{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:10:04Z","timestamp":1794406204296,"version":"4.9.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K02792"],"award-info":[{"award-number":["25K02792"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K12748"],"award-info":[{"award-number":["25K12748"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08992"],"award-info":[{"award-number":["23K08992"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004420","name":"Wakayama Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004420","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","award":["N285"],"award-info":[{"award-number":["N285"]}],"id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.isci.2026.114908","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:35:46Z","timestamp":1770482146000},"page":"114908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of nicotine on the olfactory memory and its relationship with TRPA1"],"prefix":"10.1016","volume":"29","author":[{"given":"Kazuya","family":"Mizobata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sakatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuya","family":"Saika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Akaike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-5319","authenticated-orcid":false,"given":"Muneki","family":"Hotomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.114908_bib1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/alr.22078","article-title":"Olfactory dysfunction and cognition among older adults in the United States","volume":"8","author":"Choi","year":"2018","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.isci.2026.114908_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-014-1261-7","article-title":"Olfactory bulb involvement in neurodegenerative diseases","volume":"127","author":"Attems","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.isci.2026.114908_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1017\/S1355617713001409","article-title":"Olfactory impairment and subjective olfactory complaints independently predict conversion to dementia: a longitudinal, population-based study","volume":"20","author":"Stanciu","year":"2014","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.isci.2026.114908_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.0000000000001132","article-title":"Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community","volume":"84","author":"Devanand","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2026.114908_bib5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12883-016-0725-x","article-title":"Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai aging study","volume":"16","author":"Liang","year":"2016","journal-title":"BMC Neurol."},{"key":"10.1016\/j.isci.2026.114908_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jamaneurol.2015.2952","article-title":"Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia","volume":"73","author":"Roberts","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.isci.2026.114908_bib7","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1212\/WNL.0000000000003558","article-title":"Olfaction and risk of dementia in a biracial cohort of older adults","volume":"88","author":"Yaffe","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2026.114908_bib8","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/ggi.13621","article-title":"Association of olfactory impairment with indexes of sarcopenia and frailty in community-dwelling older adults","volume":"19","author":"Harita","year":"2019","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.isci.2026.114908_bib9","first-page":"277","article-title":"The development of the olfactory mucosa in the mouse: light microscopy","volume":"119","author":"Cuschieri","year":"1975","journal-title":"J. Anat."},{"key":"10.1016\/j.isci.2026.114908_bib10","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nn1882","article-title":"Contribution of olfactory neural stem cells to tissue maintenance and regeneration","volume":"10","author":"Leung","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.114908_bib11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/sj.embor.7401029","article-title":"The scent of life. The exquisite complexity of the sense of smell in animals and humans","volume":"8","author":"Rinaldi","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.isci.2026.114908_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuro.2019.02.008","article-title":"Nicotine improved the olfactory impairment in MPTP-induced mouse model of Parkinson's disease","volume":"73","author":"Yang","year":"2019","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.isci.2026.114908_bib13","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.neuron.2009.05.022","article-title":"Odor representations in olfactory cortex: \u201csparse\u201d coding, global inhibition, and oscillations","volume":"62","author":"Poo","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.114908_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.neuron.2009.09.005","article-title":"Representations of odor in the piriform cortex","volume":"63","author":"Stettler","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.114908_bib15","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cell.2011.07.041","article-title":"Driving opposing behaviors with ensembles of piriform neurons","volume":"146","author":"Choi","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114908_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainresrev.2007.05.004","article-title":"Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex","volume":"56","author":"Ikemoto","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.isci.2026.114908_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nature13162","article-title":"Coordination of entorhinal-hippocampal ensemble activity during associative learning","volume":"510","author":"Igarashi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.114908_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino16.248","article-title":"Position paper on olfactory dysfunction","volume":"54","author":"Hummel","year":"2017","journal-title":"Rhinology"},{"key":"10.1016\/j.isci.2026.114908_bib19","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00441-020-03381-9","article-title":"Human olfactory dysfunction: causes and consequences","volume":"383","author":"Sch\u00e4fer","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.isci.2026.114908_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(94)91678-0","article-title":"Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity","volume":"644","author":"Akaike","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.114908_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12576-022-00859-9","article-title":"Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats","volume":"73","author":"Uchida","year":"2023","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.isci.2026.114908_bib22","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1248\/yakushi.19-00159","article-title":"[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the \u03b14\u03b22 Nicotinic Acetylcholine Receptor]","volume":"139","author":"Takechi","year":"2019","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.isci.2026.114908_bib23","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1002\/lary.27992","article-title":"Smoking cessation improves olfactory functions","volume":"130","author":"Dinc","year":"2020","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2026.114908_bib24","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1002\/lary.28552","article-title":"The Association Between Smoking on Olfactory Dysfunction in 3,900 Patients With Olfactory Loss","volume":"131","author":"Fjaeldstad","year":"2021","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2026.114908_bib25","first-page":"273","article-title":"The effect of smoking on the olfactory function","volume":"45","author":"Katotomichelakis","year":"2007","journal-title":"Rhinology"},{"key":"10.1016\/j.isci.2026.114908_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinsphys.2023.104582","article-title":"Chronic nicotine exposure influences learning and memory in the honey bee","volume":"151","author":"Mustard","year":"2023","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.isci.2026.114908_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(97)00556-8","article-title":"Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors","volume":"765","author":"Kaneko","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.114908_bib28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12576-020-00758-x","article-title":"Effects of nicotine on regional blood flow in the olfactory bulb in response to olfactory nerve stimulation","volume":"70","author":"Uchida","year":"2020","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.isci.2026.114908_bib29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00424-012-1158-z","article-title":"The transient receptor potential channel TRPA1: from gene to pathophysiology","volume":"464","author":"Nilius","year":"2012","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.isci.2026.114908_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1093925","article-title":"Inflammation-the role of TRPA1 channel","volume":"14","author":"Yao","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2026.114908_bib31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/978-3-642-54215-2_23","article-title":"TRPA1","volume":"222","author":"Zygmunt","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.isci.2026.114908_bib32","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1113\/JP284076","article-title":"TRPA1 channel in the airway underlies protection against airborne threats by modulating respiration and behaviour","volume":"602","author":"Kuwaki","year":"2024","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.114908_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0092-8674(03)00272-1","article-title":"painless, a Drosophila gene essential for nociception","volume":"113","author":"Tracey","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114908_bib34","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nn.2379","article-title":"Nicotine activates the chemosensory cation channel TRPA1","volume":"12","author":"Talavera","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.114908_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ph14121336","article-title":"The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice","volume":"14","author":"Konkoly","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.isci.2026.114908_bib36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0012-1606(80)90062-7","article-title":"Olfactory marker protein during ontogeny: immunohistochemical localization","volume":"74","author":"Farbman","year":"1980","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2026.114908_bib37","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0266-19.2019","article-title":"Sequential Maturation of Olfactory Sensory Neurons in the Mature Olfactory Epithelium","volume":"6","author":"Liberia","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.isci.2026.114908_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0166-4328(03)00073-1","article-title":"Interactive effects of testosterone and superior cervical ganglionectomy on attraction thresholds to volatile urinary odors in gonadectomized mice","volume":"144","author":"Pankevich","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.isci.2026.114908_bib39","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1037\/0735-7044.114.5.912","article-title":"Predator odor as an unconditioned fear stimulus in rats: elicitation of freezing by trimethylthiazoline, a component of fox feces","volume":"114","author":"Wallace","year":"2000","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.isci.2026.114908_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/chemse\/bjaa005","article-title":"The Impact of Ovariectomy on Olfactory Neuron Regeneration in Mice","volume":"45","author":"Yamada","year":"2020","journal-title":"Chem. Senses"},{"key":"10.1016\/j.isci.2026.114908_bib41","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/jnr.21155","article-title":"Methimazole-induced cell death in rat olfactory receptor neurons occurs via apoptosis triggered through mitochondrial cytochrome c-mediated caspase-3 activation pathway","volume":"85","author":"Sakamoto","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.isci.2026.114908_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046338","article-title":"Odor memory stability after reinnervation of the olfactory bulb","volume":"7","author":"Blanco-Hern\u00e1ndez","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.114908_bib43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fnagi.2018.00183","article-title":"Cigarette Smoke-Induced Cell Death Causes Persistent Olfactory Dysfunction in Aged Mice","volume":"10","author":"Ueha","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.isci.2026.114908_bib44","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb j"},{"key":"10.1016\/j.isci.2026.114908_bib45","unstructured":"Sandhu, A., Hosseini, S.A., and Saadabadi, A. (2025). Nicotine Replacement Therapy. In StatPearls (StatPearls Publishing. Copyright \u00a9 2025, StatPearls Publishing LLC.)"},{"key":"10.1016\/j.isci.2026.114908_bib46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00414-019-02035-y","article-title":"Evaluation of the distribution of nicotine intravenous injection: an adult autopsy case report with a review of literature","volume":"134","author":"Aoki","year":"2020","journal-title":"Int. J. Legal Med."},{"key":"10.1016\/j.isci.2026.114908_bib47","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7326\/0003-4819-111-2-112","article-title":"Daily use of smokeless tobacco: systemic effects","volume":"111","author":"Benowitz","year":"1989","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.isci.2026.114908_bib48","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1262\/jrd.17031","article-title":"Neural encoding of olfactory recognition memory","volume":"51","author":"S\u00e1nchez-Andrade","year":"2005","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.isci.2026.114908_bib49","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1165\/rcmb.2013-0348TR","article-title":"Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung","volume":"50","author":"Nyunoya","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2026.114908_bib50","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.toxlet.2016.11.023","article-title":"Laryngeal mucus hypersecretion is exacerbated after smoking cessation and ameliorated by glucocorticoid administration","volume":"265","author":"Ueha","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.isci.2026.114908_bib51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ana.21508","article-title":"Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking","volume":"65","author":"Sonnen","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.isci.2026.114908_bib52","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1007\/s12035-019-1639-6","article-title":"Olfactory Training Prevents Olfactory Dysfunction Induced by Bulbar Excitotoxic Lesions: Role of Neurogenesis and Dopaminergic Interneurons","volume":"56","author":"Marin","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.isci.2026.114908_bib53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/alz.12398","article-title":"Pathogenesis of sporadic Alzheimer\u2019s disease by deficiency of NMDA receptor subunit GluN3A","volume":"18","author":"Zhong","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"10.1016\/j.isci.2026.114908_bib54","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ccell.2018.05.001","article-title":"Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance","volume":"33","author":"Takahashi","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2026.114908_bib55","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1158\/1541-7786.MCR-09-0304","article-title":"Nicotine enhances the antiapoptotic function of Mcl-1 through phosphorylation","volume":"7","author":"Zhao","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.isci.2026.114908_bib56","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1037\/a0020293","article-title":"Olfactory bulb habituation to odor stimuli","volume":"124","author":"Chaudhury","year":"2010","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.isci.2026.114908_bib57","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0006-8993(00)03102-4","article-title":"Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action","volume":"888","author":"File","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.114908_bib58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnmol.2019.00098","article-title":"TRPA1 Activation-Induced Myelin Degradation Plays a Key Role in Motor Dysfunction After Intracerebral Hemorrhage","volume":"12","author":"Xia","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.isci.2026.114908_bib59","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh0102","article-title":"The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production","volume":"9","author":"Kakae","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.114908_bib60","first-page":"102","article-title":"Zinc sulphate-induced anosmia decreases the nerve fibre density in the anterior cerebral artery of the rat. Auton","volume":"94","author":"van Denderen","year":"2001","journal-title":"Neurosci"},{"key":"10.1016\/j.isci.2026.114908_bib61","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1001\/jama.2022.0395","article-title":"Treatment of Tobacco Smoking: A Review","volume":"327","author":"Rigotti","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2026.114908_bib62","doi-asserted-by":"crossref","first-page":"e700","DOI":"10.1212\/WNL.0000000000006919","article-title":"Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain","volume":"92","author":"Dintica","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2026.114908_bib63","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.114908_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2022.100051","article-title":"The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration","volume":"103","author":"Sakatani","year":"2023","journal-title":"Lab. Invest."},{"key":"10.1016\/j.isci.2026.114908_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.651495","article-title":"Exposure to Cigarette Smoke Enhances Pneumococcal Transmission Among Littermates in an Infant Mouse Model","volume":"11","author":"Murakami","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.isci.2026.114908_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2023.100256","article-title":"Engineered Knockout of TRPA1 Inhibits Laser-Induced Choroidal Neovascularization Along With Associated TGF\u03b21 Expression and Neutrophil Infiltration","volume":"103","author":"Usui","year":"2023","journal-title":"Lab. Invest."},{"key":"10.1016\/j.isci.2026.114908_bib67","article-title":"Olfactory assays for mouse models of neurodegenerative disease","volume":"90","author":"Lehmkuhl","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.isci.2026.114908_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2024.102200","article-title":"Complement Component 3 Promotes Regeneration of Olfactory Receptor Neurons","volume":"105","author":"Kuwazoe","year":"2025","journal-title":"Lab. Invest."},{"key":"10.1016\/j.isci.2026.114908_bib69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1749-6632.1987.tb43476.x","article-title":"A standardized olfactometer in Japan. A review over ten years","volume":"510","author":"Takagi","year":"1987","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2026.114908_bib70","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/chemse\/bjn029","article-title":"Sniffing behavior of mice during performance in odor-guided tasks","volume":"33","author":"Wesson","year":"2008","journal-title":"Chem. Senses"},{"key":"10.1016\/j.isci.2026.114908_bib71","article-title":"Simple behavioral assessment of mouse olfaction","volume":"Chapter 8","author":"Yang","year":"2009","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.isci.2026.114908_bib72","article-title":"Olfactory Avoidance Test (Mouse)","volume":"7","author":"Takahashi","year":"2017","journal-title":"Bio. Protoc."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422600283X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422600283X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:53:43Z","timestamp":1788951223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422600283X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S258900422600283X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.114908","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of nicotine on the olfactory memory and its relationship with TRPA1","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.114908","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114908"}}