{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:15:00Z","timestamp":1788952500781,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019944","name":"Sanofi-Aventis Deutschland GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.isci.2026.115136","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:54:15Z","timestamp":1772006055000},"page":"115136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping lung function in late-onset Pompe disease using label-free functional MRI"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4431-3162","authenticated-orcid":false,"given":"Lina","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Heiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Bayerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Zsch\u00fcntzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Regensburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"T\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Vorgerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Schlaffke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Vogt-Wolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merle","family":"Cla\u00dfen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Stoecklein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Buehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Woelfle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Uder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mensch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Winterholler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Trollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Raming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Knieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115136_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/01.gim.0000218152.87434.f3","article-title":"Pompe disease diagnosis and management guideline","volume":"8","author":"Kishnani","year":"2006","journal-title":"Genet. Med."},{"key":"10.1016\/j.isci.2026.115136_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/bj0860011","article-title":"alpha-Glucosidase deficiency in generalized glycogenstorage disease (Pompe\u2019s disease)","volume":"86","author":"HERS","year":"1963","journal-title":"Biochem. J."},{"key":"10.1016\/j.isci.2026.115136_bib3","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s13311-018-0655-y","article-title":"Pompe Disease: From Basic Science to Therapy","volume":"15","author":"Kohler","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.isci.2026.115136_bib4","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/S0140-6736(08)61555-X","article-title":"Pompe\u2019s disease","volume":"372","author":"van der Ploeg","year":"2008","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.isci.2026.115136_bib5","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.21037\/jtd-cus-2020-007","article-title":"Respiratory failure and sleep-disordered breathing in late-onset Pompe disease: a narrative review","volume":"12","author":"Shah","year":"2020","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.isci.2026.115136_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13023-020-01353-4","article-title":"Late-onset Pompe disease (LOPD) in Belgium: clinical characteristics and outcome measures","volume":"15","author":"Vanherpe","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.isci.2026.115136_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54314-8","article-title":"Dynamic respiratory muscle function in late-onset Pompe disease","volume":"9","author":"Smith","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115136_bib8","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1212\/WNL.57.7.1290","article-title":"Sleep-disordered breathing and respiratory failure in acid maltase deficiency","volume":"57","author":"Mellies","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2026.115136_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/oxfordjournals.qjmed.a068789","article-title":"Respiratory involvement in primary muscle disorders: assessment and management","volume":"86","author":"Howard","year":"1993","journal-title":"Q. J. Med."},{"key":"10.1016\/j.isci.2026.115136_bib10","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00415-005-0922-9","article-title":"The natural course of non-classic Pompe\u2019s disease; a review of 225 published cases","volume":"252","author":"Winkel","year":"2005","journal-title":"J. Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-52143-6","article-title":"Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in late-onset Pompe disease","volume":"15","author":"Tan","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115136_bib12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00415-016-8219-8","article-title":"Survival and long-term outcomes in late-onset Pompe disease following alglucosidase alfa treatment: a systematic review and meta-analysis","volume":"264","author":"Schoser","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib13","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa0909859","article-title":"A randomized study of alglucosidase alfa in late-onset Pompe\u2019s disease","volume":"362","author":"van der Ploeg","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2026.115136_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16383","article-title":"Start, switch and stop (triple-S) criteria for enzyme replacement therapy of late-onset Pompe disease: European Pompe Consortium recommendation update 2024","volume":"31","author":"Schoser","year":"2024","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2147\/TCRM.S362871","article-title":"Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives","volume":"19","author":"El Haddad","year":"2023","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.isci.2026.115136_bib16","doi-asserted-by":"crossref","DOI":"10.3791\/66380","article-title":"Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V\/Q) Assessment","author":"Voskrebenzev","year":"2024","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.isci.2026.115136_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.621257","article-title":"Correlation Between Respiratory Accessory Muscles and Diaphragm Pillars MRI and Pulmonary Function Test in Late-Onset Pompe Disease Patients","volume":"12","author":"Reyes-Leiva","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12890-015-0058-3","article-title":"Lung MRI and impairment of diaphragmatic function in Pompe disease","volume":"15","author":"Wens","year":"2015","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.isci.2026.115136_bib19","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm1196-1236","article-title":"Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging","volume":"2","author":"Edelman","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.115136_bib20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1148\/radiology.200.2.8685356","article-title":"Human lung air spaces: potential for MR imaging with hyperpolarized He-3","volume":"200","author":"MacFall","year":"1996","journal-title":"Radiology"},{"key":"10.1016\/j.isci.2026.115136_bib21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/mrm.1082","article-title":"Dynamic (19)F-MRI of pulmonary ventilation using sulfur hexafluoride (SF(6)) gas","volume":"45","author":"Schreiber","year":"2001","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.isci.2026.115136_bib22","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1007\/s00330-022-08940-y","article-title":"MRI changes in diaphragmatic motion and curvature in Pompe disease over time","volume":"32","author":"Harlaar","year":"2022","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.isci.2026.115136_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4088","article-title":"Free-breathing quantification of regional ventilation derived by phase-resolved functional lung (PREFUL) MRI","volume":"32","author":"Klime\u0161","year":"2019","journal-title":"NMR Biomed."},{"key":"10.1016\/j.isci.2026.115136_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.5270","article-title":"Influence of echo time on pulmonary ventilation and perfusion derived by phase-resolved functional lung (PREFUL) MRI using multi-echo ultrashort echo time acquisition","volume":"37","author":"Behrendt","year":"2024","journal-title":"NMR Biomed."},{"key":"10.1016\/j.isci.2026.115136_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jmri.27027","article-title":"Validation of Automated Perfusion-Weighted Phase-Resolved Functional Lung (PREFUL)-MRI in Patients With Pulmonary Diseases","volume":"52","author":"Behrendt","year":"2020","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib63","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/jmri.28995","article-title":"Multicenter Standardization of Phase-Resolved Functional Lung MRI in Patients With Suspected Chronic Thromboembolic Pulmonary Hypertension","volume":"59","author":"Moher Alsady","year":"2024","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jmri.27385","article-title":"Repeatability of Phase-Resolved Functional Lung (PREFUL)-MRI Ventilation and Perfusion Parameters in Healthy Subjects and COPD Patients","volume":"53","author":"P\u00f6hler","year":"2021","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib27","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/jmri.29221","article-title":"Comparison of Free-Breathing 3D Phase-Resolved Functional Lung (PREFUL) MRI With Dynamic 19F Ventilation MRI in Patients With Obstructive Lung Disease and Healthy Volunteers","volume":"60","author":"Klime\u0161","year":"2024","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1148\/radiol.2018171993","article-title":"Free-breathing Pulmonary MR Imaging to Quantify Regional Ventilation","volume":"287","author":"Capaldi","year":"2018","journal-title":"Radiology"},{"key":"10.1016\/j.isci.2026.115136_bib61","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/jmri.27543","article-title":"Repeatability of dynamic 3D phase-resolved functional lung (PREFUL) ventilation MR Imaging in patients with chronic obstructive pulmonary disease and healthy volunteers","volume":"54","author":"Klime\u0161","year":"2021","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib62","doi-asserted-by":"crossref","DOI":"10.1148\/ryct.210147","article-title":"PREFUL MRI Depicts Dual Bronchodilator Changes in COPD: A Retrospective Analysis of a Randomized Controlled Trial","volume":"4","author":"Voskrebenzev","year":"2022","journal-title":"Radiol. Cardiothorac. Imaging"},{"key":"10.1016\/j.isci.2026.115136_bib29","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1016\/j.acra.2020.05.008","article-title":"Comparison of Functional Free-Breathing Pulmonary 1H and Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis","volume":"28","author":"Couch","year":"2021","journal-title":"Acad. Radiol."},{"key":"10.1016\/j.isci.2026.115136_bib30","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/jmri.28470","article-title":"129 Xe and Free-Breathing 1 H Ventilation MRI in Patients With Cystic Fibrosis: A Dual-Center Study","volume":"57","author":"Marshall","year":"2023","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib31","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/mrm.29566","article-title":"Inter- and intravisit repeatability of free-breathing MRI in pediatric cystic fibrosis lung disease","volume":"89","author":"Munidasa","year":"2023","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.isci.2026.115136_bib68","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1002\/mrm.26893","article-title":"Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients","volume":"79","author":"Voskrebenzev","year":"2018","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.isci.2026.115136_bib32","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.acra.2014.10.003","article-title":"Free-breathing pulmonary 1H and Hyperpolarized 3He MRI: comparison in COPD and bronchiectasis","volume":"22","author":"Capaldi","year":"2015","journal-title":"Acad. Radiol."},{"key":"10.1016\/j.isci.2026.115136_bib33","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.221250","article-title":"Pulmonary Dysfunction after Pediatric COVID-19","volume":"306","author":"Heiss","year":"2023","journal-title":"Radiology"},{"key":"10.1016\/j.isci.2026.115136_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/biom13091279","article-title":"A Comprehensive Update on Late-Onset Pompe Disease","volume":"13","author":"Labella","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.isci.2026.115136_bib55","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/jamaneurol.2023.0552","article-title":"Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks: A Phase 3 Randomized Clinical Trial","volume":"80","author":"Kishnani","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib56","doi-asserted-by":"crossref","first-page":"e1756","DOI":"10.1212\/WNL.0000000000008441","article-title":"Large variation in effects during 10 years of enzyme therapy in adults with Pompe disease","volume":"93","author":"Harlaar","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2026.115136_bib57","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S1474-4422(21)00331-8","article-title":"Safety and efficacy of cipaglucosidase alfa plus miglustat versus alglucosidase alfa plus placebo in late-onset Pompe disease (PROPEL): an international, randomised, double-blind, parallel-group, phase 3 trial","volume":"20","author":"Schoser","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib58","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1007\/s00415-024-12236-0","article-title":"104-week efficacy and safety of cipaglucosidase alfa plus miglustat in adults with late-onset Pompe disease: a phase III open-label extension study (ATB200-07)","volume":"271","author":"Schoser","year":"2024","journal-title":"J. Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib59","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s41687-024-00805-w","article-title":"Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease","volume":"8","author":"Kishnani","year":"2024","journal-title":"J. Patient-Rep. Outcomes"},{"key":"10.1016\/j.isci.2026.115136_bib60","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S1474-4422(21)00241-6","article-title":"Safety and efficacy of avalglucosidase alfa versus alglucosidase alfa in patients with late-onset Pompe disease (COMET): a phase 3, randomised, multicentre trial","volume":"20","author":"Diaz-Manera","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2026.115136_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3233\/JND-190426","article-title":"Advancements in AAV-mediated Gene Therapy for Pompe Disease","volume":"7","author":"Salabarria","year":"2020","journal-title":"J. Neuromuscul. Dis."},{"key":"10.1016\/j.isci.2026.115136_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.170199","article-title":"AAV-mediated delivery of secreted acid \u03b1-glucosidase with enhanced uptake corrects neuromuscular pathology in Pompe mice","volume":"8","author":"Meena","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2026.115136_bib42","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1056\/NEJMoa2407766","article-title":"AAV9-Mediated Gene Therapy for Infantile-Onset Pompe\u2019s Disease","volume":"392","author":"Ma","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2026.115136_bib43","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/jmri.28165","article-title":"Clinical Feasibility of Structural and Functional MRI in Free-Breathing Neonates and Infants","volume":"55","author":"Zanette","year":"2022","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13613-025-01526-z","article-title":"Lung electrical impedance tomography during positioning, weaning and chest physiotherapy in mechanically ventilated critically ill patients: a narrative review","volume":"15","author":"Bayat","year":"2025","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.isci.2026.115136_bib45","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41390-025-03929-x","article-title":"Electrical impedance tomography in neonates: a review","volume":"98","author":"Ako","year":"2025","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.isci.2026.115136_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244638","article-title":"Comparison of phase-resolved functional lung (PREFUL) MRI derived perfusion and ventilation parameters at 1.5T and 3T in healthy volunteers","volume":"15","author":"Glandorf","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115136_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.70101","article-title":"Dual-Center Repeatability, Consistency, and Comparison of 3D Phase-Resolved Functional (PREFUL) Ventilation MRI at 3 and 1.5 T in Healthy Volunteers","volume":"38","author":"Klime\u0161","year":"2025","journal-title":"NMR Biomed."},{"key":"10.1016\/j.isci.2026.115136_bib47","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1148\/radiol.2019190452","article-title":"Opportunities in Interventional and Diagnostic Imaging by Using High-Performance Low-Field-Strength MRI","volume":"293","author":"Campbell-Washburn","year":"2019","journal-title":"Radiology"},{"key":"10.1016\/j.isci.2026.115136_bib48","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/jmri.26342","article-title":"Comparison of quantitative regional perfusion-weighted phase resolved functional lung (PREFUL) MRI with dynamic gadolinium-enhanced regional pulmonary perfusion MRI in COPD patients","volume":"49","author":"Kaireit","year":"2019","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib65","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/jmri.27452","article-title":"Flow Volume Loop and Regional Ventilation Assessment Using Phase-Resolved Functional Lung (PREFUL) MRI: Comparison With 129 Xenon Ventilation MRI and Lung Function Testing","volume":"53","author":"Kaireit","year":"2021","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.isci.2026.115136_bib49","article-title":"Phase-resolved MRI for measurement of pulmonary perfusion and ventilation defects in comparison with dynamic contrast-enhanced MRI and 129Xe MRI","volume":"11","author":"Ouyang","year":"2024","journal-title":"BMJ Open Respir. Res."},{"key":"10.1016\/j.isci.2026.115136_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12054","article-title":"A dual center and dual vendor comparison study of automated perfusion-weighted phase-resolved functional lung magnetic resonance imaging with dynamic contrast-enhanced magnetic resonance imaging in patients with cystic fibrosis","volume":"12","author":"Behrendt","year":"2022","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.isci.2026.115136_bib66","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.nmd.2012.10.024","article-title":"The Rasch-built Pompe-specific activity (R-PAct) scale","volume":"23","author":"van der Beek","year":"2013","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.isci.2026.115136_bib67","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed \u201cUp & Go\u201d: a test of basic functional mobility for frail elderly persons","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.isci.2026.115136_bib70","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/jmri.26799","article-title":"MRI-derived regional flow-volume loop parameters detect early-stage chronic lung allograft dysfunction","volume":"50","author":"Moher Alsady","year":"2019","journal-title":"J. Magn. Reson. Imaging."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226005110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226005110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:36:33Z","timestamp":1788950193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226005110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2589004226005110"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115136","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping lung function in late-onset Pompe disease using label-free functional MRI","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115136"}}