{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:50:17Z","timestamp":1791597017433,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP230103097"],"award-info":[{"award-number":["DP230103097"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2030\/21"],"award-info":[{"award-number":["2030\/21"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1394\/25"],"award-info":[{"award-number":["1394\/25"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2825\/22"],"award-info":[{"award-number":["2825\/22"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010800","name":"Hadassah Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020909","name":"Australia Israel Medical Research Improving Global Health Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1156567"],"award-info":[{"award-number":["APP1156567"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.isci.2026.117482","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:50:55Z","timestamp":1788868255000},"page":"117482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preterm birth disrupts nephron progenitor cell dynamics predisposing to renal disease"],"prefix":"10.1016","volume":"29","author":[{"given":"Athar","family":"Amleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Piran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L.M.","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviad","family":"Schnapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Combes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oded","family":"Volovelsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-4448","authenticated-orcid":false,"given":"Morris","family":"Nechama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117482_bib1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/S0140-6736(25)01853-7","article-title":"Global, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023","volume":"406","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.117482_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.isci.2026.117482_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.161316","article-title":"Low nephron endowment increases susceptibility to renal stress and chronic kidney disease","volume":"8","author":"Good","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2026.117482_bib4","doi-asserted-by":"crossref","DOI":"10.5041\/RMMJ.10061","article-title":"Low nephron number and its clinical consequences","volume":"2","author":"Luyckx","year":"2011","journal-title":"Rambam Maimonides Med. J."},{"key":"10.1016\/j.isci.2026.117482_bib5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00467-020-04534-2","article-title":"Nephron number and its determinants: a 2020 update","volume":"36","author":"Charlton","year":"2021","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib6","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1111\/j.1523-1755.2005.09712.x","article-title":"Low birth weight, nephron number, and kidney disease","author":"Luyckx","year":"2005","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.isci.2026.117482_bib7","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1001\/archinte.165.8.923","article-title":"Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease","volume":"165","author":"Hsu","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.isci.2026.117482_bib8","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0140-6736(23)00878-4","article-title":"National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis","volume":"402","author":"Ohuma","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.117482_bib9","doi-asserted-by":"crossref","DOI":"10.2196\/42271","article-title":"Improving Prediction of Survival for Extremely Premature Infants Born at 23 to 29 Weeks Gestational Age in the Neonatal Intensive Care Unit: Development and Evaluation of Machine Learning Models","volume":"12","author":"Li","year":"2024","journal-title":"JMIR Med. Inform."},{"key":"10.1016\/j.isci.2026.117482_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/children11101213","article-title":"Preterm Birth and Kidney Health: From the Womb to the Rest of Life","volume":"11","author":"Tain","year":"2024","journal-title":"Children"},{"key":"10.1016\/j.isci.2026.117482_bib11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ebiom.2017.12.016","article-title":"Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants","volume":"27","author":"Ryan","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.isci.2026.117482_bib12","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ekir.2023.10.032","article-title":"Human Nephrogenesis can Persist Beyond 40 Postnatal Days in Preterm Infants","volume":"9","author":"Carpenter","year":"2024","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.isci.2026.117482_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1363097","article-title":"Impact of preterm birth on kidney health and development","volume":"11","author":"Deffrennes","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.isci.2026.117482_bib14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fped.2020.00230","article-title":"Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature","volume":"8","author":"Sanderson","year":"2020","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.isci.2026.117482_bib15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.2215\/CJN.0000000000000517","article-title":"Preterm Births Increases the Odds for Glomerular Diseases","volume":"19","author":"Critzer-Fox","year":"2024","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrneph.2014.251","article-title":"Birth weight, malnutrition and kidney-associated outcomes--a global concern","volume":"11","author":"Luyckx","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib17","article-title":"Nephrotoxic Medications and Associated Acute Kidney Injury in Very Low Birth Weight Infants","volume":"4","author":"Barhight","year":"2017","journal-title":"J. Clin. Nephrol. Res."},{"key":"10.1016\/j.isci.2026.117482_bib18","article-title":"Kidney Injuries and Evolution of Chronic Kidney Diseases Due to Neonatal Hyperoxia Exposure Based on Animal Studies","volume":"23","author":"Huang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.117482_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00489-y","article-title":"Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth","volume":"11","author":"Cwiek","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117482_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-00103-5","article-title":"Preterm birth increases susceptibility to hyperglycemia induced glomerular alterations in male mice","volume":"15","author":"Cwiek","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117482_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-65844-1","article-title":"Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats","volume":"14","author":"DeFreitas","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117482_bib22","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008300","article-title":"Mammalian kidney development: principles, progress, and projections","volume":"4","author":"Little","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.isci.2026.117482_bib23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/bs.ctdb.2015.10.010","article-title":"Development of the Mammalian Kidney","volume":"117","author":"McMahon","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.isci.2026.117482_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.stem.2008.05.020","article-title":"Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development","volume":"3","author":"Kobayashi","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2026.117482_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13073-019-0615-0","article-title":"Single-cell analysis reveals congruence between kidney organoids and human fetal kidney","volume":"11","author":"Combes","year":"2019","journal-title":"Genome Med."},{"key":"10.1016\/j.isci.2026.117482_bib26","doi-asserted-by":"crossref","DOI":"10.1242\/dev.197475","article-title":"Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF","volume":"148","author":"Li","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.117482_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094867","article-title":"The Impact of Mouse Preterm Birth Induction by RU-486 on Microglial Activation and Subsequent Hypomyelination","volume":"23","author":"Morin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2026.117482_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-213X-11-15","article-title":"Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production","volume":"11","author":"Brunskill","year":"2011","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.isci.2026.117482_bib29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ydbio.2007.08.021","article-title":"Cessation of renal morphogenesis in mice","volume":"310","author":"Hartman","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2026.117482_bib30","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1073\/pnas.1712955115","article-title":"Hamartin regulates cessation of mouse nephrogenesis independently of Mtor","volume":"115","author":"Volovelsky","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117482_bib31","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41581-022-00620-w","article-title":"Regulation of nephron progenitor cell lifespan and nephron endowment","volume":"18","author":"Perl","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib32","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1101\/gad.10.12.1467","article-title":"Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2","volume":"10","author":"Hatini","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2026.117482_bib33","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1681\/ASN.2020040401","article-title":"Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction","volume":"31","author":"Huh","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib34","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.devcel.2012.04.018","article-title":"FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man","volume":"22","author":"Barak","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.117482_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jtbi.2013.08.033","article-title":"Modelling cell turnover in a complex tissue during development","volume":"338","author":"Lefevre","year":"2013","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.isci.2026.117482_bib36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.devcel.2014.02.017","article-title":"Global quantification of tissue dynamics in the developing mouse kidney","volume":"29","author":"Short","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.117482_bib37","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1681\/ASN.2016111246","article-title":"Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism","volume":"28","author":"Liu","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib38","article-title":"Defining the dynamic chromatin landscape of mouse nephron progenitors","volume":"8","author":"Hilliard","year":"2019","journal-title":"Biol. Open"},{"key":"10.1016\/j.isci.2026.117482_bib39","doi-asserted-by":"crossref","first-page":"F1668","DOI":"10.1152\/ajprenal.00163.2009","article-title":"Is nephrogenesis affected by preterm birth? Studies in a non-human primate model","volume":"297","author":"Gubhaju","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.isci.2026.117482_bib40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1203\/PDR.0b013e3181975f52","article-title":"The effects of postnatal retinoic acid administration on nephron endowment in the preterm baboon kidney","volume":"65","author":"Sutherland","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.isci.2026.117482_bib41","article-title":"Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk","volume":"146","author":"Combes","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.117482_bib42","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1681\/ASN.2017080890","article-title":"Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney","volume":"29","author":"Lindstr\u00f6m","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib43","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s00467-010-1747-z","article-title":"Role of fibroblast growth factor receptor signaling in kidney development","volume":"26","author":"Bates","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib44","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/dev.040287","article-title":"Non-cell-autonomous retinoid signaling is crucial for renal development","volume":"137","author":"Rosselot","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.117482_bib45","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.stemcr.2015.01.021","article-title":"The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through \u03b2-catenin signaling","volume":"4","author":"Lindstr\u00f6m","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.isci.2026.117482_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111777","article-title":"Ferroptosis contributed to endoplasmic reticulum stress in preterm birth by targeting LHX1 and IRE-1","volume":"132","author":"Qiu","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.isci.2026.117482_bib47","article-title":"LIM homeobox 1 (LHX1) induces endoplasmic reticulum stress and promotes preterm birth","volume":"10","author":"Qiu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.isci.2026.117482_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphys.2025.100152","article-title":"From acute tubular injury to tubular repair and chronic kidney diseases - KIM-1 as a promising biomarker for predicting renal tubular pathology","volume":"8","author":"Zhang","year":"2025","journal-title":"Curr. Res. Physiol."},{"key":"10.1016\/j.isci.2026.117482_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10024-003-3029-2","article-title":"Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants","volume":"7","author":"Rodr\u00edguez","year":"2004","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.isci.2026.117482_bib50","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.devcel.2019.10.005","article-title":"Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney","volume":"51","author":"Ransick","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.117482_bib51","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1681\/ASN.2010121266","article-title":"Accelerated maturation and abnormal morphology in the preterm neonatal kidney","volume":"22","author":"Sutherland","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib52","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1017\/S2040174420001208","article-title":"Renal morphology and glomerular capillarisation in young adult sheep born moderately preterm","volume":"12","author":"Sutherland","year":"2021","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.isci.2026.117482_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/nu15194207","article-title":"Nutrition and Developmental Origins of Kidney Disease","volume":"15","author":"Nguyen","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2026.117482_bib54","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1046\/j.1523-1755.2003.00018.x","article-title":"Glomerular number and size in autopsy kidneys: the relationship to birth weight","volume":"63","author":"Hughson","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.isci.2026.117482_bib55","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1681\/ASN.2004090783","article-title":"Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation","volume":"16","author":"Keijzer-Veen","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1124\/pr.109.002071","article-title":"Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines","volume":"62","author":"Gillies","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.isci.2026.117482_bib57","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/1933719111401659","article-title":"Preterm birth and the kidney: implications for long-term renal health","volume":"18","author":"Gubhaju","year":"2011","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.isci.2026.117482_bib58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.celrep.2014.02.033","article-title":"The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment","volume":"7","author":"Cebrian","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.117482_bib59","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.1038\/s41598-021-89326-w","article-title":"Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2","volume":"11","author":"Meijer","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117482_bib60","doi-asserted-by":"crossref","first-page":"54010","DOI":"10.18632\/oncotarget.9833","article-title":"New insights into the unfolded protein response in stem cells","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2026.117482_bib61","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1681\/ASN.2016060666","article-title":"Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment","volume":"28","author":"Tonneijck","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2026.117482_bib62","article-title":"Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study","volume":"365","author":"Crump","year":"2019","journal-title":"Br. Med. J."},{"key":"10.1016\/j.isci.2026.117482_bib63","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/bmj.320.7240.967","article-title":"Association between postnatal catch-up growth and obesity in childhood: prospective cohort study","volume":"320","author":"Ong","year":"2000","journal-title":"Br. Med. J."},{"key":"10.1016\/j.isci.2026.117482_bib64","first-page":"319","article-title":"Growth of preterm born children","volume":"70","author":"Euser","year":"2008","journal-title":"Horm. Res."},{"key":"10.1016\/j.isci.2026.117482_bib65","article-title":"Tauroursodeoxycholic Acid (TUDCA) Reduces ER Stress and Lessens Disease Activity in Ulcerative Colitis","author":"Lamm","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.isci.2026.117482_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.674316","article-title":"Suppression of Endoplasmic Reticulum Stress by 4-PBA Protects Against Hyperoxia-Induced Acute Lung Injury via Up-Regulating Claudin-4 Expression","volume":"12","author":"Pao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.117482_bib67","author":"Andrews"},{"key":"10.1016\/j.isci.2026.117482_bib68","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbae076","article-title":"Improve-RRBS: a novel tool to correct the 3' trimming of reduced representation sequencing reads","volume":"4","author":"F\u00f3thi","year":"2024","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.isci.2026.117482_bib69","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s13104-024-06951-0","article-title":"Sequence-matching adapter trimmers generate consistent quality and assembly metrics for Illumina sequencing of RNA viruses","volume":"17","author":"Nabakooza","year":"2024","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.isci.2026.117482_bib70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117482_bib71","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117482_bib72","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117482_bib73","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117482_bib74","doi-asserted-by":"crossref","first-page":"W207","DOI":"10.1093\/nar\/gkad347","article-title":"g:Profiler-interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update)","volume":"51","author":"Kolberg","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117482_bib75","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117482_bib76","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117482_bib77","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.devcel.2010.04.008","article-title":"Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development","volume":"18","author":"Costantini","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.117482_bib78","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1681\/ASN.2020091321","article-title":"Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney","volume":"32","author":"Makayes","year":"2021","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226028610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226028610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:09:48Z","timestamp":1791594588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226028610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":78,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2589004226028610"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117482","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preterm birth disrupts nephron progenitor cell dynamics predisposing to renal disease","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117482"}}