{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:25:04Z","timestamp":1794349504112,"version":"4.9.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202201020261"],"award-info":[{"award-number":["202201020261"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A03J3190"],"award-info":[{"award-number":["2025A03J3190"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900578"],"award-info":[{"award-number":["81900578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011101"],"award-info":[{"award-number":["2019A1515011101"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.isci.2026.115837","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:33:34Z","timestamp":1776872014000},"page":"115837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["NDUFAF2 promotes abdominal aortic aneurysm formation through mitochondrial dysfunction-induced apoptosis"],"prefix":"10.1016","volume":"29","author":[{"given":"Haipeng","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huining","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbiao","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henghui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115837_bib1","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1093\/eurheartj\/ehad386","article-title":"Pathogenesis and management of abdominal aortic aneurysm","volume":"44","author":"Golledge","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2026.115837_bib2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1161\/CIRCULATIONAHA.123.066110","article-title":"Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis","volume":"149","author":"Zhang","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.115837_bib3","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/cvr\/cvae117","article-title":"Single-cell RNA sequencing identifies interferon-inducible monocytes\/macrophages as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk","volume":"120","author":"Le","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2026.115837_bib4","series-title":"StatPearls [Internet]","article-title":"Abdominal Aortic Aneurysm Rupture","author":"Jeanmonod","year":"2025"},{"key":"10.1016\/j.isci.2026.115837_bib5","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3390\/jcm9061974","article-title":"Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm","volume":"9","author":"Zalewski","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.isci.2026.115837_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1369785","article-title":"Advances and challenges in regenerative therapies for abdominal aortic aneurysm","volume":"11","author":"Chao","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.isci.2026.115837_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-023-01325-7","article-title":"The mechanism and therapy of aortic aneurysms","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2026.115837_bib8","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.7150\/ijbs.93544","article-title":"Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis","volume":"20","author":"Chen","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib9","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.7150\/ijms.96395","article-title":"Glutamine Protects against Mouse Abdominal Aortic Aneurysm through Modulating VSMC Apoptosis and M1 Macrophage Activation","volume":"21","author":"Wang","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib10","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.3390\/ijms20092319","article-title":"Nogo-B Receptor Directs Mitochondria-Associated Membranes to Regulate Vascular Smooth Muscle Cell Proliferation","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib11","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1161\/CIRCRESAHA.124.324323","article-title":"Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm","volume":"134","author":"Wen","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.115837_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110102","article-title":"GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis","volume":"759","author":"Xie","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.isci.2026.115837_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114978","article-title":"Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6\/Jak2\/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells","volume":"198","author":"Hsu","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2026.115837_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242116004","article-title":"Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress","volume":"24","author":"Sulistyowati","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib15","article-title":"Thrombosis in the pathogenesis of abdominal aortic aneurysm","volume":"4","author":"Bontekoe","year":"2023","journal-title":"JVS. Vasc. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib16","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.14336\/AD.2023.0215","article-title":"Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms","volume":"14","author":"Xie","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.isci.2026.115837_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14640","article-title":"PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells","volume":"30","author":"Xu","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.isci.2026.115837_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12944-025-02611-9","article-title":"Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation","volume":"24","author":"Zhao","year":"2025","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.isci.2026.115837_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1039\/D3FO01235B","article-title":"Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p\/TRAF6 axis","volume":"15","author":"Cai","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.isci.2026.115837_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176397","article-title":"Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence","volume":"968","author":"Wei","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.115837_bib21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1152\/physiolgenomics.00053.2023","article-title":"PANoptosis in vascular smooth muscle cells regulated by TNF-\u03b1\/IL-1\u03b2 can be a new target for alleviating the progression of abdominal aortic aneurysm","volume":"56","author":"Li","year":"2024","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.isci.2026.115837_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114247","article-title":"PANoptosis is a prominent cell death feature in thoracic aortic aneurysm or dissection","volume":"442","author":"Xu","year":"2024","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2026.115837_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/cvr\/cvad168","article-title":"Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm","volume":"120","author":"Wagenh\u00e4user","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2026.115837_bib24","article-title":"NINJ1 Facilitates Abdominal Aortic Aneurysm Formation via Blocking TLR4-ANXA2 Interaction and Enhancing Macrophage Infiltration","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41419-023-06370-2","article-title":"Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2026.115837_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202402937","article-title":"Enhanced Vascular Smooth Muscle Cell and Extracellular Matrix Repair Using a Metal-Organic Framework-Based Co-Delivery System for Abdominal Aortic Aneurysm Therapy","volume":"14","author":"Lei","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.isci.2026.115837_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2023.2168635","article-title":"Ndufaf2, a protein in mitochondrial complex I, interacts in vivo with methionine sulfoxide reductases","volume":"28","author":"Park","year":"2023","journal-title":"Redox Rep."},{"key":"10.1016\/j.isci.2026.115837_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/JCI175560","article-title":"Primary cilia formation requires the Leigh syndrome-associated mitochondrial protein NDUFAF2","volume":"134","author":"Lo","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.115837_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/2912968","article-title":"Upregulation of NDUFAF2 in Lung Adenocarcinoma Is a Novel Independent Prognostic Biomarker","volume":"2023","author":"Zou","year":"2023","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.isci.2026.115837_bib30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13023-024-03094-0","article-title":"Lack of mitochondrial complex I assembly factor NDUFAF2 results in a distinctive infantile-onset brainstem neurodegenerative disease with early lethality","volume":"19","author":"Abu Hanna","year":"2024","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.isci.2026.115837_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.023601","article-title":"Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms","volume":"10","author":"Lu","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.isci.2026.115837_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911078","article-title":"Role of Extracellular Matrix and Inflammation in Abdominal Aortic Aneurysm","volume":"23","author":"Stepien","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib33","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.3390\/ijms24043483","article-title":"Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling","volume":"24","author":"Xia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115837_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s44318-023-00001-4","article-title":"Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4-\/- mouse","volume":"43","author":"Yin","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2026.115837_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s44161-024-00606-w","article-title":"Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm","volume":"4","author":"Zhang","year":"2025","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.isci.2026.115837_bib36","article-title":"SIRT1-dependent PGC-1\u03b1 deacetylation by SRT1720 rescues progression of atherosclerosis by enhancing mitochondrial function","volume":"1869","author":"Sung","year":"2024","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.isci.2026.115837_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117892","article-title":"Gualou-Xiebai herb pair ameliorate atherosclerosis in HFD-induced ApoE-\/- mice and inhibit the ox-LDL-induced injury of HUVECs by regulating the Nrf2-mediated ferroptosis","volume":"326","author":"Zhu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.isci.2026.115837_bib38","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/genes14030566","article-title":"Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts","volume":"14","author":"Choi","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.isci.2026.115837_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111805","article-title":"Leptin attenuates diabetic cardiomyopathy-induced cardiac remodeling via regulating cGAS\/STING signaling and Opa1-mediated mitochondrial fusion","volume":"132","author":"Zhang","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.isci.2026.115837_bib40","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2024.2404794","article-title":"WTAP-mediated m6A modification of TRIM22 promotes diabetic nephropathy by inducing mitochondrial dysfunction via ubiquitination of OPA1","volume":"29","author":"Zhang","year":"2024","journal-title":"Redox Rep."},{"key":"10.1016\/j.isci.2026.115837_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/biomedicines12010003","article-title":"Oxidative Stress and the Pathogenesis of Aortic Aneurysms","volume":"12","author":"Kazaleh","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.isci.2026.115837_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6237960","article-title":"Mitochondrial Dysfunction and Increased DNA Damage in Vascular Smooth Muscle Cells of Abdominal Aortic Aneurysm (AAA-SMC)","volume":"2023","author":"Tavris","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.isci.2026.115837_bib43","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1186\/s12967-023-04468-x","article-title":"Integrated machine learning survival framework develops a prognostic model based on inter-crosstalk definition of mitochondrial function and cell death patterns in a large multicenter cohort for lower-grade glioma","volume":"21","author":"Qin","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.isci.2026.115837_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1197152","article-title":"PANoptosis-based molecular subtyping and HPAN-index predicts therapeutic response and survival in hepatocellular carcinoma","volume":"14","author":"Song","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115837_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41698-023-00456-y","article-title":"Implications of different cell death patterns for prognosis and immunity in lung adenocarcinoma","volume":"7","author":"Zhou","year":"2023","journal-title":"npj Precis. Oncol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226012125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226012125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:37:21Z","timestamp":1794346641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226012125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2589004226012125"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115837","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NDUFAF2 promotes abdominal aortic aneurysm formation through mitochondrial dysfunction-induced apoptosis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115837","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115837"}}