{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:37:35Z","timestamp":1793655455653,"version":"4.5.1"},"reference-count":199,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2025-19252970"],"award-info":[{"award-number":["RS-2025-19252970"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-02213506"],"award-info":[{"award-number":["RS-2025-02213506"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-19612989"],"award-info":[{"award-number":["RS-2025-19612989"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.isci.2026.115447","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:42:35Z","timestamp":1774078955000},"page":"115447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-8507","authenticated-orcid":false,"given":"Juhyun","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115447_bib1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/da.20767","article-title":"Considering PTSD for DSM-5","volume":"28","author":"Friedman","year":"2011","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.isci.2026.115447_bib2","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1001\/jamacardio.2021.2530","article-title":"Posttraumatic Stress Disorder and Cardiovascular Disease: State of the Science, Knowledge Gaps, and Research Opportunities","volume":"6","author":"O'Donnell","year":"2021","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.isci.2026.115447_bib3","first-page":"191","article-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM)","volume":"25","author":"Battle","year":"2013","journal-title":"Codas"},{"key":"10.1016\/j.isci.2026.115447_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5110105","article-title":"Posttraumatic Stress Disorder: Overview of Evidence-Based Assessment and Treatment","volume":"5","author":"Lancaster","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.isci.2026.115447_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/YCO.0b013e32833f5585","article-title":"Current research on cognitive aspects of anxiety disorders","volume":"24","author":"Ferreri","year":"2011","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib6","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1017\/S0033291717000708","article-title":"Posttraumatic stress disorder in the World Mental Health Surveys","volume":"47","author":"Koenen","year":"2017","journal-title":"Psychol. Med."},{"key":"10.1016\/j.isci.2026.115447_bib7","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.biopsych.2018.02.007","article-title":"Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder","volume":"83","author":"Mellon","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib8","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s11682-024-00927-1","article-title":"Metabolic syndrome is associated with reduced default mode network functional connectivity in young post-9\/11 Veterans","volume":"18","author":"Knoff","year":"2024","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.isci.2026.115447_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1375068","article-title":"Effect of post-traumatic stress disorder on type 2 diabetes and the mediated effect of obesity: a Mendelian randomization study","volume":"15","author":"Yu","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2026.115447_bib10","article-title":"Persistent PTSD symptoms are associated with plasma metabolic alterations relevant to long-term health: A metabolome-wide investigation in women","author":"Zhu","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.isci.2026.115447_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2023.111558","article-title":"The mind-body connection: Posttraumatic stress disorder affects outcomes in type 2 diabetes","volume":"185","author":"Serier","year":"2024","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.isci.2026.115447_bib12","doi-asserted-by":"crossref","first-page":"e2651","DOI":"10.1055\/s-0043-1772749","article-title":"Symptoms of Posttraumatic Stress Disorder are Associated with Altered Glucose Parameters in Early and Late Gestation","volume":"41","author":"Bublitz","year":"2024","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.isci.2026.115447_bib13","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/WNR.0b013e3283300fbc","article-title":"Duration of posttraumatic stress disorder predicts hippocampal grey matter loss","volume":"20","author":"Felmingham","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.isci.2026.115447_bib14","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1038\/npp.2013.122","article-title":"Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder","volume":"38","author":"Chen","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2026.115447_bib15","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jpsychires.2010.10.014","article-title":"Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder","volume":"45","author":"Golub","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.isci.2026.115447_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41583-018-0039-7","article-title":"Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man","volume":"19","author":"Fenster","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/jamapsychiatry.2016.3325","article-title":"An Integrated Neuroscience Perspective on Formulation and Treatment Planning for Posttraumatic Stress Disorder: An Educational Review","volume":"74","author":"Ross","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jts.21887","article-title":"Reduced corpus-callosum volume in posttraumatic stress disorder highlights the importance of interhemispheric connectivity for associative memory","volume":"27","author":"Saar-Ashkenazy","year":"2014","journal-title":"J. Trauma Stress"},{"key":"10.1016\/j.isci.2026.115447_bib19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archgenpsychiatry.2011.70","article-title":"The neurobiological role of the dorsolateral prefrontal cortex in recovery from trauma. Longitudinal brain imaging study among survivors of the South Korean subway disaster","volume":"68","author":"Lyoo","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042560","article-title":"Decreased premotor cortex volume in victims of urban violence with posttraumatic stress disorder","volume":"7","author":"Rocha-Rego","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115447_bib21","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1176\/appi.ajp.157.8.1252","article-title":"Low cortisol and risk for PTSD in adult offspring of holocaust survivors","volume":"157","author":"Yehuda","year":"2000","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.isci.2026.115447_bib22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ecl.2013.05.004","article-title":"Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment","volume":"42","author":"Daskalakis","year":"2013","journal-title":"Endocrinol Metab. Clin. N. Am."},{"key":"10.1016\/j.isci.2026.115447_bib23","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.metabol.2011.06.012","article-title":"The effects of glucocorticoids on adipose tissue lipid metabolism","volume":"60","author":"Peckett","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.115447_bib24","article-title":"Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective","volume":"9","author":"Kim","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.isci.2026.115447_bib25","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbi.2012.02.003","article-title":"Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study","volume":"26","author":"O'Donovan","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038915","article-title":"Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review","volume":"7","author":"Edmondson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115447_bib27","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ahj.2013.07.031","article-title":"Posttraumatic stress disorder and risk for coronary heart disease: a meta-analytic review","volume":"166","author":"Edmondson","year":"2013","journal-title":"Am. Heart J."},{"key":"10.1016\/j.isci.2026.115447_bib28","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/aje\/kwu022","article-title":"Chronic physical health consequences of being injured during the terrorist attacks on World Trade Center on September 11, 2001","volume":"179","author":"Brackbill","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.isci.2026.115447_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.amjcard.2011.02.340","article-title":"Post-traumatic stress disorder, coronary atherosclerosis, and mortality","volume":"108","author":"Ahmadi","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.isci.2026.115447_bib30","first-page":"785","article-title":"[Takotsubo cardiomyopathy: a consensus document]","volume":"9","author":"Novo","year":"2008","journal-title":"G. Ital. Cardiol."},{"key":"10.1016\/j.isci.2026.115447_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijpsycho.2010.04.009","article-title":"Heart rate responses to standardized trauma-related pictures in acute posttraumatic stress disorder","volume":"78","author":"Ehlers","year":"2010","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.isci.2026.115447_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.30773\/pi.2019.0112","article-title":"Posttraumatic Stress Disorder and Alterations in Resting Heart Rate Variability: A Systematic Review and Meta-Analysis","volume":"17","author":"Ge","year":"2020","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.isci.2026.115447_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.expneurol.2016.05.014","article-title":"Noradrenergic dysregulation in the pathophysiology of PTSD","volume":"284","author":"Hendrickson","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.isci.2026.115447_bib34","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1017\/S003329172000207X","article-title":"Autonomic dysfunction in posttraumatic stress disorder indexed by heart rate variability: a meta-analysis","volume":"50","author":"Schneider","year":"2020","journal-title":"Psychol. Med."},{"key":"10.1016\/j.isci.2026.115447_bib35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/09540261.2019.1580686","article-title":"The association between PTSD and cardiovascular disease and its risk factors in male veterans of the Iraq\/Afghanistan conflicts: a systematic review","volume":"31","author":"Dyball","year":"2019","journal-title":"Int. Rev. Psychiatr."},{"key":"10.1016\/j.isci.2026.115447_bib36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S2215-0366(16)30377-7","article-title":"Post-traumatic stress disorder and cardiovascular disease","volume":"4","author":"Edmondson","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2021.100384","article-title":"A prospective examination of sex differences in posttraumatic autonomic functioning","volume":"15","author":"Seligowski","year":"2021","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.isci.2026.115447_bib38","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1002\/ajh.27468","article-title":"Posttraumatic stress disorder increases thrombosis risk: Evidence from a biobank data set","volume":"99","author":"Chong Lau","year":"2024","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.isci.2026.115447_bib39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbi.2018.08.015","article-title":"Posttraumatic stress disorder is associated with enhanced interleukin-6 response to mental stress in subjects with a recent myocardial infarction","volume":"75","author":"Lima","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib40","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/eurheartj\/ehae149","article-title":"Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure","volume":"45","author":"Gharios","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2026.115447_bib41","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/HYPERTENSIONAHA.117.10496","article-title":"Associations of Initial Injury Severity and Posttraumatic Stress Disorder Diagnoses With Long-Term Hypertension Risk After Combat Injury","volume":"71","author":"Howard","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.isci.2026.115447_bib42","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/eurheartj\/ehq354","article-title":"Stiffness of large arteries and cardiovascular risk in patients with post-traumatic stress disorder","volume":"32","author":"Walczewska","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2026.115447_bib43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbi.2024.01.006","article-title":"PTSD increases risk for major adverse cardiovascular events through neural and cardio-inflammatory pathways","volume":"117","author":"Seligowski","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib44","article-title":"Vagal control moderates the association between endothelial function and PTSD symptoms in women with T2DM","volume":"26","author":"Seligowski","year":"2022","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.isci.2026.115447_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbi.2017.11.013","article-title":"Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women","volume":"69","author":"Sumner","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib46","first-page":"548","article-title":"Hypercoagulation in chronic post-traumatic stress disorder","volume":"13","author":"Robicsek","year":"2011","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.isci.2026.115447_bib47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbi.2013.01.081","article-title":"Association between posttraumatic stress disorder and inflammation: a twin study","volume":"30","author":"Plantinga","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib48","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.psychres.2009.06.005","article-title":"Posttraumatic stress disorder and soluble cellular adhesion molecules at rest and in response to a trauma-specific interview in patients after myocardial infarction","volume":"179","author":"von K\u00e4nel","year":"2010","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.isci.2026.115447_bib49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/jamapsychiatry.2013.4374","article-title":"Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk","volume":"71","author":"Eraly","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib50","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1176\/appi.ajp.21111113","article-title":"Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy","volume":"179","author":"Seligowski","year":"2022","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.isci.2026.115447_bib51","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/10641963.2021.2018598","article-title":"Insertion\/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure","volume":"44","author":"Kong","year":"2022","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.isci.2026.115447_bib52","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jpsychires.2024.08.027","article-title":"Genetic association between post-traumatic stress disorder and cardiovascular disease: A scoping review","volume":"178","author":"Lim","year":"2024","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.isci.2026.115447_bib53","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.psychres.2018.04.058","article-title":"Relationship between serum lipid concentrations and posttraumatic stress symptoms in the bereaved after the Sewol ferry disaster: A prospective cohort study","volume":"266","author":"Tae","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.isci.2026.115447_bib54","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fpsyt.2015.00049","article-title":"Circulating levels of hormones, lipids, and immune mediators in post-traumatic stress disorder - a 3-month follow-up study","volume":"6","author":"Jergovi\u0107","year":"2015","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.isci.2026.115447_bib55","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3325\/cmj.2008.4.506","article-title":"Changes in plasma lipid concentrations and risk of coronary artery disease in army veterans suffering from chronic posttraumatic stress disorder","volume":"49","author":"Dzubur Kulenovi\u0107","year":"2008","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.isci.2026.115447_bib56","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3346\/jkms.2004.19.3.431","article-title":"Serum lipid concentrations in Croatian veterans with post-traumatic stress disorder,post-traumatic stress disorder comorbid with major depressive disorder,or major depressive disorder","volume":"19","author":"Karlovi\u0107","year":"2004","journal-title":"J. Kor. Med. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.psyneuen.2017.09.020","article-title":"Plasma lipoproteins in posttraumatic stress disorder patients compared to healthy controls and their associations with the HPA- and HPT-axis","volume":"86","author":"Vries","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib58","article-title":"Metabolic syndrome risk in relation to posttraumatic stress disorder among trauma-exposed civilians in Gansu Province, China","volume":"99","author":"Ma","year":"2020","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.isci.2026.115447_bib59","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1001\/archpsyc.61.4.394","article-title":"Cortisol and catecholamines in posttraumatic stress disorder: an epidemiologic community study","volume":"61","author":"Young","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib60","doi-asserted-by":"crossref","first-page":"E172","DOI":"10.1152\/ajpendo.00544.2001","article-title":"Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans","volume":"283","author":"Djurhuus","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.115447_bib61","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbalip.2014.08.011","article-title":"Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology","volume":"1851","author":"Cermenati","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2026.115447_bib62","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mcn.2009.07.013","article-title":"Cholesterol involvement in the pathogenesis of neurodegenerative diseases","volume":"43","author":"Liu","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib63","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuropharm.2012.06.053","article-title":"Lipid rafts, synaptic transmission and plasticity: impact in age-related neurodegenerative diseases","volume":"64","author":"Sebasti\u00e3o","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2026.115447_bib64","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0140-6736(92)91589-Z","article-title":"Low serum cholesterol and suicide","volume":"339","author":"Brunner","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.115447_bib65","first-page":"1169","article-title":"Low serum cholesterol and suicide","volume":"339","author":"Salter","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.115447_bib66","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-1781(03)00071-4","article-title":"Correlation between serum lipid, lipoprotein concentrations and anxious state, depressive state or major depressive disorder","volume":"118","author":"Huang","year":"2003","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.isci.2026.115447_bib67","article-title":"Post-Traumatic Stress Disorder Is Associated with Elevated Plasma Cholesterol in Female TT Homozygotes of LDLR rs5925","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib68","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/CIRCULATIONAHA.119.041914","article-title":"The Mind-Heart-Body Connection","volume":"140","author":"Levine","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115447_bib69","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/bs5010027","article-title":"Post-Traumatic Stress Disorder among Cardiac Patients: Prevalence, Risk Factors, and Considerations for Assessment and Treatment","volume":"5","author":"Tulloch","year":"2014","journal-title":"Behav. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1742395318785237","article-title":"Cardiovascular disease among United States military veterans: Evidence of a waning healthy soldier effect using the National Health Interview Survey","volume":"16","author":"Hinojosa","year":"2020","journal-title":"Chron. Illness"},{"key":"10.1016\/j.isci.2026.115447_bib71","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jacl.2013.04.001","article-title":"Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association","volume":"7","author":"Bays","year":"2013","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.isci.2026.115447_bib72","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/jnc.12007","article-title":"Importance of cholesterol in dopamine transporter function","volume":"123","author":"Jones","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.isci.2026.115447_bib73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.31887\/DCNS.2011.13.2\/jsherin","article-title":"Post-traumatic stress disorder: the neurobiological impact of psychological trauma","volume":"13","author":"Sherin","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib74","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12888-020-2432-9","article-title":"Posttraumatic stress disorder and risk of selected autoimmune diseases among US military personnel","volume":"20","author":"Bookwalter","year":"2020","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib75","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1001\/jama.2018.7028","article-title":"Association of Stress-Related Disorders With Subsequent Autoimmune Disease","volume":"319","author":"Song","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2026.115447_bib76","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7403796","article-title":"Regulation of Inflammation in Autoimmune Disease","volume":"2019","author":"Duan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.isci.2026.115447_bib77","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.comppsych.2019.06.007","article-title":"The differential effects of PTSD, MDD, and dissociation on CRP in trauma-exposed women","volume":"93","author":"Powers","year":"2019","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib78","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1111\/ejn.15031","article-title":"C-Reactive Protein: Marker of risk for post-traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery","volume":"55","author":"Friend","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib79","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1007\/s12035-023-03320-z","article-title":"Post-traumatic Stress Disorder: Focus on Neuroinflammation","volume":"60","author":"Li","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.isci.2026.115447_bib80","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrn3339","article-title":"Biological studies of post-traumatic stress disorder","volume":"13","author":"Pitman","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib81","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.biopsych.2013.03.024","article-title":"Role of prefrontal cortex glucocorticoid receptors in stress and emotion","volume":"74","author":"McKlveen","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib82","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jalz.2017.04.014","article-title":"Post-traumatic stress disorder and risk of dementia among members of a health care delivery system","volume":"14","author":"Flatt","year":"2018","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.isci.2026.115447_bib83","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/j.2040-4603.2016.tb00694.x","article-title":"Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response","volume":"6","author":"Herman","year":"2016","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.isci.2026.115447_bib84","article-title":"Post traumatic stress disorder associated hypothalamic-pituitary-adrenal axis dysregulation and physical illness","volume":"41","author":"Lawrence","year":"2024","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.isci.2026.115447_bib85","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.expneurol.2016.07.024","article-title":"New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility","volume":"284","author":"Daskalakis","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.isci.2026.115447_bib86","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1176\/ajp.156.4.585","article-title":"Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder","volume":"156","author":"Baker","year":"1999","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.isci.2026.115447_bib87","series-title":"Endotext","article-title":"Corticotropin releasing hormone and the immune\/inflammatory response","author":"Nezi","year":"2000"},{"key":"10.1016\/j.isci.2026.115447_bib88","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1046\/j.1460-9568.2002.02040.x","article-title":"Effects of transgenic overproduction of CRH on anxiety-like behaviour","volume":"15","author":"van Gaalen","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib89","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jad.2019.01.029","article-title":"Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake","volume":"248","author":"Wang","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.isci.2026.115447_bib90","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/npp.2016.146","article-title":"Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond","volume":"42","author":"Michopoulos","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2026.115447_bib91","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pnpbp.2008.11.002","article-title":"Homocysteine and serum lipids concentration in male war veterans with posttraumatic stress disorder","volume":"33","author":"Jendricko","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib92","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2003.11.018","article-title":"Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder","volume":"55","author":"Rohleder","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib93","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.56","article-title":"Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis","volume":"4","author":"Tursich","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib94","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41598-023-28373-x","article-title":"Posttraumatic stress disorder and diabetes-related outcomes in patients with type 1 diabetes","volume":"13","author":"Lunkenheimer","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115447_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281125","article-title":"Association of pro-inflammatory cytokines with trauma and post-traumatic stress disorder visiting a tertiary care hospital in Kathmandu","volume":"18","author":"Koirala","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115447_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12030387","article-title":"Changes in the Serum Levels of Cytokines: IL-1beta, IL-4, IL-8 and IL-10 in Depression with and without Posttraumatic Stress Disorder","volume":"12","author":"Og\u0142odek","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.isci.2026.115447_bib97","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.biopsych.2019.07.007","article-title":"Human Extinction Learning Is Accelerated by an Angiotensin Antagonist via Ventromedial Prefrontal Cortex and Its Connections With Basolateral Amygdala","volume":"86","author":"Zhou","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib98","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41386-019-0553-y","article-title":"Angiotensin involvement in trauma processing-exploring candidate neurocognitive mechanisms of preventing post-traumatic stress symptoms","volume":"45","author":"Shkreli","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2026.115447_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10253890802046281","article-title":"Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models","volume":"12","author":"Grippo","year":"2009","journal-title":"Stress"},{"key":"10.1016\/j.isci.2026.115447_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2010.10.001","article-title":"Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications","volume":"36","author":"Saavedra","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib101","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1017\/S0033291718001496","article-title":"Associations of trauma exposure and post-traumatic stress disorder with the activity of the renin-angiotensin-aldosterone-system in the general population","volume":"49","author":"Terock","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.isci.2026.115447_bib102","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1080\/15622975.2021.2018724","article-title":"The neurobiology of childhood trauma-aldosterone and blood pressure changes in a community sample","volume":"23","author":"Terock","year":"2022","journal-title":"World J. Biol. Psychiatr."},{"key":"10.1016\/j.isci.2026.115447_bib103","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41386-020-00923-1","article-title":"The renin-angiotensin system in PTSD: a replication and extension","volume":"46","author":"Seligowski","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2026.115447_bib104","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41398-020-01043-6","article-title":"Evaluation of an angiotensin Type 1 receptor blocker on the reconsolidation of fear memory","volume":"10","author":"Swiercz","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib105","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.biopsych.2019.05.027","article-title":"Angiotensin II Type 2 Receptor-Expressing Neurons in the Central Amygdala Influence Fear-Related Behavior","volume":"86","author":"Yu","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib106","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4088\/JCP.11m07316","article-title":"The renin-angiotensin pathway in posttraumatic stress disorder: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are associated with fewer traumatic stress symptoms","volume":"73","author":"Khoury","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib107","article-title":"Sex-dependent effects of angiotensin type 2 receptor expressing medial prefrontal cortex (mPFC) interneurons in fear extinction learning","author":"Smith","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2026.115447_bib108","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1038\/s41598-017-07416-0","article-title":"A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes","volume":"7","author":"Bang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115447_bib109","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.neuroscience.2010.09.029","article-title":"Angiotensin II induced cerebral microvascular inflammation and increased blood-brain barrier permeability via oxidative stress","volume":"171","author":"Zhang","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2026.115447_bib110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbi.2015.10.017","article-title":"Candesartan ameliorates impaired fear extinction induced by innate immune activation","volume":"52","author":"Qui\u00f1ones","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib111","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.psyneuen.2018.05.012","article-title":"A peripheral immune response to remembering trauma contributes to the maintenance of fear memory in mice","volume":"94","author":"Young","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib112","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.psyneuen.2017.01.024","article-title":"Threat-related amygdala activity is associated with peripheral CRP concentrations in men but not women","volume":"78","author":"Swartz","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib113","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2019.05.035","article-title":"The role of thiols in antioxidant systems","volume":"140","author":"Ulrich","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2026.115447_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.661455","article-title":"Increased Oxidative Stress in the Prefrontal Cortex as a Shared Feature of Depressive- and PTSD-Like Syndromes: Effects of a Standardized Herbal Antioxidant","volume":"8","author":"de Munter","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.isci.2026.115447_bib115","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00406-015-0638-5","article-title":"Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors","volume":"266","author":"Atli","year":"2016","journal-title":"Eur. Arch. Psychiatr. Clin. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib116","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010345","article-title":"Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain","volume":"21","author":"Manukhina","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib117","first-page":"123","article-title":"Investigation of Thiol\/Disulfide Balance and Oxidative DNA Damage in Patients Experiencing Avalanche Disaster and with a Diagnosis of Post-Traumatic Stress Disorder","volume":"22","author":"Kurhan","year":"2021","journal-title":"Alpha Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib118","article-title":"Dysregulation in microRNA expression is associated with alterations in immune functions in combat veterans with post-traumatic stress disorder","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115447_bib119","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3389\/fphar.2020.00986","article-title":"Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function","volume":"11","author":"Yao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2026.115447_bib120","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1038\/s41467-020-15930-5","article-title":"PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies","volume":"11","author":"Bhatt","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115447_bib121","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yfrne.2018.01.001","article-title":"An energetic view of stress: Focus on mitochondria","volume":"49","author":"Picard","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.isci.2026.115447_bib122","article-title":"An orchestrating role of mitochondria in the origin and development of post-traumatic stress disorder","volume":"13","author":"Lushchak","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2026.115447_bib123","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fpsyg.2019.00302","article-title":"Identification of Key Genes and Pathways in Post-traumatic Stress Disorder Using Microarray Analysis","volume":"10","author":"Bian","year":"2019","journal-title":"Front. Psychol."},{"key":"10.1016\/j.isci.2026.115447_bib124","doi-asserted-by":"crossref","first-page":"223","DOI":"10.7150\/ijbs.4.223","article-title":"Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays","volume":"4","author":"Su","year":"2008","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib125","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2022.5130","article-title":"Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke","volume":"49","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.isci.2026.115447_bib126","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1007\/s11064-022-03655-4","article-title":"Leptin Attenuates Fear Memory by Inhibiting Astrocytic NLRP3 Inflammasome in Post-traumatic Stress Disorder Model","volume":"48","author":"Ji","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.isci.2026.115447_bib127","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ajmg.b.31212","article-title":"Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder","volume":"156B","author":"Smith","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.isci.2026.115447_bib128","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbi.2010.12.001","article-title":"Suppressed monocyte gene expression profile in men versus women with PTSD","volume":"25","author":"Neylan","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib129","first-page":"551","article-title":"Changes of cytolytic cells and perforin expression in patients with posttraumatic stress disorder","volume":"42","author":"Skarpa","year":"2001","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.isci.2026.115447_bib130","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbi.2021.03.005","article-title":"Acute stress increases monocyte levels and modulates receptor expression in healthy females","volume":"94","author":"van de Wouw","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib131","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1014296","article-title":"Acute stress induces an inflammation dominated by innate immunity represented by neutrophils in mice","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115447_bib132","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of stress on immune function: the good, the bad, and the beautiful","volume":"58","author":"Dhabhar","year":"2014","journal-title":"Immunol. Res."},{"key":"10.1016\/j.isci.2026.115447_bib133","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/da.22084","article-title":"Cytokine targets in the brain: impact on neurotransmitters and neurocircuits","volume":"30","author":"Miller","year":"2013","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.isci.2026.115447_bib134","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1570159X15666171123201142","article-title":"Imaging the Role of Inflammation in Mood and Anxiety-related Disorders","volume":"16","author":"Felger","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.isci.2026.115447_bib135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/da.22155","article-title":"Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy","volume":"31","author":"Rosso","year":"2014","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.isci.2026.115447_bib136","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1007\/s11064-012-0808-z","article-title":"Astrocytes as GABA-ergic and GABA-ceptive cells","volume":"37","author":"Yoon","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.isci.2026.115447_bib137","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12031-019-01354-4","article-title":"Interleukine-17 Administration Modulates Adult Hippocampal Neurogenesis and Improves Spatial Learning in Mice","volume":"69","author":"Tfilin","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib138","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030343","article-title":"Interleukine-17 Modulates Neurogenesis and Behavior Following Exposure to Trauma in Mice","volume":"11","author":"Willinger","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.isci.2026.115447_bib139","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030876","article-title":"Within the Brain: The Renin Angiotensin System","volume":"19","author":"Jackson","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1113\/expphysiol.2008.046326","article-title":"Region-specific changes in sympathetic nerve activity in angiotensin II-salt hypertension in the rat","volume":"95","author":"Osborn","year":"2010","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.isci.2026.115447_bib141","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.coph.2010.11.004","article-title":"AT2 receptor signaling and sympathetic regulation","volume":"11","author":"Gao","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2026.115447_bib142","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/ajh\/hpz075","article-title":"Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-alpha","volume":"32","author":"Xue","year":"2019","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.isci.2026.115447_bib143","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ajmg.b.32313","article-title":"An angiotensin-converting enzyme (ACE) polymorphism may mitigate the effects of angiotensin-pathway medications on posttraumatic stress symptoms","volume":"168B","author":"Nylocks","year":"2015","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.isci.2026.115447_bib144","doi-asserted-by":"crossref","first-page":"15009","DOI":"10.1523\/JNEUROSCI.0892-11.2011","article-title":"Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress","volume":"31","author":"Krause","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib145","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.biopsych.2013.08.024","article-title":"Angiotensin type 1 receptor inhibition enhances the extinction of fear memory","volume":"75","author":"Marvar","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib146","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.regpep.2004.03.005","article-title":"Angiotensin II and angiotensin-(1-7) inhibit the inner cortex Na+ -ATPase activity through AT2 receptor","volume":"120","author":"De Souza","year":"2004","journal-title":"Regul. Pept."},{"key":"10.1016\/j.isci.2026.115447_bib147","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2007.01.037","article-title":"Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress","volume":"1142","author":"Armando","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.115447_bib148","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1210\/endo.142.9.8366","article-title":"Peripheral administration of an angiotensin II AT(1) receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation Stress","volume":"142","author":"Armando","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib149","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2116289119","article-title":"Inhibition of the angiotensin II type 2 receptor AT(2)R is a novel therapeutic strategy for glioblastoma","volume":"119","author":"Perryman","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115447_bib150","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036762","article-title":"Janus Kinase 2\/Signal Transducer and Activator of Transcription 3\/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E(2)-Induced Oxidative Stress in Hypertension","volume":"14","author":"Fan","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.isci.2026.115447_bib151","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/sj.bjp.0705448","article-title":"Angiotensin AT2 receptors: cardiovascular hope or hype?","volume":"140","author":"Widdop","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.115447_bib152","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.pnpbp.2005.08.006","article-title":"Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis","volume":"29","author":"Herman","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib153","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1196\/annals.1410.012","article-title":"Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress","volume":"1148","author":"Jankord","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib154","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.physbeh.2015.03.033","article-title":"Blunted hypothalamo-pituitary adrenal axis response to predator odor predicts high stress reactivity","volume":"147","author":"Whitaker","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.isci.2026.115447_bib155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/B978-0-444-64123-6.00004-7","article-title":"Hypothalamic-pituitary-adrenal axis and stress","volume":"175","author":"Leistner","year":"2020","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.isci.2026.115447_bib156","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1080\/10253890.2020.1803824","article-title":"Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder","volume":"23","author":"Hadad","year":"2020","journal-title":"Stress"},{"key":"10.1016\/j.isci.2026.115447_bib157","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/j.2040-4603.2015.tb00644.x","article-title":"Hypothalamic-Pituitary--Adrenal Axis-Feedback Control","volume":"5","author":"Keller-Wood","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.isci.2026.115447_bib158","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12888-021-03170-w","article-title":"Posttraumatic stress disorder (PTSD) and depression severity in sexually assaulted women: hypothalamic-pituitary-adrenal (HPA) axis alterations","volume":"21","author":"D'Elia","year":"2021","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib159","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.psyneuen.2014.04.001","article-title":"The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms","volume":"45","author":"Mouthaan","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib160","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/j.psyneuen.2013.05.017","article-title":"Cortisol at the emergency room rape visit as a predictor of PTSD and depression symptoms over time","volume":"38","author":"Walsh","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib161","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9241835","article-title":"Natural Adrenocorticotropic Hormone (ACTH) Relieves Acute Inflammation in Gout Patients by Changing the Function of Macrophages","volume":"2022","author":"Xu","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"10.1016\/j.isci.2026.115447_bib162","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.2522\/ptj.20130597","article-title":"Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation","volume":"94","author":"Hannibal","year":"2014","journal-title":"Phys. Ther."},{"key":"10.1016\/j.isci.2026.115447_bib163","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1073\/pnas.0438019100","article-title":"A mechanism converting psychosocial stress into mononuclear cell activation","volume":"100","author":"Bierhaus","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115447_bib164","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression","volume":"24","author":"De Bosscher","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.isci.2026.115447_bib165","doi-asserted-by":"crossref","first-page":"E506","DOI":"10.1152\/ajpendo.00589.2007","article-title":"Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man","volume":"294","author":"Gustavson","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.115447_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102674","article-title":"Microglia-mediated synaptic pruning as a key deficit in neurodevelopmental disorders: Hype or hope?","volume":"79","author":"Mordelt","year":"2023","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.isci.2026.115447_bib167","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.semcdb.2019.01.001","article-title":"Microglia: Neuroimmune-sensors of stress","volume":"94","author":"Frank","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.115447_bib168","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137185","article-title":"The Role of Microglia in the (Mal)adaptive Response to Traumatic Experience in an Animal Model of PTSD","volume":"23","author":"Nahum","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115447_bib169","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/milmed\/usz260","article-title":"Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction","volume":"185","author":"Bersani","year":"2020","journal-title":"Mil. Med."},{"key":"10.1016\/j.isci.2026.115447_bib170","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192416517","article-title":"Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress","volume":"19","author":"Og\u0142odek","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.isci.2026.115447_bib171","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3389\/fnmol.2018.00450","article-title":"Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis","volume":"11","author":"Pan","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110118","article-title":"Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD","volume":"105","author":"Ney","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2022.106099","article-title":"The intracellular cholesterol pool in steroidogenic cells plays a role in basal steroidogenesis","volume":"220","author":"Bassi","year":"2022","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.isci.2026.115447_bib174","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.psyneuen.2012.03.018","article-title":"Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: A prospective study","volume":"37","author":"van Zuiden","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib175","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.humimm.2009.07.007","article-title":"Apoptosis differs in dendritic cell subsets early after severe trauma","volume":"70","author":"Maier","year":"2009","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.isci.2026.115447_bib176","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jss.2008.06.038","article-title":"Significant decline of peripheral myeloid dendritic cells following multiple trauma","volume":"154","author":"Henrich","year":"2009","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.isci.2026.115447_bib177","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.pnpbp.2010.02.018","article-title":"Natural killer cell cytotoxicity and lymphocyte perforin expression in veterans with posttraumatic stress disorder","volume":"34","author":"Gotovac","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib178","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1176\/appi.ajp.158.3.484","article-title":"Suppression of cellular immunity in men with a past history of posttraumatic stress disorder","volume":"158","author":"Kawamura","year":"2001","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.isci.2026.115447_bib179","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijpsycho.2013.12.001","article-title":"Effects of psychological stress on neutrophil phagocytosis and bactericidal activity in humans--a meta-analysis","volume":"91","author":"Tsukamoto","year":"2014","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.isci.2026.115447_bib180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2014.03.016","article-title":"The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD: evidence from a randomized controlled trial","volume":"54","author":"Morath","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.isci.2026.115447_bib181","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.bbi.2009.07.003","article-title":"Substantial reduction of naive and regulatory T cells following traumatic stress","volume":"23","author":"Sommershof","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115447_bib182","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.psyneuen.2016.01.024","article-title":"PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit","volume":"67","author":"Aiello","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib183","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1016\/j.neuron.2021.05.017","article-title":"The advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research","volume":"109","author":"Bienvenu","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.115447_bib184","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2025.01.011","article-title":"Mouse model of post-traumatic stress disorder negatively impacts cardiac homeostasis","volume":"201","author":"Corker","year":"2025","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2026.115447_bib185","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1073\/pnas.1400113111","article-title":"Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder","volume":"111","author":"Cho","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115447_bib186","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2007.05.041","article-title":"Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model","volume":"148","author":"Kohda","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2026.115447_bib187","doi-asserted-by":"crossref","first-page":"R315","DOI":"10.1152\/ajpregu.00343.2014","article-title":"Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease","volume":"309","author":"Brudey","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.isci.2026.115447_bib188","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/FBP.0000000000000467","article-title":"Animal models of post-traumatic stress disorder and novel treatment targets","volume":"30","author":"Aspesi","year":"2019","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.isci.2026.115447_bib189","doi-asserted-by":"crossref","DOI":"10.3390\/nu18030530","article-title":"From Dysbiosis to Distress: The Gut-Brain Connection in Trauma-Related Disorders","volume":"18","author":"Marano","year":"2026","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2026.115447_bib190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117092","article-title":"Acute and chronic plasma metabolomic and liver transcriptomic stress effects in a mouse model with features of post-traumatic stress disorder","volume":"10","author":"Gautam","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115447_bib191","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fnins.2013.00089","article-title":"Animal models of post-traumatic stress disorder: face validity","volume":"7","author":"Goswami","year":"2013","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2026.115447_bib192","article-title":"Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches","volume":"12","author":"Hoskins","year":"2021","journal-title":"Eur. J. Psychotraumatol."},{"key":"10.1016\/j.isci.2026.115447_bib193","article-title":"Mechanisms and Clinical Implications of the Post-traumatic Stress Disorder (PTSD)-Cardiovascular Disease Link","volume":"17","author":"Sidik","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.isci.2026.115447_bib194","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJMoa1507598","article-title":"Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans","volume":"378","author":"Raskind","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2026.115447_bib195","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.biopsych.2021.05.012","article-title":"Randomized, Placebo-Controlled Trial of the Angiotensin Receptor Antagonist Losartan for Posttraumatic Stress Disorder","volume":"90","author":"Stein","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib196","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S2215-0366(20)30311-4","article-title":"Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study","volume":"7","author":"Molero","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib197","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.psyneuen.2015.11.001","article-title":"A randomized, double-blind, placebo-controlled, crossover trial of mifepristone in Gulf War veterans with chronic multisymptom illness","volume":"64","author":"Golier","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.isci.2026.115447_bib198","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/wps.20252","article-title":"Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis","volume":"14","author":"Vancampfort","year":"2015","journal-title":"World Psychiatry"},{"key":"10.1016\/j.isci.2026.115447_bib199","doi-asserted-by":"crossref","first-page":"e763","DOI":"10.1161\/CIR.0000000000000947","article-title":"Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association","volume":"143","author":"Levine","year":"2021","journal-title":"Circulation"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226008229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226008229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:05:19Z","timestamp":1790694319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226008229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":199,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2589004226008229"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115447","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115447"}}