{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:49:27Z","timestamp":1791596967133,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-20-CE91-0002"],"award-info":[{"award-number":["ANR-20-CE91-0002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["Project I 4939-B"],"award-info":[{"award-number":["Project I 4939-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-U01AI152038"],"award-info":[{"award-number":["NIH-U01AI152038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-P50AR080594"],"award-info":[{"award-number":["NIH-P50AR080594"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-37AI1052453"],"award-info":[{"award-number":["NIH-37AI1052453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010109","name":"Medizinische Universit\u00e4t Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","award":["Type 2 Innovation Grant"],"award-info":[{"award-number":["Type 2 Innovation Grant"]}],"id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.isci.2026.117306","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:33:08Z","timestamp":1787851988000},"page":"117306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A stromal \u03b2-defensin, DEFB124, contributes to cutaneous host defense against Staphylococcus aureus"],"prefix":"10.1016","volume":"29","author":[{"given":"Aaroh","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomofumi","family":"Numata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Roso","family":"Mares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Dokoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kotzbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vocanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaykumar","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-7861","authenticated-orcid":false,"given":"Richard L.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117306_bib1","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1016\/j.cub.2015.11.017","article-title":"Antimicrobial peptides","volume":"26","author":"Zhang","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2026.117306_bib2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri.2016.29","article-title":"The immunology of host defence peptides: beyond antimicrobial activity","volume":"16","author":"Hancock","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib3","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm1616","article-title":"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.117306_bib4","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117306_bib5","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nri1180","article-title":"Defensins: antimicrobial peptides of innate immunity","volume":"3","author":"Ganz","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib6","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.immuni.2022.06.021","article-title":"Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a\/b to prevent skin dysbiosis and bacterial infection","volume":"55","author":"Dong","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.117306_bib7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/jid.2012.319","article-title":"Human Beta-Defensin 3 Induces Maturation of Human Langerhans Cell\u2013Like Dendritic Cells: An Antimicrobial Peptide that Functions as an Endogenous Adjuvant","volume":"133","author":"Ferris","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.isci.2026.117306_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abp9675","article-title":"Human \u03b2-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling","volume":"14","author":"R\u00fcckert","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2026.117306_bib9","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1073\/pnas.042692699","article-title":"Discovery of five conserved \u03b2-defensin gene clusters using a computational search strategy","volume":"99","author":"Schutte","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117306_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2133.2010.09781.x","article-title":"Expression of antimicrobial peptides in cutaneous infections after skin surgery","volume":"163","author":"Kesting","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.isci.2026.117306_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nri3228","article-title":"Epithelial antimicrobial defence of the skin and intestine","volume":"12","author":"Gallo","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib12","doi-asserted-by":"crossref","first-page":"12270","DOI":"10.1074\/jbc.M112.411884","article-title":"The Novel Human \u03b2-Defensin 114 Regulates Lipopolysaccharide (LPS)-mediated Inflammation and Protects Sperm from Motility Loss\u2217","volume":"288","author":"Yu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.117306_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/psc.2611","article-title":"Production and characterization of recombinant human beta-defensin DEFB120","volume":"20","author":"Liu","year":"2014","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.isci.2026.117306_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002289","article-title":"A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility","volume":"3","author":"Tollner","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2026.117306_bib15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/all.70060","article-title":"Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis","volume":"81","author":"D'Avino","year":"2026","journal-title":"Allergy"},{"key":"10.1016\/j.isci.2026.117306_bib16","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.4049\/jimmunol.171.6.3262","article-title":"Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes","volume":"171","author":"Nomura","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tim.2017.11.008","article-title":"Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship","volume":"26","author":"Geoghegan","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.isci.2026.117306_bib18","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jid.2024.01.001","article-title":"Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis","volume":"144","author":"Gallo","year":"2024","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.isci.2026.117306_bib19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.immuni.2015.03.014","article-title":"Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis","volume":"42","author":"Kobayashi","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.117306_bib20","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309243121","article-title":"Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation","volume":"121","author":"Kline","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117306_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/ACI.0b013e328364ddfd","article-title":"Expression of antimicrobial peptides in atopic dermatitis and possible immunoregulatory functions","volume":"13","author":"Kopfnagel","year":"2013","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib22","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.jid.2016.05.127","article-title":"Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression","volume":"136","author":"Nakatsuji","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.isci.2026.117306_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112494","article-title":"Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus","volume":"42","author":"Nakatsuji","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.117306_bib24","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.jaci.2019.06.047","article-title":"Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial","volume":"144","author":"Bissonnette","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib25","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jaci.2019.07.013","article-title":"Oral Janus kinase\/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis","volume":"144","author":"Pavel","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jaci.2020.06.012","article-title":"Atopic dermatitis displays stable and dynamic skin transcriptome signatures","volume":"147","author":"M\u00f6bus","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib27","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jaci.2018.07.028","article-title":"Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab","volume":"143","author":"Brunner","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/420747","article-title":"Genevestigator V3: A Reference Expression Database for the Meta-Analysis of Transcriptomes","volume":"2008","author":"Hruz","year":"2008","journal-title":"Adv. Bioinformatics"},{"key":"10.1016\/j.isci.2026.117306_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/physiolgenomics.00104.2005","article-title":"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract","volume":"23","author":"Patil","year":"2005","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.isci.2026.117306_bib30","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1101\/gr.131029.111","article-title":"Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis","volume":"22","author":"Kong","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.isci.2026.117306_bib31","first-page":"D609","article-title":"UniProt: the Universal Protein Knowledgebase in 2025","volume":"53","author":"Bateman","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117306_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: Tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.isci.2026.117306_bib33","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni732","article-title":"Dermcidin: a novel human antibiotic peptide secreted by sweat glands","volume":"2","author":"Schittek","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib34","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.4049\/jimmunol.174.12.8003","article-title":"Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo","volume":"174","author":"Rieg","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib35","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.jid.2022.12.024","article-title":"The Proteome of Hand Eczema Assessed by Tape Stripping","volume":"143","author":"S\u00f8lberg","year":"2023","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.isci.2026.117306_bib36","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2337\/db20-0188","article-title":"Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers","volume":"69","author":"Theocharidis","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2026.117306_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.18632\/aging.100755","article-title":"Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging","volume":"7","author":"Breitenbach","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.isci.2026.117306_bib38","article-title":"Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19","author":"Tsitsiklis","year":"2021","journal-title":"Res. Sq"},{"key":"10.1016\/j.isci.2026.117306_bib39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4111\/kju.2014.55.6.417","article-title":"Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells","volume":"55","author":"Kim","year":"2014","journal-title":"Korean J. Urol."},{"key":"10.1016\/j.isci.2026.117306_bib40","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1111\/cas.13815","article-title":"Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21","volume":"109","author":"Tanikawa","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.isci.2026.117306_bib41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0888-7543(02)00034-4","article-title":"Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis","volume":"81","author":"Rodr\u00edguez-Jim\u00e9nez","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.isci.2026.117306_bib42","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12964-024-01637-3","article-title":"Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2026.117306_bib43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.1260972","article-title":"Dermal adipocytes protect against invasive Staphylococcus aureus skin infection","volume":"347","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117306_bib44","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jaci.2025.12.1009","article-title":"Staphylococcus aureus in atopic dermatitis: How a common bacterium exploits and drives disease","volume":"157","author":"Chehadeh","year":"2026","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib45","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nri3010","article-title":"Immunity against Staphylococcus aureus cutaneous infections","volume":"11","author":"Miller","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib46","doi-asserted-by":"crossref","first-page":"984","DOI":"10.4049\/jimmunol.179.2.984","article-title":"IL-4 and IL-13 Negatively Regulate TNF-\u03b1- and IFN-\u03b3-Induced \u03b2-Defensin Expression through STAT-6, Suppressor of Cytokine Signaling (SOCS)-1, and SOCS-31","volume":"179","author":"Albanesi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib47","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1128\/IAI.00596-16","article-title":"Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization","volume":"84","author":"Archer","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2026.117306_bib48","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jaci.2023.05.026","article-title":"Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment","volume":"152","author":"Simpson","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib49","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/sj.gt.3302472","article-title":"Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection","volume":"12","author":"Sawamura","year":"2005","journal-title":"Gene Ther."},{"key":"10.1016\/j.isci.2026.117306_bib50","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1128\/IAI.71.7.3730-3739.2003","article-title":"Staphylococcus aureus Susceptibility to Innate Antimicrobial Peptides, \u03b2-Defensins and CAP18, Expressed by Human Keratinocytes","volume":"71","author":"Midorikawa","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2026.117306_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/srep37639","article-title":"Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes","volume":"6","author":"Amos","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117306_bib52","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s00018-002-8493-8","article-title":"The short proline-rich antibacterial peptide family","volume":"59","author":"Otvos","year":"2002","journal-title":"Cel. Mol. Life Sci."},{"key":"10.1016\/j.isci.2026.117306_bib53","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41392-023-01553-x","article-title":"Mechanisms and regulation of defensins in host defense","volume":"8","author":"Fu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.isci.2026.117306_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2025.100436","article-title":"Atopic Dermatitis like mouse model using early inoculation of patient-derived S. aureus together with MC903","volume":"6","author":"Joshi","year":"2026","journal-title":"JID Innov."},{"key":"10.1016\/j.isci.2026.117306_bib55","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/35023079","article-title":"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen","volume":"406","author":"Stover","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117306_bib56","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.jaci.2020.01.042","article-title":"Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis","volume":"145","author":"He","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib57","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/s41423-026-01442-7","article-title":"Fibroblast-derived CCL2 orchestrates immune responses and defends against Staphylococcus aureus skin infection","volume":"23","author":"Dokoshi","year":"2026","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib58","doi-asserted-by":"crossref","first-page":"eads0519","DOI":"10.1126\/sciimmunol.ads0519","article-title":"Psychological stress increases skin infection through the action of TGF\u03b2 to suppress immune-acting fibroblasts","volume":"10","author":"Chan","year":"2025","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2026.117306_bib59","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2--a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117306_bib60","doi-asserted-by":"crossref","first-page":"D1087","DOI":"10.1093\/nar\/gkv1278","article-title":"APD3: the antimicrobial peptide database as a tool for research and education","volume":"44","author":"Wang","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117306_bib61","doi-asserted-by":"crossref","DOI":"10.1172\/JCI196108","article-title":"Dermal fibroblasts respond to interleukin-4 and 13 and promote T-cell recruitment in atopic dermatitis","volume":"136","author":"Numata","year":"2026","journal-title":"J. Clin. Investig."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226026842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226026842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:56:25Z","timestamp":1791593785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226026842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2589004226026842"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117306","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A stromal \u03b2-defensin, DEFB124, contributes to cutaneous host defense against Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117306"}}