{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:17:35Z","timestamp":1783477055258,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271237"],"award-info":[{"award-number":["82271237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930029"],"award-info":[{"award-number":["81930029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071218"],"award-info":[{"award-number":["82071218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230042"],"award-info":[{"award-number":["82230042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.isci.2025.113949","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:48:40Z","timestamp":1762390120000},"page":"113949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice"],"prefix":"10.1016","volume":"28","author":[{"given":"Xiaoheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilian","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoshuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningsheng","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.113949_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia Biology: One Century of Evolving Concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113949_bib2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.molmed.2019.08.013","article-title":"Microglia as Dynamic Cellular Mediators of Brain Function","volume":"25","author":"Wright-Jin","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.isci.2025.113949_bib3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.devcel.2016.07.006","article-title":"Microglia: Phagocytosing to Clear, Sculpt, and Eliminate","volume":"38","author":"Hong","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2025.113949_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tins.2012.11.007","article-title":"Microglia: actively surveying and shaping neuronal circuit structure and function","volume":"36","author":"Wake","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib5","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.113949_bib6","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.113949_bib7","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","article-title":"Microglia regulate the number of neural precursor cells in the developing cerebral cortex","volume":"33","author":"Cunningham","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nn.3358","article-title":"Layer V cortical neurons require microglial support for survival during postnatal development","volume":"16","author":"Ueno","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk1131","article-title":"Regulation of myelination by microglia","volume":"7","author":"Santos","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2025.113949_bib10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12974-020-01811-7","article-title":"Embryonic microglia influence developing hypothalamic glial populations","volume":"17","author":"Marsters","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.isci.2025.113949_bib11","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/glia.23961","article-title":"How microglia sense and regulate neuronal activity","volume":"69","author":"Umpierre","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.isci.2025.113949_bib12","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/s41593-018-0192-3","article-title":"Epigenetic regulation of brain region-specific microglia clearance activity","volume":"21","author":"Ayata","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib13","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nn.4222","article-title":"Microglial brain region-dependent diversity and selective regional sensitivities to aging","volume":"19","author":"Grabert","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav0581","article-title":"Cerebellar modulation of the reward circuitry and social behavior","volume":"363","author":"Carta","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.113949_bib15","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuron.2014.07.016","article-title":"The cerebellum, sensitive periods, and autism","volume":"83","author":"Wang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.113949_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.neuro.31.060407.125606","article-title":"Cerebellum and nonmotor function","volume":"32","author":"Strick","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib17","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/s41586-022-04711-3","article-title":"Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning","volume":"605","author":"Chen","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.113949_bib18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41583-019-0152-2","article-title":"Emerging connections between cerebellar development, behaviour and complex brain disorders","volume":"20","author":"Sathyanesan","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib19","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.jmb.2019.01.016","article-title":"Role of Microglia in Ataxias","volume":"431","author":"Ferro","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.isci.2025.113949_bib20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuron.2012.02.032","article-title":"GABAergic inhibition regulates developmental synapse elimination in the cerebellum","volume":"74","author":"Nakayama","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.113949_bib21","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63668","article-title":"Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors","volume":"10","author":"Beekhof","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.isci.2025.113949_bib22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tcb.2016.02.006","article-title":"Microglia: Architects of the Developing Nervous System","volume":"26","author":"Frost","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.isci.2025.113949_bib23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/35081558","article-title":"Genetic regulation of cerebellar development","volume":"2","author":"Wang","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41593-020-00754-9","article-title":"Diversity and dynamism in the cerebellum","volume":"24","author":"De Zeeuw","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-neuro-091421-125115","article-title":"The Cerebellar Cortex","volume":"45","author":"Hull","year":"2022","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neulet.2018.05.013","article-title":"Insights into cerebellar development and connectivity","volume":"688","author":"Beckinghausen","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2025.113949_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41583-019-0244-z","article-title":"The m(6)A epitranscriptome: transcriptome plasticity in brain development and function","volume":"21","author":"Livneh","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/jnc.14481","article-title":"The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity","volume":"147","author":"Widagdo","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.isci.2025.113949_bib29","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113949_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41422-018-0113-8","article-title":"A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.isci.2025.113949_bib31","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fncel.2018.00323","article-title":"Bidirectional Microglia-Neuron Communication in Health and Disease","volume":"12","author":"Szepesi","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib33","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/ni.1897","article-title":"The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3","volume":"11","author":"Kim","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.113949_bib34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cell.2020.03.021","article-title":"Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development","volume":"181","author":"Utz","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113949_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.molmed.2018.11.004","article-title":"Transcriptional and Epigenetic Regulation of Microglia in Health and Disease","volume":"25","author":"Yeh","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.isci.2025.113949_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.113949_bib37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41586-019-0924-x","article-title":"Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution","volume":"566","author":"Masuda","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.113949_bib38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2025.113949_bib39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuron.2018.12.006","article-title":"Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing","volume":"101","author":"Li","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.113949_bib40","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tins.2021.04.001","article-title":"Little cells of the little brain: microglia in cerebellar development and function","volume":"44","author":"Stoessel","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib41","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0896-6273(04)00069-8","article-title":"Microglia promote the death of developing Purkinje cells","volume":"41","author":"Mar\u00edn-Teva","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.113949_bib42","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1038\/s41467-018-05100-z","article-title":"Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum","volume":"9","author":"Nakayama","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113949_bib43","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1016\/j.neuron.2023.09.031","article-title":"IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development","volume":"111","author":"Guedes","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.113949_bib44","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1084\/jem.20182037","article-title":"CSF-1 controls cerebellar microglia and is required for motor function and social interaction","volume":"216","author":"Kana","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2025.113949_bib45","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/ni.3585","article-title":"Sall1 is a transcriptional regulator defining microglia identity and function","volume":"17","author":"Buttgereit","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.113949_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad8670","article-title":"Microglia development follows a stepwise program to regulate brain homeostasis","volume":"353","author":"Matcovitch-Natan","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.113949_bib47","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.tins.2022.10.007","article-title":"Interferon \u03b3: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration","volume":"45","author":"Kann","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1110593","article-title":"Breaking down the cellular responses to type I interferon neurotoxicity in the brain","volume":"14","author":"Viengkhou","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.113949_bib49","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.cell.2024.02.020","article-title":"Type-I-interferon-responsive microglia shape cortical development and behavior","volume":"187","author":"Escoubas","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113949_bib50","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-023-01315-6","article-title":"Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience","volume":"26","author":"Udeochu","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib51","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0036-15.2015","article-title":"Morphological and Phagocytic Profile of Microglia in the Developing Rat Cerebellum","volume":"2","author":"Perez-Pouchoulen","year":"2015","journal-title":"eNeuro"},{"key":"10.1016\/j.isci.2025.113949_bib52","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/dneu.22572","article-title":"Cerebellar microglia are dynamically unique and survey Purkinje neurons in vivo","volume":"78","author":"Stowell","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.isci.2025.113949_bib53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.aat0474","article-title":"Microglia and early brain development: An intimate journey","volume":"362","author":"Thion","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.isci.2025.113949_bib54","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuron.2020.11.007","article-title":"Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions","volume":"109","author":"Cser\u00e9p","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2025.113949_bib55","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.celrep.2016.12.039","article-title":"GFR\u03b11 Regulates Purkinje Cell Migration by Counteracting NCAM Function","volume":"18","author":"Sergaki","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.113949_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/cells13020184","article-title":"Microglia-Derived Insulin-like Growth Factor 1 Is Critical for Neurodevelopment","volume":"13","author":"Rusin","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.isci.2025.113949_bib57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/cdd.2010.78","article-title":"Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth","volume":"18","author":"Croci","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2025.113949_bib58","doi-asserted-by":"crossref","first-page":"15366","DOI":"10.1523\/JNEUROSCI.5188-09.2009","article-title":"AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development","volume":"29","author":"Bitoun","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib59","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.tips.2021.11.015","article-title":"Progranulin as a therapeutic target in neurodegenerative diseases","volume":"43","author":"Rhinn","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.isci.2025.113949_bib60","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1038\/s41467-024-49596-0","article-title":"Adult microglial TGF\u03b21 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice","volume":"15","author":"Bedolla","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.113949_bib61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique TGF-\u03b2-dependent molecular and functional signature in microglia","volume":"17","author":"Butovsky","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib62","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cellimm.2011.05.001","article-title":"CCL5 induces a pro-inflammatory profile in microglia in vitro","volume":"270","author":"Skuljec","year":"2011","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.isci.2025.113949_bib63","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.celrep.2020.01.010","article-title":"Microglia Heterogeneity in the Single-Cell Era","volume":"30","author":"Masuda","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.113949_bib64","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.immuni.2018.02.014","article-title":"High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease","volume":"48","author":"Mrdjen","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2025.113949_bib65","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2652","article-title":"Tests to assess motor phenotype in mice: a user's guide","volume":"10","author":"Brooks","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.113949_bib66","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1743-0003-11-62","article-title":"Detection of subtle neurological alterations by the Catwalk XT gait analysis system","volume":"11","author":"Chen","year":"2014","journal-title":"J. NeuroEng. Rehabil."},{"key":"10.1016\/j.isci.2025.113949_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe3600","article-title":"Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology","volume":"7","author":"Cheng","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2025.113949_bib68","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113949_bib69","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.113949_bib70","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.isci.2025.113949_bib71","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.isci.2025.113949_bib72","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225022102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225022102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:05:50Z","timestamp":1783476350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225022102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":72,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2589004225022102"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.113949","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.113949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113949"}}