{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:23:55Z","timestamp":1794248635287,"version":"4.9.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"India Ministry of Science & Technology Department of Science and Technology","doi-asserted-by":"publisher","award":["JCB\/2021\/000035"],"award-info":[{"award-number":["JCB\/2021\/000035"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015653","name":"CSIR - Central Scientific Instruments Organisation","doi-asserted-by":"publisher","award":["37WS(0020)\/2023-24 \/EMR-II\/ASPIRE"],"award-info":[{"award-number":["37WS(0020)\/2023-24 \/EMR-II\/ASPIRE"]}],"id":[{"id":"10.13039\/501100015653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Anusandhan National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014128","name":"Centre for DNA Fingerprinting and Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["IIRPSG-2024-01-01453"],"award-info":[{"award-number":["IIRPSG-2024-01-01453"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.isci.2026.116792","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:58:43Z","timestamp":1784840323000},"page":"116792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mycobacterium tuberculosis PPE2 protein-derived peptide ameliorates DSS-induced colitis by depleting mast cells"],"prefix":"10.1016","volume":"29","author":[{"given":"Pooja","family":"Kushwaha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangita","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.116792_bib1","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.116792_bib2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1046\/j.1365-2249.2000.01094.x","article-title":"Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient Ws\/Ws rats","volume":"119","author":"Araki","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.isci.2026.116792_bib3","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1097\/MIB.0000000000000142","article-title":"The multifaceted mast cell in inflammatory bowel disease","volume":"20","author":"Hamilton","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.isci.2026.116792_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/cells8020135","article-title":"Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis","volume":"8","author":"Albert-Bayo","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.isci.2026.116792_bib5","first-page":"772","article-title":"Mast cells in gastrointestinal disease","volume":"6","author":"Ramsay","year":"2010","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2026.116792_bib6","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1002\/eji.201847504","article-title":"Mast cells at the crossroads of microbiota and IBD","volume":"48","author":"De Zuani","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.116792_bib7","article-title":"Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome","volume":"34","author":"Hasler","year":"2022","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.isci.2026.116792_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/srep39706","article-title":"The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production","volume":"7","author":"Bhat","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.116792_bib9","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.4049\/jimmunol.1801143","article-title":"Mycobacterium tuberculosis PPE2 protein interacts with p67(phox) and inhibits reactive oxygen species production","volume":"203","author":"Srivastava","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.116792_bib10","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114891","article-title":"Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation","volume":"14","author":"Pal","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.isci.2026.116792_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/IR:34:2:97","article-title":"Development, migration, and survival of mast cells","volume":"34","author":"Okayama","year":"2006","journal-title":"Immunol. Res."},{"key":"10.1016\/j.isci.2026.116792_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","article-title":"Mast cells and inflammation","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2026.116792_bib13","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1053\/j.gastro.2020.12.076","article-title":"Inflamed ulcerative colitis regions associated with MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target","volume":"160","author":"Chen","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.116792_bib14","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20805.1","article-title":"Ulcerative colitis: recent advances in the understanding of disease pathogenesis","volume":"9","author":"Porter","year":"2020","journal-title":"F1000Res."},{"key":"10.1016\/j.isci.2026.116792_bib15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.febslet.2004.04.081","article-title":"Poorer NF-kappa B signaling by microfilariae in macrophages from BALB\/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae","volume":"567","author":"Mukhopadhyay","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2026.116792_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264400","article-title":"Differential colitis susceptibility of Th1- and Th2-biased mice: a multi-omics approach","volume":"17","author":"Mukhopadhyay","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.116792_bib17","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","article-title":"Cytokine networks in the pathophysiology of inflammatory bowel disease","volume":"50","author":"Friedrich","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.116792_bib18","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ajpath.2015.12.016","article-title":"TNF-alpha modulation of intestinal tight junction permeability is mediated by NIK\/IKK-alpha axis activation of the canonical NF-kappaB pathway","volume":"186","author":"Al-Sadi","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2026.116792_bib19","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","article-title":"IL-1\u03b2 causes an increase in intestinal epithelial tight junction permeability","volume":"178","author":"Al-Sadi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.116792_bib20","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/j.gastro.2019.07.058","article-title":"Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression","volume":"157","author":"Kuo","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.116792_bib21","first-page":"G1279","article-title":"Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin","volume":"276","author":"Youakim","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.isci.2026.116792_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/gut.35.3.353","article-title":"Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis","volume":"35","author":"Pullan","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.isci.2026.116792_bib23","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.936497","article-title":"Renal manifestations in inflammatory bowel disease: a cohort study during the biologic era","volume":"28","author":"Dincer","year":"2022","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.isci.2026.116792_bib24","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/MPG.0000000000001492","article-title":"Hepatic issues and complications associated with inflammatory bowel disease: a clinical report from the naspghan inflammatory bowel disease and hepatology committees","volume":"64","author":"Saubermann","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.isci.2026.116792_bib25","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1038\/s41598-021-84761-1","article-title":"DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice","volume":"11","author":"Kwon","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.116792_bib26","doi-asserted-by":"crossref","first-page":"F1422","DOI":"10.1152\/ajprenal.00319.2013","article-title":"CXCR2 knockout mice are protected against DSS-colitis-induced acute kidney injury and inflammation","volume":"305","author":"Ranganathan","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.isci.2026.116792_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2020.152051","article-title":"PPE2 protein of Mycobacterium tuberculosis affects myeloid hematopoiesis in mice","volume":"226","author":"Pal","year":"2021","journal-title":"Immunobiology"},{"key":"10.1016\/j.isci.2026.116792_bib28","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1113\/expphysiol.2012.065854","article-title":"Lipopolysaccharide enhances Fc\u03b5RI-mediated mast cell degranulation by increasing Ca2+ entry through store-operated Ca2+ channels: implications for lipopolysaccharide exacerbating allergic asthma","volume":"97","author":"Yang","year":"2012","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.isci.2026.116792_bib29","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/s42003-022-04298-5","article-title":"An integrated map of fibroblastic populations in human colon mucosa and cancer tissues","volume":"5","author":"Li","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.isci.2026.116792_bib30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.diff.2016.05.002","article-title":"Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease","volume":"92","author":"Roulis","year":"2016","journal-title":"Differentiation."},{"key":"10.1016\/j.isci.2026.116792_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.giec.2016.08.001","article-title":"Anatomy and physiology of the small bowel","volume":"27","author":"Volk","year":"2017","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"10.1016\/j.isci.2026.116792_bib32","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/ibd.22953","article-title":"JCV+ patients with inflammatory bowel disease show elevated plasma levels of MIG and SCF","volume":"18","author":"Comar","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.isci.2026.116792_bib33","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.celrep.2018.07.085","article-title":"Paneth cells respond to inflammation and contribute to tissue regeneration by acquiring stem-like features through SCF\/c-Kit signaling","volume":"24","author":"Schmitt","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.116792_bib34","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/ibd\/izad003","article-title":"Inhibition of soluble stem cell factor promotes intestinal mucosal repair","volume":"29","author":"Garcia-Hernandez","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.isci.2026.116792_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2023-100012","article-title":"Horizon scanning: new and future therapies in the management of inflammatory bowel disease","volume":"1","author":"Kumar","year":"2023","journal-title":"eGastroenterology"},{"key":"10.1016\/j.isci.2026.116792_bib36","doi-asserted-by":"crossref","DOI":"10.1177\/2040622319899297","article-title":"Emerging treatments for inflammatory bowel disease","volume":"11","author":"Hazel","year":"2020","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.isci.2026.116792_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fgstr.2024.1335380","article-title":"The continuing value of mesalazine as first-line therapy for patients with moderately active ulcerative colitis","volume":"3","author":"Paridaens","year":"2024","journal-title":"Front. Gastroenterol."},{"key":"10.1016\/j.isci.2026.116792_bib38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejpb.2021.07.014","article-title":"Mesalazine and inflammatory bowel disease - from well-established therapies to progress beyond the state of the art","volume":"167","author":"Veloso","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.isci.2026.116792_bib39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bpg.2011.10.013","article-title":"Aminosalicylates","volume":"25","author":"Campregher","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.isci.2026.116792_bib40","article-title":"Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-\u03baB and STAT3 activation","volume":"7","author":"Jin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.116792_bib41","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00018-022-04471-3","article-title":"5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism","volume":"79","author":"Huang","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.isci.2026.116792_bib42","article-title":"ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.116792_bib43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.coph.2015.11.005","article-title":"Mast cells and inflammatory bowel disease","volume":"25","author":"Boeckxstaens","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2026.116792_bib44","article-title":"Post-inflammatory abdominal pain in patients with inflammatory bowel disease during remission: a comprehensive review","volume":"3","author":"Takahashi","year":"2021","journal-title":"Crohns Colitis"},{"key":"10.1016\/j.isci.2026.116792_bib45","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1007\/s10753-024-02182-4","article-title":"Pristimerin alleviates DSS-induced colitis in mice by modulating intestinal barrier function, gut microbiota balance and host metabolism","volume":"48","author":"Wang","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.isci.2026.116792_bib46","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2547029","article-title":"Gut microbiota dysbiosis affects intestinal sensitivity through epithelium-to-neuron signaling: novel insights from a colon organoid-based model to improve visceral pain therapy","volume":"17","author":"Margiotta","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.isci.2026.116792_bib47","doi-asserted-by":"crossref","first-page":"15.25.1","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.isci.2026.116792_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067976","article-title":"Measuring myeloperoxidase activity in biological samples","volume":"8","author":"Pulli","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.116792_bib49","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.1302520","article-title":"Does \u03b2-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of \u03b2-hexosaminidase in mast cell granules","volume":"193","author":"Fukuishi","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.116792_bib50","first-page":"4557","article-title":"A guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.isci.2026.116792_bib51","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2829","article-title":"Purification of total RNA from DSS-treated murine tissue via lithium chloride precipitation","volume":"8","author":"Viennois","year":"2018","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.isci.2026.116792_bib52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.isci.2026.116792_bib53","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41467-019-13853-4","article-title":"GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis","volume":"11","author":"Regan-Komito","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.116792_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158104","article-title":"Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice","volume":"11","author":"Meurer","year":"2016","journal-title":"PLoS One"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422602170X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422602170X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:09:26Z","timestamp":1794247766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422602170X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S258900422602170X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.116792","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycobacterium tuberculosis PPE2 protein-derived peptide ameliorates DSS-induced colitis by depleting mast cells","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.116792","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116792"}}