{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:51:45Z","timestamp":1789761105336,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["RO1DK092460"],"award-info":[{"award-number":["RO1DK092460"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["R01DK119646"],"award-info":[{"award-number":["R01DK119646"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["W81XWH-16-1-0668"],"award-info":[{"award-number":["W81XWH-16-1-0668"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["W81XWH-20-1-0400"],"award-info":[{"award-number":["W81XWH-20-1-0400"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1DK092460"],"award-info":[{"award-number":["RO1DK092460"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK119646"],"award-info":[{"award-number":["R01DK119646"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR240750"],"award-info":[{"award-number":["PR240750"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR191945"],"award-info":[{"award-number":["PR191945"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.isci.2025.114074","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T08:03:21Z","timestamp":1764144201000},"page":"114074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A higher serum lipase cut-off improves the diagnosis of acute pancreatitis in patients with non-epigastric abdominal pain"],"prefix":"10.1016","volume":"28","author":[{"given":"Sarah","family":"Jahangir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elmallahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hally","family":"Chaffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Rajalingamgari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Morsy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Summers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Snozek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.114074_bib1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1053\/j.gastro.2021.10.017","article-title":"Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021","volume":"162","author":"Peery","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2025.114074_bib2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/MPA.0b013e3180cac24b","article-title":"Direct medical costs of acute pancreatitis hospitalizations in the United States","volume":"35","author":"Fagenholz","year":"2007","journal-title":"Pancreas"},{"key":"10.1016\/j.isci.2025.114074_bib3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.isci.2025.114074_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.14309\/ajg.0000000000002645","article-title":"American College of Gastroenterology Guidelines: Management of Acute Pancreatitis","volume":"119","author":"Tenner","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.isci.2025.114074_bib5","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.pan.2025.04.020","article-title":"Supported and Endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society","volume":"25","author":"IAP\/APA\/EPC\/IPC\/JPS Working Group Electronic address info@internationalpancreatology org","year":"2025","journal-title":"Pancreatology"},{"key":"10.1016\/j.isci.2025.114074_bib6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.pan.2022.04.013","article-title":"Impact of abdominal imaging on the diagnosis of acute pancreatitis in patients with painless lipase elevation","volume":"22","author":"Chaffin","year":"2022","journal-title":"Pancreatology"},{"key":"10.1016\/j.isci.2025.114074_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/01.mpa.0000153618.48137.ef","article-title":"Rapid urinary trypsinogen-2 test strip in the diagnosis of acute pancreatitis","volume":"30","author":"Chen","year":"2005","journal-title":"Pancreas"},{"key":"10.1016\/j.isci.2025.114074_bib8","first-page":"1130","article-title":"Comparison of urine trypsinogen-2 test strip with serum lipase in the diagnosis of acute pancreatitis","volume":"49","author":"Kylanpaa-Back","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.isci.2025.114074_bib9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/MPA.0b013e3182480ab7","article-title":"Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis","volume":"41","author":"Mayumi","year":"2012","journal-title":"Pancreas"},{"key":"10.1016\/j.isci.2025.114074_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1445-2197.2005.02579.x","article-title":"Serum elastase in the diagnosis of acute pancreatitis: a prospective study","volume":"75","author":"Wilson","year":"2005","journal-title":"ANZ J. Surg."},{"key":"10.1016\/j.isci.2025.114074_bib11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2214\/AJR.19.22667","article-title":"Trends in Use of Diagnostic Imaging for Abdominal Pain in U.S. Emergency Departments","volume":"216","author":"Wang","year":"2021","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.isci.2025.114074_bib12","doi-asserted-by":"crossref","first-page":"S316","DOI":"10.1016\/j.jacr.2019.05.017","article-title":"ACR Appropriateness Criteria(R) Acute Pancreatitis","volume":"16","author":"Expert Panel on Gastrointestinal Imaging","year":"2019","journal-title":"J. Am. Coll. Radiol."},{"key":"10.1016\/j.isci.2025.114074_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0016-5085(95)90277-5","article-title":"Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)","volume":"109","author":"van Dullemen","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2025.114074_bib14","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0140-6736(83)92719-8","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"321","author":"Robin Warren","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2025.114074_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJM199907153410301","article-title":"Neostigmine for the treatment of acute colonic pseudo-obstruction","volume":"341","author":"Ponec","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2025.114074_bib16","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3748\/wjg.v25.i9.1080","article-title":"Computed tomography scan imaging in diagnosing acute uncomplicated pancreatitis: Usefulness vs cost","volume":"25","author":"Kothari","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2025.114074_bib17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1053\/j.gastro.2024.12.029","article-title":"Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2024","volume":"168","author":"Peery","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2025.114074_bib18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1258\/0004563011900876","article-title":"Measurement of pancreatic lipase activity in serum by a kinetic colorimetric assay using a new chromogenic substrate","volume":"38","author":"Panteghini","year":"2001","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.isci.2025.114074_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040297","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"4","author":"Vandenbroucke","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.isci.2025.114074_bib20","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/MPA.0000000000000561","article-title":"Origin, Presentation, and Clinical Course of Nonpancreatic Hyperlipasemia","volume":"45","author":"Da","year":"2016","journal-title":"Pancreas"},{"key":"10.1016\/j.isci.2025.114074_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pan.2017.02.005","article-title":"Defining the diagnostic value of hyperlipasemia for acute pancreatitis in the critically ill","volume":"17","author":"Cohen","year":"2017","journal-title":"Pancreatology"},{"key":"10.1016\/j.isci.2025.114074_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000658-199508000-00008","article-title":"Postburn pancreatitis","volume":"222","author":"Ryan","year":"1995","journal-title":"Ann. Surg."},{"key":"10.1016\/j.isci.2025.114074_bib23","doi-asserted-by":"crossref","DOI":"10.5812\/traumamon.20773","article-title":"Association Between the Pancreatic Enzyme Level and Organ Failure in Trauma Patients","volume":"21","author":"Subramanian","year":"2016","journal-title":"Trauma Mon."},{"key":"10.1016\/j.isci.2025.114074_bib24","first-page":"445","article-title":"Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death","volume":"67","author":"Malinoski","year":"2009","journal-title":"J. Trauma"},{"key":"10.1016\/j.isci.2025.114074_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1726-4901(10)70015-0","article-title":"Elevated amylase and lipase levels in the neurosurgery intensive care unit","volume":"73","author":"Lee","year":"2010","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.isci.2025.114074_bib26","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1378\/chest.127.1.246","article-title":"Clinical significance of increased lipase levels on admission to the ICU","volume":"127","author":"Manjuck","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.isci.2025.114074_bib27","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/oxfordjournals.bja.a013472","article-title":"Continuous measurements of microcirculatory blood flow in gastrointestinal organs during acute haemorrhage","volume":"84","author":"Krejci","year":"2000","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.isci.2025.114074_bib28","first-page":"267","article-title":"Regional blood flow during continuous low-dose endotoxin infusion","volume":"18","author":"Fish","year":"1986","journal-title":"Circ. Shock"},{"key":"10.1016\/j.isci.2025.114074_bib29","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1097\/00003246-200009000-00019","article-title":"Dynamic study of the distribution of microcirculatory blood flow in multiple splanchnic organs in septic shock","volume":"28","author":"Hiltebrand","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.isci.2025.114074_bib30","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1378\/chest.100.6.1703","article-title":"Effect of PGE1 on altered distribution of regional blood flows in hyperdynamic sepsis","volume":"100","author":"Raper","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.isci.2025.114074_bib31","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.pan.2020.09.023","article-title":"A single center randomized double blind controlled trial of pentoxifylline in acute pancreatitis: Challenges and opportunities","volume":"20","author":"Vege","year":"2020","journal-title":"Pancreatology"},{"key":"10.1016\/j.isci.2025.114074_bib32","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cgh.2011.03.032","article-title":"Early fluid resuscitation reduces morbidity among patients with acute pancreatitis","volume":"9","author":"Warndorf","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2025.114074_bib33","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1097\/MPA.0000000000001141","article-title":"Practice Patterns and Utilization of Tube Feedings in Acute Pancreatitis Patients at a Large US Referral Center","volume":"47","author":"Machicado","year":"2018","journal-title":"Pancreas"},{"key":"10.1016\/j.isci.2025.114074_bib34","first-page":"410","article-title":"Pancreatic enzymes in patients with end-stage renal disease maintained on hemodialysis","volume":"83","author":"Vaziri","year":"1988","journal-title":"Am. J. Gastroenterol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225023351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225023351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:32:39Z","timestamp":1783474359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225023351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2589004225023351"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.114074","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A higher serum lipase cut-off improves the diagnosis of acute pancreatitis in patients with non-epigastric abdominal pain","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.114074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114074"}}