{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:01:11Z","timestamp":1774004471439,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017585","name":"First Hospital of Jilin University","doi-asserted-by":"publisher","award":["HLKY20240107"],"award-info":[{"award-number":["HLKY20240107"]}],"id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.isci.2025.114319","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:26:32Z","timestamp":1764750392000},"page":"114319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic hepatitis b coinfection and survival in pediatric T-ALL: A propensity-matched analysis"],"prefix":"10.1016","volume":"29","author":[{"given":"Yutong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianmei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3442-6881","authenticated-orcid":false,"given":"Jian","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2025.114319_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1182\/blood.2019001557","article-title":"How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children","volume":"135","author":"Teachey","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.isci.2025.114319_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39152-z","article-title":"Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis","volume":"13","author":"Bhasin","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2025.114319_bib3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A review of human carcinogens--Part B: biological agents","volume":"10","author":"Bouvard","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib4","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1470-2045(10)70167-4","article-title":"Hepatitis B virus infection and risk of non-Hodgkin lymphoma in South Korea: a cohort study","volume":"11","author":"Engels","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000468973","article-title":"Risk of Onset of Hematological Malignancies in Patients Infected with the Hepatitis B Virus: Results from a Large-Scale Retrospective Cohort Study in China","volume":"137","author":"Li","year":"2017","journal-title":"Acta Haematol."},{"key":"10.1016\/j.isci.2025.114319_bib6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12874-020-00994-0","article-title":"A review of the use of propensity score diagnostics in papers published in high-ranking medical journals","volume":"20","author":"Granger","year":"2020","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.isci.2025.114319_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw323","article-title":"Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies","volume":"109","author":"Yao","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.isci.2025.114319_bib8","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1182\/blood-2007-09-112920","article-title":"Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95","volume":"111","author":"M\u00f6ricke","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.isci.2025.114319_bib9","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1200\/JCO.2006.06.2679","article-title":"Superiority of allogeneic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: results from ALL-BFM 90 and 95","volume":"24","author":"Schrauder","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib10","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1056\/NEJMra1400972","article-title":"Acute Lymphoblastic Leukemia in Children","volume":"373","author":"Hunger","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2025.114319_bib11","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1200\/JCO.20.00256","article-title":"Children's Oncology Group AALL0434: A Phase III Randomized Clinical Trial Testing Nelarabine in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia","volume":"38","author":"Dunsmore","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib12","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1093\/annonc\/mdt221","article-title":"Results of treatment of advanced-stage lymphoblastic lymphoma at St Jude Children's Research Hospital from 1962 to 2002","volume":"24","author":"Sandlund","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib13","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group","volume":"30","author":"Hunger","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib14","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1182\/blood-2015-09-670729","article-title":"Dexamethasone vs prednisone in induction treatment of pediatric ALL: results of the randomized trial AIEOP-BFM ALL 2000","volume":"127","author":"M\u00f6ricke","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.isci.2025.114319_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1470-2045(12)70600-9","article-title":"Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial","volume":"14","author":"Vora","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib16","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S1470-2045(15)00363-0","article-title":"Intravenous pegylated asparaginase versus intramuscular native Escherichia coli L-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial","volume":"16","author":"Place","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3892\/mmr.2017.6554","article-title":"Combination of bortezomib and daunorubicin in the induction of apoptosis in T-cell acute lymphoblastic leukemia","volume":"16","author":"Du","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.isci.2025.114319_bib18","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1200\/JCO.21.02678","article-title":"Children's Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma","volume":"40","author":"Teachey","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1200\/JCO.22.02875","article-title":"Eflornithine as Postimmunotherapy Maintenance in High-Risk Neuroblastoma: Externally Controlled, Propensity Score-Matched Survival Outcome Comparisons","volume":"42","author":"Oesterheld","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib20","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1200\/JCO.21.01285","article-title":"Association of Chronic Hepatitis B Infection and Antiviral Treatment With the Development of the Extrahepatic Malignancies: A Nationwide Cohort Study","volume":"40","author":"Lee","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib21","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3350\/cmh.2023.0057","article-title":"Treated chronic hepatitis B is a good prognostic factor of diffuse large B-cell lymphoma","volume":"29","author":"Park","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.isci.2025.114319_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00277-023-05554-2","article-title":"NOTCH pathway mutation contributes to inferior prognosis in HBV-infected chronic lymphocytic leukemia","volume":"103","author":"Shang","year":"2024","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.isci.2025.114319_bib23","first-page":"256","article-title":"The lymphocyte immunophenotypical pattern in chronic lymphocytic leukemia associated with hepatitis viral infections","volume":"4","author":"Bumbea","year":"2011","journal-title":"J. Med. Life"},{"key":"10.1016\/j.isci.2025.114319_bib24","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1016\/S2352-3026(23)00072-8","volume":"10","author":"Sato","year":"2023","journal-title":"Lancet. Haematol."},{"key":"10.1016\/j.isci.2025.114319_bib25","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL)","volume":"9","author":"Bene","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2025.114319_bib26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1200\/JCO.2013.48.6522","article-title":"Intensive chemotherapy for childhood acute lymphoblastic leukemia: results of the randomized intercontinental trial ALL IC-BFM 2002","volume":"32","author":"Stary","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1470-2045(08)70070-6","article-title":"Current management and challenges of malignant disease in the CNS in paediatric leukaemia","volume":"9","author":"Pui","year":"2008","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib28","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1200\/JCO.19.01692","article-title":"Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16","volume":"37","author":"Jeha","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib29","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1056\/NEJMoa0900386","article-title":"Treating childhood acute lymphoblastic leukemia without cranial irradiation","volume":"360","author":"Pui","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2025.114319_bib30","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/sj.leu.2403348","article-title":"Comparative analysis of flow cytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia","volume":"18","author":"Neale","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2025.114319_bib31","article-title":"Outcome of ALL With ALL-BFM-95 Protocol in Nepal","volume":"9","author":"Sharma Poudyal","year":"2023","journal-title":"JCO Glob. Oncol."},{"key":"10.1016\/j.isci.2025.114319_bib32","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jhep.2011.11.030","article-title":"Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: a systematic review","volume":"57","author":"Papatheodoridis","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2025.114319_bib33","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2141.2005.05497.x","article-title":"Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study","volume":"129","author":"Harrison","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.isci.2025.114319_bib34","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/cncr.34741","article-title":"Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: A multicenter study","volume":"129","author":"Zhang","year":"2023","journal-title":"Cancer"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225025805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004225025805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:49:02Z","timestamp":1773996542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004225025805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2589004225025805"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2025.114319","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic hepatitis b coinfection and survival in pediatric T-ALL: A propensity-matched analysis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.114319","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114319"}}