{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:50:29Z","timestamp":1791597029663,"version":"4.3.4"},"reference-count":65,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["2017NJMU028"],"award-info":[{"award-number":["2017NJMU028"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.isci.2026.117400","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:47:01Z","timestamp":1788814021000},"page":"117400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nine anthropometric insulin resistance indices predict mortality and life expectancy across glucose states"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0053-8159","authenticated-orcid":false,"given":"Yi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yameng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117400_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11906-009-0010-0","article-title":"Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases","volume":"11","author":"Schulman","year":"2009","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.isci.2026.117400_bib2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1172\/JCI67166","article-title":"Insulin resistance in the vasculature","volume":"123","author":"Mather","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.117400_bib3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12944-023-01981-2","article-title":"Association of cardiometabolic factors and insulin resistance surrogates with mortality in participants from the Korean Genome and Epidemiology Study","volume":"22","author":"Kityo","year":"2023","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.isci.2026.117400_bib4","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1017\/S0265021507001111","article-title":"Correlation of calculated indices of insulin resistance (QUICKI and HOMA) with the euglycaemic hyperinsulinaemic clamp technique for evaluating insulin resistance in critically ill patients","volume":"24","author":"Holzinger","year":"2007","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.isci.2026.117400_bib5","first-page":"1","article-title":"Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research)","volume":"2016","author":"Yang","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.isci.2026.117400_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects","volume":"6","author":"Simental-Mend\u00eda","year":"2008","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"10.1016\/j.isci.2026.117400_bib7","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp","volume":"95","author":"Guerrero-Romero","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.117400_bib8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.numecd.2021.11.017","article-title":"Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome","volume":"32","author":"Son","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.isci.2026.117400_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/4678526","article-title":"Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review","volume":"2020","author":"S\u00e1nchez-Garc\u00eda","year":"2020","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.isci.2026.117400_bib10","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/S2666-7568(22)00247-1","article-title":"Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study","volume":"4","author":"Lopez-Jaramillo","year":"2023","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.isci.2026.117400_bib11","article-title":"Association of the triglyceride-glucose index with all-cause and cause-specific mortality: a population-based cohort study of 3.5 million adults in China","volume":"49","author":"He","year":"2024","journal-title":"Lancet Reg. Health West. Pac."},{"key":"10.1016\/j.isci.2026.117400_bib12","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1311890","article-title":"Cardiovascular risk and events in 17 low-middle-and high-income countries","volume":"371","author":"Yusuf","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.isci.2026.117400_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/eci.12583","article-title":"The TyG index may predict the development of cardiovascular events","volume":"46","author":"S\u00e1nchez-\u00cd\u00f1igo","year":"2016","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.isci.2026.117400_bib14","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.amjmed.2006.01.009","article-title":"Etiology of insulin resistance","volume":"119","author":"Petersen","year":"2006","journal-title":"Am. J. Med."},{"key":"10.1016\/j.isci.2026.117400_bib15","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.117400_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12933-024-02572-w","article-title":"Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank","volume":"24","author":"Qiao","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12933-022-01546-0","article-title":"Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis","volume":"21","author":"Liu","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12933-024-02241-y","article-title":"Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies","volume":"23","author":"Yin","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib19","first-page":"1498","article-title":"Association of triglyceride-glucose index and its combination with adiposity-related indices with the incidence of myocardial infarction: a cohort study from the UK Biobank","volume":"48","author":"Zhou","year":"2024","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.isci.2026.117400_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12933-023-02115-9","article-title":"The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003-2018","volume":"23","author":"Dang","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/a-1766-0202","article-title":"Triglyceride-Glucose Index and the Risk of Stroke: A Systematic Review and Dose-Response Meta-Analysis","volume":"54","author":"Feng","year":"2022","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.isci.2026.117400_bib22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12933-024-02215-0","article-title":"Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome","volume":"23","author":"Wei","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s12933-025-02963-7","article-title":"Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank","volume":"24","author":"Ding","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13098-025-01616-9","article-title":"Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis","volume":"17","author":"Rabiee Rad","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.isci.2026.117400_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2007.12.035","article-title":"Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance","volume":"132","author":"Chibalin","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117400_bib26","doi-asserted-by":"crossref","DOI":"10.2174\/011573403X314035241006185109","article-title":"Insulin Resistance, Hyperinsulinemia and Atherosclerosis: Insights into Pathophysiological Aspects and Future Therapeutic Prospects","volume":"21","author":"Papaetis","year":"2025","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.isci.2026.117400_bib27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1210\/er.2018-00141","article-title":"Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents","volume":"40","author":"Di Pino","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.isci.2026.117400_bib28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s40292-020-00408-8","article-title":"Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes","volume":"27","author":"Mancusi","year":"2020","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"10.1016\/j.isci.2026.117400_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/181643","article-title":"Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and \u03b2-Cell Dysfunction","volume":"2015","author":"Keane","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.isci.2026.117400_bib30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4239\/wjd.v6.i3.456","article-title":"Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus","volume":"6","author":"Tangvarasittichai","year":"2015","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.isci.2026.117400_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12933-022-01548-y","article-title":"TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients","volume":"21","author":"Zhao","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-03138-6","article-title":"A population-based study of TyG index distribution and its relationship to cardiometabolic risk factors in children and adolescents","volume":"11","author":"Yoon","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117400_bib33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12022-013-9288-1","article-title":"Morphological and inflammatory changes in visceral adipose tissue during obesity","volume":"25","author":"Revelo","year":"2014","journal-title":"Endocr. Pathol."},{"key":"10.1016\/j.isci.2026.117400_bib34","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3389\/fphys.2019.01607","article-title":"Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes","volume":"10","author":"Zatterale","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2026.117400_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092828","article-title":"Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4","volume":"12","author":"Renovato-Martins","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2026.117400_bib36","article-title":"Body Roundness Index and Waist-Hip Ratio Result in Better Cardiovascular Disease Risk Stratification: Results From a Large Chinese Cross-Sectional Study","volume":"9","author":"Li","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.isci.2026.117400_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039504","article-title":"A new body shape index predicts mortality hazard independently of body mass index","volume":"7","author":"Krakauer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.117400_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12933-025-02604-z","article-title":"The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker","volume":"24","author":"He","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib39","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.isci.2026.117400_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2026.117400_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.isci.2026.117400_bib42","first-page":"311","article-title":"Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-\u03b2-tubulin mediated synergistic mechanism of \u201cmitophagy-unfolded protein response\u201d and mitophagy","volume":"23","author":"Chang","year":"2025","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.isci.2026.117400_bib43","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jgr.2025.04.006","article-title":"Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model","volume":"49","author":"Pu","year":"2025","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.isci.2026.117400_bib44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1186\/s12951-025-03667-6","article-title":"A novel ligustrazine-based nanodelivery system protects against doxorubicin-induced cardiotoxicity by targeting the SIRT5-DUSP1 axis for mitochondrial repair","volume":"23","author":"Shi","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.isci.2026.117400_bib45","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-025-03420-z","article-title":"Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.isci.2026.117400_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157288","article-title":"Astragaloside VI attenuates mechanical stress-induced cardiac remodeling through piezo1-VDAC1 dependent endoplasmic reticulum unfolded protein response","volume":"148","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.isci.2026.117400_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2024.106650","article-title":"Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies","volume":"175","author":"Wu","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.isci.2026.117400_bib48","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","article-title":"DNA-PKcs-Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia-Induced Cardiac Dysfunction in Type 1 Diabetes","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.isci.2026.117400_bib49","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.7150\/ijbs.102424","article-title":"Targeting mitochondria by lipid-selenium conjugate drug results in malate\/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression","volume":"20","author":"Chang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2026.117400_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101034","article-title":"Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury","volume":"14","author":"Yang","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.isci.2026.117400_bib51","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1002\/ptr.70008","article-title":"Potential Candidates of Natural Antioxidants From Herbs for Treating Lung Disorders: Focus on Redox Balance and Natural Products","volume":"39","author":"Chang","year":"2025","journal-title":"Phytother Res."},{"key":"10.1016\/j.isci.2026.117400_bib52","article-title":"The effect of unhealthy lifestyle on the pathogenesis of sick sinus syndrome: A life-guiding review","volume":"103","author":"Chang","year":"2024","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.isci.2026.117400_bib53","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.7150\/ijbs.95853","article-title":"Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia\/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2026.117400_bib54","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","article-title":"The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction","volume":"22","author":"An","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib55","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12933-025-02921-3","article-title":"Association of the triglyceride-glucose index combined with a body shape index with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stage 0-3: findings from two prospective cohorts","volume":"24","author":"Chen","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib56","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/jcm12031128","article-title":"Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and Risk of All-Cause Mortality and Cardiovascular Mortality: A 20-Year Follow-Up Cohort Study of 42,875 US Adults","volume":"12","author":"Xia","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.isci.2026.117400_bib57","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1186\/s40001-025-02611-6","article-title":"Association of the systemic immune-inflammatory index and systemic inflammatory response index with all-cause and cardiovascular mortality in individuals with metabolic inflammatory syndrome","volume":"30","author":"Jiang","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.isci.2026.117400_bib58","doi-asserted-by":"crossref","first-page":"E4104","DOI":"10.1073\/pnas.1506264112","article-title":"Quantification of biological aging in young adults","volume":"112","author":"Belsky","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117400_bib59","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.mad.2005.10.004","article-title":"A new approach to the concept and computation of biological age","volume":"127","author":"Klemera","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.isci.2026.117400_bib60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12933-025-02587-x","article-title":"The association between novel metabolic parameters and all-cause\/cardiovascular mortality in patients with metabolic syndrome is modified by age","volume":"24","author":"Liu","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2026.117400_bib61","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Despr\u00e9s","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117400_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70400","article-title":"Association Between Dietary Alcohol Intake and Migraine or Severe Headache Miscellaneous Pain: The NHANES 1999-2004","volume":"15","author":"Tang","year":"2025","journal-title":"Brain Behav."},{"key":"10.1016\/j.isci.2026.117400_bib63","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-025-03524-0","article-title":"Dietary antioxidants and CKM-depression comorbidity: a primary analysis with a secondary evaluation of all-cause mortality using six machine learning algorithms","volume":"30","author":"Tang","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.isci.2026.117400_bib64","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2337\/dc13-2357","article-title":"Cardiovascular risk profile in subjects with prediabetes and new-onset type 2 diabetes identified by HbA(1c) according to American Diabetes Association criteria","volume":"37","author":"Di Pino","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.isci.2026.117400_bib65","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/dme.12691","article-title":"Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age","volume":"32","author":"Woo","year":"2015","journal-title":"Diabet. Med."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226027781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226027781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:16:17Z","timestamp":1791594977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226027781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2589004226027781"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117400","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nine anthropometric insulin resistance indices predict mortality and life expectancy across glucose states","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117400"}}