{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:45:23Z","timestamp":1791841523023,"version":"4.3.4"},"reference-count":64,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210103122"],"award-info":[{"award-number":["DP210103122"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1077633"],"award-info":[{"award-number":["APP1077633"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1117940"],"award-info":[{"award-number":["APP1117940"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1144303"],"award-info":[{"award-number":["APP1144303"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2002921"],"award-info":[{"award-number":["APP2002921"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1047918"],"award-info":[{"award-number":["APP1047918"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001043","name":"CASS Foundation Ltd","doi-asserted-by":"publisher","award":["7319"],"award-info":[{"award-number":["7319"]}],"id":[{"id":"10.13039\/501100001043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023630","name":"Faculty of Information Technology, Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005106","name":"Australian Solar Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.isci.2026.115854","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:38:57Z","timestamp":1776901137000},"page":"115854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["cGAS\/STING sensing in dendritic cells discriminates between daptomycin sensitive and resistant Staphylococcus aureus clinical isolates"],"prefix":"10.1016","volume":"29","author":[{"given":"Timothy","family":"Patton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazneen","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhih-Hang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Kostoulias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Shan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Lundie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Balka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Venkatraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Oorschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharifeh","family":"Askary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peck","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus","family":"Shoppee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton Y.","family":"Peleg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"De Nardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"O\u2019Keeffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115854_bib1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(20)32063-8","article-title":"Confronting antimicrobial resistance beyond the COVID-19 pandemic and the 2020 US election","volume":"396","author":"Strathdee","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.115854_bib2","author":"O\u2019Neil"},{"key":"10.1016\/j.isci.2026.115854_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2026.115854_bib4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5694\/j.1326-5377.2009.tb02841.x","article-title":"Staphylococcus aureus bacteraemia: a major cause of mortality in Australia and New Zealand","volume":"191","author":"Turnidge","year":"2009","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.isci.2026.115854_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028316","article-title":"Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus","volume":"7","author":"Peleg","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115854_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJMoa053783","article-title":"Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus","volume":"355","author":"Fowler","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2026.115854_bib7","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/01.md.0000091185.93122.40","article-title":"A prospective multicenter study of Staphylococcus aureus bacteremia: incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistance","volume":"82","author":"Chang","year":"2003","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.isci.2026.115854_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/00365540802441711","article-title":"Persistent Staphylococcus aureus bacteremia: incidence and outcome trends over time","volume":"41","author":"Khatib","year":"2009","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.isci.2026.115854_bib9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/00365540510038488","article-title":"The role of vancomycin in the persistence or recurrence of Staphylococcus aureus bacteraemia","volume":"37","author":"Siegman-Igra","year":"2005","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.isci.2026.115854_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/imcb.12295","article-title":"Daptomycin-resistant Staphylococcus aureus clinical isolates are poorly sensed by dendritic cells","volume":"98","author":"Patton","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.isci.2026.115854_bib11","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1073\/pnas.1812066116","article-title":"Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation","volume":"116","author":"Jiang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115854_bib12","article-title":"The Influence of Antibiotic Resistance on Innate Immune Responses to Staphylococcus aureus Infection","volume":"11","author":"Jahan","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.isci.2026.115854_bib13","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.4049\/jimmunol.2100389","article-title":"Role of Endosomal TLRs in Staphylococcus aureus Infection","volume":"207","author":"Lentini","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib14","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.4049\/jimmunol.1201055","article-title":"Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9","volume":"189","author":"Parker","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007560","article-title":"Influenza-induced immune suppression to methicillin-resistant Staphylococcus aureus is mediated by TLR9","volume":"15","author":"Mart\u00ednez-Col\u00f3n","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2026.115854_bib16","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1128\/IAI.66.1.336-342.1998","article-title":"Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells","volume":"66","author":"Bayles","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2026.115854_bib17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.tim.2017.05.008","article-title":"The Emerging Roles of STING in Bacterial Infections","volume":"25","author":"Marinho","year":"2017","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib18","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2337\/dbi18-0052","article-title":"The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism","volume":"68","author":"Bai","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2026.115854_bib19","first-page":"1","article-title":"STING signaling and host defense against microbial infection","volume":"51","author":"Ahn","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.isci.2026.115854_bib20","article-title":"STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2402764121","article-title":"Type VII secretion system extracellular protein B targets STING to evade host anti-Staphylococcus aureus immunity","volume":"121","author":"Gao","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115854_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006496","article-title":"Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense","volume":"13","author":"Scumpia","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2026.115854_bib23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2022.04.006","article-title":"The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis","volume":"55","author":"Erttmann","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.115854_bib24","doi-asserted-by":"crossref","first-page":"26970","DOI":"10.1074\/jbc.M116.747709","article-title":"New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus","volume":"291","author":"Bowman","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115854_bib25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41586-019-1605-5","article-title":"Cyclic GMP-AMP signalling protects bacteria against viral infection","volume":"574","author":"Cohen","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115854_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002217","article-title":"c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress","volume":"7","author":"Corrigan","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2026.115854_bib27","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.cell.2014.11.017","article-title":"Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery","volume":"159","author":"Cho","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115854_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41396-018-0241-7","article-title":"Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature","volume":"13","author":"Cruz-Loya","year":"2019","journal-title":"ISME J."},{"key":"10.1016\/j.isci.2026.115854_bib29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev.mi.45.100191.003033","article-title":"Prokaryotic osmoregulation: genetics and physiology","volume":"45","author":"Csonka","year":"1991","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib30","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1016\/j.ijbiomac.2020.08.224","article-title":"Reversible and irreversible fluorescence activity of the Enhanced Green Fluorescent Protein in pH: Insights for the development of pH-biosensors","volume":"164","author":"Dos Santos","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.isci.2026.115854_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.163.1.1","article-title":"Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2","volume":"163","author":"Yoshimura","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib32","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.1074\/jbc.274.25.17406","article-title":"Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2","volume":"274","author":"Schwandner","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115854_bib33","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.4049\/jimmunol.165.10.5392","article-title":"Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection","volume":"165","author":"Takeuchi","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.200501113","article-title":"Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain","volume":"170","author":"Stuart","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.isci.2026.115854_bib35","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1574-695X.2007.00218.x","article-title":"The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signalling pathway","volume":"49","author":"Mae","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2010.09.007","article-title":"TLR2 enhances NADPH oxidase activity and killing of Staphylococcus aureus by PMN","volume":"135","author":"Jann","year":"2011","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.isci.2026.115854_bib37","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/AAC.47.11.3407-3414.2003","article-title":"Lysostaphin disrupts Staphylococcus aureus and Staphylococcus epidermidis biofilms on artificial surfaces","volume":"47","author":"Wu","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.isci.2026.115854_bib38","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1084\/jem.20092720","article-title":"Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC","volume":"207","author":"Lauterbach","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.115854_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.794776","article-title":"Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations","volume":"13","author":"Pang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib40","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112712","article-title":"Termination of STING responses is mediated via ESCRT-dependent degradation","volume":"42","author":"Balka","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2026.115854_bib41","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41467-023-36132-9","article-title":"ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling","volume":"14","author":"Gentili","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115854_bib42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41556-023-01098-9","article-title":"STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes","volume":"25","author":"Kuchitsu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2026.115854_bib43","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1111\/febs.15640","article-title":"Molecular and spatial mechanisms governing STING signalling","volume":"288","author":"Balka","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.isci.2026.115854_bib44","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.chom.2022.03.028","article-title":"Thymidine starvation promotes c-di-AMP-dependent inflammation during pathogenic bacterial infection","volume":"30","author":"Tang","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.isci.2026.115854_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001409","article-title":"A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages","volume":"3","author":"Kubica","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115854_bib46","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12997","article-title":"In or out: Phagosomal escape of Staphylococcus aureus","volume":"21","author":"Moldovan","year":"2019","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib47","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3389\/fimmu.2020.01066","article-title":"Phagocytosis: Our Current Understanding of a Universal Biological Process","volume":"11","author":"Uribe-Querol","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib48","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.3389\/fimmu.2019.02622","article-title":"Differential Responses of Human Dendritic Cells to Live or Inactivated Staphylococcus aureus: Impact on Cytokine Production and T Helper Expansion","volume":"10","author":"Cruciani","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib49","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/mmi.14841","article-title":"Cytosolic detection of phagosomal bacteria-Mechanisms underlying PAMP exodus from the phagosome into the cytosol","volume":"116","author":"Ragland","year":"2021","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib50","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/s41564-020-0777-y","article-title":"Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems","volume":"5","author":"Millman","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41579-019-0278-2","article-title":"The pan-immune system of bacteria: antiviral defence as a community resource","volume":"18","author":"Bernheim","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib52","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41586-023-06743-9","article-title":"Bacterial cGAS senses a viral RNA to initiate immunity","volume":"623","author":"Banh","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115854_bib53","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41586-019-0953-5","article-title":"Bacterial cGAS-like enzymes synthesize diverse nucleotide signals","volume":"567","author":"Whiteley","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115854_bib54","doi-asserted-by":"crossref","first-page":"e00647-17","DOI":"10.1128\/IAI.00647-17","article-title":"High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung","volume":"86","author":"Rosen","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2026.115854_bib55","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1016\/j.vaccine.2009.04.053","article-title":"c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection","volume":"27","author":"Hu","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.isci.2026.115854_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073512","article-title":"Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus","volume":"8","author":"Dengler","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.115854_bib57","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tim.2024.08.006","article-title":"The role of cyclic nucleotides in bacterial antimicrobial resistance and tolerance","volume":"33","author":"Liu","year":"2025","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.isci.2026.115854_bib58","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.smim.2014.09.002","article-title":"Crosstalk between Mycobacterium tuberculosis and the host cell","volume":"26","author":"Dey","year":"2014","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib59","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/ni.2475","article-title":"Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes","volume":"14","author":"Hasan","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.115854_bib60","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1182\/blood-2007-06-097576","article-title":"In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis","volume":"111","author":"Steiner","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.115854_bib61","doi-asserted-by":"crossref","first-page":"7851","DOI":"10.1128\/IAI.69.12.7851-7857.2001","article-title":"Evaluation of a tetracycline-inducible promoter in Staphylococcus aureus in vitro and in vivo and its application in demonstrating the role of sigB in microcolony formation","volume":"69","author":"Bateman","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2026.115854_bib62","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-7519-8_7","article-title":"Generation of Innate Immune Reporter Cells Using Retroviral Transduction","volume":"1714","author":"Cardona Gloria","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2026.115854_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.056","article-title":"TBK1 and IKKepsilon Act Redundantly to Mediate STING-Induced NF-kappaB Responses in Myeloid Cells","volume":"31","author":"Balka","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.115854_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110693","article-title":"IKKvarepsilon induces STING non-IFN immune responses via a mechanism analogous to TBK1","volume":"27","author":"Venkatraman","year":"2024","journal-title":"iScience"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226012290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226012290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:56:01Z","timestamp":1791838561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226012290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2589004226012290"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115854","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"cGAS\/STING sensing in dendritic cells discriminates between daptomycin sensitive and resistant Staphylococcus aureus clinical isolates","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115854"}}