{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:52:36Z","timestamp":1791337956186,"version":"4.3.1"},"reference-count":80,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["GJHZ20220913142804008"],"award-info":[{"award-number":["GJHZ20220913142804008"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["JCYJ20220530112817040"],"award-info":[{"award-number":["JCYJ20220530112817040"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["ZDSYS20220606101604009"],"award-info":[{"award-number":["ZDSYS20220606101604009"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005149","name":"Cancer Hospital Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["E010122002"],"award-info":[{"award-number":["E010122002"]}],"id":[{"id":"10.13039\/501100005149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273308"],"award-info":[{"award-number":["82273308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472934"],"award-info":[{"award-number":["82472934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22107045"],"award-info":[{"award-number":["22107045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202111003"],"award-info":[{"award-number":["SZSM202111003"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.isci.2026.114786","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:41:08Z","timestamp":1769532068000},"page":"114786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic hydrogel for the construction of patient-derived bladder cancer organoids with aggressive growth"],"prefix":"10.1016","volume":"29","author":[{"given":"Jin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohaer","family":"Kadeerhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.114786_bib1","first-page":"12","article-title":"Cancer statistics","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.isci.2026.114786_bib2","doi-asserted-by":"crossref","DOI":"10.1177\/17588359211047352","article-title":"Metastatic Urothelial Cancer: a rapidly changing treatment landscape","volume":"13","author":"Stecca","year":"2021","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.isci.2026.114786_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612596","article-title":"BCG-Unresponsive Non-Muscle-Invasive Bladder Cancer: Current Treatment Landscape and Novel Emerging Molecular Targets","volume":"24","author":"Claps","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.114786_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41585-022-00578-1","article-title":"Recurrence mechanisms of non-muscle-invasive bladder cancer - a clinical perspective","volume":"19","author":"Teoh","year":"2022","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.isci.2026.114786_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.eururo.2014.09.007","article-title":"Multicenter assessment of neoadjuvant chemotherapy for muscle-invasive bladder cancer","volume":"67","author":"Zargar","year":"2015","journal-title":"Eur. Urol."},{"key":"10.1016\/j.isci.2026.114786_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.eururo.2020.03.055","article-title":"European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines","volume":"79","author":"Witjes","year":"2021","journal-title":"Eur. Urol."},{"key":"10.1016\/j.isci.2026.114786_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/rb\/rbaa028","article-title":"Effect of different aged cartilage ECM on chondrogenesis of BMSCs in vitro and in vivo","volume":"7","author":"Wang","year":"2020","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.isci.2026.114786_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijbiomac.2021.12.086","article-title":"Decellularized liver ECM-based 3D scaffolds: Compositional, physical, chemical, rheological, thermal, mechanical, and in vitro biological evaluations","volume":"200","author":"Ergun","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.isci.2026.114786_bib9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd.2016.175","article-title":"Screening out irrelevant cell-based models of disease","volume":"15","author":"Horvath","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.isci.2026.114786_bib10","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/ng.3967","article-title":"Patient-derived xenografts undergo mouse-specific tumor evolution","volume":"49","author":"Ben-David","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.114786_bib11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrc.2017.85","article-title":"Interrogating open issues in cancer medicine with patient-derived xenografts","volume":"17","author":"Byrne","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2026.114786_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13045-022-01278-4","article-title":"Tumor organoids: applications in cancer modeling and potentials in precision medicine","volume":"15","author":"Xu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.isci.2026.114786_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15174339","article-title":"Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas","volume":"15","author":"Xu","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.isci.2026.114786_bib14","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1038\/s41467-019-11867-6","article-title":"Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening","volume":"10","author":"Kim","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114786_bib15","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1158\/1078-0432.CCR-19-1376","article-title":"Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer","volume":"26","author":"Shi","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.isci.2026.114786_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-024-04128-x","article-title":"Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2","volume":"16","author":"Sui","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.isci.2026.114786_bib17","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s41467-020-15155-6","article-title":"An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity","volume":"11","author":"Calandrini","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114786_bib18","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.3389\/fonc.2020.01775","article-title":"Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy","volume":"10","author":"Esser","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2026.114786_bib19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cell.2018.03.017","article-title":"Tumor evolution and drug response in patient-derived organoid models of bladder cancer","volume":"173","author":"Lee","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114786_bib20","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1038\/s41467-023-37696-2","article-title":"Bladder cancer organoids as a functional system to model different disease stages and therapy response","volume":"14","author":"Minoli","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114786_bib21","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/s41467-020-15548-7","article-title":"Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages","volume":"11","author":"Rosenbluth","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114786_bib22","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s43018-022-00337-6","article-title":"A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology","volume":"3","author":"Guillen","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.isci.2026.114786_bib23","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.114786_bib24","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1136\/gutjnl-2019-320019","article-title":"Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles","volume":"69","author":"Yan","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.isci.2026.114786_bib25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2014.08.016","article-title":"Organoid cultures derived from patients with advanced prostate cancer","volume":"159","author":"Gao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114786_bib26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nprot.2016.006","article-title":"Organoid culture systems for prostate epithelial and cancer tissue","volume":"11","author":"Drost","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2026.114786_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz0868","article-title":"Physical traits of cancer","volume":"370","author":"Nia","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.114786_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13619-022-00137-4","article-title":"Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal","volume":"11","author":"Meng","year":"2022","journal-title":"Cell Regen."},{"key":"10.1016\/j.isci.2026.114786_bib29","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue cells feel and respond to the stiffness of their substrate","volume":"310","author":"Discher","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.114786_bib30","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.114786_bib31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1177\/1535370214560973","article-title":"Metastatic bladder cancer cells distinctively sense and respond to physical cues of collagen fibril-mimetic nanotopography","volume":"240","author":"Iuliano","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.isci.2026.114786_bib32","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1111\/cas.14078","article-title":"Tumor-associated macrophages promote bladder tumor growth through PI3K\/AKT signal induced by collagen","volume":"110","author":"Qiu","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.isci.2026.114786_bib33","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.2147\/OTT.S194568","article-title":"Collagen stiffness promoted non-muscle-invasive bladder cancer progression to muscle-invasive bladder cancer","volume":"12","author":"Zhu","year":"2019","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.isci.2026.114786_bib34","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2174\/1566524021666210225100041","article-title":"The prognostic value of cytokeratin and extracellular collagen expression in urinary bladder cancer","volume":"22","author":"Ingenwerth","year":"2022","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.isci.2026.114786_bib35","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s12672-025-03136-4","article-title":"Collagen gene signature in the tumor microenvironment predicts survival and guides prognosis in bladder cancer","volume":"16","author":"Huang","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.isci.2026.114786_bib36","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3171\/2016.6.JNS152797","article-title":"Association of collagen architecture with glioblastoma patient survival","volume":"126","author":"Pointer","year":"2017","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.isci.2026.114786_bib37","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1158\/1078-0432.CCR-16-1516","article-title":"Structure and function of a prostate Cancer dissemination\u2013permissive extracellular matrix","volume":"23","author":"Penet","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.isci.2026.114786_bib38","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1039\/c5ib00040h","article-title":"Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration","volume":"7","author":"Acerbi","year":"2015","journal-title":"Integr. Biol."},{"key":"10.1016\/j.isci.2026.114786_bib39","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/1097-0282(200009)54:3<222::AID-BIP80>3.0.CO;2-K","article-title":"Time-lapse confocal reflection microscopy of collagen fibrillogenesis and extracellular matrix assembly in vitro","volume":"54","author":"Brightman","year":"2000","journal-title":"Biopolymers"},{"key":"10.1016\/j.isci.2026.114786_bib40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.actbio.2020.03.019","article-title":"Rapid fabrication of collagen bundles mimicking tumor-associated collagen architectures","volume":"108","author":"Gong","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.isci.2026.114786_bib41","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.devcel.2019.03.026","article-title":"The extracellular matrix modulates the metastatic journey","volume":"49","author":"Kai","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.114786_bib42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4161\/cam.20567","article-title":"Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers","volume":"6","author":"Conklin","year":"2012","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.isci.2026.114786_bib43","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1074\/jbc.M110709200","article-title":"Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen","volume":"277","author":"Di Lullo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.114786_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14923","article-title":"Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration","volume":"8","author":"Ray","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114786_bib45","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.celrep.2018.09.030","article-title":"Microtubule-actomyosin mechanical cooperation during contact guidance sensing","volume":"25","author":"Tabdanov","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.114786_bib46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.actbio.2022.11.011","article-title":"Self-assembly of mesoscale collagen architectures and applications in 3D cell migration","volume":"155","author":"Liu","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.isci.2026.114786_bib47","first-page":"384","article-title":"Biomimetic hydrogels with mesoscale collagen architecture for patient-derived tumor organoids culture","volume":"38","author":"Wang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.isci.2026.114786_bib48","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/s41467-022-28788-6","article-title":"Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids","volume":"13","author":"Prince","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.114786_bib49","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1002\/fsn3.3469","article-title":"Use of cellulose microfibers from olive pomace to reinforce green composites for sustainable packaging applications","volume":"11","author":"Amara","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.isci.2026.114786_bib50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.biopha.2018.05.122","article-title":"Oncogene miR-187-5p is associated with cellular proliferation, migration, invasion, apoptosis and an increased risk of recurrence in bladder cancer","volume":"105","author":"Li","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.isci.2026.114786_bib51","doi-asserted-by":"crossref","first-page":"13686","DOI":"10.1039\/D5TB00833F","article-title":"Cellulose microfiber-mediated mesoscale architecture promotes the expansion of patient-derived lung cancer organoids while preserving their malignant characteristics","volume":"13","author":"Zhou","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.isci.2026.114786_bib52","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msac084","article-title":"Attribution of cancer origins to endogenous, exogenous, and preventable mutational processes","volume":"39","author":"Cannataro","year":"2022","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.isci.2026.114786_bib53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1055\/s-0037-1621710","article-title":"Fibrolamellar carcinoma: recent advances and unresolved questions on the molecular mechanisms","volume":"38","author":"Lalazar","year":"2018","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.isci.2026.114786_bib54","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1111\/bph.70130","article-title":"Bioactive ligands targeting ectopic olfactory receptors: Implications for therapeutic strategies","volume":"182","author":"Zhao","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.114786_bib55","first-page":"153","article-title":"Alterations in SAMD9, AHSG, FRG2C, and FGFR4 genes in a case of late-onset massive tumoral calcinosis","volume":"9","author":"Leow","year":"2023","journal-title":"AACE Clin. Case Rep."},{"key":"10.1016\/j.isci.2026.114786_bib56","doi-asserted-by":"crossref","DOI":"10.1177\/00368504221148340","article-title":"Kinesin family member 3A induces related diseases via wingless-related integration site\/\u03b2-catenin signaling pathway","volume":"106","author":"Liu","year":"2023","journal-title":"Sci. Prog."},{"key":"10.1016\/j.isci.2026.114786_bib57","first-page":"301","article-title":"The Hippo pathway: an emerging role in urologic cancers","volume":"9","author":"Cinar","year":"2021","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"10.1016\/j.isci.2026.114786_bib58","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.phrs.2018.02.025","article-title":"The role of STAG2 in bladder cancer","volume":"131","author":"Aquila","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.isci.2026.114786_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2022.100814","article-title":"Therapeutic significance of ARID1A mutation in bladder cancer","volume":"31","author":"Conde","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.isci.2026.114786_bib60","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12451","article-title":"Silencing circ-BIRC6 inhibits the proliferation, invasion, migration and epithelial-mesenchymal transition of bladder cancer cells by targeting the miR-495-3p\/XBP1 signaling axis","volume":"24","author":"Zhou","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.isci.2026.114786_bib61","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/2211-5463.12600","article-title":"Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer","volume":"9","author":"Ding","year":"2019","journal-title":"FEBS open bio"},{"key":"10.1016\/j.isci.2026.114786_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013821","article-title":"FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy","volume":"5","author":"Kompier","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.114786_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021092","article-title":"Mutational Landscape of Bladder Cancer in Mexican Patients: KMT2D Mutations and chr11q15.5 Amplifications Are Associated with Muscle Invasion","volume":"24","author":"P\u00e9rez-Montiel","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.114786_bib64","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/labinvest.3780458","article-title":"Alteration of the LRP1B gene region is associated with high grade of urothelial cancer","volume":"82","author":"Langbein","year":"2002","journal-title":"Lab. Invest."},{"key":"10.1016\/j.isci.2026.114786_bib65","doi-asserted-by":"crossref","first-page":"16366","DOI":"10.18632\/oncotarget.3879","article-title":"PBRM1 suppresses bladder cancer by cyclin B1 induced cell cycle arrest","volume":"6","author":"Huang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2026.114786_bib66","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/ng.2800","article-title":"Frequent truncating mutations of STAG2 in bladder cancer","volume":"45","author":"Solomon","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.114786_bib67","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1002\/tox.24409","article-title":"RB1 Mutations Induce Smoking-Related Bladder Cancer by Modulating the Cytochrome P450 Pathway","volume":"39","author":"Mao","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.isci.2026.114786_bib68","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.ajpath.2010.11.061","article-title":"Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression","volume":"178","author":"Karni-Schmidt","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2026.114786_bib69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41588-024-02030-z","article-title":"Comprehensive genomic characterization of early-stage bladder cancer","volume":"57","author":"Prip","year":"2025","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.114786_bib70","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.cell.2018.07.036","article-title":"Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer","volume":"174","author":"Robertson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114786_bib71","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-022-05277-w","article-title":"Maturation and circuit integration of transplanted human cortical organoids","volume":"610","author":"Revah","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.114786_bib72","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.cellbio.22.010305.104315","article-title":"Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer","volume":"22","author":"Nelson","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.114786_bib73","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/jbm.a.35914","article-title":"Biomaterial microarchitecture: a potent regulator of individual cell behavior and multicellular organization","volume":"105","author":"Hogrebe","year":"2017","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.isci.2026.114786_bib74","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-0716-1574-4_2","article-title":"Structure of Collagen","volume":"2347","author":"Zhao","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2026.114786_bib75","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1007\/s11010-023-04670-x","article-title":"Adipokines and epithelial-mesenchymal transition (EMT) in cancer","volume":"478","author":"Akrida","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2026.114786_bib76","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.114786_bib77","first-page":"1754","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics (Oxford, England)"},{"key":"10.1016\/j.isci.2026.114786_bib78","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2026.114786_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.114786_bib80","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw520","article-title":"FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing","volume":"44","author":"Shen","year":"2016","journal-title":"Nucleic Acids Res."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226001616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226001616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:38:34Z","timestamp":1791337114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226001616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2589004226001616"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.114786","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic hydrogel for the construction of patient-derived bladder cancer organoids with aggressive growth","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.114786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114786"}}