{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:23:32Z","timestamp":1794248612946,"version":"4.9.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171021"],"award-info":[{"award-number":["32171021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.isci.2026.117108","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T21:02:01Z","timestamp":1785963721000},"page":"117108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["PVT inhibition mitigates neuropathology and cognitive deficits in chronic cerebral hypoperfusion"],"prefix":"10.1016","volume":"29","author":[{"given":"Yuying","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaifen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-6772","authenticated-orcid":false,"given":"Le","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117108_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/595821","article-title":"Cognitive impairment in heart failure","volume":"2012","author":"Dardiotis","year":"2012","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.isci.2026.117108_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s40478-023-01590-1","article-title":"Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment","volume":"11","author":"Rajeev","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.isci.2026.117108_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/nep3.74","article-title":"Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline","volume":"3","author":"Stuckey","year":"2025","journal-title":"Neuroprotection"},{"key":"10.1016\/j.isci.2026.117108_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4103\/bc.bc_105_23","article-title":"Causal relationship between hypertension and ischemic stroke: A two-sample Mendelian randomization study","volume":"10","author":"Zhang","year":"2024","journal-title":"Brain Circ."},{"key":"10.1016\/j.isci.2026.117108_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2023.12.008","article-title":"Vascular risk burden is a key player in the early progression of Alzheimer's disease","volume":"136","author":"Ferrari-Souza","year":"2024","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.isci.2026.117108_bib6","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.117108_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","article-title":"Cerebral microvascular pathology in aging and Alzheimer's disease","volume":"64","author":"Farkas","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.isci.2026.117108_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.3","article-title":"Vascular cognitive impairment","volume":"4","author":"van der Flier","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.isci.2026.117108_bib9","doi-asserted-by":"crossref","first-page":"e1534","DOI":"10.1016\/S2214-109X(24)00264-X","article-title":"The global macroeconomic burden of Alzheimer's disease and other dementias: estimates and projections for 152 countries or territories","volume":"12","author":"Chen","year":"2024","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.isci.2026.117108_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102758","article-title":"Global, regional, and national burden of ischemic stroke, 1990-2021: an analysis of data from the global burden of disease study 2021","volume":"75","author":"Li","year":"2024","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.isci.2026.117108_bib11","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1042\/CS20160727","article-title":"Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia","volume":"131","author":"Duncombe","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.isci.2026.117108_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149295","article-title":"Lindera aggregata improves intestinal function and alleviates depressive behaviors through the BDNF\/TrkB\/CREB signaling pathway induced by CUMS in mice","volume":"1846","author":"Wang","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.117108_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection","volume":"115","author":"Lai","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.isci.2026.117108_bib14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/nep3.70009","article-title":"Role of astrocyte in neuroinflammation-induced loss in neuroplasticity and subsequent onset of depression: A systematic review","volume":"3","author":"Singhal","year":"2025","journal-title":"Neuroprotection"},{"key":"10.1016\/j.isci.2026.117108_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101372","article-title":"Neuronal excitation\/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology","volume":"69","author":"Maest\u00fa","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.isci.2026.117108_bib16","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/brain\/aww034","article-title":"New hope for ameliorating stroke-induced deficits?","volume":"139","author":"Fink","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.isci.2026.117108_bib17","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/s41586-024-08540-4","article-title":"A crucial role for the cortical amygdala in shaping social encounters","volume":"639","author":"Aubry","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117108_bib18","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/s41467-022-29384-4","article-title":"Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions","volume":"13","author":"Roy","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117108_bib19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ibneur.2025.08.013","article-title":"Brain-wide mapping of acute hypoxia-induced neuronal activation in mice: A c-Fos immunofluorescence study","volume":"19","author":"Yu","year":"2025","journal-title":"IBRO Neurosci. Rep."},{"key":"10.1016\/j.isci.2026.117108_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81818","article-title":"Molecular and spatial profiling of the paraventricular nucleus of the thalamus","volume":"12","author":"Gao","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.isci.2026.117108_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41593-019-0572-3","article-title":"Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus","volume":"23","author":"Gao","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.117108_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archneurol.2011.1175","article-title":"Brain excitability in stroke: the yin and yang of stroke progression","volume":"69","author":"Carmichael","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.isci.2026.117108_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-08178-w","article-title":"Time-dependent expression of neural oxidative and inflammatory biomarkers in ischemic stroke using a transient MCAO rat model","volume":"15","author":"Habotta","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117108_bib24","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1161\/STROKEAHA.123.045174","article-title":"Stroke Recovery-Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition","volume":"55","author":"Harquel","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.isci.2026.117108_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.117108_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s40001-026-03840-z","article-title":"Neuroinflammation and blood-brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications","volume":"31","author":"Luo","year":"2026","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.isci.2026.117108_bib27","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1161\/01.STR.0000143725.19053.60","article-title":"White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion","volume":"35","author":"Shibata","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.isci.2026.117108_bib28","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.4103\/NRR.NRR-D-24-00716","article-title":"Intermittent hypoxic perconditioning improves cognitive function in a mouse model of vascular cognitive impairment and dementia with comorbidities by recovering cerebral blood flow","volume":"21","author":"Jin","year":"2026","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.isci.2026.117108_bib29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jcbfm.2013.188","article-title":"Selective neuronal loss in ischemic stroke and cerebrovascular disease","volume":"34","author":"Baron","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.isci.2026.117108_bib30","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/01.STR.25.10.2091","article-title":"Specific changes in human brain following reperfusion after cardiac arrest","volume":"25","author":"Fujioka","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.isci.2026.117108_bib31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41592-020-0792-1","article-title":"Machine learning analysis of whole mouse brain vasculature","volume":"17","author":"Todorov","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2026.117108_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnint.2012.00020","article-title":"Upside down crossed cerebellar diaschisis: proposing chronic stimulation of the dentatothalamocortical pathway for post-stroke motor recovery","volume":"6","author":"Machado","year":"2012","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.isci.2026.117108_bib33","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neuron.2023.12.004","article-title":"Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice","volume":"112","author":"Li","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.117108_bib34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12974-022-02480-4","article-title":"Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance","volume":"19","author":"Zheng","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.isci.2026.117108_bib35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","article-title":"Pathobiology of ischaemic stroke: an integrated view","volume":"22","author":"Dirnagl","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2026.117108_bib36","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.117108_bib37","doi-asserted-by":"crossref","first-page":"1012.e25","DOI":"10.1016\/j.neurobiolaging.2011.10.033","article-title":"Selective white matter abnormalities in a novel rat model of vascular dementia","volume":"33","author":"Kitamura","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.isci.2026.117108_bib38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/STROKEAHA.110.595256","article-title":"Collateral flow predicts response to endovascular therapy for acute ischemic stroke","volume":"42","author":"Bang","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.isci.2026.117108_bib39","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2026.117108_bib40","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2026.117108_bib41","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tins.2021.03.001","article-title":"The paraventricular nucleus of the thalamus: an integrative node underlying homeostatic behavior","volume":"44","author":"Penzo","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2026.117108_bib42","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s00429-022-02478-x","article-title":"Dual medial prefrontal cortex and hippocampus projecting neurons in the paraventricular nucleus of the thalamus","volume":"227","author":"Viena","year":"2022","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.isci.2026.117108_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41582-018-0014-y","article-title":"Cerebral small vessel disease: from a focal to a global perspective","volume":"14","author":"Ter Telgte","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.isci.2026.117108_bib44","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.isci.2026.117108_bib45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.117108_bib46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuron.2013.12.025","article-title":"Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration","volume":"81","author":"Tononi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.117108_bib47","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40478-022-01498-2","article-title":"Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models","volume":"11","author":"Vasciaveo","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.isci.2026.117108_bib48","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/CIRCRESAHA.121.319902","article-title":"Sex Differences in Myocardial and Vascular Aging","volume":"130","author":"Ji","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.117108_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2026.115274","article-title":"Exploring sexual dimorphism in behavioral and neuropathological outcomes in mice after bilateral common carotid arteries occlusion","volume":"309","author":"Splendor","year":"2026","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.isci.2026.117108_bib50","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.isci.2026.117108_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.102989","article-title":"Unbiased quantification of the spatial distribution of murine cells using point pattern analysis","volume":"5","author":"Manrique-Castano","year":"2024","journal-title":"STAR Protoc."},{"key":"10.1016\/j.isci.2026.117108_bib52","series-title":"Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2019"},{"key":"10.1016\/j.isci.2026.117108_bib53","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68372","article-title":"PBN-PVT projections modulate negative affective states in mice","volume":"11","author":"Zhu","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.isci.2026.117108_bib54","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117108_bib55","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.cell.2016.05.007","article-title":"Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes","volume":"165","author":"Renier","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117108_bib56","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12915-022-01398-w","article-title":"Improved biomarker discovery through a plot twist in transcriptomic data analysis","volume":"20","author":"S\u00e1nchez-Baiz\u00e1n","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.isci.2026.117108_bib57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The Open Field Test for Measuring Locomotor Activity and Anxiety-Like Behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2026.117108_bib58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41467-024-55678-w","article-title":"Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer\u2019s disease","volume":"16","author":"Wu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117108_bib59","article-title":"A quantitative analysis of spontaneous alternation behaviors on a Y-maze reveals adverse effects of acute social isolation on spatial working memory","volume":"13","author":"Kim","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117108_bib60","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nprot.2006.170","article-title":"Assessing nest building in mice","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2026.117108_bib61","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1523\/JNEUROSCI.5685-07.2008","article-title":"Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling","volume":"28","author":"Naidoo","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117108_bib62","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1152\/physiolgenomics.00139.2006","article-title":"Novel method for high-throughput phenotyping of sleep in mice","volume":"28","author":"Pack","year":"2007","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.isci.2026.117108_bib63","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41386-023-01790-2","article-title":"Modulation of learning safety signals by acute stress: paraventricular thalamus and prefrontal inhibition","volume":"49","author":"Wang","year":"2024","journal-title":"Neuropsychopharmacology"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226024867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226024867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:02:10Z","timestamp":1794247330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226024867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2589004226024867"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117108","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PVT inhibition mitigates neuropathology and cognitive deficits in chronic cerebral hypoperfusion","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117108"}}