{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:51:53Z","timestamp":1781833913471,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["WKJ-ZJ-2447"],"award-info":[{"award-number":["WKJ-ZJ-2447"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo","doi-asserted-by":"publisher","award":["2024021020"],"award-info":[{"award-number":["2024021020"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LQN26H040009"],"award-info":[{"award-number":["LQN26H040009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LQN25H040002"],"award-info":[{"award-number":["LQN25H040002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.isci.2026.115678","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:42:34Z","timestamp":1775842954000},"page":"115678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["LINC00632 combines with ER\u03b1 to target VISTA expression, ameliorating endometriosis progression"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-4257","authenticated-orcid":false,"given":"Jue","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-9383","authenticated-orcid":false,"given":"Yichen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115678_bib1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2026.115678_bib2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/humupd\/dmp007","article-title":"Recurrence of endometriosis and its control","volume":"15","author":"Guo","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.isci.2026.115678_bib3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.fertnstert.2024.07.033","article-title":"Recurrence after surgery for endometrioma: a systematic review and meta-analyses","volume":"122","author":"Veth","year":"2024","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2026.115678_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.isci.2026.115678_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.isci.2026.115678_bib6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/humupd\/dmz018","article-title":"The endometrial immune environment of women with endometriosis","volume":"25","author":"Vallv\u00e9-Juanico","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.isci.2026.115678_bib7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13578-021-00613-5","article-title":"Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing","volume":"11","author":"Zou","year":"2021","journal-title":"Cell Biosci."},{"key":"10.1016\/j.isci.2026.115678_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103752","article-title":"Endometriosis and autoimmunity","volume":"24","author":"Blanco","year":"2025","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.isci.2026.115678_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10555-025-10246-6","article-title":"Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis","volume":"44","author":"Ezdoglian","year":"2025","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.isci.2026.115678_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0191-1","article-title":"Immune checkpoint inhibitors: recent progress and potential biomarkers","volume":"50","author":"Darvin","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.isci.2026.115678_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12964-023-01157-6","article-title":"The tumor promoter cysteinyl leukotriene receptor 1 regulates PD-L1 expression in colon cancer cells via the Wnt\/\u03b2-catenin signaling axis","volume":"21","author":"Satapathy","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2026.115678_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.humpath.2018.10.028","article-title":"Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis","volume":"85","author":"Barreta","year":"2019","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.isci.2026.115678_bib13","doi-asserted-by":"crossref","first-page":"6266","DOI":"10.3390\/ijms25116266","article-title":"Immune Checkpoints in Endometriosis-A New Insight in the Pathogenesis","volume":"25","author":"Suszczyk","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115678_bib14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.20100619","article-title":"VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses","volume":"208","author":"Wang","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115678_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.625808","article-title":"Structural Basis of VSIG3: The Ligand for VISTA","volume":"12","author":"Xie","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115678_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008364","article-title":"Expression of VISTA regulated via IFN-\u03b3 governs endogenous T-cell function and exhibits correlation with the efficacy of CD19 CAR-T cell treated B-malignant mice","volume":"12","author":"Tang","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.isci.2026.115678_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112366","article-title":"Immunomodulation in Endometriosis: Investigating the interrelationship between VISTA expression and Escherichia.Shigella-Associated metabolites","volume":"137","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.isci.2026.115678_bib23","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.molcel.2015.10.037","article-title":"AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation","volume":"60","author":"Chang","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.115678_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104750","article-title":"Regulation of the CD8+ T Cell and PDL1\/PD1 Axis in Gastric Cancer: Unraveling the Molecular Landscape","volume":"212","author":"Yong","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.isci.2026.115678_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010908","article-title":"B4GALT5 inhibits CD8(+) T-cell response by downregulating MHC-I level through ERAD pathway in PDAC","volume":"13","author":"Xing","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.isci.2026.115678_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev-immunol-082223-044122","article-title":"Molecular Mechanisms Governing CD8 T Cell Differentiation and Checkpoint Inhibitor Response in Cancer","volume":"43","author":"Rausch","year":"2025","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115678_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/imm.13786","article-title":"The dysfunction of CD8(+) T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis","volume":"172","author":"Huang","year":"2024","journal-title":"Immunology"},{"key":"10.1016\/j.isci.2026.115678_bib28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s40364-024-00693-8","article-title":"A pair of promising immune checkpoints PSGL-1 and VISTA from immunotolerance to immunotherapy","volume":"12","author":"Peng","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.isci.2026.115678_bib29","doi-asserted-by":"crossref","first-page":"C42","DOI":"10.1530\/RAF-21-0053","article-title":"Nonhormonal therapy for endometriosis based on energy metabolism regulation","volume":"2","author":"Kobayashi","year":"2021","journal-title":"Reprod. Fertil."},{"key":"10.1016\/j.isci.2026.115678_bib30","article-title":"NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21","volume":"35","author":"Witt","year":"2023","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.isci.2026.115678_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-065X.2009.00797.x","article-title":"PSGL-1 function in immunity and steady state homeostasis","volume":"230","author":"Carlow","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.isci.2026.115678_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.it.2017.02.002","article-title":"PSGL-1: A New Player in the Immune Checkpoint Landscape","volume":"38","author":"Tinoco","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2026.115678_bib33","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1016\/j.apsb.2023.08.003","article-title":"Identification and optimization of peptide inhibitors to block VISTA\/PSGL-1 interaction for cancer immunotherapy","volume":"13","author":"Niu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.isci.2026.115678_bib34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0897.2005.00254.x","article-title":"Increase of activated mast cells in human endometriosis","volume":"53","author":"Sugamata","year":"2005","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.isci.2026.115678_bib35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1517\/14728222.2012.661415","article-title":"Mast cells in endometriosis: guilty or innocent bystanders?","volume":"16","author":"Kirchhoff","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.isci.2026.115678_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.961599","article-title":"Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology","volume":"13","author":"McCallion","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115678_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092106","article-title":"Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer","volume":"20","author":"Sammarco","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115678_bib38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41467-020-20600-7","article-title":"Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy","volume":"12","author":"Somasundaram","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115678_bib39","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1074\/mcp.RA117.000037","article-title":"Quantitative Mass Spectrometry Analysis of PD-L1 Protein Expression, N-glycosylation and Expression Stoichiometry with PD-1 and PD-L2 in Human Melanoma","volume":"16","author":"Morales-Betanzos","year":"2017","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.isci.2026.115678_bib40","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/15476286.2019.1581597","article-title":"Time resolved gene expression analysis during tamoxifen adaption of MCF-7 cells identifies long non-coding RNAs with prognostic impact","volume":"16","author":"Porsch","year":"2019","journal-title":"RNA Biol."},{"key":"10.1016\/j.isci.2026.115678_bib18","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1210\/en.2014-1490","article-title":"Molecular classification of endometriosis and disease stage using high-dimensional genomic data","volume":"155","author":"Tamaresis","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.isci.2026.115678_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12958-019-0465-z","article-title":"Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility","volume":"17","author":"Bhat","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.isci.2026.115678_bib21","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1093\/humrep\/14.12.2944","article-title":"Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis","volume":"14","author":"Somigliana","year":"1999","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2026.115678_bib22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/humrep\/des369","article-title":"Natural therapies assessment for the treatment of endometriosis","volume":"28","author":"Ricci","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2026.115678_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-1-60327-475-3_15","article-title":"Structural analysis of protein-RNA interactions with mass spectrometry","volume":"488","author":"Kvaratskhelia","year":"2008","journal-title":"Methods Mol. Biol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226010539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226010539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:18:57Z","timestamp":1781831937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226010539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2589004226010539"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115678","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LINC00632 combines with ER\u03b1 to target VISTA expression, ameliorating endometriosis progression","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115678"}}