{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:55:13Z","timestamp":1794318913870,"version":"4.9.0"},"reference-count":127,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ40399"],"award-info":[{"award-number":["2022JJ40399"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.isci.2026.115217","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:28:08Z","timestamp":1772641688000},"page":"115217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The interplay of ketones and succinate: Seeking metabolic balance and novel therapeutic strategies in myocardial hypertrophy and heart failure"],"prefix":"10.1016","volume":"29","author":[{"given":"Yaling","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-7675","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115217_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ihj.2015.02.012","article-title":"Hypertrophy to failure: what goes wrong with the fibers of the heart?","volume":"67","author":"Maulik","year":"2015","journal-title":"Indian Heart J."},{"key":"10.1016\/j.isci.2026.115217_bib2","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac Energy Metabolism in Heart Failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.115217_bib3","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/CIRCRESAHA.124.326044","article-title":"Metabolic Coordination Structures Contribute to Diabetic Myocardial Dysfunction","volume":"136","author":"Wu","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.115217_bib4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1196\/annals.1341.019","article-title":"Metabolic energetics and genetics in the heart","volume":"1047","author":"Taegtmeyer","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1139\/cjpp-2024-0270","article-title":"Epigenetic regulation by ketone bodies in cardiac diseases and repair","volume":"103","author":"Gurusamy","year":"2025","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.isci.2026.115217_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115217_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tcb.2013.11.008","article-title":"Succinate: a metabolic signal in inflammation","volume":"24","author":"Mills","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.isci.2026.115217_bib8","article-title":"Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115217_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.plefa.2003.11.001","article-title":"Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry","volume":"70","author":"Fukao","year":"2004","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.isci.2026.115217_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1620\/tjem.215.227","article-title":"Liver-specific silencing of the human gene encoding succinyl-CoA: 3-ketoacid CoA transferase","volume":"215","author":"Orii","year":"2008","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115217_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0065-2571(66)90027-6","article-title":"The regulation of the release of ketone bodies by the liver","volume":"4","author":"Krebs","year":"1966","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.isci.2026.115217_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/iub.572","article-title":"The monocarboxylate transporter family--role and regulation","volume":"64","author":"Halestrap","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.isci.2026.115217_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cell.2024.10.032","article-title":"A beta-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites","volume":"188","author":"Moya-Garzon","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115217_bib14","doi-asserted-by":"crossref","first-page":"H1060","DOI":"10.1152\/ajpheart.00646.2012","article-title":"Ketone body metabolism and cardiovascular disease","volume":"304","author":"Cotter","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2026.115217_bib15","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/cvr\/cvz045","article-title":"Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency","volume":"115","author":"Ho","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2026.115217_bib16","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/jimd.12243","article-title":"Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting","volume":"43","author":"Otsuka","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.isci.2026.115217_bib17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2016.03.036","article-title":"Metabolic Regulation of Gene Expression by Histone Lysine beta-Hydroxybutyrylation","volume":"62","author":"Xie","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.115217_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nchembio.2217","article-title":"Structure of p300 in complex with acyl-CoA variants","volume":"13","author":"Kaczmarska","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2026.115217_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071414","article-title":"Histone Deacetylase Inhibitors as Anticancer Drugs","volume":"18","author":"Eckschlager","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib20","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/qjmed\/hcae034","article-title":"Function and mechanism of lysine crotonylation in health and disease","volume":"117","author":"Hou","year":"2024","journal-title":"QJM"},{"key":"10.1016\/j.isci.2026.115217_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41421-019-0103-0","article-title":"Molecular basis for hierarchical histone de-beta-hydroxybutyrylation by SIRT3","volume":"5","author":"Zhang","year":"2019","journal-title":"Cell Discov."},{"key":"10.1016\/j.isci.2026.115217_bib22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.115217_bib23","article-title":"Acidosis Licenses the NLRP3 Inflammasome-Inhibiting Effects of Beta-Hydroxybutyrate and Short-Chain Carboxylic Acids","author":"Mank","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2026.115217_bib24","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1038\/ncomms4944","article-title":"The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages","volume":"5","author":"Rahman","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115217_bib25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.metabol.2015.10.001","article-title":"Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2","volume":"65","author":"Graff","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.115217_bib26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.7150\/ijms.89370","article-title":"NAD(+)-A Hub of Energy Metabolism in Heart Failure","volume":"21","author":"Wu","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043534","article-title":"Ketone Bodies and Cardiovascular Disease: An Alternate Fuel Source to the Rescue","volume":"24","author":"Manolis","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib28","article-title":"Metabolic gene expression and epigenetic effects of the ketone body beta-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos","volume":"8","author":"Sangalli","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115217_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.115217_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12933-025-02646-3","article-title":"BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2","volume":"24","author":"Xu","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.115217_bib31","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1093\/cvr\/cvaa298","article-title":"Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure","volume":"117","author":"Nakamura","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2026.115217_bib32","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yjmcc.2016.11.002","article-title":"Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury","volume":"101","author":"Dong","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2026.115217_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yjmcc.2023.11.001","article-title":"beta-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice","volume":"186","author":"Chu","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2026.115217_bib34","first-page":"954","article-title":"[Effect of Ketone Body beta-Hydroxybutyrate to Attenuate Inflammation-Induced Mitochondrial Oxidative Stress in Vascular Endothelial Cells]","volume":"52","author":"Ji","year":"2021","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.isci.2026.115217_bib35","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jacbts.2024.11.004","article-title":"beta-Hydroxybutyrate Facilitates Homeostasis of Hypoxic Endothelial Cells After Myocardial Infarction via Histone Lysine beta-Hydroxybutyrylation of CPT1A","volume":"10","author":"Li","year":"2025","journal-title":"JACC, Basic Transl. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib36","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.molcel.2018.07.036","article-title":"beta-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4","volume":"71","author":"Han","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.115217_bib37","doi-asserted-by":"crossref","first-page":"L864","DOI":"10.1152\/ajplung.00128.2009","article-title":"Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition","volume":"297","author":"Guo","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.isci.2026.115217_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006573","article-title":"Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure","volume":"13","author":"Byrne","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.isci.2026.115217_bib40","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12916-022-02352-x","article-title":"Ketone body beta-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.isci.2026.115217_bib38","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/metabo11050258","article-title":"Butyrate Prevents TGF-beta1-Induced Alveolar Myofibroblast Differentiation and Modulates Energy Metabolism","volume":"11","author":"Lee","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.isci.2026.115217_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5512322","article-title":"Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function","volume":"2021","author":"Tao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.isci.2026.115217_bib42","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/CIRCULATIONAHA.119.045033","article-title":"Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure","volume":"141","author":"Selvaraj","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115217_bib43","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029960","article-title":"Elevated Plasma Levels of Ketone Bodies Are Associated With All-Cause Mortality and Incidence of Heart Failure in Older Adults: The CHS","volume":"12","author":"Niezen","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.isci.2026.115217_bib44","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/ejhf.3324","article-title":"Circulating beta-hydroxybutyrate levels in advanced heart failure with reduced ejection fraction: Determinants and prognostic impact","volume":"26","author":"Monzo","year":"2024","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.isci.2026.115217_bib45","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/CIRCRESAHA.120.317933","article-title":"Targeting Mitochondria-Inflammation Circuit by beta-Hydroxybutyrate Mitigates HFpEF","volume":"128","author":"Deng","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.115217_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.681513","article-title":"Beta-Hydroxybutyrate, Friend or Foe for Stressed Hearts","volume":"2","author":"Chu","year":"2021","journal-title":"Front. Aging"},{"key":"10.1016\/j.isci.2026.115217_bib47","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1161\/CIRCULATIONAHA.115.017545","article-title":"Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure","volume":"133","author":"Bedi","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115217_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155818","article-title":"Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation","volume":"154","author":"Pherwani","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.115217_bib49","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/eurheartj\/ehad176","article-title":"Circulating ketone bodies as signals for cardiovascular disease and mortality","volume":"44","author":"Voorrips","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2026.115217_bib50","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1161\/CIRCULATIONAHA.115.017355","article-title":"The Failing Heart Relies on Ketone Bodies as a Fuel","volume":"133","author":"Aubert","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115217_bib51","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1161\/CIRCULATIONAHA.123.067971","article-title":"Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial","volume":"149","author":"Berg-Hansen","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115217_bib52","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1161\/CIRCULATIONAHA.124.069732","article-title":"Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction","volume":"150","author":"Gopalasingam","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115217_bib53","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1002\/ehf2.13634","article-title":"Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart","volume":"8","author":"Takahara","year":"2021","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.isci.2026.115217_bib54","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.004953","article-title":"Increased Cardiac Uptake of Ketone Bodies and Free Fatty Acids in Human Heart Failure and Hypertrophic Left Ventricular Remodeling","volume":"11","author":"Voros","year":"2018","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.isci.2026.115217_bib55","first-page":"1","article-title":"Age-Induced Accumulation of Succinate Promotes Cardiac Fibrogenesis","volume":"0","author":"Wang","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.115217_bib56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00395-023-01015-z","article-title":"Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts","volume":"118","author":"Li","year":"2023","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.isci.2026.115217_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154915","article-title":"Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure","volume":"125","author":"Bull\u00f3","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.115217_bib58","doi-asserted-by":"crossref","first-page":"27580","DOI":"10.1074\/jbc.273.42.27580","article-title":"Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes","volume":"273","author":"Johnson","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115217_bib59","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41467-017-02713-8","article-title":"Crystal structure of an assembly intermediate of respiratory Complex II","volume":"9","author":"Sharma","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115217_bib60","doi-asserted-by":"crossref","first-page":"19932","DOI":"10.1074\/jbc.RA118.005144","article-title":"Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration","volume":"293","author":"Fink","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115217_bib61","doi-asserted-by":"crossref","first-page":"C460","DOI":"10.1152\/ajpcell.00211.2007","article-title":"Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria","volume":"294","author":"Chen","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.isci.2026.115217_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adr4458","article-title":"Succinate-loaded tumor cell-derived microparticles reprogram tumor-associated macrophage metabolism","volume":"17","author":"Lu","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2026.115217_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202503109","article-title":"The Role of HINT3 in Myocardial Ischemia-Reperfusion Injury in Male Mice: Mechanisms Involving SDHA and its Acetylation","volume":"12","author":"Yu","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib64","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.celrep.2018.04.104","article-title":"Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.115217_bib65","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1161\/CIRCULATIONAHA.119.042791","article-title":"Targeting Succinate Metabolism in Ischemia\/Reperfusion Injury","volume":"140","author":"Kula-Alwar","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115217_bib66","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115217_bib67","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115217_bib68","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115217_bib69","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nchembio.495","article-title":"Identification of lysine succinylation as a new post-translational modification","volume":"7","author":"Zhang","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2026.115217_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1336057","article-title":"Protein succinylation: regulating metabolism and beyond","volume":"11","author":"Hou","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.isci.2026.115217_bib71","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.molcel.2019.03.021","article-title":"Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation","volume":"74","author":"Wang","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.115217_bib72","doi-asserted-by":"crossref","first-page":"H347","DOI":"10.1152\/ajpheart.00900.2015","article-title":"Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart","volume":"311","author":"Fukushima","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2026.115217_bib73","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0167-4781(92)90485-I","article-title":"Succinylation of histone amino groups facilitates transcription of nucleosomal cores","volume":"1129","author":"Pi\u00f1eiro","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2026.115217_bib74","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41421-023-00573-9","article-title":"HDAC1\/2\/3 are major histone desuccinylases critical for promoter desuccinylation","volume":"9","author":"Li","year":"2023","journal-title":"Cell Discov."},{"key":"10.1016\/j.isci.2026.115217_bib75","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.isci.2018.03.012","article-title":"3rd: Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism","volume":"2","author":"Smestad","year":"2018","journal-title":"iScience"},{"key":"10.1016\/j.isci.2026.115217_bib76","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1111\/jcmm.16676","article-title":"Histone succinylation and its function on the nucleosome","volume":"25","author":"Liu","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.isci.2026.115217_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.570421","article-title":"Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy","volume":"11","author":"Greenwell","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2026.115217_bib78","article-title":"Peroxisome-generated succinate induces lipid accumulation and oxidative stress in the kidneys of diabetic mice","volume":"298","author":"Wang","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115217_bib79","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","author":"Baysal","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.115217_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12692-x","article-title":"Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission","volume":"7","author":"Ko","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115217_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13121579","article-title":"Succinate Regulates Endothelial Mitochondrial Function and Barrier Integrity","volume":"13","author":"Atallah","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.isci.2026.115217_bib82","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The vascular endothelium and human diseases","volume":"9","author":"Rajendran","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib83","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/jth.14734","article-title":"Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C(4)","volume":"18","author":"Tang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.isci.2026.115217_bib84","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","author":"Selak","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2026.115217_bib85","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/CS20120468","article-title":"Renin inhibition in the treatment of diabetic kidney disease","volume":"124","author":"Komers","year":"2013","journal-title":"Clin. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003868","article-title":"PKC\/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection","volume":"9","author":"Shio","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.isci.2026.115217_bib87","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ni.1657","article-title":"Triggering the succinate receptor GPR91 on dendritic cells enhances immunity","volume":"9","author":"Rubic","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115217_bib88","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.115217_bib89","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1093\/eurheartj\/ehab605","article-title":"Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection","volume":"42","author":"Cui","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2026.115217_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103576","article-title":"Succinate predisposes mice to atrial fibrillation by impairing mitochondrial function via SUCNR1\/AMPK axis","volume":"81","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2026.115217_bib91","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/j.1471-4159.2004.02682.x","article-title":"Involvement of p42\/p44 MAPK, p38 MAPK, JNK and nuclear factor-kappa B in interleukin-1beta-induced matrix metalloproteinase-9 expression in rat brain astrocytes","volume":"90","author":"Wu","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.isci.2026.115217_bib92","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1172\/JCI7362","article-title":"Mechanical strain activates BNP gene transcription through a p38\/NF-kappaB-dependent mechanism","volume":"104","author":"Liang","year":"1999","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.115217_bib93","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12964-014-0078-2","article-title":"Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation","volume":"12","author":"Aguiar","year":"2014","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2026.115217_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.124","article-title":"Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases","volume":"2","author":"Xu","year":"2023","journal-title":"iMeta"},{"key":"10.1016\/j.isci.2026.115217_bib95","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ceca.2009.11.003","article-title":"Succinate modulates Ca(2+) transient and cardiomyocyte viability through PKA-dependent pathway","volume":"47","author":"Aguiar","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.isci.2026.115217_bib96","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2026.115217_bib97","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.isci.2026.115217_bib98","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.7150\/ijbs.95853","article-title":"Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia\/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib99","article-title":"Gut commensal bacterium Bacteroides vulgatus exacerbates helminth-induced cardiac fibrosis through succinate accumulation","volume":"21","author":"Wang","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2026.115217_bib100","first-page":"311","article-title":"Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-beta-tubulin mediated synergistic mechanism of \u201cmitophagy-unfolded protein response\u201d and mitophagy","volume":"23","author":"Chang","year":"2025","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.isci.2026.115217_bib101","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jare.2024.10.030","article-title":"Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy","volume":"75","author":"Wang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.isci.2026.115217_bib102","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.7150\/ijbs.102424","article-title":"Targeting mitochondria by lipid-selenium conjugate drug results in malate\/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression","volume":"20","author":"Chang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib103","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1113\/JP284270","article-title":"On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart","volume":"601","author":"Kadir","year":"2023","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.115217_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1266973","article-title":"Succinate metabolism: a promising therapeutic target for inflammation, ischemia\/reperfusion injury and cancer","volume":"11","author":"Zhang","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.115217_bib105","article-title":"Succinate\/IL-1beta Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115217_bib106","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1749-6632.2009.04704.x","article-title":"A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes","volume":"1171","author":"Balietti","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2026.115217_bib107","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.molcel.2024.12.025","article-title":"OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth","volume":"85","author":"Guo","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.115217_bib108","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jacc.2020.12.065","article-title":"Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease: JACC State-of-the-Art Review","volume":"77","author":"Yurista","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2026.115217_bib109","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12699","article-title":"Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina","volume":"17","author":"Izuta","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2026.115217_bib110","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/bi901627u","article-title":"Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria","volume":"49","author":"Cimen","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2026.115217_bib111","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10545-013-9589-z","article-title":"A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency","volume":"36","author":"Shafqat","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.isci.2026.115217_bib112","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.abb.2010.05.007","article-title":"Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells","volume":"499","author":"Hasan","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.isci.2026.115217_bib113","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.molmet.2014.07.010","article-title":"Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling","volume":"3","author":"Schugar","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2026.115217_bib114","doi-asserted-by":"crossref","first-page":"E168","DOI":"10.1152\/ajpendo.00227.2018","article-title":"Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity","volume":"316","author":"Ngo","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.115217_bib115","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14368","article-title":"Ketogenic beta-hydroxybutyrate regulates beta-hydroxybutyrylation of TCA cycle-associated enzymes and attenuates disease-associated pathologies in Alzheimer's mice","volume":"24","author":"Han","year":"2025","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2026.115217_bib116","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1177\/25424823241309024","article-title":"Gut microbiome synthesizes important core metabolites to prevent cognitive decline and mitigate onset and progression of Alzheimer's disease","volume":"8","author":"Al-Abbas","year":"2024","journal-title":"J. Alzheimers Dis. Rep."},{"key":"10.1016\/j.isci.2026.115217_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2023.123906","article-title":"LC-MS\/MS method for quantitative profiling of ketone bodies, alpha-keto acids, lactate, pyruvate and their stable isotopically labelled tracers in human plasma: An analytical panel for clinical metabolic kinetics and interactions","volume":"1230","author":"Afshar","year":"2023","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.isci.2026.115217_bib118","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1126\/science.abc8861","article-title":"Comprehensive quantification of fuel use by the failing and nonfailing human heart","volume":"370","author":"Murashige","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.115217_bib119","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cmet.2022.10.002","article-title":"Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease","volume":"35","author":"Li","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115217_bib120","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007546","article-title":"Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury","volume":"7","author":"Kohlhauer","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.isci.2026.115217_bib121","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/s41467-020-15983-6","article-title":"SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115217_bib122","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40104-022-00825-w","article-title":"Sirtuin 3 regulation: a target to alleviate beta-hydroxybutyric acid-induced mitochondrial dysfunction in bovine granulosa cells","volume":"14","author":"Zhao","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.isci.2026.115217_bib123","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1038\/s41467-022-31548-1","article-title":"Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115217_bib124","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.cmet.2020.03.017","article-title":"Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation","volume":"31","author":"Al Batran","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115217_bib125","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1111\/dom.13488","article-title":"Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low-grade inflammation the neglected component?","volume":"20","author":"Prattichizzo","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.isci.2026.115217_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166507","article-title":"Dyck JRB: Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis","volume":"1868","author":"Soni","year":"2022","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"10.1016\/j.isci.2026.115217_bib127","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2337\/diab.38.4.454","article-title":"Contribution of alpha- and beta-receptors to ketogenic and lipolytic effects of norepinephrine in humans","volume":"38","author":"Keller","year":"1989","journal-title":"Diabetes"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226005924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226005924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:36:17Z","timestamp":1790692577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226005924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":127,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2589004226005924"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115217","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interplay of ketones and succinate: Seeking metabolic balance and novel therapeutic strategies in myocardial hypertrophy and heart failure","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115217"}}