{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:50:11Z","timestamp":1791597011863,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573280"],"award-info":[{"award-number":["82573280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303864"],"award-info":[{"award-number":["82303864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.isci.2026.117167","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:57:05Z","timestamp":1786665425000},"page":"117167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hashimoto\u2019s thyroiditis influences tumor cell states and intratumoral microbiota in papillary thyroid carcinoma"],"prefix":"10.1016","volume":"29","author":[{"given":"Yue","family":"Che","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117167_bib1","first-page":"47","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"key":"10.1016\/j.isci.2026.117167_bib2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1158\/1055-9965.EPI-21-1440","article-title":"Epidemiology of Thyroid Cancer","volume":"31","author":"Kitahara","year":"2022","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.isci.2026.117167_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102649","article-title":"Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation","volume":"19","author":"Ralli","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.isci.2026.117167_bib4","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.18526","article-title":"Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes","volume":"4","author":"Xu","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.isci.2026.117167_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s40618-018-0882-4","article-title":"Decreased staging of differentiated thyroid cancer in patients with chronic lymphocytic thyroiditis","volume":"42","author":"Borowczyk","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.isci.2026.117167_bib6","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.surg.2013.07.021","article-title":"The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma","volume":"154","author":"Jara","year":"2013","journal-title":"Surgery"},{"key":"10.1016\/j.isci.2026.117167_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.758339","article-title":"Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution","volume":"9","author":"Pan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.117167_bib8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type-specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117167_bib9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11060-023-04318-2","article-title":"Evidence for an intra-tumoral microbiome in pituitary neuroendocrine tumors with different clinical phenotypes","volume":"163","author":"Ye","year":"2023","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.isci.2026.117167_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.102","article-title":"Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma","volume":"2","author":"Li","year":"2023","journal-title":"iMeta"},{"key":"10.1016\/j.isci.2026.117167_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-03814-x","article-title":"Tumor microbiome diversity influences papillary thyroid cancer invasion","volume":"5","author":"Yuan","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.isci.2026.117167_bib12","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.csbj.2021.03.032","article-title":"The intratumor microbiome predicts prognosis across gender and subtypes in papillary thyroid carcinoma","volume":"19","author":"Gnanasekar","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.isci.2026.117167_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.eng.2023.01.007","article-title":"Intratumoral Bacteria Dysbiosis Is Associated with Human Papillary Thyroid Cancer and Correlated with Oncogenic Signaling Pathways","volume":"28","author":"Yu","year":"2023","journal-title":"Engineering"},{"key":"10.1016\/j.isci.2026.117167_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.tem.2014.09.001","article-title":"Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked?","volume":"25","author":"Ehlers","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.117167_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1339473","article-title":"Impact of Hashimoto's thyroiditis on the tumor microenvironment in papillary thyroid cancer: insights from single-cell analysis","volume":"15","author":"Ma","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2026.117167_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bib\/bbr056","article-title":"Lessons from a decade of integrating cancer copy number alterations with gene expression profiles","volume":"13","author":"Huang","year":"2012","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.isci.2026.117167_bib17","doi-asserted-by":"crossref","first-page":"e004285","DOI":"10.1136\/jitc-2021-004285","article-title":"Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis","volume":"11","author":"Perry","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.isci.2026.117167_bib18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12967-021-03167-9","article-title":"Alterations of thyroid microbiota across different thyroid microhabitats in patients with thyroid carcinoma","volume":"19","author":"Dai","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.isci.2026.117167_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113195","article-title":"The RIG-I-like receptor signaling pathway triggered by Staphylococcus aureus promotes breast cancer metastasis","volume":"142","author":"Zhao","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.isci.2026.117167_bib20","article-title":"Intratumoral microbiome impacts immune infiltrates in tumor microenvironment and predicts prognosis in esophageal squamous cell carcinoma patients","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.isci.2026.117167_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.lmd.2025.100045","article-title":"Review of metabolomics and microbiomics in esophageal cancer: From pathogenesis to prognosis","volume":"2","author":"Cao","year":"2025","journal-title":"LabMed Discovery"},{"key":"10.1016\/j.isci.2026.117167_bib22","article-title":"Pan-cancer analysis reveals intratumoral microbial diversity in multiple cancers by amplicon technology","volume":"15","author":"Liu","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.isci.2026.117167_bib23","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.117167_bib24","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.jtho.2019.07.023","article-title":"Gram-Negative Pneumonia Augments Non-Small Cell Lung Cancer Metastasis through Host Toll-like Receptor 4 Activation","volume":"14","author":"Gowing","year":"2019","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.isci.2026.117167_bib25","article-title":"Bacteroidetes promotes esophageal squamous carcinoma invasion and metastasis through LPS-mediated TLR4\/Myd88\/NF-kappaB pathway and inflammatory changes","volume":"14","author":"Wu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117167_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411790","article-title":"Significance of Lipopolysaccharides in Gastric Cancer and Their Potential as a Biomarker for Nivolumab Sensitivity","volume":"24","author":"Nakazawa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.117167_bib27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/thy.1998.8.737","article-title":"Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from the National Thyroid Cancer Treatment Cooperative Registry","volume":"8","author":"Cooper","year":"1998","journal-title":"Thyroid"},{"key":"10.1016\/j.isci.2026.117167_bib28","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1073\/pnas.1015557108","article-title":"Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice","volume":"108","author":"Franco","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117167_bib29","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tem.2019.05.008","article-title":"Microbiota and Thyroid Interaction in Health and Disease","volume":"30","author":"Fr\u00f6hlich","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.117167_bib30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/femsre\/fuu010","article-title":"Microbial endocrinology: the interplay between the microbiota and the endocrine system","volume":"39","author":"Neuman","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.isci.2026.117167_bib31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12866-022-02739-z","article-title":"Analysis of gut microbiota diversity in Hashimoto's thyroiditis patients","volume":"22","author":"Liu","year":"2022","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.isci.2026.117167_bib32","doi-asserted-by":"crossref","first-page":"14391","DOI":"10.2147\/JIR.S552936","article-title":"Multi-Niche Microbial Profiling in Papillary Thyroid Carcinoma and Thyroid Nodules: Linking Oral, Gut, and Tissue Microbiota","volume":"18","author":"Chang","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.isci.2026.117167_bib33","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1089\/thy.2009.0195","article-title":"Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer","volume":"19","author":"Pilli","year":"2009","journal-title":"Thyroid"},{"key":"10.1016\/j.isci.2026.117167_bib34","article-title":"High Throughput Detection of Variation in Single-Cell Whole transcriptome through Streamlined scFAST-Seq","author":"Sang","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2026.117167_bib35","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2026.117167_bib36","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117167_bib37","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/s41467-021-26343-3","article-title":"Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma","volume":"12","author":"Pu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117167_bib38","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: enriching a GOld mine","volume":"49","author":"Gene Ontology","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117167_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.isci.2026.117167_bib40","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117167_bib41","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2026.117167_bib42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41592-023-02092-7","article-title":"Multigroup analysis of compositions of microbiomes with covariate adjustments and repeated measures","volume":"21","author":"Lin","year":"2024","journal-title":"Nat. Methods"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226025459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226025459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:07:21Z","timestamp":1791594441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226025459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2589004226025459"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117167","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hashimoto\u2019s thyroiditis influences tumor cell states and intratumoral microbiota in papillary thyroid carcinoma","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117167"}}