025.113928_bib41","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nm.3653","article-title":"Preparing the ground for tissue regeneration: from mechanism to therapy","volume":"20","author":"Forbes","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2025.113928_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1165\/rcmb.2018-0101PS","article-title":"The Emerging Role of Neutrophils in Repair after Acute Lung Injury","volume":"59","author":"Bl\u00e1zquez-Prieto","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2025.113928_bib43","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev-physiol-030212-183756","article-title":"Regulation and repair of the alveolar-capillary barrier in acute lung injury","volume":"75","author":"Bhattacharya","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.isci.2025.113928_bib44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.isci.2025.113928_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714833","article-title":"Non-Randomized Trial of Dornase Alfa for Acute Respiratory Distress Syndrome Secondary to Covid-19","volume":"12","author":"Holliday","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf8748","article-title":"Neutrophil-intrinsic TNF receptor signaling orchestrates host defense against Staphylococcus aureus","volume":"9","author":"Youn","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2025.113928_bib47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pharmthera.2018.05.011","article-title":"Therapeutic targeting of cathepsin C: from pathophysiology to treatment","volume":"190","author":"Korkmaz","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.isci.2025.113928_bib48","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1681\/ASN.2021081112","article-title":"Targeting Cathepsin C in PR3-ANCA Vasculitis","volume":"33","author":"Jerke","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2025.113928_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029318","article-title":"Neutrophil extracellular trap formation is associated with IL-1\u03b2 and autophagy-related signaling in gout","volume":"6","author":"Mitroulis","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.113928_bib50","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1161\/ATVBAHA.117.309897","article-title":"Novel Role of IL (Interleukin)-1\u03b2 in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms","volume":"38","author":"Meher","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2025.113928_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048111","article-title":"Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition","volume":"7","author":"Keshari","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2025.113928_bib52","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ccell.2023.03.008","article-title":"Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-\u03b2 activation","volume":"41","author":"Mousset","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2025.113928_bib53","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.4049\/jimmunol.167.10.5940","article-title":"Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1beta","volume":"167","author":"Suzuki","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib54","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.intimp.2016.03.036","article-title":"Administration of SB239063, a potent p38 MAPK inhibitor, alleviates acute lung injury induced by intestinal ischemia reperfusion in rats associated with AQP4 downregulation","volume":"38","author":"Xiong","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.isci.2025.113928_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105107","article-title":"Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion","volume":"148","author":"Zhao","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.isci.2025.113928_bib56","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/ATVBAHA.114.304292","article-title":"Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses","volume":"35","author":"Her\u00edas","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2025.113928_bib57","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1073\/pnas.96.15.8627","article-title":"Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo","volume":"96","author":"Pham","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.113928_bib58","first-page":"46","article-title":"Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles","volume":"9","author":"Wu","year":"2022","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.isci.2025.113928_bib59","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1038\/s12276-022-00889-8","article-title":"Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury","volume":"54","author":"Yang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.isci.2025.113928_bib60","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201368","article-title":"Lack of bombesin receptor-activated protein attenuates bleomycin-induced pulmonary fibrosis in mice","volume":"5","author":"Wang","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.isci.2025.113928_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.746964","article-title":"Tanreqing Inhibits LPS-Induced Acute Lung Injury In Vivo and In Vitro Through Downregulating STING Signaling Pathway","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2025.113928_bib62","doi-asserted-by":"crossref","first-page":"349","DOI":"10.7150\/ijbs.66215","article-title":"ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells","volume":"18","author":"Du","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2025.113928_bib63","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.jaci.2021.09.037","article-title":"Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity","volume":"149","author":"Hurrell","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.105948","article-title":"Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis","volume":"26","author":"Parthasarathy","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.isci.2025.113928_bib65","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41467-024-45210-5","article-title":"PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury","volume":"15","author":"Du","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113928_bib66","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jaci.2022.09.032","article-title":"Airway epithelial ITGB4 deficiency induces airway remodeling in a mouse model","volume":"151","author":"Yuan","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2025.113928_bib67","article-title":"Amelioration of systemic antitumor immune responses in cocktail therapy by immunomodulatory nanozymes","volume":"8","author":"Wang","year":"2022","journal-title":"Sci. Adv."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225021893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225021893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:33:05Z","timestamp":1783474385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225021893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":68,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2589004225021893"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.113928","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.113928","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113928"}}