{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:51:10Z","timestamp":1781833870187,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018630","name":"Shanghai Municipal People's Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023-107"],"award-info":[{"award-number":["2023-107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024ZD0530300"],"award-info":[{"award-number":["2024ZD0530300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460707"],"award-info":[{"award-number":["82460707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471076"],"award-info":[{"award-number":["32471076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060653"],"award-info":[{"award-number":["82060653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021ZD0204300"],"award-info":[{"award-number":["2021ZD0204300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32425028"],"award-info":[{"award-number":["32425028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92357304"],"award-info":[{"award-number":["92357304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32330042"],"award-info":[{"award-number":["32330042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430042"],"award-info":[{"award-number":["82430042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160682"],"award-info":[{"award-number":["82160682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012600","name":"ShanghaiTech University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.isci.2026.115542","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:17:57Z","timestamp":1774930677000},"page":"115542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dependent and independent mechanisms"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-7704","authenticated-orcid":false,"given":"Shuang","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Z.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei L.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115542_bib1","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/S0140-6736(15)00981-2","article-title":"Perioperative thermoregulation and heat balance","volume":"387","author":"Sessler","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.115542_bib2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/ALN.0b013e31817f6d76","article-title":"Temperature monitoring and perioperative thermoregulation","volume":"109","author":"Sessler","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.isci.2026.115542_bib3","first-page":"86","article-title":"Inadvertent perioperative hypothermia: a literature review","volume":"22","author":"Knaepel","year":"2012","journal-title":"J. Perioper. Pract."},{"key":"10.1016\/j.isci.2026.115542_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.aorn.2017.03.003","article-title":"Inadvertent Perioperative Hypothermia: Current Nursing Knowledge","volume":"105","author":"Giuliano","year":"2017","journal-title":"AORN J."},{"key":"10.1016\/j.isci.2026.115542_bib5","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.12968\/bjon.2009.18.18.44553","article-title":"Prevention of inadvertent perioperative hypothermia","volume":"18","author":"Burger","year":"2009","journal-title":"Br. J. Nurs."},{"key":"10.1016\/j.isci.2026.115542_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn3174","article-title":"Neuroprotective mechanisms of hypothermia in brain ischaemia","volume":"13","author":"Yenari","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12630-010-9420-3","article-title":"Sleep and general anesthesia","volume":"58","author":"Franks","year":"2011","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.isci.2026.115542_bib8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev-neuro-060909-153200","article-title":"General anesthesia and altered states of arousal: a systems neuroscience analysis","volume":"34","author":"Brown","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1124\/pharmrev.122.000717","article-title":"Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep-Wake State: A Decade of Discovery","volume":"75","author":"Bao","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.isci.2026.115542_bib10","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1038\/s41467-018-06590-7","article-title":"Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice","volume":"9","author":"Kroeger","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115542_bib11","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3389\/fneur.2018.00790","article-title":"Sleep-Wake Cycling and Energy Conservation: Role of Hypocretin and the Lateral Hypothalamus in Dynamic State-Dependent Resource Optimization","volume":"9","author":"Latifi","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.isci.2026.115542_bib12","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fnins.2019.00336","article-title":"The Temperature Dependence of Sleep","volume":"13","author":"Harding","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuron.2018.02.022","article-title":"Regulation of Body Temperature by the Nervous System","volume":"98","author":"Tan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.115542_bib14","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1038\/s41467-023-40504-6","article-title":"A parabrachial-hypothalamic parallel circuit governs cold defense in mice","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115542_bib15","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1073\/pnas.1616255114","article-title":"A hypothalamic circuit that controls body temperature","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115542_bib16","doi-asserted-by":"crossref","first-page":"11954","DOI":"10.1523\/JNEUROSCI.2643-09.2009","article-title":"Parallel preoptic pathways for thermoregulation","volume":"29","author":"Yoshida","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib17","doi-asserted-by":"crossref","first-page":"6956","DOI":"10.1523\/JNEUROSCI.0100-17.2017","article-title":"Cold-Induced Thermogenesis and Inflammation-Associated Cold-Seeking Behavior Are Represented by Different Dorsomedial Hypothalamic Sites: A Three-Dimensional Functional Topography Study in Conscious Rats","volume":"37","author":"Wanner","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.autneu.2016.02.010","article-title":"Central neural control of thermoregulation and brown adipose tissue","volume":"196","author":"Morrison","year":"2016","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib19","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/s41593-018-0249-3","article-title":"Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake","volume":"21","author":"Pi\u00f1ol","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib20","article-title":"Role of Dorsomedial Hypothalamus GABAergic Neurons in Sleep-Wake States in Response to Changes in Ambient Temperature in Mice","volume":"23","author":"Li","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115542_bib21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.neuropharm.2006.03.031","article-title":"Glutamate receptors in the raphe pallidus mediate brown adipose tissue thermogenesis evoked by activation of dorsomedial hypothalamic neurons","volume":"51","author":"Cao","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2026.115542_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2004.08.030","article-title":"Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: implications for the circadian control of behavioural state","volume":"130","author":"Deurveilher","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2026.115542_bib23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2017.01.014","article-title":"Neural Circuitry of Wakefulness and Sleep","volume":"93","author":"Scammell","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.115542_bib24","article-title":"GABAergic neurons in the dorsomedial hypothalamus regulate states of consciousness in sevoflurane anesthesia","volume":"26","author":"Wang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.isci.2026.115542_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/1570159X19666210225152728","article-title":"Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States","volume":"20","author":"Wu","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.isci.2026.115542_bib26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-physiol-020518-114546","article-title":"Central Mechanisms for Thermoregulation","volume":"81","author":"Morrison","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.isci.2026.115542_bib27","doi-asserted-by":"crossref","first-page":"R1207","DOI":"10.1152\/ajpregu.00109.2011","article-title":"Central circuitries for body temperature regulation and fever","volume":"301","author":"Nakamura","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.isci.2026.115542_bib28","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/35010109","article-title":"Identification of sleep-promoting neurons in vitro","volume":"404","author":"Gallopin","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115542_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/smrv.2001.0170","article-title":"Brain structures and mechanisms involved in the generation of NREM sleep: focus on the preoptic hypothalamus","volume":"5","author":"McGinty","year":"2001","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.isci.2026.115542_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135212","article-title":"Patterns of neural activity in the mouse brain: Wakefulness vs. General anesthesia","volume":"735","author":"Yatziv","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2026.115542_bib31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/ALN.0000000000000383","article-title":"Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer","volume":"121","author":"Han","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.isci.2026.115542_bib32","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1111\/j.1460-9568.1995.tb01148.x","article-title":"BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disagreement with mRNA levels","volume":"7","author":"Nawa","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib33","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nm.2687","article-title":"Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin","volume":"18","author":"Liao","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.115542_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/23328940.2021.1993734","article-title":"Genetic identification of preoptic neurons that regulate body temperature in mice","volume":"9","author":"Machado","year":"2022","journal-title":"Temperature (Austin)"},{"key":"10.1016\/j.isci.2026.115542_bib35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41422-024-01064-6","article-title":"Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation","volume":"35","author":"Chen","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.isci.2026.115542_bib36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2016.08.028","article-title":"Warm-Sensitive Neurons that Control Body Temperature","volume":"167","author":"Tan","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115542_bib37","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.cub.2019.12.063","article-title":"Activation of Preoptic GABAergic or Glutamatergic Neurons Modulates Sleep-Wake Architecture, but Not Anesthetic State Transitions","volume":"30","author":"Vanini","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2026.115542_bib38","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.cub.2018.05.064","article-title":"A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia","volume":"28","author":"Machado","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2026.115542_bib39","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1093\/cercor\/bhac258","article-title":"A role of prefrontal cortico-hypothalamic projections in wake promotion","volume":"33","author":"Zhong","year":"2023","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.isci.2026.115542_bib40","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1111\/j.1460-9568.2007.05843.x","article-title":"Stress- and lipopolysaccharide-induced c-fos expression and nNOS in hypothalamic neurons projecting to medullary raphe in rats: a triple immunofluorescent labeling study","volume":"26","author":"Sarkar","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.isci.2026.115542_bib41","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cmet.2014.05.018","article-title":"Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia","volume":"20","author":"Kataoka","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115542_bib42","article-title":"Primate preoptic neurons drive hypothermia and cold defense","volume":"4","author":"Zhang","year":"2023","journal-title":"Innovation"},{"key":"10.1016\/j.isci.2026.115542_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42255-023-00804-z","article-title":"Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound","volume":"5","author":"Yang","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.isci.2026.115542_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0140-6736(55)93381-X","article-title":"Elective cardiac arrest","volume":"269","author":"Melrose","year":"1955","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.115542_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physiol.00025.2021","article-title":"Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly","volume":"37","author":"Tveita","year":"2022","journal-title":"Physiology"},{"key":"10.1016\/j.isci.2026.115542_bib46","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainres.2009.02.062","article-title":"Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia","volume":"1269","author":"Baumann","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.115542_bib47","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1001\/jama.2017.8978","article-title":"Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial","volume":"318","author":"Kirkegaard","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2026.115542_bib48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuron.2022.11.008","article-title":"Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice","volume":"111","author":"Zhou","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.115542_bib49","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/j.2040-4603.2014.tb00571.x","article-title":"Thermoregulatory modeling for cold stress","volume":"4","author":"Xu","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.isci.2026.115542_bib50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.isci.2026.115542_bib51","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1038\/s41467-020-20050-1","article-title":"Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115542_bib52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jgg.2018.11.004","article-title":"Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus","volume":"46","author":"Luo","year":"2019","journal-title":"J. Genet. Genomics."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422600917X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422600917X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:07:34Z","timestamp":1781831254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422600917X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S258900422600917X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115542","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dependent and independent mechanisms","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115542","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115542"}}