{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:23:11Z","timestamp":1794248591934,"version":"4.9.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.isci.2026.116972","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:02:36Z","timestamp":1785412956000},"page":"116972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fstl1 determines luminal size of mouse trachea through negative regulation of BMP4 signaling"],"prefix":"10.1016","volume":"29","author":[{"given":"Yueyue","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7425-130X","authenticated-orcid":false,"given":"Wen","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.116972_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/dvdy.22504","article-title":"Patterning and plasticity in development of the respiratory lineage","volume":"240","author":"Domyan","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.isci.2026.116972_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.900447","article-title":"Tracheal Ring Formation","volume":"10","author":"Iber","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.116972_bib3","doi-asserted-by":"crossref","DOI":"10.1242\/dev.198192","article-title":"Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies","volume":"148","author":"Kishimoto","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.116972_bib4","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1038\/s41467-018-05189-2","article-title":"Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus","volume":"9","author":"Kishimoto","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.116972_bib5","doi-asserted-by":"crossref","first-page":"16287","DOI":"10.1073\/pnas.0902274106","article-title":"beta-Catenin promotes respiratory progenitor identity in mouse foregut","volume":"106","author":"Harris-Johnson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.116972_bib6","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1038\/s41467-018-05043-5","article-title":"The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis","volume":"9","author":"Yin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.116972_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ydbio.2008.07.021","article-title":"Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis","volume":"322","author":"Li","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2026.116972_bib8","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1378\/chest.127.3.984","article-title":"Tracheomalacia and tracheobronchomalacia in children and adults: an in-depth review","volume":"127","author":"Carden","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.isci.2026.116972_bib9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1126\/science.1204831","article-title":"Control of mitotic spindle angle by the RAS-regulated ERK1\/2 pathway determines lung tube shape","volume":"333","author":"Tang","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.116972_bib10","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s00018-018-2805-0","article-title":"Follistatin-like 1 in development and human diseases","volume":"75","author":"Mattiotti","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.isci.2026.116972_bib11","doi-asserted-by":"crossref","first-page":"7058","DOI":"10.1073\/pnas.1007293108","article-title":"Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development","volume":"108","author":"Geng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.116972_bib12","article-title":"Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.116972_bib13","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/jcb.25865","article-title":"Orientation of the Mitotic Spindle in the Development of Tubular Organs","volume":"118","author":"Zhong","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.isci.2026.116972_bib14","article-title":"Fstl1 antagonizes BMP signaling and regulates ureter development","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.116972_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2023.110677","article-title":"Single-cell transcriptome analysis reveals cellular heterogeneity and highlights Fstl1-regulated alveolar myofibroblasts in mouse lung at birth","volume":"115","author":"Zhang","year":"2023","journal-title":"Genomics"},{"key":"10.1016\/j.isci.2026.116972_bib16","article-title":"Mouse embryonic lung culture, a system to evaluate the molecular mechanisms of branching","volume":"30","author":"Carraro","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.isci.2026.116972_bib17","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1038\/s41467-020-17968-x","article-title":"Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis","volume":"11","author":"Han","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.116972_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13059-018-1416-2","article-title":"Single-cell RNA-seq analysis unveils a prevalent epithelial\/mesenchymal hybrid state during mouse organogenesis","volume":"19","author":"Dong","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2026.116972_bib19","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.cell.2018.09.009","article-title":"Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting","volume":"175","author":"Cohen","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.116972_bib20","doi-asserted-by":"crossref","DOI":"10.1242\/dev.163014","article-title":"Niche-mediated BMP\/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation","volume":"145","author":"Chung","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.116972_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.modgep.2006.10.009","article-title":"Developmental expression of mouse Follistatin-like 1 (Fstl1): Dynamic regulation during organogenesis of the kidney and lung","volume":"7","author":"Adams","year":"2007","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.isci.2026.116972_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1084\/jem.20121878","article-title":"Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice","volume":"212","author":"Dong","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.116972_bib23","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1073\/pnas.0909501107","article-title":"Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium","volume":"107","author":"Umezu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226023503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226023503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:58:07Z","timestamp":1794247087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226023503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2589004226023503"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.116972","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fstl1 determines luminal size of mouse trachea through negative regulation of BMP4 signaling","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.116972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116972"}}