{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T19:41:07Z","timestamp":1794426067768,"version":"4.9.1"},"reference-count":122,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014593","name":"Biointech","doi-asserted-by":"publisher","award":["2022.04809"],"award-info":[{"award-number":["2022.04809"]}],"id":[{"id":"10.13039\/501100014593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG2727 \\u2013 445549683"],"award-info":[{"award-number":["RTG2727 \\u2013 445549683"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1366"],"award-info":[{"award-number":["SFB1366"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CE 140\/2-2"],"award-info":[{"award-number":["CE 140\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["319 394046768-SFB 1366"],"award-info":[{"award-number":["319 394046768-SFB 1366"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TP07"],"award-info":[{"award-number":["TP07"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["B10N"],"award-info":[{"award-number":["B10N"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR179"],"award-info":[{"award-number":["TRR179"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 35\/1503-1 FUGG"],"award-info":[{"award-number":["INST 35\/1503-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SPP1937"],"award-info":[{"award-number":["SPP1937"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TRR156"],"award-info":[{"award-number":["SFB-TRR156"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["B1.1"],"award-info":[{"award-number":["B1.1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031691","name":"\u00c1llatorvostudom\u00e1nyi Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008658","name":"Deutsches Krebsforschungszentrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001661","name":"Universit\u00e4t Heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003542","name":"Ministerium f\u00fcr Wissenschaft, Forschung und Kunst Baden-W\u00fcrttemberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","award":["CEECINST\/00091\/2018"],"award-info":[{"award-number":["CEECINST\/00091\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["74114180"],"award-info":[{"award-number":["74114180"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.isci.2026.115492","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:35:05Z","timestamp":1774600505000},"page":"115492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Functional segregation of HIF-1\u03b1 and AhR controls NK cell responsiveness under hypoxia"],"prefix":"10.1016","volume":"29","author":[{"given":"Sebastiano","family":"Giorgetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cortopassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Chanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta P.","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Sticht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Ast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Platten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Cerwenka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-2256","authenticated-orcid":false,"given":"Ana","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115492_bib1","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231222","article-title":"Five decades of natural killer cell discovery","volume":"221","author":"Lanier","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115492_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","article-title":"The cancer metabolic reprogramming and immune response","volume":"20","author":"Xia","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.isci.2026.115492_bib4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41419-024-06697-4","article-title":"Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy","volume":"15","author":"Mai","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2026.115492_bib5","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nri.2017.103","article-title":"Regulation of immunity and inflammation by hypoxia in immunological niches","volume":"17","author":"Taylor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.it.2023.08.008","article-title":"pH sensing at the intersection of tissue homeostasis and inflammation","volume":"44","author":"Hajjar","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk3327","article-title":"Extracellular matrix proteins regulate NK cell function in peripheral tissues","volume":"8","author":"Bunting","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.115492_bib8","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.immuni.2020.05.001","article-title":"Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1\u03b1 Unleashes NK Cell Activity","volume":"52","author":"Ni","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.115492_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250342","article-title":"Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation","volume":"54","author":"Jeong","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines6020056","article-title":"Hypoxia, Metabolism and Immune Cell Function","volume":"6","author":"Krzywinska","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.isci.2026.115492_bib11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1582-4934.2011.01258.x","article-title":"Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia","volume":"15","author":"Carreau","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.isci.2026.115492_bib12","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1172\/JCI137553","article-title":"Hypoxia-inducible factors and innate immunity in liver cancer","volume":"130","author":"Yuen","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.115492_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2026.115492_bib14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2026.115492_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn1849","article-title":"Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments","volume":"10","author":"Kennedy","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.115492_bib16","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ccell.2017.10.003","article-title":"An HIF-1\u03b1\/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression","volume":"32","author":"Palazon","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2026.115492_bib17","doi-asserted-by":"crossref","first-page":"9394","DOI":"10.1038\/s41467-024-53593-8","article-title":"HIF1\u03b1-regulated glycolysis promotes activation-induced cell death and IFN-\u03b3 induction in hypoxic T cells","volume":"15","author":"Shen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115492_bib18","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s41467-017-01599-w","article-title":"Loss of HIF-1\u03b1 in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis","volume":"8","author":"Krzywinska","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115492_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68484","article-title":"HIF1\u03b1 is required for NK cell metabolic adaptation during virus infection","volume":"10","author":"Victorino","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.isci.2026.115492_bib20","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1038\/s41467-021-25065-w","article-title":"NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence","volume":"12","author":"Sobecki","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115492_bib21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.yexcr.2017.03.041","article-title":"A compendium of proteins that interact with HIF-1\u03b1","volume":"356","author":"Semenza","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2026.115492_bib22","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1073\/pnas.94.11.5667","article-title":"Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor","volume":"94","author":"Kallio","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115492_bib23","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","article-title":"An essential role for p300\/CBP in the cellular response to hypoxia","volume":"93","author":"Arany","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115492_bib24","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.jbchem.a021812","article-title":"CBP\/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt)","volume":"122","author":"Kobayashi","year":"1997","journal-title":"J. Biochem."},{"key":"10.1016\/j.isci.2026.115492_bib25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/carcin\/15.5.801","article-title":"Interindividual difference in expression of human Ah receptor and related P450 genes","volume":"15","author":"Hayashi","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.isci.2026.115492_bib26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev-immunol-032713-120245","article-title":"The aryl hydrocarbon receptor: multitasking in the immune system","volume":"32","author":"Stockinger","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib27","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.4049\/jimmunol.0903670","article-title":"An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells","volume":"185","author":"Mezrich","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib28","doi-asserted-by":"crossref","first-page":"19961","DOI":"10.1073\/pnas.1014465107","article-title":"Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism","volume":"107","author":"Nguyen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115492_bib29","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1126\/science.1214914","article-title":"Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles","volume":"334","author":"Kiss","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.115492_bib30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature13684","article-title":"AhR sensing of bacterial pigments regulates antibacterial defence","volume":"512","author":"Moura-Alves","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115492_bib31","doi-asserted-by":"crossref","first-page":"12391","DOI":"10.1073\/pnas.1302856110","article-title":"Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor","volume":"110","author":"Shin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115492_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.624284","article-title":"AHR Regulates NK Cell Migration via ASB2-Mediated Ubiquitination of Filamin A","volume":"12","author":"Shin","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib33","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1182\/bloodadvances.2021004533","article-title":"Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function","volume":"5","author":"Trikha","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.isci.2026.115492_bib34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.celrep.2014.05.042","article-title":"The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells","volume":"8","author":"Hughes","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.115492_bib35","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/eji.201747289","article-title":"The aryl hydrocarbon receptor modulates the function of human CD56(bright) NK cells","volume":"48","author":"Moreno-Nieves","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib36","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nm.3868","article-title":"Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-\u03b1","volume":"21","author":"Mascanfroni","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.115492_bib37","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.4049\/jimmunol.160.10.4738","article-title":"A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells","volume":"160","author":"Tomura","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1074-7613(00)80543-9","article-title":"Defective NK cell activity and Th1 response in IL-18-deficient mice","volume":"8","author":"Takeda","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.115492_bib39","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.4049\/jimmunol.157.9.3967","article-title":"IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones","volume":"157","author":"Tsutsui","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0092-8674(02)00827-9","article-title":"IRAK-M is a negative regulator of Toll-like receptor signaling","volume":"110","author":"Kobayashi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115492_bib41","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1084\/jem.186.12.1957","article-title":"Association with FcRgamma is essential for activation signal through NKR-P1 (CD161) in natural killer (NK) cells and NK1.1+ T cells","volume":"186","author":"Arase","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115492_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/imr.13313","article-title":"ITAM-based receptors in natural killer cells","volume":"323","author":"Aguilar","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.isci.2026.115492_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac016","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia-I-Mompel","year":"2022","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.isci.2026.115492_bib44","doi-asserted-by":"crossref","first-page":"11508","DOI":"10.1021\/bi980087p","article-title":"Activation of the Ah receptor by tryptophan and tryptophan metabolites","volume":"37","author":"Heath-Pagliuso","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2026.115492_bib45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1084\/jem.20081438","article-title":"Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells","volume":"206","author":"Veldhoen","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115492_bib46","doi-asserted-by":"crossref","first-page":"38801","DOI":"10.1074\/jbc.M110.131573","article-title":"Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect","volume":"285","author":"Diani-Moore","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115492_bib47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02977789","article-title":"Induction of phase I, II and III drug metabolism\/transport by xenobiotics","volume":"28","author":"Xu","year":"2005","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.isci.2026.115492_bib48","first-page":"5006","article-title":"AHR\/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis","volume":"25","author":"Nguyen","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2026.115492_bib49","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1210\/me.2007-0211","article-title":"RelB, a new partner of aryl hydrocarbon receptor-mediated transcription","volume":"21","author":"Vogel","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.isci.2026.115492_bib50","doi-asserted-by":"crossref","first-page":"17680","DOI":"10.1073\/pnas.1012977107","article-title":"I\u03baB\u03b6 is essential for natural killer cell activation in response to IL-12 and IL-18","volume":"107","author":"Miyake","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115492_bib51","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/s41467-018-04719-2","article-title":"Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice","volume":"9","author":"Loftus","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115492_bib52","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1182\/blood-2010-07-294702","article-title":"I\u03baB\u03b6 augments IL-12- and IL-18-mediated IFN-\u03b3 production in human NK cells","volume":"117","author":"Kannan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.115492_bib53","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.cell.2023.07.034","article-title":"A pan-cancer single-cell panorama of human natural killer cells","volume":"186","author":"Tang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115492_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1156493","article-title":"Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages","volume":"14","author":"Schmidt","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib55","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.4049\/jimmunol.1100912","article-title":"Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis","volume":"187","author":"Kadow","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib56","doi-asserted-by":"crossref","first-page":"32529","DOI":"10.1074\/jbc.271.51.32529","article-title":"Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1","volume":"271","author":"Semenza","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115492_bib57","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.4049\/jimmunol.157.11.4781","article-title":"Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation","volume":"157","author":"Cho","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib58","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.4049\/jimmunol.156.8.2754","article-title":"Herpesvirus saimiri immortalized gamma delta T cell line activated by IL-12","volume":"156","author":"Klein","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib59","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.7839144","article-title":"Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms","volume":"267","author":"D\u00e9rijard","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.115492_bib60","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1182\/blood.V96.5.1844","article-title":"Importance of the MKK6\/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity","volume":"96","author":"Visconti","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.115492_bib61","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1093\/emboj\/18.20.5601","article-title":"p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons","volume":"18","author":"Goh","year":"1999","journal-title":"Embo j"},{"key":"10.1016\/j.isci.2026.115492_bib62","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1182\/blood-2004-07-2782","article-title":"Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells","volume":"105","author":"Mavropoulos","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.115492_bib63","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.4049\/jimmunol.179.10.7101","article-title":"MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65","volume":"179","author":"Saha","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib64","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/intimm\/12.3.253","article-title":"Selective induction of p38 mitogen-activated protein kinase activity following A6H co-stimulation in primary human CD4(+) T cells","volume":"12","author":"Labuda","year":"2000","journal-title":"Int. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122046","article-title":"Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers","volume":"10","author":"Puccetti","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115492_bib66","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature10491","article-title":"An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor","volume":"478","author":"Opitz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115492_bib67","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41568-022-00491-0","article-title":"Natural killer cells in antitumour adoptive cell immunotherapy","volume":"22","author":"Laskowski","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2026.115492_bib68","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrc.2015.5","article-title":"NK cells and cancer: you can teach innate cells new tricks","volume":"16","author":"Morvan","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2026.115492_bib69","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/JLB.MR0718-269R","article-title":"Mechanisms of natural killer cell-mediated cellular cytotoxicity","volume":"105","author":"Prager","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.isci.2026.115492_bib70","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood-2009-08-238469","article-title":"Regulation of human NK-cell cytokine and chemokine production by target cell recognition","volume":"115","author":"Fauriat","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.115492_bib71","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.4049\/jimmunol.1900718","article-title":"Activation Receptor-Dependent IFN-\u03b3 Production by NK Cells Is Controlled by Transcription, Translation, and the Proteasome","volume":"203","author":"Piersma","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib72","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1038\/s41467-021-25715-z","article-title":"Metabolic requirements of NK cells during the acute response against retroviral infection","volume":"12","author":"Littwitz-Salomon","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115492_bib73","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3389\/fimmu.2019.02278","article-title":"NK Cell Metabolism and Tumor Microenvironment","volume":"10","author":"Terr\u00e9n","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib74","article-title":"Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering","volume":"9","author":"Li","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.115492_bib75","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/eji.201343448","article-title":"Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC","volume":"43","author":"Balsamo","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib76","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.3389\/fimmu.2018.02358","article-title":"Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration","volume":"9","author":"Parodi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib77","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.4049\/jimmunol.165.6.3190","article-title":"Synergistic induction of the Tap-1 gene by IFN-gamma and lipopolysaccharide in macrophages is regulated by STAT1","volume":"165","author":"Cramer","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib78","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1084\/jem.158.3.670","article-title":"Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity","volume":"158","author":"Nathan","year":"1983","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115492_bib79","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4049\/jimmunol.1102727","article-title":"Autocrine IFN-\u03b3 promotes naive CD8 T cell differentiation and synergizes with IFN-\u03b1 to stimulate strong function","volume":"189","author":"Curtsinger","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib80","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/ni1138","article-title":"Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming","volume":"5","author":"Mart\u00edn-Fontecha","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib81","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.4049\/jimmunol.2300283","article-title":"IL-15 Priming Alters IFN-\u03b3 Regulation in Murine NK Cells","volume":"211","author":"Cimpean","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib82","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1128\/MCB.22.6.1742-1753.2002","article-title":"Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control","volume":"22","author":"Hodge","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.115492_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004441","article-title":"Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells","volume":"10","author":"Luetke-Eversloh","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2026.115492_bib84","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/cimm.1998.1376","article-title":"Constitutive and induced IL-18 receptor expression by various peripheral blood cell subsets as determined by anti-hIL-18R monoclonal antibody","volume":"189","author":"Kunikata","year":"1998","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib85","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.161.7.3400","article-title":"IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production","volume":"161","author":"Yoshimoto","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib86","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fimmu.2014.00187","article-title":"The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions","volume":"5","author":"Nandagopal","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib87","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302069","article-title":"Myc controls NK cell development, IL-15-driven expansion, and translational machinery","volume":"6","author":"Khameneh","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.isci.2026.115492_bib88","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/ni.2936","article-title":"The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells","volume":"15","author":"Mar\u00e7ais","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib89","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3389\/fimmu.2013.00450","article-title":"Regulation of mouse NK cell development and function by cytokines","volume":"4","author":"Mar\u00e7ais","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib90","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.4049\/jimmunol.1401558","article-title":"mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function","volume":"193","author":"Donnelly","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib91","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ni.3838","article-title":"Srebp-controlled glucose metabolism is essential for NK cell functional responses","volume":"18","author":"Assmann","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib92","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41392-023-01608-z","article-title":"Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease","volume":"8","author":"Panwar","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2026.115492_bib93","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/s41467-018-04366-7","article-title":"Single cell analysis of kynurenine and System L amino acid transport in T cells","volume":"9","author":"Sinclair","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115492_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.884004","article-title":"Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression","volume":"10","author":"Rejano-Gordillo","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.115492_bib95","article-title":"The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress","author":"Holfelder","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2026.115492_bib96","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.molcel.2024.01.007","article-title":"I\u03baB\u03b6 is a dual-use coactivator of NF-\u03baB and POU transcription factors","volume":"84","author":"Alpsoy","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.115492_bib97","doi-asserted-by":"crossref","first-page":"E5825","DOI":"10.1073\/pnas.1509971112","article-title":"I\u03baB\u03b6 is a key driver in the development of psoriasis","volume":"112","author":"Johansen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115492_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1188253","article-title":"The central inflammatory regulator I\u03baB\u03b6: induction, regulation and physiological functions","volume":"14","author":"Feng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib99","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4049\/jimmunol.162.1.314","article-title":"A NF-kappa B\/c-myc-dependent survival pathway is targeted by corticosteroids in immature thymocytes","volume":"162","author":"Wang","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib100","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41375-022-01749-0","article-title":"mTOR inhibition amplifies the anti-lymphoma effect of PI3K\u03b2\/\u03b4 blockage in diffuse large B-cell lymphoma","volume":"37","author":"Xu","year":"2023","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2026.115492_bib101","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1074\/jbc.REV120.011188","article-title":"Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine","volume":"295","author":"Singhal","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115492_bib102","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41575-021-00430-8","article-title":"AHR in the intestinal microenvironment: safeguarding barrier function","volume":"18","author":"Stockinger","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2026.115492_bib103","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4326194","article-title":"Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells","volume":"2016","author":"Vondr\u00e1\u010dek","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.isci.2026.115492_bib104","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-pathmechdis-031521-024831","article-title":"Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology","volume":"18","author":"Martini","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.isci.2026.115492_bib105","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.molmed.2013.02.007","article-title":"Tryptophan metabolism: entering the field of aging and age-related pathologies","volume":"19","author":"van der Goot","year":"2013","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.isci.2026.115492_bib106","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.isci.2026.115492_bib107","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cmet.2020.06.010","article-title":"Amino Assets: How Amino Acids Support Immunity","volume":"32","author":"Kelly","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115492_bib108","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.4049\/jimmunol.1402001","article-title":"Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion","volume":"194","author":"Madera","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib109","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ni880","article-title":"Functional interactions between dendritic cells and NK cells during viral infection","volume":"4","author":"Andrews","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41416-019-0664-6","article-title":"The therapeutic potential of targeting tryptophan catabolism in cancer","volume":"122","author":"Opitz","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.isci.2026.115492_bib111","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1038\/s41467-020-17750-z","article-title":"Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine","volume":"11","author":"Campesato","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115492_bib112","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006728","article-title":"Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2\/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes","volume":"11","author":"Solvay","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.isci.2026.115492_bib113","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.it.2018.10.010","article-title":"The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment","volume":"39","author":"Shinde","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2026.115492_bib114","doi-asserted-by":"crossref","first-page":"20768","DOI":"10.1073\/pnas.1009201107","article-title":"An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis","volume":"107","author":"Quintana","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115492_bib115","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007495","article-title":"Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy","volume":"11","author":"Kober","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.isci.2026.115492_bib116","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2026.115492_bib117","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.115492_bib118","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115492_bib119","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.115492_bib120","doi-asserted-by":"crossref","first-page":"D691","DOI":"10.1093\/nar\/gkq1018","article-title":"Reactome: a database of reactions, pathways and biological processes","volume":"39","author":"Croft","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.115492_bib121","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gkh036","article-title":"The Gene Ontology (GO) database and informatics resource","volume":"32","author":"Harris","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.115492_bib122","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226008679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226008679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:37:22Z","timestamp":1790692642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226008679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":122,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2589004226008679"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115492","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional segregation of HIF-1\u03b1 and AhR controls NK cell responsiveness under hypoxia","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115492","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115492"}}