{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:53:13Z","timestamp":1791337993307,"version":"4.3.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470443"],"award-info":[{"award-number":["82470443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82530049"],"award-info":[{"award-number":["82530049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.isci.2026.114630","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T16:17:31Z","timestamp":1767802651000},"page":"114630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["N6-methyladenosine (m6A) modification of TXNIP in 3\u2032UTR instigates abdominal aorta aneurysm in mice"],"prefix":"10.1016","volume":"29","author":[{"given":"Fransky","family":"Hantelys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Hui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.114630_bib1","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.107.735274","article-title":"Medical management of small abdominal aortic aneurysms","volume":"117","author":"Baxter","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.114630_bib2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/bjs.8984","article-title":"Current prevalence of abdominal aortic aneurysm in 70-year-old women","volume":"100","author":"Svensj\u00f6","year":"2013","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.isci.2026.114630_bib3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0741-5214(99)70049-2","article-title":"The association between cigarette smoking and abdominal aortic aneurysms","volume":"30","author":"Wilmink","year":"1999","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.isci.2026.114630_bib4","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nm.2711","article-title":"Activation of AMP-activated protein kinase \u03b12 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo","volume":"18","author":"Wang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.114630_bib5","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1161\/01.ATV.0000174129.77391.55","article-title":"Biomechanical determinants of abdominal aortic aneurysm rupture","volume":"25","author":"Vorp","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2026.114630_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2011.03.006","article-title":"Current status of medical management for abdominal aortic aneurysm","volume":"217","author":"Golledge","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.isci.2026.114630_bib7","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/CIRCRESAHA.116.308895","article-title":"Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm","volume":"119","author":"Chen","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.114630_bib8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nm.1958","article-title":"Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms","volume":"15","author":"Satoh","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.114630_bib9","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/nm1335","article-title":"Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase","volume":"11","author":"Yoshimura","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.114630_bib10","first-page":"993","article-title":"Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms","volume":"150","author":"L\u00f3pez-Candales","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2026.114630_bib11","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1152\/physrev.00003.2017","article-title":"Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease","volume":"97","author":"Lacolley","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2026.114630_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3164\/jcbn.11-36SR","article-title":"Thioredoxin binding protein (TBP)-2\/Txnip and \u03b1-arrestin proteins in cancer and diabetes mellitus","volume":"50","author":"Masutani","year":"2012","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.isci.2026.114630_bib13","doi-asserted-by":"crossref","first-page":"21884","DOI":"10.1074\/jbc.M600427200","article-title":"The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange","volume":"281","author":"Patwari","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.114630_bib14","doi-asserted-by":"crossref","first-page":"16898","DOI":"10.1074\/jbc.M109.010504","article-title":"Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells","volume":"284","author":"Cha-Molstad","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.114630_bib15","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1073\/pnas.1715930115","article-title":"Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action","volume":"115","author":"Nagaraj","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.114630_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbagrm.2018.01.010","article-title":"Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors","volume":"1861","author":"Lampe","year":"2018","journal-title":"Biochim. Biophys. Acta. Gene Regul. Mech."},{"key":"10.1016\/j.isci.2026.114630_bib17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13287-022-03037-1","article-title":"Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome","volume":"13","author":"Hu","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.isci.2026.114630_bib18","doi-asserted-by":"crossref","first-page":"797","DOI":"10.21037\/atm.2019.12.65","article-title":"Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm","volume":"7","author":"He","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.isci.2026.114630_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molcel.2014.09.001","article-title":"Dynamic RNA modifications in posttranscriptional regulation","volume":"56","author":"Wang","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.114630_bib20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature14234","article-title":"N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions","volume":"518","author":"Liu","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.114630_bib21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nrm1618","article-title":"Translational control in stress and apoptosis","volume":"6","author":"Holcik","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.114630_bib22","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.molcel.2007.11.018","article-title":"New modes of translational control in development, behavior, and disease","volume":"28","author":"Sonenberg","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.114630_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.atherosclerosis.2015.05.020","article-title":"Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice","volume":"241","author":"Byon","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.isci.2026.114630_bib24","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/CIRCULATIONAHA.117.030972","article-title":"Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo","volume":"136","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.114630_bib25","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1002\/jcb.25967","article-title":"Regulatory Role of N(6) -methyladenosine (m(6) A) Methylation in RNA Processing and Human Diseases","volume":"118","author":"Wei","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.isci.2026.114630_bib26","doi-asserted-by":"crossref","first-page":"H1660","DOI":"10.1152\/ajpheart.00028.2009","article-title":"ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice","volume":"296","author":"Cassis","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2026.114630_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2026.114630_bib28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bbagrm.2018.10.006","article-title":"m(6)A-mediated translation regulation","volume":"1862","author":"Meyer","year":"2019","journal-title":"Biochim. Biophys. Acta. Gene Regul. Mech."},{"key":"10.1016\/j.isci.2026.114630_bib29","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5\u2032 UTR m(6)A Promotes Cap-Independent Translation","volume":"163","author":"Meyer","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114630_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature03205","article-title":"Regulation of cap-dependent translation by eIF4E inhibitory proteins","volume":"433","author":"Richter","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.114630_bib31","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012302","article-title":"Toward a genome-wide landscape of translational control","volume":"5","author":"Larsson","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.isci.2026.114630_bib32","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1093\/nar\/gkab343","article-title":"The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response","volume":"49","author":"Zong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.114630_bib33","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114630_bib34","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2032 UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114630_bib35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0968-0004(03)00002-1","article-title":"Translational control by the 3\u2032-UTR: the ends specify the means","volume":"28","author":"Mazumder","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2026.114630_bib36","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2337\/db08-0055","article-title":"Thioredoxin-interacting protein is killing my beta-cells","volume":"57","author":"Corbett","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2026.114630_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/bcr2599","article-title":"Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer","volume":"12","author":"Cadenas","year":"2010","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.isci.2026.114630_bib38","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.7150\/thno.81388","article-title":"Nicotine exacerbates atherosclerosis and plaque instability via NLRP3 inflammasome activation in vascular smooth muscle cells","volume":"13","author":"An","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.isci.2026.114630_bib39","article-title":"The m(6)A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m(6)A-Dependent Manner","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.114630_bib40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41392-020-00453-8","article-title":"HIF-1\u03b1-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2026.114630_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102218","article-title":"Dual regulation of TxNIP by ChREBP and FoxO1 in liver","volume":"24","author":"Noblet","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.isci.2026.114630_bib42","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00178-18","article-title":"Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation","volume":"38","author":"Ye","year":"2018","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.114630_bib43","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.celrep.2017.05.041","article-title":"Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin","volume":"19","author":"Waldhart","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.114630_bib44","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.molcel.2013.01.035","article-title":"AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1","volume":"49","author":"Wu","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.114630_bib45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.molcel.2016.03.021","article-title":"The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells","volume":"62","author":"Lin","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.114630_bib46","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11684-018-0654-8","article-title":"RNA m(6)A modification and its function in diseases","volume":"12","author":"Tong","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.isci.2026.114630_bib47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCULATIONAHA.118.036146","article-title":"The N(6)-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy","volume":"139","author":"Dorn","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.114630_bib48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ejhf.1672","article-title":"Changes in m6A RNA methylation contribute to heart failure progression by modulating translation","volume":"22","author":"Berulava","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.isci.2026.114630_bib49","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3892\/ijmm.2020.4746","article-title":"Role of m6A RNA methylation in cardiovascular disease (Review)","volume":"46","author":"Qin","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.isci.2026.114630_bib50","article-title":"Endothelial downregulation of nuclear m6A reader YTHDC1 promotes pulmonary vascular remodeling in sugen hypoxia model of pulmonary hypertension","volume":"10","author":"Zheng","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.isci.2026.114630_bib51","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/CIRCRESAHA.122.321538","article-title":"TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis","volume":"132","author":"Woo","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.114630_bib52","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12943-021-01447-y","article-title":"METTL3\/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N(6)-methyladenosine modification of PD-L1 mRNA in breast cancer","volume":"21","author":"Wan","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.isci.2026.114630_bib53","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nprot.2006.82","article-title":"Immunoprecipitation of mRNA-protein complexes","volume":"1","author":"Peritz","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2026.114630_bib54","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50094","article-title":"Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia","volume":"8","author":"Hantelys","year":"2019","journal-title":"eLife"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226000052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226000052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:49:10Z","timestamp":1791337750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226000052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2589004226000052"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.114630","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N6-methyladenosine (m6A) modification of TXNIP in 3\u2032UTR instigates abdominal aorta aneurysm in mice","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.114630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114630"}}