{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:38:35Z","timestamp":1793997515133,"version":"4.8.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["288164"],"award-info":[{"award-number":["288164"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007793","name":"Kristian Gerhard Jebsen Foundation","doi-asserted-by":"publisher","award":["SKGJ-MED-023"],"award-info":[{"award-number":["SKGJ-MED-023"]}],"id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009471","name":"ExtraFoundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.isci.2026.114764","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:43:44Z","timestamp":1769561024000},"page":"114764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2996-9590","authenticated-orcid":false,"given":"Haakon","family":"Berven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Svensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Eikeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Tvedten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika V.","family":"Sheard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig Amdahl","family":"Af Geijerstam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"S\u00f8gnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Arnsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"\u00c5rseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Skjeie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arve","family":"Hjellbrekke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir-Olve","family":"Skeie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamila N.","family":"Torres Cleuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo S.","family":"Nido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Haugarvoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Riemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-5191","authenticated-orcid":false,"given":"Charalampos","family":"Tzoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"D\u00f6lle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.114764_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.114764_bib2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","article-title":"NAD+ in Brain Aging and Neurodegenerative Disorders","volume":"30","author":"Lautrup","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.114764_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149590","article-title":"The therapeutic perspective of NAD+ precursors in age-related diseases","volume":"702","author":"Iqbal","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2026.114764_bib4","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/mrm.27971","article-title":"Single-Voxel 1H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD+) in humans at 7T using a 32-channel volume coil","volume":"83","author":"Bagga","year":"2020","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.isci.2026.114764_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10522-013-9489-5","article-title":"Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence","volume":"15","author":"Braidy","year":"2014","journal-title":"Biogerontology"},{"key":"10.1016\/j.isci.2026.114764_bib6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/embj.201386917","article-title":"Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging","volume":"33","author":"Stein","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2026.114764_bib7","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1073\/pnas.1417921112","article-title":"In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences","volume":"112","author":"Zhu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.114764_bib8","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.12120.1","article-title":"NAD + biosynthesis, aging, and disease","volume":"7","author":"Johnson","year":"2018","journal-title":"F1000Res."},{"key":"10.1016\/j.isci.2026.114764_bib9","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1161\/CIRCULATIONAHA.116.026099","article-title":"Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy","volume":"137","author":"Diguet","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.114764_bib10","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1161\/CIRCULATIONAHA.116.022495","article-title":"Normalization of NAD+ Redox Balance as a Therapy for Heart Failure","volume":"134","author":"Lee","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.114764_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2016.09.013","article-title":"Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice","volume":"24","author":"Mills","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.114764_bib12","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/acel.12461","article-title":"Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice","volume":"15","author":"de Picciotto","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2026.114764_bib13","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1016\/j.celrep.2018.05.009","article-title":"The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson\u2019s Disease","volume":"23","author":"Sch\u00f6ndorf","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.114764_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature25143","article-title":"Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.114764_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep26933","article-title":"Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice","volume":"6","author":"Trammell","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.114764_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11011-018-0346-8","article-title":"Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer\u2019s disease model mice","volume":"34","author":"Xie","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.isci.2026.114764_bib17","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.aaf2693","article-title":"NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice","volume":"352","author":"Zhang","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.114764_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tjnut.2024.10.017","article-title":"Long-Term Administration of Nicotinamide Mononucleotide Mitigates High-fat-diet-induced Physiological Decline in aging mice","volume":"155","author":"Zhou","year":"2025","journal-title":"J. Nutr."},{"key":"10.1016\/j.isci.2026.114764_bib19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aac4854","article-title":"NAD+ in aging, metabolism, and neurodegeneration","volume":"350","author":"Verdin","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.114764_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.114764_bib21","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cmet.2016.09.004","article-title":"NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair","volume":"24","author":"Fang","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.114764_bib22","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041193","article-title":"Roles of NAD+ in Health and Aging","volume":"14","author":"Lautrup","year":"2024","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.isci.2026.114764_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/ggi.14513","article-title":"Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study","volume":"23","author":"Akasaka","year":"2023","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.isci.2026.114764_bib24","doi-asserted-by":"crossref","first-page":"7793","DOI":"10.1038\/s41467-023-43514-6","article-title":"NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson\u2019s disease","volume":"14","author":"Berven","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114764_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cmet.2022.02.001","article-title":"The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson\u2019s disease","volume":"34","author":"Brakedal","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.114764_bib26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ajcn\/nqy132","article-title":"A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects","volume":"108","author":"Dollerup","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2026.114764_bib27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3390\/nu14040755","article-title":"Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study","volume":"14","author":"Kim","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2026.114764_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s11357-023-00999-9","article-title":"A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment","volume":"46","author":"Orr","year":"2024","journal-title":"GeroScience"},{"key":"10.1016\/j.isci.2026.114764_bib29","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.abe9985","article-title":"Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women","volume":"372","author":"Yoshino","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.114764_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/mds.29645","article-title":"Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia","volume":"39","author":"Presterud","year":"2024","journal-title":"Mov. Disord."},{"key":"10.1016\/j.isci.2026.114764_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12948","article-title":"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans","volume":"7","author":"Trammell","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114764_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186459","article-title":"An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers","volume":"12","author":"Airhart","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.114764_bib34","doi-asserted-by":"crossref","first-page":"9772","DOI":"10.1038\/s41598-019-46120-z","article-title":"Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults","volume":"9","author":"Conze","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.114764_bib35","article-title":"Dynamics of blood NAD and glutathione in health, disease, aging and under NAD-booster treatment","author":"Euro","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2026.114764_bib36","article-title":"Association of Human Whole Blood NAD+ Contents With Aging","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2026.114764_bib37","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.tem.2025.03.013","article-title":"NAD augmentation as a disease-modifying strategy for neurodegeneration","volume":"36","author":"D\u00f6lle","year":"2025","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"10.1016\/j.isci.2026.114764_bib38","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.cmet.2022.11.004","article-title":"NAD precursors cycle between host tissues and the gut microbiome","volume":"34","author":"Chellappa","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.114764_bib39","first-page":"170","article-title":"Mouse models of human disease: An evolutionary perspective","volume":"2016","author":"Perlman","year":"2016","journal-title":"Evol. Med. Public Health"},{"key":"10.1016\/j.isci.2026.114764_bib40","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.celrep.2019.07.043","article-title":"Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures","volume":"28","author":"Elhassan","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.114764_bib41","first-page":"2284","article-title":"Acute nicotinamide riboside supplementation increases human cerebral NAD+ levels in vivo","volume":"92","author":"Nanga","year":"2024","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.isci.2026.114764_bib43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.gde.2017.03.014","article-title":"NMNAT: It\u2019s an NAD+ Synthase, It\u2019s a Chaperone It\u2019s a Neuroprotector","volume":"44","author":"Brazill","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.isci.2026.114764_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/JCI174824","article-title":"A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder","volume":"134","author":"Szot","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.114764_bib45","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cmet.2020.02.001","article-title":"Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway","volume":"31","author":"Shats","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.114764_bib47","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.3390\/cells11152416","article-title":"NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson\u2019s Disease","volume":"11","author":"Curtis","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.isci.2026.114764_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2022.108659","article-title":"The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging","volume":"427","author":"White","year":"2023","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2026.114764_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr1538","article-title":"Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation","volume":"11","author":"Yaku","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.114764_bib53","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/jmri.24478","article-title":"Gannet: A batch-processing tool for the quantitative analysis of gamma-aminobutyric acid\u2013edited MR spectroscopy spectra","volume":"40","author":"Edden","year":"2014","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.114764_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185356","article-title":"OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB","volume":"12","author":"Purvis","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.114764_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/bs.irn.2017.01.008","article-title":"The New Diagnostic Criteria for Parkinson\u2019s Disease","volume":"132","author":"Postuma","year":"2017","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.isci.2026.114764_bib50","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/mds.20213","article-title":"Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations","volume":"19","author":"Goetz","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.isci.2026.114764_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4169","article-title":"3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H-31P nuclear Overhauser effects and NAD+","volume":"34","author":"Peeters","year":"2021","journal-title":"NMR Biomed."},{"key":"10.1016\/j.isci.2026.114764_bib55","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/jmre.1997.1244","article-title":"Improved Method for Accurate and Efficient Quantification of MRS Data with Use of Prior Knowledge","volume":"129","author":"Vanhamme","year":"1997","journal-title":"J. Magn. Reson."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226001392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226001392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:09:39Z","timestamp":1788952179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226001392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2589004226001392"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.114764","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.114764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114764"}}