{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:17:04Z","timestamp":1791825424819,"version":"4.3.4"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2022ZQNZD004"],"award-info":[{"award-number":["2022ZQNZD004"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372318"],"award-info":[{"award-number":["82372318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.isci.2026.115397","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:42:31Z","timestamp":1773765751000},"page":"115397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Circadian disruption exacerbates MASH by reducing Akkermansia muciniphila via the FXR-CYP7A1-bile acid axis"],"prefix":"10.1016","volume":"29","author":[{"given":"Hanxin","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanying","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115397_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41574-018-0142-x","article-title":"The arrival of circadian medicine","volume":"15","author":"Panda","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.isci.2026.115397_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12639","article-title":"Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies","volume":"68","author":"Sato","year":"2020","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.isci.2026.115397_bib3","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1172\/JCI80590","article-title":"Role of the circadian system in cardiovasculardisease","volume":"128","author":"Thosar","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.115397_bib4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jhep.2019.03.020","article-title":"The circadian clock and liver function in health and disease","volume":"71","author":"Mukherji","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2026.115397_bib5","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1053\/j.gastro.2015.11.043","article-title":"Circadian Clock Control of Liver Metabolic Functions","volume":"150","author":"Reinke","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.115397_bib6","doi-asserted-by":"crossref","DOI":"10.20517\/2394-5079.2024.88","article-title":"Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease\/non-alcoholic steatohepatitis and risk of hepatic cancer","author":"Singh","year":"2024","journal-title":"Hepatoma Res."},{"key":"10.1016\/j.isci.2026.115397_bib7","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMra1802337","article-title":"Circadian Mechanisms in Medicine","volume":"384","author":"Allada","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2026.115397_bib8","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1111\/jgh.15005","article-title":"Effects of constant light exposure on sphingolipidomics and progression of NASH in high-fat-fed rats","volume":"35","author":"Yue","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2026.115397_bib9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2026.115397_bib10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.isci.2026.115397_bib11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.115397_bib12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1053\/j.gastro.2020.10.057","article-title":"Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health-Pathophysiology and Therapeutic Strategies","volume":"160","author":"Aron-Wisnewsky","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.115397_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2221485","article-title":"Akkermansia muciniphila inhibits nonalcoholic steatohepatitis by orchestrating TLR2-activated \u03b3\u03b4T17 cell and macrophage polarization","volume":"15","author":"Han","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.isci.2026.115397_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.apsb.2024.10.010","article-title":"Akkermansia muciniphila-derived acetate activates the hepatic AMPK\/SIRT1\/PGC-1\u03b1 axis to alleviate ferroptosis in metabolic-associated fatty liver disease","volume":"15","author":"Zhuge","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.isci.2026.115397_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70066","article-title":"Akkermansia muciniphila-derived hypoacylated rough-type lipopolysaccharides alleviate diet-induced obesity via activation of TLR4-IL-23-IL-22 immune axis","volume":"4","author":"Sun","year":"2025","journal-title":"iMeta"},{"key":"10.1016\/j.isci.2026.115397_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105482","article-title":"Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease","volume":"111","author":"Hu","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.isci.2026.115397_bib17","article-title":"Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma","volume":"6","author":"Wu","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.isci.2026.115397_bib18","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2252764","article-title":"Akkermansia muciniphila supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses","volume":"15","author":"Li","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.isci.2026.115397_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1367589","article-title":"Untargeted metabolomics based on ultra-high performance liquid chromatography-mass spectrometry\/MS reveals the lipid-lowering mechanism of taurine in hyperlipidemia mice","volume":"11","author":"Guo","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.isci.2026.115397_bib20","article-title":"Taurine Inhibits Ferroptosis Mediated by the Crosstalk between Tumor Cells and Tumor-Associated Macrophages in Prostate Cancer","volume":"11","author":"Xiao","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.isci.2026.115397_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00726-017-2505-3","article-title":"Taurine supplementation can increase lipolysis and affect the contribution of energy systems during front crawl maximal effort","volume":"50","author":"De Carvalho","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.isci.2026.115397_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00726-018-2659-7","article-title":"Anti-obesity effect of taurine through inhibition of adipogenesis in white fat tissue but not in brown fat tissue in a high-fat diet-induced obese mouse model","volume":"51","author":"Kim","year":"2019","journal-title":"Amino Acids"},{"key":"10.1016\/j.isci.2026.115397_bib23","first-page":"40","article-title":"Drugs for Non-alcoholic Steatohepatitis (NASH): Quest for the Holy Grail","volume":"9","author":"Sharma","year":"2021","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.isci.2026.115397_bib24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jhep.2024.07.034","article-title":"Targeting the liver clock improves fibrosis by restoring TGF-\u03b2 signaling","volume":"82","author":"Crouchet","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2026.115397_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nn1395","article-title":"Constant light desynchronizes mammalian clock neurons","volume":"8","author":"Ohta","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.115397_bib26","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3109\/07420528.2015.1072002","article-title":"Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases","volume":"32","author":"Smolensky","year":"2015","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.isci.2026.115397_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.113772","article-title":"Circadian rhythm disorders elevate macrophages cytokines release and promote multiple tissues\/organs dysfunction in mice","volume":"249","author":"Sun","year":"2022","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.isci.2026.115397_bib28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cmet.2013.12.016","article-title":"Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides","volume":"19","author":"Adamovich","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115397_bib29","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1080\/07420528.2022.2132865","article-title":"Circadian clock disruption aggravates alcohol liver disease in an acute mouse model","volume":"39","author":"Gao","year":"2022","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.isci.2026.115397_bib30","doi-asserted-by":"crossref","first-page":"G364","DOI":"10.1152\/ajpgi.00010.2018","article-title":"Emerging role of circadian clock disruption in alcohol-induced liver disease","volume":"315","author":"Bailey","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.isci.2026.115397_bib31","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.3748\/wjg.v28.i27.3282","article-title":"Hepatitis B and circadian rhythm of the liver","volume":"28","author":"Skrlec","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2026.115397_bib32","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s41467-021-21821-0","article-title":"Circadian control of hepatitis B virus replication","volume":"12","author":"Zhuang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115397_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-51698-8","article-title":"An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection","volume":"15","author":"Mukherji","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115397_bib34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jhep.2014.01.004","article-title":"The impact of chronic hepatitis C infection on the circadian clock and sleep","volume":"60","author":"Shouval","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2026.115397_bib35","article-title":"Integrative analysis indicates the prognostic value of circadian rhythm disruption in liver cancer: Potential for therapeutic targeting","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115397_bib36","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gutjnl-2014-308778","article-title":"Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology","volume":"65","author":"Dao","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.isci.2026.115397_bib37","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.3389\/fmicb.2017.01765","article-title":"Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila","volume":"8","author":"Cani","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.isci.2026.115397_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1927633","article-title":"Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis","volume":"13","author":"Rao","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.isci.2026.115397_bib39","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s40168-023-01567-1","article-title":"Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6","volume":"11","author":"Zhu","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.isci.2026.115397_bib40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41579-024-01106-1","article-title":"Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential","volume":"23","author":"Ioannou","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.isci.2026.115397_bib41","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1039\/D3FO04051H","article-title":"Akkermansia muciniphila attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice","volume":"14","author":"Shen","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.isci.2026.115397_bib42","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41575-021-00566-7","article-title":"Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology","volume":"19","author":"Fuchs","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2026.115397_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-53673-9","article-title":"Exposing 24-hour cycles in bile acids of male humans","volume":"15","author":"Bello","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115397_bib44","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1001\/archinte.159.22.2647","article-title":"The continuing importance of bile acids in liver and intestinal disease","volume":"159","author":"Hofmann","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.isci.2026.115397_bib45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/j.2040-4603.2020.tb00108.x","article-title":"Intestinal Absorption of Bile Acids in Health and Disease","volume":"10","author":"Ticho","year":"2019","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.isci.2026.115397_bib46","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/alcalc\/34.4.529","article-title":"Reversal of ethanol-induced hepatic steatosis and lipid peroxidation by taurine: a study in rats","volume":"34","author":"Kerai","year":"1999","journal-title":"Alcohol"},{"key":"10.1016\/j.isci.2026.115397_bib47","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00726-018-2605-8","article-title":"Taurine attenuates the development of hepatic steatosis through the inhibition of oxidative stress in a model of nonalcoholic fatty liver disease in vivo and in vitro","volume":"50","author":"Murakami","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.isci.2026.115397_bib48","doi-asserted-by":"crossref","first-page":"G1274","DOI":"10.1152\/ajpgi.2001.280.6.G1274","article-title":"Role of taurine in preventing acetaminophen-induced hepatic injury in the rat","volume":"280","author":"Waters","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.isci.2026.115397_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12060524","article-title":"Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice","volume":"12","author":"Murakami","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.isci.2026.115397_bib50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.biochi.2008.09.006","article-title":"Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits","volume":"91","author":"Winiarska","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.isci.2026.115397_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119579","article-title":"The molecular targets of taurine confer anti-hyperlipidemic effects","volume":"278","author":"Dong","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.isci.2026.115397_bib52","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/S0024-3205(02)01507-2","article-title":"Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine","volume":"70","author":"Murakami","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.isci.2026.115397_bib53","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1097-2765(00)80348-2","article-title":"Endogenous bile acids are ligands for the nuclear receptor FXR\/BAR","volume":"3","author":"Wang","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.115397_bib54","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.isci.2026.115397_bib55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.coph.2020.04.008","article-title":"Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders","volume":"53","author":"Fiorucci","year":"2020","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2026.115397_bib56","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/j.gastro.2011.10.028","article-title":"Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis","volume":"142","author":"Modica","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.115397_bib57","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.115397_bib58","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1194\/jlr.M001602","article-title":"FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa\/fa) obese rats","volume":"51","author":"Cipriani","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.isci.2026.115397_bib59","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.drudis.2012.05.012","article-title":"Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis","volume":"17","author":"Adorini","year":"2012","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.isci.2026.115397_bib60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41522-023-00399-z","article-title":"Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism","volume":"9","author":"Liu","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.isci.2026.115397_bib61","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1053\/j.gastro.2020.01.049","article-title":"Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?","volume":"158","author":"Aron-Wisnewsky","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.115397_bib62","article-title":"Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6(+) natural killer T cells","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115397_bib63","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1930872","article-title":"A microbial signature following bariatric surgery is robustly consistent across multiple cohorts","volume":"13","author":"Fouladi","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.isci.2026.115397_bib64","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/s42255-024-01134-4","article-title":"Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis","volume":"6","author":"Das","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.isci.2026.115397_bib65","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.cell.2024.03.034","article-title":"Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway","volume":"187","author":"Nie","year":"2024","journal-title":"Cell"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226007728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226007728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:53:25Z","timestamp":1790693605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226007728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2589004226007728"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115397","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circadian disruption exacerbates MASH by reducing Akkermansia muciniphila via the FXR-CYP7A1-bile acid axis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115397"}}