{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:13:24Z","timestamp":1788228804587,"version":"build-2803163510"},"reference-count":93,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20252BAC200112"],"award-info":[{"award-number":["20252BAC200112"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["2026Y0027"],"award-info":[{"award-number":["2026Y0027"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010909","name":"Excellent Young Scientists Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501420"],"award-info":[{"award-number":["82501420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004637","name":"Nanchang University","doi-asserted-by":"publisher","award":["YFYLCYJPY202437"],"award-info":[{"award-number":["YFYLCYJPY202437"]}],"id":[{"id":"10.13039\/501100004637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.isci.2026.116401","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:53:51Z","timestamp":1782248031000},"page":"116401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vestibular disorders and monoamine neurotransmitters: Current evidence"],"prefix":"10.1016","volume":"29","author":[{"given":"Yujie","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4407-4445","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.116401_bib1","doi-asserted-by":"crossref","first-page":"R583","DOI":"10.1016\/j.cub.2005.07.053","article-title":"The vestibular system","volume":"15","author":"Day","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2026.116401_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.12706","article-title":"The origins of vestibular science","volume":"1343","author":"Wiest","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2026.116401_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-4886(71)90228-7","article-title":"The otolith organs and their influence on oculomotor movements","volume":"30","author":"Fluur","year":"1971","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.isci.2026.116401_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3233\/VES-2006-164-507","article-title":"Vestibulo-ocular function in anxiety disorders","volume":"16","author":"Furman","year":"2007","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.isci.2026.116401_bib5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s101620010012","article-title":"Semicircular canal-otolith organ interaction during off-vertical axis rotation in humans","volume":"2","author":"Furman","year":"2001","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.isci.2026.116401_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0361-9230(03)00055-8","article-title":"Central vestibular system: vestibular nuclei and posterior cerebellum","volume":"60","author":"Barmack","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.isci.2026.116401_bib7","first-page":"20","article-title":"Vertigo: a review of common peripheral and central vestibular disorders","volume":"9","author":"Thompson","year":"2009","journal-title":"Ochsner J."},{"key":"10.1016\/j.isci.2026.116401_bib8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00415-006-0340-7","article-title":"Central vestibular disorders","volume":"254","author":"Dieterich","year":"2007","journal-title":"J. Neurol."},{"key":"10.1016\/j.isci.2026.116401_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neucli.2013.10.138","article-title":"Vestibular compensation and vestibular rehabilitation. Current concepts and new trends","volume":"44","author":"Deveze","year":"2014","journal-title":"Neurophysiologie clinique = Clinical neurophysiology"},{"key":"10.1016\/j.isci.2026.116401_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70037","article-title":"Advanced progress of vestibular compensation in vestibular neural networks","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.isci.2026.116401_bib11","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1007\/s12035-024-04208-2","article-title":"Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation","volume":"61","author":"Wu","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.isci.2026.116401_bib12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/MOO.0b013e32833de71f","article-title":"Mechanisms of vestibular compensation: recent advances","volume":"18","author":"Dutia","year":"2010","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2026.116401_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.anl.2023.11.009","article-title":"Vestibular compensation: Neural mechanisms and clinical implications for the treatment of vertigo","volume":"51","author":"Takeda","year":"2024","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.isci.2026.116401_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1543730","article-title":"Monoamine signaling and neuroinflammation: mechanistic connections and implications for neuropsychiatric disorders","volume":"16","author":"Saggu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.116401_bib15","first-page":"541","article-title":"Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases","volume":"10","author":"Di","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2026.116401_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/609428","article-title":"Monoamine reuptake inhibitors in Parkinson's disease","volume":"2015","author":"Huot","year":"2015","journal-title":"Parkinson's disease"},{"key":"10.1016\/j.isci.2026.116401_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5152\/iao.2017.3042","article-title":"Effects of Selective Seratonine Re-Uptake Inhibitors on Meniere's Disease","volume":"13","author":"K\u0131ro\u011flu","year":"2017","journal-title":"J. Int. Adv. Otol."},{"key":"10.1016\/j.isci.2026.116401_bib18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/NRE-2012-00814","article-title":"Benign paroxysmal positional vertigo (BPPV): influence of pharmacotherapy and rehabilitation therapy on patients' recovery rate and life quality","volume":"31","author":"Maslovara","year":"2012","journal-title":"NeuroRehabilitation"},{"key":"10.1016\/j.isci.2026.116401_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0091-3057(95)02135-3","article-title":"Role of 5-HT in stress, anxiety, and depression","volume":"54","author":"Graeff","year":"1996","journal-title":"Pharmacology, biochemistry, and behavior"},{"key":"10.1016\/j.isci.2026.116401_bib20","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuroscience.2006.02.053","article-title":"Serotonergic and nonserotonergic neurons in the dorsal raphe nucleus send collateralized projections to both the vestibular nuclei and the central amygdaloid nucleus","volume":"140","author":"Halberstadt","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2026.116401_bib21","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors","volume":"71","author":"Hoyer","year":"2002","journal-title":"Pharmacology, biochemistry, and behavior"},{"key":"10.1016\/j.isci.2026.116401_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s43440-019-00047-4","article-title":"Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part II. Some contributions of Manfred G\u00f6thert","volume":"72","author":"G\u00f6thert","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.isci.2026.116401_bib23","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s10571-021-01064-9","article-title":"The Roles of Serotonin in Neuropsychiatric Disorders","volume":"42","author":"Pourhamzeh","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.isci.2026.116401_bib24","first-page":"385","article-title":"5-HT receptor subtypes outside the central nervous system. Roles in the physiology of the gut","volume":"3","author":"Gershon","year":"1990","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2026.116401_bib25","first-page":"19","article-title":"5-Hydroxytryptamine-receptor subtypes","volume":"8","author":"Brodde","year":"1990","journal-title":"Clin. Physiol. Biochem."},{"key":"10.1016\/j.isci.2026.116401_bib26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-0173(91)90001-O","article-title":"Neurochemical mechanisms of recovery from peripheral vestibular lesions (vestibular compensation)","volume":"16","author":"Smith","year":"1991","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.isci.2026.116401_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr0797","article-title":"Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT(3A) receptor","volume":"11","author":"Haloi","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.116401_bib28","article-title":"Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model","volume":"15","author":"Choi","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.116401_bib29","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2026.116401_bib30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13041-017-0306-y","article-title":"The role of 5-HT receptors in depression","volume":"10","author":"Yohn","year":"2017","journal-title":"Mol. Brain"},{"key":"10.1016\/j.isci.2026.116401_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neubiorev.2004.08.008","article-title":"Serotonin1B receptors: from protein to physiological function and behavior","volume":"28","author":"Sari","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.isci.2026.116401_bib32","doi-asserted-by":"crossref","first-page":"9015","DOI":"10.3390\/ijms22169015","article-title":"5-HT Receptors and the Development of New Antidepressants","volume":"22","author":"\u015alifirski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.116401_bib33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1001\/archotol.128.5.554","article-title":"Serotonin reuptake inhibitors for dizziness with psychiatric symptoms","volume":"128","author":"Staab","year":"2002","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2026.116401_bib34","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1176\/appi.psy.46.4.334","article-title":"Fluoxetine for vestibular dysfunction and anxiety: a prospective pilot study","volume":"46","author":"Simon","year":"2005","journal-title":"Psychosomatics"},{"key":"10.1016\/j.isci.2026.116401_bib39","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3892\/etm.2013.1412","article-title":"Successful treatment of relapsed Meniere's disease using selective serotonin reuptake inhibitors: A report of three cases","volume":"7","author":"Goto","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.isci.2026.116401_bib96","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/00005537-200409000-00025","article-title":"A prospective trial of sertraline for chronic subjective dizziness","volume":"114","author":"Staab","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2026.116401_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174114","article-title":"Effectiveness of betahistine (48 mg\/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study","volume":"12","author":"Parfenov","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.116401_bib97","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s40261-019-00858-6","volume":"39","author":"Scholtz","year":"2019","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.isci.2026.116401_bib36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1001\/jamaoto.2024.2241","article-title":"Efficacy of a Serotonin-Norepinephrine Reuptake Inhibitor as a Treatment for Meniere Disease: A Randomized Clinical Trial","volume":"150","author":"Rizk","year":"2024","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2026.116401_bib37","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1039\/C5AN00110B","article-title":"Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC-ECD","volume":"140","author":"Zhang","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.isci.2026.116401_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/WNR.0000000000000977","article-title":"Preliminary study on the mechanism underlying the interaction of balance dysfunction and anxiety disorder","volume":"30","author":"Zhai","year":"2019","journal-title":"Neuroreport"},{"key":"10.1016\/j.isci.2026.116401_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrn1034","article-title":"The role of histamine and the tuberomamillary nucleus in the nervous system","volume":"4","author":"Haas","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.116401_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnsys.2012.00033","article-title":"Histamine neurons in the tuberomamillary nucleus: a whole center or distinct subpopulations?","volume":"6","author":"Blandina","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.isci.2026.116401_bib42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/ATVBAHA.109.201079","article-title":"Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins","volume":"30","author":"Rozenberg","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2026.116401_bib43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1398-9995.1997.tb04813.x","article-title":"Highlights in cardiovascular effects of histamine and H1-receptor antagonists","volume":"52","author":"Genovese","year":"1997","journal-title":"Allergy"},{"key":"10.1016\/j.isci.2026.116401_bib44","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1567-5769(02)00010-3","article-title":"Histamine H1 receptors are involved in mouse nasal allergic responses: a demonstration with H1 receptor-deficient mice","volume":"2","author":"Kayasuga","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.isci.2026.116401_bib45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4414\/smw.2009.12468","article-title":"Pathophysiology of itching and sneezing in allergic rhinitis","volume":"139","author":"Pfaar","year":"2009","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.isci.2026.116401_bib46","first-page":"4443","article-title":"Histamine inhibits cell proliferation and modulates the expression of Bcl-2 family proteins via the H2 receptor in human pancreatic cancer cells","volume":"26","author":"Cricco","year":"2006","journal-title":"Anticancer research"},{"key":"10.1016\/j.isci.2026.116401_bib47","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.drudis.2009.02.011","article-title":"The histamine H3 receptor as a therapeutic drug target for CNS disorders","volume":"14","author":"Gemkow","year":"2009","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.isci.2026.116401_bib48","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/j.1365-2222.2009.03374.x","article-title":"Histamine, histamine receptors and their role in immune pathology","volume":"39","author":"Jutel","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.isci.2026.116401_bib49","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1038\/sj.bjp.0706440","article-title":"Histamine and its receptors","volume":"147","author":"Parsons","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.116401_bib50","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1017\/S0022215120002509","article-title":"The benefits of betahistine or vestibular rehabilitation (Tetrax biofeedback) on the quality of life and fall risk in patients with M\u00e9ni\u00e8re's disease","volume":"134","author":"Liu","year":"2020","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.isci.2026.116401_bib51","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00508-015-0905-5","article-title":"Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice","volume":"128","author":"Scholtz","year":"2016","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.isci.2026.116401_bib52","article-title":"Betahistine for symptoms of vertigo","volume":"2020","author":"Murdin","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.isci.2026.116401_bib53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/VES-130496","article-title":"Betahistine treatment in managing vertigo and improving vestibular compensation: clarification","volume":"23","author":"Lacour","year":"2013","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.isci.2026.116401_bib54","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3390\/brainsci11030360","article-title":"Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats","volume":"11","author":"Fukuda","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.isci.2026.116401_bib55","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejphar.2007.04.052","article-title":"Histaminergic ligands improve vestibular compensation in the cat: behavioural, neurochemical and molecular evidence","volume":"568","author":"Tighilet","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.116401_bib56","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.anl.2023.08.009","article-title":"Effects of high-dose betahistine on intractable dizziness in patients with uncompensated unilateral vestibulopathy","volume":"51","author":"Takeda","year":"2024","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.isci.2026.116401_bib57","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/jgs.19377","article-title":"Vestibular Suppressant Utilization and Subsequent Falls Among Patients 65 Years and Older With Dizziness in the United States","volume":"73","author":"Marmor","year":"2025","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.isci.2026.116401_bib58","doi-asserted-by":"crossref","DOI":"10.4172\/2471-271X.1000120","article-title":"Dopamine: Receptors, Functions, Synthesis, Pathways, Locations and Mental Disorders: Review of Literatures","volume":"2","author":"Ayano","year":"2016","journal-title":"J. Ment. Disord. Treat."},{"key":"10.1016\/j.isci.2026.116401_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/bph.12906","article-title":"Dopamine receptors - IUPHAR Review 13","volume":"172","author":"Beaulieu","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.116401_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/403039","article-title":"Dopamine receptors and Parkinson's disease","volume":"2011","author":"Hisahara","year":"2011","journal-title":"International journal of medicinal chemistry"},{"key":"10.1016\/j.isci.2026.116401_bib61","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0149-7634(99)00063-9","article-title":"Structure and function of dopamine receptors","volume":"24","author":"Vallone","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.isci.2026.116401_bib62","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainres.2015.11.024","article-title":"Differential cognitive actions of norepinephrine a2 and a1 receptor signaling in the prefrontal cortex","volume":"1641","author":"Berridge","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.116401_bib63","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ando.2020.03.012","article-title":"Adrenergic receptors and cardiovascular effects of catecholamines","volume":"82","author":"Motiejunaite","year":"2021","journal-title":"Ann. Endocrinol."},{"key":"10.1016\/j.isci.2026.116401_bib64","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/01.CIR.0000023896.70583.9F","article-title":"Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles","volume":"106","author":"Sun","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.116401_bib65","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1523\/JNEUROSCI.3780-09.2010","article-title":"Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptors","volume":"30","author":"Jhaveri","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.116401_bib66","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/JP280610","article-title":"5-HT(1A) receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function","volume":"599","author":"Han","year":"2021","journal-title":"The Journal of physiology"},{"key":"10.1016\/j.isci.2026.116401_bib67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0378-5955(95)00147-X","article-title":"Monoamines (noradrenaline, dopamine, serotonin) in the rat cochlear nuclei: endogenous levels and turnover","volume":"90","author":"Cransac","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2026.116401_bib68","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3390\/biom13111637","article-title":"The Effects of Unilateral Labyrinthectomy on Monoamine Neurotransmitters in the Medial Vestibular Nucleus of Rats","volume":"13","author":"Wang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.isci.2026.116401_bib98","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0378-5955(96)00116-5","article-title":"Aging effects on monoamines in rat medial vestibular and cochlear nuclei","volume":"100","author":"Cransac","year":"1996","journal-title":"Hear Res."},{"key":"10.1016\/j.isci.2026.116401_bib69","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/phrs.1996.0020","article-title":"Vestibular compensation in aged rats with unilateral labyrinthectomy treated with dopaminergic drugs","volume":"33","author":"Drago","year":"1996","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.isci.2026.116401_bib99","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3950\/jibiinkoka.106.1143","article-title":"[Immunohistochemical study for monoamine neurons in the brain of unilateral inner ear impaired rats]","volume":"106","author":"Kuruma","year":"2003","journal-title":"Nihon Jibiinkoka Gakkai kaiho"},{"key":"10.1016\/j.isci.2026.116401_bib70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2202-5-32","article-title":"Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat","volume":"5","author":"Lozada","year":"2004","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.isci.2026.116401_bib100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neulet.2008.03.073","article-title":"Monoamine transporter and enzyme expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss","volume":"437","author":"Goddard","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2026.116401_bib71","article-title":"Changes in Histamine Receptors (H1, H2, and H3) Expression in Rat Medial Vestibular Nucleus and Flocculus after Unilateral Labyrinthectomy: Histamine Receptors in Vestibular Compensation","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.116401_bib72","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1523\/JNEUROSCI.1350-18.2018","article-title":"Histamine H1 Receptor Contributes to Vestibular Compensation","volume":"39","author":"Chen","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.116401_bib73","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/pr.114.010249","article-title":"International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors","volume":"67","author":"Panula","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.isci.2026.116401_bib74","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrn3526","article-title":"The histaminergic network in the brain: basic organization and role in disease","volume":"14","author":"Panula","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.116401_bib75","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1113\/jphysiol.2006.107805","article-title":"Changes in the histaminergic system during vestibular compensation in the cat","volume":"573","author":"Tighilet","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.116401_bib76","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(02)01795-8","article-title":"Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms","volume":"446","author":"Tighilet","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.116401_bib77","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0378-5955(88)90043-3","article-title":"Histamine and related substances influence neurotransmission in the semicircular canal","volume":"35","author":"Housley","year":"1988","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2026.116401_bib78","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/bph.14803","article-title":"Effect of the novel histamine H(4) receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss","volume":"177","author":"Petremann","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2026.116401_bib79","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainres.2007.04.012","article-title":"Auditory and vestibular defects and behavioral alterations after neonatal administration of streptomycin to Lewis rats: Similarities and differences to the circling (ci2\/ci2) Lewis rat mutant","volume":"1155","author":"Schirmer","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.116401_bib80","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0006-8993(96)00692-0","article-title":"DA1 and DA2 receptor regulation in the striatum of young and old rats after peripheral vestibular lesion","volume":"736","author":"Giardino","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.116401_bib81","first-page":"159","article-title":"Vestibular compensation is affected by treatment with dopamine active agents","volume":"131","author":"Petrosini","year":"1993","journal-title":"Arch. Ital. Biol."},{"key":"10.1016\/j.isci.2026.116401_bib82","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13863","article-title":"a bioactive constituent of Mentha, attenuates motion sickness in mice model: Involvement of dopaminergic system","volume":"45","author":"Deshetty","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.isci.2026.116401_bib83","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0306-4522(93)90293-O","article-title":"Effects of noradrenaline on the firing rate of vestibular neurons","volume":"53","author":"Licata","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2026.116401_bib84","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.neuroscience.2008.02.014","article-title":"Noradrenaline modulates neuronal responses to GABA in vestibular nuclei","volume":"153","author":"Di Mauro","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2026.116401_bib85","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1472-8206.1994.tb00789.x","article-title":"Modulation of neurotransmitter release via histamine H3 heteroreceptors","volume":"8","author":"Schlicker","year":"1994","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.isci.2026.116401_bib86","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2026.116401_bib87","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1113\/jphysiol.2006.120493","article-title":"Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats","volume":"577","author":"Bergquist","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.116401_bib88","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/WNR.0000000000001377","article-title":"Involvement of 5-HT2A, 5-HT2B and 5-HT2C receptors in mediating the ventrolateral orbital cortex-induced antiallodynia in a rat model of neuropathic pain","volume":"31","author":"Xu","year":"2020","journal-title":"Neuroreport"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226017761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226017761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:17:28Z","timestamp":1788225448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226017761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":93,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2589004226017761"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.116401","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vestibular disorders and monoamine neurotransmitters: Current evidence","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.116401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116401"}}