{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:45:15Z","timestamp":1791841515176,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.isci.2026.115938","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:32:18Z","timestamp":1777602738000},"page":"115938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tanshinone IIA inhibits epithelial-mesenchymal transition in ovarian cancer by promoting NR3C2 transcriptional activation of ING1"],"prefix":"10.1016","volume":"29","author":[{"given":"Xiaoqin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duoyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.115938_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26104611","article-title":"Ovarian Cancer-Epidemiology, Classification, Pathogenesis, Treatment, and Estrogen Receptors\u2019 Molecular Backgrounds","volume":"26","author":"Smolarz","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115938_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12943-024-01967-3","article-title":"Drug resistance in ovarian cancer: from mechanism to clinical trial","volume":"23","author":"Wang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.isci.2026.115938_bib3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1186\/s12967-025-06508-0","article-title":"Role of tumor microenvironment in ovarian cancer metastasis and clinical advancements","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.isci.2026.115938_bib4","article-title":"Ovarian cancer targeted therapy: current landscape and future challenges","volume":"15","author":"Wang","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2026.115938_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16040783","article-title":"A Recipe for Successful Metastasis: Transition and Migratory Modes of Ovarian Cancer Cells","volume":"16","author":"Sliwa","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.isci.2026.115938_bib6","article-title":"The mechanisms of tanshinone in the treatment of tumors","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2026.115938_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1142\/S0192415X22500070","article-title":"Tanshinone IIA: New Perspective on the Anti-Tumor Mechanism of A Traditional Natural Medicine","volume":"50","author":"Zhang","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.isci.2026.115938_bib8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s43440-023-00507-y","article-title":"Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy","volume":"75","author":"Alam","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.isci.2026.115938_bib9","first-page":"6554","article-title":"Tanshinone IIA reverses EGF- and TGF-beta1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K\/Akt\/ERK signaling pathway","volume":"18","author":"Zhang","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.isci.2026.115938_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2024.106541","article-title":"The multifaceted role of the mineralocorticoid receptor in cancers","volume":"242","author":"Doan","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.isci.2026.115938_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41419-025-07575-3","article-title":"The NR3C2-SIRT1 signaling axis promotes autophagy and inhibits epithelial mesenchymal transition in colorectal cancer","volume":"16","author":"Li","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2026.115938_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2022.102324","article-title":"Newly identified tumor suppressor functions of ING proteins","volume":"68","author":"Heliez","year":"2023","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2026.115938_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2023.151341","article-title":"ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat","volume":"102","author":"Yang","year":"2023","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.isci.2026.115938_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2748","article-title":"Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells","volume":"10","author":"Glass","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.115938_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41540-025-00508-y","article-title":"Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model","volume":"11","author":"Oliver","year":"2025","journal-title":"npj Syst. Biol. Appl."},{"key":"10.1016\/j.isci.2026.115938_bib16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fphar.2019.00202","article-title":"Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2026.115938_bib17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40164-022-00255-4","article-title":"Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b\/STARD13 axis","volume":"11","author":"Li","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.isci.2026.115938_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jare.2024.04.009","article-title":"Tanshinone IIA destabilizes SLC7A11 by regulating PIAS4-mediated SUMOylation of SLC7A11 through KDM1A, and promotes ferroptosis in breast cancer","volume":"69","author":"Luo","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.isci.2026.115938_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/v17010055","article-title":"Plant Compounds Inhibit the Growth of W12 Cervical Precancer Cells Containing Episomal or Integrant HPV DNA; Tanshinone IIA Synergizes with Curcumin in Cervical Cancer Cells","volume":"17","author":"Einbond","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.isci.2026.115938_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081616","article-title":"Tanshinone IIA Inhibits Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Modulation of STAT3-CCL2 Signaling","volume":"18","author":"Huang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115938_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104433","article-title":"Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer","volume":"106","author":"Zeng","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.isci.2026.115938_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2024.119705","article-title":"Snail transcription factors - Characteristics, regulation and molecular targets relevant in vital cellular activities of ovarian cancer cells","volume":"1871","author":"Kielbik","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.isci.2026.115938_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26094041","article-title":"From Defense to Disease: How the Immune System Fuels Epithelial-Mesenchymal Transition in Ovarian Cancer","volume":"26","author":"Kos","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.115938_bib24","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s10565-022-09785-3","article-title":"CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p\/NR3C2-mediated epithelial-mesenchymal transition signaling pathway","volume":"39","author":"Li","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.isci.2026.115938_bib25","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/jcmm.17706","article-title":"NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK","volume":"27","author":"Liu","year":"2023","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.isci.2026.115938_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091258","article-title":"Master Regulators of Epithelial-Mesenchymal Transition and WNT Signaling Pathways in Juvenile Nasopharyngeal Angiofibromas","volume":"9","author":"Calanca","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.isci.2026.115938_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110710","article-title":"DNA methylation of RUNX3 promotes the progression of gallbladder cancer through repressing SLC7A11-mediated ferroptosis","volume":"108","author":"Cai","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.isci.2026.115938_bib28","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/hep.22675","article-title":"Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner","volume":"49","author":"Zhu","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2026.115938_bib29","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210077","article-title":"CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity","volume":"11","author":"Rusu","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.isci.2026.115938_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12935-025-03674-5","article-title":"Cancer-secreted exosomal miR-1825 induces angiogenesis to promote colorectal cancer metastasis","volume":"25","author":"Sun","year":"2025","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.isci.2026.115938_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-00891-w","article-title":"Radiogenomic analysis of clinical and ultrasonic characteristics in correlation to immune-related genes in breast cancer","volume":"15","author":"Dou","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.115938_bib32","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1002\/jcp.26550","article-title":"Low NR3C2 levels correlate with aggressive features and poor prognosis in non-distant metastatic clear-cell renal cell carcinoma","volume":"233","author":"Zhao","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.isci.2026.115938_bib33","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/s41419-018-1058-z","article-title":"Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2026.115938_bib34","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/jphp.12961","article-title":"Tanshinone IIA effects on ovarian cancer cell line","volume":"70","author":"Li","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.isci.2026.115938_bib35","first-page":"1896","article-title":"Tanshinone IIA induces apoptosis of ovarian cancer cells in vitro and in vivo through attenuation of PI3K\/AKT\/JNK signaling pathways","volume":"17","author":"Zhang","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.isci.2026.115938_bib36","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1038\/s41388-024-03187-x","article-title":"NEU4-mediated desialylation enhances the activation of the oncogenic receptors for the dissemination of ovarian carcinoma","volume":"43","author":"Shi","year":"2024","journal-title":"Oncogene"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226013131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226013131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:53:34Z","timestamp":1791838414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226013131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2589004226013131"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.115938","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tanshinone IIA inhibits epithelial-mesenchymal transition in ovarian cancer by promoting NR3C2 transcriptional activation of ING1","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.115938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115938"}}