{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:51:15Z","timestamp":1781833875880,"version":"3.54.5"},"reference-count":54,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014868","name":"Jiangxi Academy of Sciences","doi-asserted-by":"publisher","award":["2024CXPT1002"],"award-info":[{"award-number":["2024CXPT1002"]}],"id":[{"id":"10.13039\/501100014868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502259"],"award-info":[{"award-number":["82502259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010857","name":"Jiangxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["20252BCF320026"],"award-info":[{"award-number":["20252BCF320026"]}],"id":[{"id":"10.13039\/501100010857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010857","name":"Jiangxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["20232BCJ22047"],"award-info":[{"award-number":["20232BCJ22047"]}],"id":[{"id":"10.13039\/501100010857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20252BAC250157"],"award-info":[{"award-number":["20252BAC250157"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20242BAB25201"],"award-info":[{"award-number":["20242BAB25201"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.isci.2026.115675","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:29:11Z","timestamp":1775809751000},"page":"115675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["F-53B exposure accelerates progression from preexisting fatty liver to non-alcoholic steatohepatitis and hepatic fibrosis"],"prefix":"10.1016","volume":"29","author":[{"given":"Chunhua","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115675_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg9065","article-title":"Per- and polyfluoroalkyl substances in the environment","volume":"375","author":"Evich","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.115675_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108860","article-title":"A research synthesis of humans, animals, and environmental compartments exposed to PFAS: A systematic evidence map and bibliometric analysis of secondary literature","volume":"190","author":"Ricolfi","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2026.115675_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107351","article-title":"Aberrant hepatic lipid metabolism associated with gut microbiota dysbiosis triggers hepatotoxicity of novel PFOS alternatives in adult zebrafish","volume":"166","author":"Wang","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2026.115675_bib4","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1021\/es401525n","article-title":"First report of a Chinese PFOS alternative overlooked for 30 years: its toxicity, persistence, and presence in the environment","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.isci.2026.115675_bib5","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1021\/acs.est.5b01010","article-title":"Identification of Novel Polyfluorinated Ether Sulfonates as PFOS Alternatives in Municipal Sewage Sludge in China","volume":"49","author":"Ruan","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.isci.2026.115675_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.121044","article-title":"The untold story of PFAS alternatives: Insights into the occurrence, ecotoxicological impacts, and removal strategies in the aquatic environment","volume":"250","author":"Hamid","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.isci.2026.115675_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171151","article-title":"Environmental occurrence, bioaccumulation and human risks of emerging fluoroalkylether substances: Insight into security of alternatives","volume":"922","author":"Feng","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.isci.2026.115675_bib8","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.scitotenv.2018.05.313","article-title":"Global distribution potential and regional environmental risk of F-53B","volume":"640\u2013641","author":"Ti","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.isci.2026.115675_bib9","doi-asserted-by":"crossref","first-page":"14156","DOI":"10.1021\/acs.est.5b04299","article-title":"Tissue Distribution and Whole Body Burden of the Chlorinated Polyfluoroalkyl Ether Sulfonic Acid F-53B in Crucian Carp (Carassius carassius): Evidence for a Highly Bioaccumulative Contaminant of Emerging Concern","volume":"49","author":"Shi","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.isci.2026.115675_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145731","article-title":"Occurrence, source apportionment, plant bioaccumulation and human exposure of legacy and emerging per- and polyfluoroalkyl substances in soil and plant leaves near a landfill in China","volume":"776","author":"Xu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.isci.2026.115675_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107108","article-title":"Human exposure to F-53B in China and the evaluation of its potential toxicity: An overview","volume":"161","author":"He","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2026.115675_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108582","article-title":"Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health?","volume":"186","author":"Hong","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2026.115675_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123544","article-title":"Hepatotoxicity induced in rats by chronic exposure to F-53B, an emerging replacement of perfluorooctane sulfonate (PFOS)","volume":"346","author":"Li","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2026.115675_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118305","article-title":"Hepatic injury and ileitis associated with gut microbiota dysbiosis in mice upon F-53B exposure","volume":"248","author":"Li","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.isci.2026.115675_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117329","article-title":"6:2 Cl-PFESA has the potential to cause liver damage and induce lipid metabolism disorders in female mice through the action of PPAR-\u03b3","volume":"287","author":"Pan","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2026.115675_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136104","article-title":"Contribution of gut microbiota to hepatic steatosis following F-53B exposure from the perspective of glucose and fatty acid metabolism","volume":"480","author":"Gu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.isci.2026.115675_bib17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.envpol.2019.03.032","article-title":"Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring","volume":"249","author":"Shi","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2026.115675_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105262","article-title":"Probing the hepatotoxicity mechanisms of novel chlorinated polyfluoroalkyl sulfonates to zebrafish larvae: Implication of structural specificity","volume":"133","author":"Yi","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2026.115675_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108687","article-title":"Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study","volume":"187","author":"Wang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2026.115675_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/03602532.2017.1293683","article-title":"Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters","volume":"49","author":"Cobbina","year":"2017","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.isci.2026.115675_bib21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2026.115675_bib22","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.metabol.2016.01.012","article-title":"Epidemiology and natural history of non-alcoholic fatty liver disease","volume":"65","author":"Fazel","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.115675_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101167","article-title":"Imaging biomarkers of NAFLD, NASH, and fibrosis","volume":"50","author":"Ajmera","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2026.115675_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2023.101231","article-title":"Liver fibrosis in NAFLD\/NASH: from pathophysiology towards diagnostic and therapeutic strategies","volume":"95","author":"Parola","year":"2024","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.isci.2026.115675_bib25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.envpol.2018.04.030","article-title":"Exposure to environmental level phenanthrene induces a NASH-like phenotype in new born rat","volume":"239","author":"Guo","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2026.115675_bib26","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1289\/EHP316","article-title":"Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL\/6J Diet-Induced Obesity Mouse Model","volume":"125","author":"Duval","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.isci.2026.115675_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155182","article-title":"Yohimbine ameliorates liver inflammation and fibrosis by regulating oxidative stress and Wnt\/\u03b2-catenin pathway","volume":"123","author":"Sharma","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.isci.2026.115675_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00204-017-2055-1","article-title":"Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein","volume":"92","author":"Sheng","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.isci.2026.115675_bib29","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1021\/acs.est.8b01268","article-title":"Predicting Relative Protein Affinity of Novel Per- and Polyfluoroalkyl Substances (PFASs) by An Efficient Molecular Dynamics Approach","volume":"52","author":"Cheng","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.isci.2026.115675_bib30","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.2337\/diabetes.51.12.3391","article-title":"Interleukin-6 induces cellular insulin resistance in hepatocytes","volume":"51","author":"Senn","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2026.115675_bib31","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2026.115675_bib32","article-title":"Bisphenols exposure and non-alcoholic fatty liver disease: from environmental trigger to molecular pathogenesis","volume":"16","author":"Li","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2026.115675_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2019.01.017","article-title":"The effects of perfluorooctanoate on high fat diet induced non-alcoholic fatty liver disease in mice","volume":"416","author":"Li","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.isci.2026.115675_bib34","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1055\/s-0042-121899","article-title":"Patients with ultrasound diagnosis of hepatic steatosis are at high metabolic risk","volume":"54","author":"K\u00e4lsch","year":"2016","journal-title":"Z. Gastroenterol."},{"key":"10.1016\/j.isci.2026.115675_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/hep.27395","article-title":"The Role of Liver Fat and Insulin Resistance as Determinants of Plasma Aminotransferase Elevation in Nonalcoholic Fatty Liver Disease","volume":"61","author":"Maximos","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2026.115675_bib36","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jhep.2004.07.010","article-title":"Silent non-alcoholic fatty liver disease - a clinical-histological study","volume":"41","author":"Sorrentino","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.isci.2026.115675_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2020.06.020","article-title":"Long-term profile of serological biomarkers, hepatic inflammation, and fibrosis in a mouse model of non-alcoholic fatty liver disease","volume":"332","author":"Toita","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.isci.2026.115675_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127950","article-title":"Comparative chronic toxicities of PFOS and its novel alternatives on the immune system associated with intestinal microbiota dysbiosis in adult zebrafish","volume":"425","author":"Huang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.isci.2026.115675_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120819","article-title":"F-53B induces hepatotoxic effects and slows self-healing in ulcerative colitis in mice","volume":"317","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2026.115675_bib40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0361-9230(00)00262-8","article-title":"Nitric oxide: an inhibitor of NF-kappaB\/Rel system in glial cells","volume":"52","author":"Colasanti","year":"2000","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.isci.2026.115675_bib41","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12020-020-02319-z","article-title":"Albumin binding function is a novel biomarker for early liver damage and disease progression in non-alcoholic fatty liver disease","volume":"69","author":"Sun","year":"2020","journal-title":"Endocrine"},{"key":"10.1016\/j.isci.2026.115675_bib42","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0092-8674(87)90583-6","article-title":"The interplay of DNA-binding proteins on the promoter of the mouse albumin gene","volume":"51","author":"Lichtsteiner","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115675_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111290","article-title":"6:2 chlorinated polyfluoroalkyl ether sulfonate (F-53B) induced nephrotoxicity associated with oxidative stress, inflammation and fibrosis in mice","volume":"405","author":"Wu","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.isci.2026.115675_bib44","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/antiox12040824","article-title":"Hyaluronan and Reactive Oxygen Species Signaling-Novel Cues from the Matrix?","volume":"12","author":"Berdiaki","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.isci.2026.115675_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13023-022-02264-2","article-title":"Association of MTHFR rs1801133 and homocysteine with Legg-Calv\u00e9-Perthes disease in Mexican patients","volume":"17","author":"Buend\u00eda-Pazar\u00e1n","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.isci.2026.115675_bib46","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1161\/CIRCULATIONAHA.105.562041","article-title":"Matrix metalloproteinase-13\/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques","volume":"112","author":"Deguchi","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115675_bib47","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.redox.2018.07.002","article-title":"Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1\/Nrf2 pathway","volume":"18","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2026.115675_bib48","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.3748\/wjg.v30.i19.2553","article-title":"HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells","volume":"30","author":"Gao","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2026.115675_bib49","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.envpol.2017.08.068","article-title":"Occurrence and seasonal variations of per- and polyfluoroalkyl substances (PFASs) including fluorinated alternatives in rivers, drain outlets and the receiving Bohai Sea of China","volume":"231","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2026.115675_bib50","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12302-025-01281-9","article-title":"Developmental exposure to environmentally relevant PFOS and PFBS disrupts adult behaviour, reproductive fitness, and lipid metabolism in Zebrafish","volume":"37","author":"Fallet","year":"2025","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.isci.2026.115675_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2025.110122","article-title":"Reproductive toxicity of perfluorobutane sulfonate in zebrafish (Danio rerio): Impacts on oxidative stress, hormone disruption and HPGL axis dysregulation","volume":"289","author":"Santhi","year":"2025","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.isci.2026.115675_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2025.110162","article-title":"Neurotoxic effects of chronic exposure to perfluorobutane sulfonate in adult zebrafish (Danio Rerio)","volume":"292","author":"Santhi","year":"2025","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.isci.2026.115675_bib53","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/ame2.12309","article-title":"Establishment of a non-alcoholic fatty liver disease model by high fat diet in adult zebrafish","volume":"7","author":"Li","year":"2024","journal-title":"Animal Model. Exp. Med."},{"key":"10.1016\/j.isci.2026.115675_bib54","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.fsi.2019.01.049","article-title":"Intestinal immunity of dogfish Scyliorhinus canicula spiral valve: A histochemical, immunohistochemical and confocal study","volume":"87","author":"Lauriano","year":"2019","journal-title":"Fish Shellfish Immunol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226010503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226010503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:10:52Z","timestamp":1781831452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226010503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2589004226010503"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115675","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"F-53B exposure accelerates progression from preexisting fatty liver to non-alcoholic steatohepatitis and hepatic fibrosis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115675"}}