{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:49:20Z","timestamp":1791838160155,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ek0109617"],"award-info":[{"award-number":["JP25ek0109617"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ek0109677"],"award-info":[{"award-number":["JP25ek0109677"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["P25ek0109674"],"award-info":[{"award-number":["P25ek0109674"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ek0109760"],"award-info":[{"award-number":["JP25ek0109760"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ek0109648"],"award-info":[{"award-number":["JP25ek0109648"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22gm6710009755"],"award-info":[{"award-number":["JP22gm6710009755"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008643","name":"Japan Brain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012628","name":"Japan Epilepsy Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011326","name":"Shiga University of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020237","name":"Japan Health Research Promotion Bureau","doi-asserted-by":"publisher","award":["2021-B-01"],"award-info":[{"award-number":["2021-B-01"]}],"id":[{"id":"10.13039\/100020237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K07869"],"award-info":[{"award-number":["JP21K07869"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K02247"],"award-info":[{"award-number":["JP24K02247"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H02877"],"award-info":[{"award-number":["JP23H02877"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H05643"],"award-info":[{"award-number":["JP22H05643"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K19499"],"award-info":[{"award-number":["JP22K19499"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K02230"],"award-info":[{"award-number":["JP24K02230"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24H01417"],"award-info":[{"award-number":["JP24H01417"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H02829"],"award-info":[{"award-number":["JP23H02829"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.isci.2026.115860","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:39:00Z","timestamp":1776901140000},"page":"115860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis"],"prefix":"10.1016","volume":"29","author":[{"given":"Hirotaka","family":"Ariyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tsukamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Miyatake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Okado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuki","family":"Itabashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunobu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuga","family":"Kurakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhki","family":"Nakatake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryunosuke","family":"Sanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Terakado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Koshimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Mizuguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Sakakibara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Fujihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukhtar","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Quinodoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Rivolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Ghafoor","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nadeem","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ansar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica H.","family":"Gerkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Rinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P.A.","family":"Stegmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margje","family":"Sinnema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak Ali","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essa","family":"Alharby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham M.","family":"Balahmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif A.M.","family":"Almontashiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Baer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Piton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla D\u00edes","family":"Curi\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cogn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ya","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Kakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomichi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-3875","authenticated-orcid":false,"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115860_bib1","doi-asserted-by":"crossref","first-page":"a000539","DOI":"10.1101\/cshperspect.a000539","article-title":"The Nuclear Envelope","volume":"2","author":"Hetzer","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.isci.2026.115860_bib2","doi-asserted-by":"crossref","first-page":"R487","DOI":"10.1016\/j.cub.2018.01.073","article-title":"The Dynamic Nature of the Nuclear Envelope","volume":"28","author":"De Magistris","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2026.115860_bib3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00412-012-0388-3","article-title":"Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation","volume":"121","author":"Schooley","year":"2012","journal-title":"Chromosoma"},{"key":"10.1016\/j.isci.2026.115860_bib4","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.febslet.2008.02.067","article-title":"Nuclear pore complex assembly through the cell cycle: regulation and membrane organization","volume":"582","author":"Antonin","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2026.115860_bib5","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1242\/jcs.037333","article-title":"Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly","volume":"122","author":"Webster","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.isci.2026.115860_bib6","doi-asserted-by":"crossref","first-page":"S311","DOI":"10.1194\/jlr.R800049-JLR200","article-title":"Membrane phospholipid synthesis and endoplasmic reticulum function","volume":"50","author":"Fagone","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.isci.2026.115860_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ceb.2015.04.005","article-title":"Establishment of NE asymmetry-targeting of membrane proteins to the inner nuclear membrane","volume":"34","author":"Ungricht","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.isci.2026.115860_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/tra.12230","article-title":"Phospholipid synthesis and transport in mammalian cells","volume":"16","author":"Vance","year":"2015","journal-title":"Traffic"},{"key":"10.1016\/j.isci.2026.115860_bib9","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.cell.2018.05.047","article-title":"The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets","volume":"174","author":"Romanauska","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115860_bib10","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.devcel.2021.07.018","article-title":"Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat","volume":"56","author":"Romanauska","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.115860_bib11","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.devcel.2019.07.009","article-title":"Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization","volume":"50","author":"Barbosa","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.115860_bib12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cmet.2011.07.013","article-title":"Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase","volume":"14","author":"Krahmer","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.115860_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/jbc.R800046200","article-title":"Acyl-CoA:lysophospholipid acyltransferases","volume":"284","author":"Shindou","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.115860_bib14","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202005026","article-title":"Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner","volume":"220","author":"So\u0142tysik","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.isci.2026.115860_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115296","article-title":"Regulation of membrane phospholipid biosynthesis in mammalian cells","volume":"206","author":"Morita","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2026.115860_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax7525","article-title":"Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition","volume":"5","author":"Wu","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.115860_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/neuonc\/noaa255","article-title":"PTRF\/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2","volume":"23","author":"Yi","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.isci.2026.115860_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4112","article-title":"Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer","volume":"32","author":"Sonkar","year":"2019","journal-title":"NMR Biomed."},{"key":"10.1016\/j.isci.2026.115860_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1182\/bloodadvances.2020002981","article-title":"The metabolic reprogramming in acute myeloid leukemia patients depends on their genotype and is a prognostic marker","volume":"5","author":"Lo Presti","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.isci.2026.115860_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev-physiol-020518-114444","article-title":"Phospholipid Remodeling in Physiology and Disease","volume":"81","author":"Wang","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.isci.2026.115860_bib21","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1038\/s41598-021-81733-3","article-title":"Alterations in cellular and organellar phospholipid compositions of HepG2 cells during cell growth","volume":"11","author":"Tsuji","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115860_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-022-05528-w","article-title":"A quantitative map of nuclear pore assembly reveals two distinct mechanisms","volume":"613","author":"Otsuka","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115860_bib23","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.200707026","article-title":"Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells","volume":"180","author":"Dultz","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.isci.2026.115860_bib24","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.cell.2010.04.036","article-title":"Cell cycle-dependent differences in nuclear pore complex assembly in metazoa","volume":"141","author":"Doucet","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115860_bib25","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1091\/mbc.e10-07-0641","article-title":"Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly","volume":"22","author":"Funakoshi","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.isci.2026.115860_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrm.2016.147","article-title":"The nuclear pore complex: understanding its function through structural insight","volume":"18","author":"Beck","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.115860_bib27","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1093\/emboj\/20.20.5703","article-title":"The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins","volume":"20","author":"Walther","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2026.115860_bib28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tcb.2008.07.009","article-title":"Structure, dynamics and function of nuclear pore complexes","volume":"18","author":"D'Angelo","year":"2008","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.isci.2026.115860_bib29","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/cdd.2011.150","article-title":"Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1","volume":"19","author":"Moudry","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2026.115860_bib57","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1046\/j.1365-2958.2000.01950.x","article-title":"Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans","volume":"36","author":"Pascon","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.isci.2026.115860_bib30","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1038\/s41467-019-11056-5","article-title":"Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking","volume":"10","author":"Mahajan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115860_bib31","doi-asserted-by":"crossref","first-page":"13890","DOI":"10.1021\/acs.chemrev.7b00218","article-title":"Super-Resolution Structured Illumination Microscopy","volume":"117","author":"Heintzmann","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.isci.2026.115860_bib32","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/humu.22844","article-title":"GeneMatcher: a matching tool for connecting investigators with an interest in the same gene","volume":"36","author":"Sobreira","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.isci.2026.115860_bib33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.isci.2026.115860_bib34","doi-asserted-by":"crossref","first-page":"C335","DOI":"10.1152\/ajpcell.00039.2010","article-title":"Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway","volume":"299","author":"Winter","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.isci.2026.115860_bib35","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.tem.2013.02.003","article-title":"Phosphatidic acid and lipid-sensing by mTOR","volume":"24","author":"Foster","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.115860_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2017.06.003","article-title":"DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy","volume":"42","author":"Nguyen","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.115860_bib58","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E22-05-0189","article-title":"A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents","volume":"33","author":"LaJoie","year":"2022","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.isci.2026.115860_bib37","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.molmed.2011.07.008","article-title":"mTOR: A pathogenic signaling pathway in developmental brain malformations","volume":"17","author":"Crino","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.isci.2026.115860_bib38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuron.2014.09.034","article-title":"The neurology of mTOR","volume":"84","author":"Lipton","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.115860_bib39","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1152\/physrev.00038.2014","article-title":"mTOR in Brain Physiology and Pathologies","volume":"95","author":"Bockaert","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2026.115860_bib40","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1469-8749.2000.tb00035.x","article-title":"Macrocephaly in autism and other pervasive developmental disorders","volume":"42","author":"Fidler","year":"2000","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.isci.2026.115860_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/aur.1266","article-title":"Macrocephaly as a clinical indicator of genetic subtypes in autism","volume":"6","author":"Klein","year":"2013","journal-title":"Autism Res."},{"key":"10.1016\/j.isci.2026.115860_bib42","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1177\/0883073807306263","article-title":"Rate of head circumference growth as a function of autism diagnosis and history of autistic regression","volume":"22","author":"Webb","year":"2007","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.isci.2026.115860_bib43","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1038\/srep05396","article-title":"Rapid generation of mouse models with defined point mutations by the CRISPR\/Cas9 system","volume":"4","author":"Inui","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115860_bib44","doi-asserted-by":"crossref","first-page":"18498","DOI":"10.1073\/pnas.1908736116","article-title":"Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice","volume":"116","author":"Fujihara","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.115860_bib45","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/s10038-019-0667-4","article-title":"Genetic abnormalities in a large cohort of Coffin-Siris syndrome patients","volume":"64","author":"Sekiguchi","year":"2019","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.isci.2026.115860_bib46","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.115860_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgad043","article-title":"The first genetic landscape of inherited retinal dystrophies in Portuguese patients identifies recurrent homozygous mutations as a frequent cause of pathogenesis","volume":"2","author":"Peter","year":"2023","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.isci.2026.115860_bib48","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.115860_bib49","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41467-020-20584-4","article-title":"AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data","volume":"12","author":"Quinodoz","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.115860_bib50","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/jmedgenet-2014-102554","article-title":"Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing","volume":"51","author":"Redin","year":"2014","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.isci.2026.115860_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002085","article-title":"DNA methylation dynamics in human induced pluripotent stem cells over time","volume":"7","author":"Nishino","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.isci.2026.115860_bib52","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.115860_bib53","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.115860_bib54","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.115860_bib55","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-2836(02)00442-4","article-title":"Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations","volume":"320","author":"Guerois","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.isci.2026.115860_bib56","doi-asserted-by":"crossref","first-page":"W382","DOI":"10.1093\/nar\/gki387","article-title":"The FoldX web server: an online force field","volume":"33","author":"Schymkowitz","year":"2005","journal-title":"Nucleic Acids Res."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226012356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226012356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:38:20Z","timestamp":1791837500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226012356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2589004226012356"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115860","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115860","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115860"}}