{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:25:58Z","timestamp":1786991158336,"version":"build-2736575974"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013041","name":"Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012304","name":"School of Medicine, Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.isci.2025.114267","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T01:01:17Z","timestamp":1764291677000},"page":"114267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation"],"prefix":"10.1016","volume":"29","author":[{"given":"Marisa","family":"Mitchell-Flack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makenzie","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Goldschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Patatanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Blosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Soo","family":"Mun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Suru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Huganir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-9870","authenticated-orcid":false,"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Pardoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.114267_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2007\/89017","article-title":"IPEX as a result of mutations in FOXP3","volume":"2007","author":"van der Vliet","year":"2007","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029025","article-title":"Effector T Cells in Multiple Sclerosis","volume":"8","author":"Kaskow","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.isci.2025.114267_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12974-017-0892-8","article-title":"Regulatory T cells in multiple sclerosis and myasthenia gravis","volume":"14","author":"Danikowski","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.isci.2025.114267_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrn.2016.37","article-title":"Synaptic AMPA receptor composition in development, plasticity and disease","volume":"17","author":"Henley","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2025.114267_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00401","article-title":"The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity","volume":"8","author":"Chater","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.isci.2025.114267_bib8","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.devcel.2016.02.012","article-title":"Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells","volume":"36","author":"Hosios","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2025.114267_bib9","doi-asserted-by":"crossref","first-page":"10294","DOI":"10.1073\/pnas.1919250117","article-title":"Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis","volume":"117","author":"Nilsson","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.114267_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00702-016-1661-z","article-title":"Glutamate, T cells and multiple sclerosis","volume":"124","author":"Levite","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.isci.2025.114267_bib11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jneuroim.2007.05.021","article-title":"Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients","volume":"188","author":"Sarchielli","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.isci.2025.114267_bib12","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1073\/pnas.0712390105","article-title":"Protection from fatal viral encephalomyelitis: AMPA receptor antagonists have a direct effect on the inflammatory response to infection","volume":"105","author":"Greene","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.114267_bib13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/annrheumdis-2013-203670","article-title":"AMPA\/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis","volume":"74","author":"Bonnet","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.isci.2025.114267_bib14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/71548","article-title":"Autoimmune encephalomyelitis ameliorated by AMPA antagonists","volume":"6","author":"Smith","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2025.114267_bib15","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The Immunological Genome Project: networks of gene expression in immune cells","volume":"9","author":"Heng","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4049\/jimmunol.178.2.683","article-title":"TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine\/paracrine granzyme B-mediated proteolytic cleavage","volume":"178","author":"Ganor","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib17","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1126\/science.284.5421.1805","article-title":"Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning","volume":"284","author":"Zamanillo","year":"1999","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.isci.2025.114267_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030354","article-title":"Enhanced Odor Discrimination and Impaired Olfactory Memory by Spatially Controlled Switch of AMPA Receptors","volume":"3","author":"Shimshek","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.isci.2025.114267_bib19","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1523\/JNEUROSCI.4237-05.2006","article-title":"Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse","volume":"26","author":"Sanchis-Segura","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2025.114267_bib20","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.4049\/jimmunol.178.7.4022","article-title":"Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells","volume":"178","author":"Davidson","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib21","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/eji.200738109","article-title":"Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg","volume":"38","author":"Horwitz","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib22","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3389\/fimmu.2019.02839","article-title":"Metabolic Pathways Involved in Regulatory T Cell Functionality","volume":"10","author":"Kempkes","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4049\/jimmunol.1701477","article-title":"mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3(+) Regulatory T Cells","volume":"201","author":"Sun","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature12297","article-title":"mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function","volume":"499","author":"Zeng","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.114267_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg1487","article-title":"Lung tumor-infiltrating T(reg) have divergent transcriptional profiles and function linked to checkpoint blockade response","volume":"8","author":"Dykema","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.20091618","article-title":"OX40 is required for regulatory T cell-mediated control of colitis","volume":"207","author":"Griseri","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2025.114267_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/intimm\/dxq001","article-title":"GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells","volume":"22","author":"Liao","year":"2010","journal-title":"Int. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib28","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.4049\/jimmunol.0802751","article-title":"GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo","volume":"182","author":"van Olffen","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib29","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/eji.201040391","article-title":"IL-6: regulator of Treg\/Th17 balance","volume":"40","author":"Kimura","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib30","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/intimm\/5.11.1461","article-title":"Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice","volume":"5","author":"Powrie","year":"1993","journal-title":"Int. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib31","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1053\/gast.2002.32959","article-title":"Monoassociation of SCID mice with Helicobacter muridarum, but not four other enterics, provokes IBD upon receipt of T cells","volume":"122","author":"Jiang","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2025.114267_bib32","doi-asserted-by":"crossref","first-page":"15830","DOI":"10.1073\/pnas.2534546100","article-title":"Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope","volume":"100","author":"Kullberg","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2025.114267_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-1-61737-979-6_9","article-title":"In vivo Treg suppression assays","volume":"707","author":"Workman","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2025.114267_bib34","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.3389\/fimmu.2019.03136","article-title":"Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation","volume":"10","author":"Colamatteo","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib35","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1600-065X.2011.01018.x","article-title":"Regulatory T cells and Foxp3","volume":"241","author":"Rudensky","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.isci.2025.114267_bib36","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1002\/eji.200425274","article-title":"Interleukin-2 is essential for CD4+CD25+ regulatory T cell function","volume":"34","author":"de la Rosa","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib37","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1084\/jem.20020190","article-title":"Interleukin 2 signaling is required for CD4(+) regulatory T cell function","volume":"196","author":"Furtado","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2025.114267_bib38","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri1435","article-title":"Tolerance, not immunity, crucially depends on IL-2","volume":"4","author":"Malek","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri3198","article-title":"Regulation and function of mTOR signalling in T cell fate decisions","volume":"12","author":"Chi","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-immunol-042617-053352","article-title":"Signaling and Function of Interleukin-2 in T Lymphocytes","volume":"36","author":"Ross","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib41","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.4049\/jimmunol.178.4.2163","article-title":"A role for mammalian target of rapamycin in regulating T cell activation versus anergy","volume":"178","author":"Zheng","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-065X.2012.01152.x","article-title":"mTOR, metabolism, and the regulation of T-cell differentiation and function","volume":"249","author":"Waickman","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.isci.2025.114267_bib43","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00109-019-01784-y","article-title":"Mevalonate promotes differentiation of regulatory T cells","volume":"97","author":"Acharya","year":"2019","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.isci.2025.114267_bib44","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.celrep.2019.05.020","article-title":"Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of T(reg) Cells","volume":"27","author":"Timilshina","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2025.114267_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41586-021-03235-6","article-title":"Lipid signalling enforces functional specialization of T(reg) cells in tumours","volume":"591","author":"Lim","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.114267_bib46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/cei\/uxab033","article-title":"The role of lipid metabolism in shaping the expansion and the function of regulatory T cells","volume":"208","author":"Pinzon Grimaldos","year":"2022","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib47","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pharmthera.2011.01.005","article-title":"Glutamate pharmacology and metabolism in peripheral primary afferents: physiological and pathophysiological mechanisms","volume":"130","author":"Miller","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.isci.2025.114267_bib48","first-page":"739","article-title":"Excitatory amino acid profiles of synovial fluid from patients with arthritis","volume":"27","author":"McNearney","year":"2000","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.isci.2025.114267_bib49","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1038\/s41598-017-05574-9","article-title":"Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury","volume":"7","author":"Bai","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.114267_bib50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41580-022-00572-w","article-title":"Metabolites as signalling molecules","volume":"24","author":"Baker","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2025.114267_bib51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2023.12.009","article-title":"Nutrient inputs and social metabolic control of T cell fate","volume":"36","author":"Bacigalupa","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2025.114267_bib52","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/sj.bjp.0704134","article-title":"Characterization of ionotropic glutamate receptors in human lymphocytes","volume":"133","author":"Lombardi","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2025.114267_bib53","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3389\/fimmu.2020.01869","article-title":"Critical Neurotransmitters in the Neuroimmune Network","volume":"11","author":"Hodo","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2025.114267_bib54","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.bpj.2018.04.038","article-title":"Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells","volume":"114","author":"Nagy","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2025.114267_bib55","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1038\/s41467-022-31149-y","article-title":"Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters","volume":"13","author":"Yu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2025.114267_bib56","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.4161\/cc.8.21.9888","article-title":"Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle","volume":"8","author":"Blackiston","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.isci.2025.114267_bib57","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.immuni.2017.09.003","article-title":"Store-Operated Ca(2+) Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming","volume":"47","author":"Vaeth","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2025.114267_bib58","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1113\/JP278658","article-title":"Relation between activity-induced intracellular sodium transients and ATP dynamics in mouse hippocampal neurons","volume":"597","author":"Gerkau","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2025.114267_bib59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-5728(01)00472-6","article-title":"Signaling pathways activated by chemokine receptor CXCR2 and AMPA-type glutamate receptors and involvement in granule cells survival","volume":"123","author":"Limatola","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.isci.2025.114267_bib60","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/16269","article-title":"The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn","volume":"397","author":"Hayashi","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.isci.2025.114267_bib61","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2025.114267_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030354","article-title":"Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors","volume":"3","author":"Shimshek","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.isci.2025.114267_bib63","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2025.114267_bib64","article-title":"Umap: Uniform manifold approximation and projection for dimension reduction","author":"McInnes","year":"2018","journal-title":"arXiv"},{"key":"10.1016\/j.isci.2025.114267_bib65","article-title":"An algorithm for fast preranked gene set enrichment analysis using cumulative statistic calculation","author":"Sergushichev","year":"2016","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2025.114267_bib66","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2025.114267_bib67","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190613","article-title":"PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation","volume":"217","author":"Damasceno","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2025.114267_bib68","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225025283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225025283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:58:03Z","timestamp":1773997083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225025283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2589004225025283"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.114267","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.114267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114267"}}