{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:13:27Z","timestamp":1788952407779,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012234","name":"Shenzhen Peacock Plan","doi-asserted-by":"publisher","award":["KQTD2016053117035204"],"award-info":[{"award-number":["KQTD2016053117035204"]}],"id":[{"id":"10.13039\/501100012234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630096"],"award-info":[{"award-number":["81630096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.isci.2026.114931","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:34:51Z","timestamp":1770395691000},"page":"114931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bazedoxifene rescues hepatocytes from chemically induced oxidative ferroptotic injury in vivo and in vitro by inhibiting protein disulfide isomerase"],"prefix":"10.1016","volume":"29","author":[{"given":"Xiangyu","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Hao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.114931_bib1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/03602532.2020.1832112","article-title":"The development and hepatotoxicity of acetaminophen: reviewing over a century of progress","volume":"52","author":"McGill","year":"2020","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.isci.2026.114931_bib2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/pds.1191","article-title":"Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States","volume":"15","author":"Nourjah","year":"2006","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.isci.2026.114931_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.580289","article-title":"Analgesic effect of acetaminophen: a review of known and novel mechanisms of action","volume":"11","author":"Ohashi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2026.114931_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-pathmechdis-051122-094016","article-title":"Acetaminophen hepatotoxicity: paradigm for understanding mechanisms of drug-induced liver injury","volume":"19","author":"Jaeschke","year":"2024","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.isci.2026.114931_bib5","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cld.2013.07.005","article-title":"Acetaminophen-related hepatotoxicity","volume":"17","author":"Bunchorntavakul","year":"2013","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.isci.2026.114931_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/bs.apha.2018.12.004","article-title":"Evaluation and treatment of acetaminophen toxicity","volume":"85","author":"Fisher","year":"2019","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.isci.2026.114931_bib7","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1007\/s00204-019-02597-1","article-title":"Emerging and established modes of cell death during acetaminophen-induced liver injury","volume":"93","author":"Jaeschke","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.isci.2026.114931_bib8","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1007\/s11095-013-1007-6","article-title":"Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis","volume":"30","author":"McGill","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.isci.2026.114931_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3565(25)29664-1","article-title":"Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo","volume":"187","author":"Jollow","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.isci.2026.114931_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2013.09.006","article-title":"Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits","volume":"141","author":"Rushworth","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.isci.2026.114931_bib11","first-page":"1202","article-title":"The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress","volume":"19","author":"Raghu","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.isci.2026.114931_bib12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.114931_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006203","article-title":"Unsolved mysteries: How does lipid peroxidation cause ferroptosis?","volume":"16","author":"Feng","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.isci.2026.114931_bib14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2026.114931_bib15","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/s41418-019-0418-2","article-title":"Lipid metabolism offers anticancer treatment by regulating ferroptosis","volume":"26","author":"Carbone","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2026.114931_bib16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbrc.2016.06.066","article-title":"Protein disulfide isomerase mediates glutathione depletion-induced cytotoxicity","volume":"477","author":"Okada","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2026.114931_bib17","first-page":"853","article-title":"Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells","volume":"55","author":"Hou","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.isci.2026.114931_bib18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3724\/abbs.2024165","article-title":"Mechanism of RSL3-induced ferroptotic cell death in HT22 cells: crucial role of protein disulfide isomerase","volume":"57","author":"Hou","year":"2024","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.isci.2026.114931_bib19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/s12964-024-01798-1","article-title":"Protein disulfide isomerase plays a crucial role in mediating chemically-induced, glutathione depletion-associated hepatocyte injury in vitro and in vivo","volume":"22","author":"Zhu","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2026.114931_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2025.110366","article-title":"Role of protein disulfide isomerase in mediating sulfasalazine-induced ferroptosis in HT22 cells: The PDI-NOS-NO-ROS\/lipid-ROS cascade","volume":"768","author":"Wu","year":"2025","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.isci.2026.114931_bib21","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.3724\/abbs.2025100","article-title":"Characterization of the mechanisms underlying sulfasalazine-induced ferroptotic cell death: role of protein disulfide isomerase-mediated NOS activation and NO accumulation","volume":"57","author":"Jia","year":"2025","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.isci.2026.114931_bib22","doi-asserted-by":"crossref","first-page":"16218","DOI":"10.1016\/S0021-9258(18)37581-1","article-title":"Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase","volume":"263","author":"Tasanen","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.114931_bib23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/j.1460-2075.1987.tb04803.x","article-title":"Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene","volume":"6","author":"Pihlajaniemi","year":"1987","journal-title":"EMBO J"},{"key":"10.1016\/j.isci.2026.114931_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0968-0004(94)90072-8","article-title":"Protein disulphide isomerase: building bridges in protein folding","volume":"19","author":"Freedman","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2026.114931_bib25","doi-asserted-by":"crossref","first-page":"24550","DOI":"10.1016\/S0021-9258(17)31426-6","article-title":"Chaperone-like activity of protein disulfide isomerase in the refolding of a protein with no disulfide bonds","volume":"269","author":"Cai","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.114931_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102703","article-title":"The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1","volume":"62","author":"Cheff","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2026.114931_bib27","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1016\/0006-2952(84)90598-7","article-title":"The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation","volume":"33","author":"Drew","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2026.114931_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11010-008-9853-y","article-title":"Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation","volume":"318","author":"Lee","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2026.114931_bib29","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2026.114931_bib30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2026.114931_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217697","article-title":"Glutathione metabolism in ferroptosis and cancer therapy","volume":"621","author":"Xue","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.isci.2026.114931_bib32","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00204-020-02714-5","article-title":"Role of ferroptosis in acetaminophen-induced hepatotoxicity","volume":"94","author":"Yamada","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.isci.2026.114931_bib33","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s12253-015-9946-3","article-title":"Ferroptosis is involved in acetaminophen induced cell death","volume":"21","author":"L\u0151rincz","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.isci.2026.114931_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/00365529509093237","article-title":"Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine","volume":"30","author":"Sakaida","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.isci.2026.114931_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177313","article-title":"4-Hydroxyestrogen metabolites strongly prevent chemically-induced ferroptotic hepatocyte injury in vitro and in vivo","volume":"993","author":"Zhang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.114931_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpet.2024.100050","article-title":"Protective effect of 2-hydroxyestrone and 2-hydroxyestradiol against chemically induced hepatotoxicity in vitro and in vivo","volume":"392","author":"Sun","year":"2025","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.isci.2026.114931_bib37","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1517\/13543784.16.10.1663","article-title":"Bazedoxifene and bazedoxifene combined with conjugated estrogens for the management of postmenopausal osteoporosis","volume":"16","author":"Lewiecki","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.isci.2026.114931_bib38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00774-019-01073-1","article-title":"Bazedoxifene improves renal function and increases renal phosphate excretion in patients with postmenopausal osteoporosis","volume":"38","author":"Masaki","year":"2020","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.isci.2026.114931_bib39","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10549-019-05183-2","article-title":"Bazedoxifene is a novel IL-6\/GP130 inhibitor for treating triple-negative breast cancer","volume":"175","author":"Tian","year":"2019","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.isci.2026.114931_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2019.01.026","article-title":"Combined bazedoxifene and paclitaxel treatments inhibit cell viability, cell migration, colony formation, and tumor growth and induce apoptosis in breast cancer","volume":"448","author":"Fu","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.isci.2026.114931_bib41","doi-asserted-by":"crossref","first-page":"66912","DOI":"10.18632\/oncotarget.11464","article-title":"Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer","volume":"8","author":"Yadav","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2026.114931_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189911","article-title":"Bazedoxifene and conjugated estrogen combination maintains metabolic homeostasis and benefits liver health","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.114931_bib43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molmet.2013.12.009","article-title":"Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice","volume":"3","author":"Kim","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2026.114931_bib44","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/JME-10-0122","article-title":"Selective estrogen receptor modulators as brain therapeutic agents","volume":"46","author":"Arevalo","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.isci.2026.114931_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.yfrne.2018.09.001","article-title":"Molecular mechanisms involved in the protective actions of selective estrogen receptor modulators in brain cells","volume":"52","author":"Baez-Jurado","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.isci.2026.114931_bib46","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00011-019-01217-z","article-title":"Bazedoxifene protects cerebral autoregulation after traumatic brain injury and attenuates impairments in blood-brain barrier damage: involvement of anti-inflammatory pathways by blocking MAPK signaling","volume":"68","author":"Lan","year":"2019","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.isci.2026.114931_bib47","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12964-025-02209-9","article-title":"Strong protection by bazedoxifene against chemically-induced ferroptotic neuronal death in vitro and in vivo","volume":"23","author":"Hao","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2026.114931_bib48","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/mc.23533","article-title":"PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation","volume":"62","author":"Luo","year":"2023","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.isci.2026.114931_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119579","article-title":"Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2\/AMPK\/PGC-1\u03b1 axis: Restoration of mitochondrial function and inhibition of ferroptosis","volume":"345","author":"Shan","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.isci.2026.114931_bib50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0753-3322(02)00284-6","article-title":"I. Arginine","volume":"56","author":"Tapiero","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.isci.2026.114931_bib51","doi-asserted-by":"crossref","first-page":"27004","DOI":"10.1074\/jbc.M114.564104","article-title":"Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1\u03b1 (Ero1\u03b1) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A","volume":"289","author":"Okumura","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.114931_bib52","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/emboj\/17.4.927","article-title":"The b' domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins","volume":"17","author":"Klappa","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.isci.2026.114931_bib53","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41589-019-0268-8","article-title":"Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding","volume":"15","author":"Okumura","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2026.114931_bib54","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1021\/acs.biochem.3c00261","article-title":"Strong protection by 4-hydroxyestrone against erastin-induced ferroptotic cell death in estrogen receptor-negative human breast cancer cells: evidence for protein disulfide isomerase as a mechanistic target for protection","volume":"63","author":"Wang","year":"2024","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2026.114931_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28020814","article-title":"Involvement of nitric oxide in protecting against radical species and autoregulation of M1-polarized macrophages through metabolic remodeling","volume":"28","author":"Fujii","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.isci.2026.114931_bib56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.niox.2021.07.003","article-title":"Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction","volume":"115","author":"Homma","year":"2021","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.isci.2026.114931_bib57","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.freeradbiomed.2006.05.002","article-title":"Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis","volume":"41","author":"Han","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2026.114931_bib58","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2026.114931_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-010715-103715","article-title":"The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies","volume":"56","author":"Martinez Molina","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226003068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226003068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:30:23Z","timestamp":1788949823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226003068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2589004226003068"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.114931","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bazedoxifene rescues hepatocytes from chemically induced oxidative ferroptotic injury in vivo and in vitro by inhibiting protein disulfide isomerase","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.114931","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114931"}}