{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:49:00Z","timestamp":1792025340302,"version":"4.4.0"},"reference-count":140,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012848","name":"Digestive Diseases Research Core Center, University of Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000963","name":"American Diabetes Association Research Foundation Inc","doi-asserted-by":"publisher","award":["1-18-IBS-100"],"award-info":[{"award-number":["1-18-IBS-100"]}],"id":[{"id":"10.13039\/100000963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK099222"],"award-info":[{"award-number":["R01DK099222"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH2010392"],"award-info":[{"award-number":["W81XWH2010392"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["ADA 1-19-PMF-019"],"award-info":[{"award-number":["ADA 1-19-PMF-019"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17POST33650045"],"award-info":[{"award-number":["17POST33650045"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["R21AI178517"],"award-info":[{"award-number":["R21AI178517"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["R01DK099222"],"award-info":[{"award-number":["R01DK099222"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["R01DK099222-02S1"],"award-info":[{"award-number":["R01DK099222-02S1"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.isci.2026.115801","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:09:15Z","timestamp":1776701355000},"page":"115801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ambient temperature regulates CD4+ T cell tonic T cell receptor signaling and responsiveness"],"prefix":"10.1016","volume":"29","author":[{"given":"Keisuke","family":"Sawada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Eom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bree A.","family":"Mahoney-Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci E.","family":"Stankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarren R.","family":"Oates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo C.","family":"Alarcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.M.A.","family":"Damen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Cannata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hargis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn W.","family":"McAlees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy J.","family":"Ulanowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Wayland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hildeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P.","family":"Lewkowich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Salomonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Moreno-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-0499","authenticated-orcid":false,"given":"Senad","family":"Divanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115801_bib1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.20120988","article-title":"Unstressing intemperate models: how cold stress undermines mouse modeling","volume":"209","author":"Karp","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115801_bib2","series-title":"The Mouse in Biomedical Research: Normative Biology, Husbandry, and Models","author":"Fox","year":"2006"},{"key":"10.1016\/j.isci.2026.115801_bib3","first-page":"170","article-title":"Mouse models of human disease: An evolutionary perspective","volume":"2016","author":"Perlman","year":"2016","journal-title":"Evol. Med. Public Health"},{"key":"10.1016\/j.isci.2026.115801_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-9086-3_1","article-title":"The Applicability of Mouse Models to the Study of Human Disease","volume":"1940","author":"Rydell-T\u00f6rm\u00e4nen","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2026.115801_bib5","article-title":"Why animal model studies are lost in translation","volume":"2","author":"Frangogiannis","year":"2022","journal-title":"J. Cardiovasc. Aging"},{"key":"10.1016\/j.isci.2026.115801_bib6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.molmet.2016.09.008","article-title":"Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL\/6 mice","volume":"5","author":"Giles","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2026.115801_bib7","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.4049\/jimmunol.1500700","article-title":"Housing Temperature-Induced Stress Is Suppressing Murine Graft-versus-Host Disease through beta2-Adrenergic Receptor Signaling","volume":"195","author":"Leigh","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.isci.2026.115801_bib8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm.4346","article-title":"Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling","volume":"23","author":"Giles","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.115801_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1095132","article-title":"Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease","volume":"14","author":"Oates","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib10","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.mucimm.2023.09.004","article-title":"Obesity amplifies influenza virus-driven disease severity in male and female mice","volume":"16","author":"Alarcon","year":"2023","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib11","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1038\/s41598-017-07471-7","article-title":"Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice","volume":"7","author":"Liao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115801_bib12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrendo.2017.48","article-title":"Warming the mouse to model human diseases","volume":"13","author":"Ganeshan","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.isci.2026.115801_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.4049\/jimmunol.1800621","article-title":"Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice","volume":"202","author":"Hylander","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.588387","article-title":"Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?","volume":"11","author":"Vialard","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib15","series-title":"Temperature Regulation in Laboratory Rodents","author":"Gordon","year":"1993"},{"key":"10.1016\/j.isci.2026.115801_bib16","doi-asserted-by":"crossref","first-page":"H1581","DOI":"10.1152\/ajpheart.01000.2007","article-title":"Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality","volume":"294","author":"Swoap","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2026.115801_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.molmet.2017.10.009","article-title":"Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study","volume":"7","author":"Fischer","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2026.115801_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.065","article-title":"Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point","volume":"31","author":"\u0160kop","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.115801_bib19","doi-asserted-by":"crossref","first-page":"R391","DOI":"10.1152\/ajpregu.00731.2003","article-title":"Effect of ambient temperature on cardiovascular parameters in rats and mice: a comparative approach","volume":"287","author":"Swoap","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.isci.2026.115801_bib20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.bbi.2007.03.007","article-title":"Effect of environmental temperature on sleep, locomotor activity, core body temperature and immune responses of C57BL\/6J mice","volume":"21","author":"Jhaveri","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2026.115801_bib21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1128\/iai.10.3.510-515.1974","article-title":"Effects of high ambient temperature on various stages of rabies virus infection in mice","volume":"10","author":"Bell","year":"1974","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2026.115801_bib22","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.96.6.1006","article-title":"Protective effect of elevated temperature on mice infected with Coe virus","volume":"96","author":"Underwood","year":"1966","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib23","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1089\/dna.2007.0581","article-title":"Effects of chronic heat stress on immune responses of the foot-and-mouth disease DNA vaccination","volume":"26","author":"Hu","year":"2007","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.isci.2026.115801_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/infdis\/110.3.201","article-title":"The effect of environmental temperature on the host-parasite relationship in mice","volume":"110","author":"Previte","year":"1962","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.isci.2026.115801_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4269\/ajtmh.1979.28.12","article-title":"Effect of temperature and clofibrate on Plasmodium berghei infection in mice","volume":"28","author":"McQuistion","year":"1979","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.isci.2026.115801_bib26","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2026.115801_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.70627","article-title":"Effects of Climate Change on the Immune System: A Narrative Review","volume":"8","author":"Imberti","year":"2025","journal-title":"Health Sci. Rep."},{"key":"10.1016\/j.isci.2026.115801_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114128","article-title":"The association between ambient temperature and clinical visits for inflammation-related diseases in rural areas in China","volume":"261","author":"Wang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2026.115801_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.122382","article-title":"Temperature and Inflammation: Investigating the impact of short-term exposure to ambient temperature on biomarkers of subclinical inflammation","volume":"285","author":"Sun","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.isci.2026.115801_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cmet.2015.10.003","article-title":"Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance","volume":"23","author":"Tian","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115801_bib31","doi-asserted-by":"crossref","first-page":"20176","DOI":"10.1073\/pnas.1304291110","article-title":"Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature","volume":"110","author":"Kokolus","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115801_bib32","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.cmet.2023.10.009","article-title":"The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease","volume":"35","author":"Sawada","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115801_bib33","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nri2870","article-title":"Functions of T cells in asthma: more than just T(H)2 cells","volume":"10","author":"Lloyd","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.761448","article-title":"T Cell Subsets in Graft Versus Host Disease and Graft Versus Tumor","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib35","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/35074122","article-title":"IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity","volume":"410","author":"Shankaran","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115801_bib36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-018-0020-8","article-title":"Regulatory mechanisms in T cell receptor signalling","volume":"18","author":"Gaud","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib37","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.cell.2014.03.047","article-title":"Deconstructing the peptide-MHC specificity of T cell recognition","volume":"157","author":"Birnbaum","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115801_bib38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2567.2011.03547.x","article-title":"T-cell receptor affinity in thymic development","volume":"135","author":"Moran","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.isci.2026.115801_bib39","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ni.2018","article-title":"Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells","volume":"12","author":"Sprent","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aas9103","article-title":"TCR signal strength controls the differentiation of CD4(+) effector and memory T cells","volume":"3","author":"Snook","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib41","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3389\/fimmu.2015.00617","article-title":"TCR Signaling in T Cell Memory","volume":"6","author":"Daniels","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib42","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41392-021-00823-w","article-title":"T cell receptor (TCR) signaling in health and disease","volume":"6","author":"Shah","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2026.115801_bib43","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/hep.28116","article-title":"High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires","volume":"63","author":"Liaskou","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2026.115801_bib44","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4049\/jimmunol.1900093","article-title":"The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection","volume":"203","author":"Fiege","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cell.2015.11.052","article-title":"Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease","volume":"164","author":"Yang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115801_bib46","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1084\/jem.20110308","article-title":"T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse","volume":"208","author":"Moran","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115801_bib47","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/eji.201646837","article-title":"CD69: from activation marker to metabolic gatekeeper","volume":"47","author":"Cibri\u00e1n","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib48","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1084\/jem.188.12.2301","article-title":"CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity","volume":"188","author":"Azzam","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115801_bib49","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1038\/ncomms3209","article-title":"Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells","volume":"4","author":"Martin","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115801_bib50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.coi.2021.09.007","article-title":"Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals","volume":"73","author":"Eggert","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib51","doi-asserted-by":"crossref","first-page":"15160","DOI":"10.1073\/pnas.1904096116","article-title":"Adaptation by naive CD4(+) T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance","volume":"116","author":"Zinzow-Kramer","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115801_bib52","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002279","article-title":"ZAP-70: an essential kinase in T-cell signaling","volume":"2","author":"Wang","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.isci.2026.115801_bib53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0092-8674(00)80901-0","article-title":"LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation","volume":"92","author":"Zhang","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115801_bib54","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211295","article-title":"Systems-level conservation of the proximal TCR signaling network of mice and humans","volume":"219","author":"Nicolas","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115801_bib55","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/s41590-023-01510-4","article-title":"CD4(+) T cell memory","volume":"24","author":"K\u00fcnzli","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-065X.2010.00951.x","article-title":"Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors","volume":"238","author":"Zhu","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.isci.2026.115801_bib57","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-immunol-032712-095956","article-title":"Metabolic regulation of T lymphocytes","volume":"31","author":"MacIver","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","article-title":"Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements","volume":"76","author":"Barnden","year":"1998","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.isci.2026.115801_bib59","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/intimm\/dxn017","article-title":"Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice","volume":"20","author":"Zheng","year":"2008","journal-title":"Int. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib60","first-page":"487","article-title":"The endogenous repertoire harbors self-reactive CD4(+) T cell clones that adopt a follicular helper T cell-like phenotype at steady state","volume":"24","author":"Lee","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib61","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/334395a0","article-title":"T-cell antigen receptor genes and T-cell recognition","volume":"334","author":"Davis","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115801_bib62","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41592-021-01142-2","article-title":"TRUST4: immune repertoire reconstruction from bulk and single-cell RNA-seq data","volume":"18","author":"Song","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2026.115801_bib63","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1890\/11-1952.1","article-title":"Coverage-based rarefaction and extrapolation: standardizing samples by completeness rather than size","volume":"93","author":"Chao","year":"2012","journal-title":"Ecology"},{"key":"10.1016\/j.isci.2026.115801_bib64","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.copbio.2020.07.010","article-title":"T-cell repertoire analysis and metrics of diversity and clonality","volume":"65","author":"Chiffelle","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.isci.2026.115801_bib65","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41577-018-0007-5","article-title":"Understanding the drivers of MHC restriction of T cell receptors","volume":"18","author":"La Gruta","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.953160","article-title":"MHC-independent alphabetaT cells: Lessons learned about thymic selection and MHC-restriction","volume":"13","author":"Van Laethem","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib67","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.immuni.2019.04.001","article-title":"The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4(+) T Cell Peripheralization to Promote Effective Adaptive Immunity","volume":"50","author":"Baptista","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.115801_bib68","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1038\/ncomms6377","article-title":"Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2","volume":"5","author":"McKinstry","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115801_bib69","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nri1248","article-title":"CD28-mediated co-stimulation: a quantitative support for TCR signalling","volume":"3","author":"Acuto","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib70","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.immunol.23.021704.115611","article-title":"The B7 family revisited","volume":"23","author":"Greenwald","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045185","article-title":"CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells","volume":"7","author":"Lim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115801_bib72","doi-asserted-by":"crossref","first-page":"737","DOI":"10.4049\/jimmunol.142.3.737","article-title":"Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells","volume":"142","author":"Hirsch","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib73","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.4049\/jimmunol.145.7.2183","article-title":"Anti-CD3 antibody induces rapid expression of cytokine genes in vivo","volume":"145","author":"Scott","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib74","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1073\/pnas.131193098","article-title":"Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A\/DSHP\/SAP","volume":"98","author":"Czar","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115801_bib75","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/ni.3386","article-title":"Control of T cell antigen reactivity via programmed TCR downregulation","volume":"17","author":"Gallegos","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib76","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.4049\/jimmunol.157.4.1508","article-title":"Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells","volume":"157","author":"Takahama","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib77","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cmet.2021.04.018","article-title":"PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease","volume":"33","author":"Moreno-Fernandez","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115801_bib78","article-title":"CD4(+) T cell activation and inflammation in NASH-related fibrosis","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib79","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2796.2011.02367.x","article-title":"Hallmarks of CD4 T cell immunity against influenza","volume":"269","author":"McKinstry","year":"2011","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.isci.2026.115801_bib80","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.smim.2004.02.004","article-title":"CD4 T cell responses to influenza infection","volume":"16","author":"Brown","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib81","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.anai.2022.07.027","article-title":"T-cell responses in asthma exacerbations","volume":"129","author":"Bryant","year":"2022","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib82","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/hep.26746","article-title":"IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice","volume":"59","author":"Harley","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2026.115801_bib83","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1093\/infdis\/jiae535","article-title":"Obesity Uncovers the Presence of Inflammatory Lung Macrophage Subsets With an Adipose Tissue Transcriptomic Signature in Influenza Virus Infection","volume":"231","author":"Alarcon","year":"2025","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.isci.2026.115801_bib84","doi-asserted-by":"crossref","first-page":"9128","DOI":"10.1038\/s41598-017-08030-w","article-title":"Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection","volume":"7","author":"Fujimoto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115801_bib85","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/S0264-410X(00)00275-9","article-title":"Inflammatory responses in influenza A virus infection","volume":"19","author":"Julkunen","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.isci.2026.115801_bib86","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/j.1365-2222.2009.03302.x","article-title":"Inhaled house dust mite induces pulmonary T helper 2 cytokine production","volume":"39","author":"Gregory","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.isci.2026.115801_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1099719","article-title":"Advances in respiratory physiology in mouse models of experimental asthma","volume":"14","author":"Carroll","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2026.115801_bib88","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fendo.2018.00235","article-title":"Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells","volume":"9","author":"Liberman","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2026.115801_bib89","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fimmu.2018.00164","article-title":"Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response","volume":"9","author":"Qiao","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib90","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00281-020-00829-6","article-title":"Adrenergic regulation of immune cell function and inflammation","volume":"42","author":"Sharma","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.isci.2026.115801_bib91","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41577-020-00464-0","article-title":"Glucocorticoids in T cell development, differentiation and function","volume":"21","author":"Taves","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib92","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1158\/2326-6066.CIR-20-0445","article-title":"Chronic Adrenergic Stress Contributes to Metabolic Dysfunction and an Exhausted Phenotype in T Cells in the Tumor Microenvironment","volume":"9","author":"Qiao","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.isci.2026.115801_bib93","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2020.02.018","article-title":"Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids","volume":"180","author":"Hong","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115801_bib94","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/eji.201646395","article-title":"Sympathetic neural signaling via the beta2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8(+) T-cell effector function","volume":"46","author":"Estrada","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65048-9","article-title":"beta-adrenergic signaling blockade attenuates metastasis through activation of cytotoxic CD4 T cells","volume":"16","author":"Fj\u00e6stad","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115801_bib96","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri3321","article-title":"Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors","volume":"12","author":"Oestreich","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib97","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1074-7613(00)80461-6","article-title":"The duration of antigenic stimulation determines the fate of naive and effector T cells","volume":"8","author":"Iezzi","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.115801_bib98","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.4049\/jimmunol.162.7.3790","article-title":"Naive human CD4+ T cells are a major source of lymphotoxin alpha","volume":"162","author":"Ohshima","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib99","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.188.2.247","article-title":"T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA","volume":"188","author":"Yang","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115801_bib100","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.4049\/jimmunol.158.9.4200","article-title":"Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help","volume":"158","author":"Sanders","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib101","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.4049\/jimmunol.148.11.3441","article-title":"Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists","volume":"148","author":"Severn","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib102","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4049\/immunohorizons.2000055","article-title":"Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4(+) T Cells","volume":"4","author":"Milam","year":"2020","journal-title":"ImmunoHorizons"},{"key":"10.1016\/j.isci.2026.115801_bib103","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.4049\/jimmunol.0803510","article-title":"Anergic T cells are metabolically anergic","volume":"183","author":"Zheng","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib104","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4049\/immunohorizons.2200051","article-title":"Strong Basal\/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4(+) T Cells","volume":"6","author":"Zinzow-Kramer","year":"2022","journal-title":"ImmunoHorizons"},{"key":"10.1016\/j.isci.2026.115801_bib105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fimmu.2014.00023","article-title":"Stressful presentations: mild cold stress in laboratory mice influences phenotype of dendritic cells in naive and tumor-bearing mice","volume":"5","author":"Kokolus","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib106","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.immuni.2018.12.021","article-title":"Intratumoral Tcf1(+)PD-1(+)CD8(+) T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy","volume":"50","author":"Siddiqui","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.115801_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102709","article-title":"Bystander activation and anti-tumor effects of CD8+ T cells following Interleukin-2 based immunotherapy is independent of CD4+ T cell help","volume":"9","author":"Monjazeb","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115801_bib108","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/248701a0","article-title":"Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system","volume":"248","author":"Zinkernagel","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115801_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110925","article-title":"Transcriptomic plasticity of cholinergic adipose macrophages in the acute thermogenic response","volume":"301","author":"Knights","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115801_bib110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature10653","article-title":"Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis","volume":"480","author":"Nguyen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115801_bib111","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.3389\/fimmu.2019.02893","article-title":"Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack","volume":"10","author":"Oates","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib112","article-title":"Diverse roles of lung macrophages in the immune response to influenza A virus","volume":"14","author":"Li","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.isci.2026.115801_bib113","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/632049","article-title":"Characterization of macrophage phenotypes in three murine models of house-dust-mite-induced asthma","volume":"2013","author":"Draijer","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.isci.2026.115801_bib114","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/rcmb.f279","article-title":"The alveolar macrophage: the forgotten cell in asthma","volume":"31","author":"Peters-Golden","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2026.115801_bib115","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3389\/fimmu.2017.01695","article-title":"Differentiation and Transmigration of CD4 T Cells in Neuroinflammation and Autoimmunity","volume":"8","author":"Sonar","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib116","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fimmu.2019.00353","article-title":"Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis","volume":"10","author":"Chemin","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1019877","article-title":"Advantages and limitations of experimental autoimmune encephalomyelitis in breaking down the role of the gut microbiome in multiple sclerosis","volume":"15","author":"Melamed","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.isci.2026.115801_bib118","article-title":"How to Model Rheumatoid Arthritis in Animals: From Rodents to Non-Human Primates","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib119","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13073-016-0335-7","article-title":"Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq","volume":"8","author":"Redmond","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.isci.2026.115801_bib120","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nbt.2938","article-title":"Linking T-cell receptor sequence to functional phenotype at the single-cell level","volume":"32","author":"Han","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2026.115801_bib121","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.636198","article-title":"Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice","volume":"12","author":"Noah","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1004339","article-title":"Regulation of T cell repertoires by commensal microbiota","volume":"12","author":"Kim","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.isci.2026.115801_bib140","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nature19348","article-title":"Single-cell analysis of mixed-lineage states leading to a binary cell fate choice","volume":"537","author":"Olsson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115801_bib138","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2026.115801_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/nu15234958","article-title":"Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases","volume":"15","author":"Wayland","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2026.115801_bib124","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ijo.2014.187","article-title":"Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL\/6 nude mice","volume":"39","author":"Stemmer","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.isci.2026.115801_bib125","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.20091918","article-title":"Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts","volume":"207","author":"Quezada","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115801_bib126","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93626","article-title":"Peroxisomal \u03b2-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease","volume":"3","author":"Moreno-Fernandez","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2026.115801_bib127","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1165\/rcmb.2022-0367OC","article-title":"Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice","volume":"68","author":"Wilburn","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2026.115801_bib128","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/hep4.1162","article-title":"Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice","volume":"2","author":"Mukherjee","year":"2018","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.isci.2026.115801_bib129","first-page":"28","article-title":"The in vivo cytokine capture assay for measurement of cytokine production in the mouse","volume":"6","author":"Finkelman","year":"2003","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102643","article-title":"Protocol for cytokine and uterine immune cell characterization in a mouse model of LPS-induced preterm birth","volume":"4","author":"Wayland","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.isci.2026.115801_bib131","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1038\/s41467-020-16571-4","article-title":"Type I interferon sensing unlocks dormant adipocyte inflammatory potential","volume":"11","author":"Chan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115801_bib132","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91288","article-title":"Type I interferons regulate susceptibility to inflammation-induced preterm birth","volume":"2","author":"Cappelletti","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2026.115801_bib133","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138812","article-title":"Maternal regulation of inflammatory cues is required for induction of preterm birth","volume":"5","author":"Cappelletti","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2026.115801_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112352","article-title":"BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth","volume":"42","author":"Doll","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.115801_bib135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.937577","article-title":"Prenatal antibiotics exposure does not influence experimental allergic asthma in mice","volume":"13","author":"Lingel","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115801_bib136","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1021\/acsnano.2c11003","article-title":"2D MoS(2) and BN Nanosheets Damage Mitochondria through Membrane Penetration","volume":"17","author":"Qiu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.isci.2026.115801_bib137","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140522","article-title":"Tobacco smoking induces metabolic reprogramming of renal cell carcinoma","volume":"131","author":"Reigle","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.115801_bib139","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/1471-2105-8-392","article-title":"Improved human disease candidate gene prioritization using mouse phenotype","volume":"8","author":"Chen","year":"2007","journal-title":"BMC Bioinf."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226011764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226011764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:58:57Z","timestamp":1783076337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226011764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":140,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2589004226011764"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115801","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ambient temperature regulates CD4+ T cell tonic T cell receptor signaling and responsiveness","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115801"}}