{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:24:28Z","timestamp":1794349468316,"version":"4.9.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2020-01665"],"award-info":[{"award-number":["2020-01665"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["211222"],"award-info":[{"award-number":["211222"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["22 2186"],"award-info":[{"award-number":["22 2186"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1158732"],"award-info":[{"award-number":["GNT1158732"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1175388"],"award-info":[{"award-number":["GNT1175388"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP220101352"],"award-info":[{"award-number":["DP220101352"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP170100823"],"award-info":[{"award-number":["DP170100823"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022890","name":"M Riewoldt Holdings Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.isci.2026.117515","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:58:51Z","timestamp":1789466331000},"page":"117515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["RpS19a depletion alters the hematopoietic translatome to drive tissue overgrowth"],"prefix":"10.1016","volume":"29","author":[{"given":"Naomi C.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Chahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Javaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf B.","family":"Schittenhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lorent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Rug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amee J.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Eyras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Shirokikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa T.","family":"Bonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie M.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-6382","authenticated-orcid":false,"given":"Olga","family":"Zaytseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117515_bib1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/nar\/gkz637","article-title":"Hallmarks of ribosomopathies","volume":"48","author":"Kampen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1242\/dmm.020529","article-title":"Ribosomopathies: how a common root can cause a tree of pathologies","volume":"8","author":"Danilova","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.isci.2026.117515_bib3","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1182\/blood-2009-10-178129","article-title":"Ribosomopathies: human disorders of ribosome dysfunction","volume":"115","author":"Narla","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib4","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1182\/blood-2011-08-375972","article-title":"Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry","volume":"119","author":"Vlachos","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V128.22.333.333","article-title":"Myelodysplastic Syndrome and Gastrointestinal Carcinomas Characterize the Cancer Risk in Diamond Blackfan Anemia: A Report from the Diamond Blackfan Anemia Registry","volume":"128","author":"Vlachos","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib6","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1182\/blood-2018-05-848937","article-title":"Increased risk of colon cancer and osteogenic sarcoma in Diamond-Blackfan anemia","volume":"132","author":"Vlachos","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3324\/haematol.2017.178111","article-title":"Cancer in the National Cancer Institute inherited bone marrow failure syndrome cohort after fifteen years of follow-up","volume":"103","author":"Alter","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.isci.2026.117515_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/genes13010056","article-title":"Early Onset Colorectal Cancer: An Emerging Cancer Risk in Patients with Diamond Blackfan Anemia","volume":"13","author":"Lipton","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.isci.2026.117515_bib9","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1182\/blood-2014-10-569616","article-title":"Ribosomopathies and the paradox of cellular hypo- to hyperproliferation","volume":"125","author":"De Keersmaecker","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.15252\/emmm.201606660","article-title":"Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations","volume":"9","author":"Ajore","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.isci.2026.117515_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/5951","article-title":"The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia","volume":"21","author":"Draptchinskaia","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.117515_bib12","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1182\/blood-2010-07-295238","article-title":"Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells","volume":"117","author":"Dutt","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib13","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1182\/blood-2011-08-371963","article-title":"Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia","volume":"118","author":"Jaako","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib14","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1182\/blood-2011-06-358200","article-title":"Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts","volume":"119","author":"Horos","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2026.1832877","article-title":"From ribosomopathies to therapeutic targets: ribosomal alterations in pediatric leukemogenesis and tumorigenesis","volume":"16","author":"Horochowska","year":"2026","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2026.117515_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0020139","article-title":"Many ribosomal protein genes are cancer genes in zebrafish","volume":"2","author":"Amsterdam","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.isci.2026.117515_bib17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1534\/genetics.105.045021","article-title":"A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation","volume":"171","author":"Coelho","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.isci.2026.117515_bib18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1534\/genetics.104.034124","article-title":"Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster","volume":"169","author":"Marygold","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.isci.2026.117515_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002408","article-title":"Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone","volume":"7","author":"Lin","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.isci.2026.117515_bib20","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/nar\/gkq931","article-title":"The Bowen\u2013Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of \u03a81191 in yeast 18S rRNA","volume":"39","author":"Meyer","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib21","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1093\/nar\/gkp1189","article-title":"The ribosome assembly factor Nep1 responsible for Bowen\u2013Conradi syndrome is a pseudouridine-N1-specific methyltransferase","volume":"38","author":"Wurm","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib22","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/nar\/gkm1172","article-title":"The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site","volume":"36","author":"Taylor","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib23","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ajhg.2009.04.017","article-title":"Mutation of a Gene Essential for Ribosome Biogenesis, EMG1, Causes Bowen-Conradi Syndrome","volume":"84","author":"Armistead","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.isci.2026.117515_bib24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1534-5807(03)00335-6","article-title":"Thicker Than Blood Conserved Mechanisms in Drosophila and Vertebrate Hematopoiesis","volume":"5","author":"Evans","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2026.117515_bib25","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.01837","article-title":"The Drosophila lymph gland as a developmental model of hematopoiesis","volume":"132","author":"Jung","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.117515_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1242\/dev.043943","article-title":"Hematopoietic stem cells in Drosophila","volume":"137","author":"Minakhina","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.117515_bib27","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ydbio.2010.08.003","article-title":"Hematopoietic progenitors and hemocyte lineages in the Drosophila lymph gland","volume":"346","author":"Krzemien","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2026.117515_bib28","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1073\/pnas.0436940100","article-title":"Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila","volume":"100","author":"Kurucz","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117515_bib29","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/humu.21383","article-title":"The ribosomal basis of diamond-blackfan anemia: mutation and database update","volume":"31","author":"Boria","year":"2010","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.isci.2026.117515_bib30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1083\/jcb.201005117","article-title":"Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits","volume":"190","author":"O\u2019Donohue","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.isci.2026.117515_bib31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.molcel.2010.09.024","article-title":"The Nucleolus under Stress","volume":"40","author":"Boulon","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.117515_bib32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bbadis.2013.12.013","article-title":"Nucleolar stress in Diamond Blackfan anemia pathophysiology","volume":"1842","author":"Ellis","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2026.117515_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4161\/nucl.23944","article-title":"Nucleolar stress in Drosophila melanogaster: RNAi-mediated depletion of Nopp140","volume":"4","author":"James","year":"2013","journal-title":"Nucleus"},{"key":"10.1016\/j.isci.2026.117515_bib34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00412-014-0490-9","article-title":"Deletion of Drosophila Nopp140 induces subcellular ribosomopathies","volume":"124","author":"He","year":"2015","journal-title":"Chromosoma"},{"key":"10.1016\/j.isci.2026.117515_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112587","article-title":"JNK signaling coordinates epithelial cell turnover through exocytosis in Drosophila ribosomal protein mutants","volume":"28","author":"Akai","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.isci.2026.117515_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature05650","article-title":"Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre","volume":"446","author":"Krzemie\u0144","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117515_bib37","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature05585","article-title":"A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors","volume":"446","author":"Mandal","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117515_bib38","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1242\/dev.122.12.4023","article-title":"A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila","volume":"122","author":"Rehorn","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.isci.2026.117515_bib39","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1074-7613(00)80410-0","article-title":"Croquemort, A Novel Drosophila Hemocyte\/Macrophage Receptor that Recognizes Apoptotic Cells","volume":"4","author":"Franc","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.117515_bib40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/dbio.2000.0123","article-title":"Postembryonic Hematopoiesis in Drosophila","volume":"230","author":"Lanot","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2026.117515_bib41","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1038\/s41467-020-18135-y","article-title":"Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila","volume":"11","author":"Cho","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117515_bib42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2026.117515_bib43","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.isci.2026.117515_bib44","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1126\/science.288.5463.146","article-title":"Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors","volume":"288","author":"Lebestky","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117515_bib45","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1080\/15384101.2019.1598725","article-title":"Dynamics of protein synthesis and degradation through the cell cycle","volume":"18","author":"Alber","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.isci.2026.117515_bib46","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.bbadis.2013.11.004","article-title":"Human diseases of the SSU processome","volume":"1842","author":"Sondalle","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2026.117515_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.88","article-title":"Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro","volume":"3","author":"Moniz","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2026.117515_bib48","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1093\/nar\/gkab606","article-title":"Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching","volume":"50","author":"Hopes","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib49","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ydbio.2005.04.018","article-title":"The expression profile of purified Drosophila germline stem cells","volume":"283","author":"Kai","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2026.117515_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1473","article-title":"Translation initiation by cap-dependent ribosome recruitment: Recent insights and open questions","volume":"9","author":"Shirokikh","year":"2018","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.isci.2026.117515_bib51","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nature18647","article-title":"Dynamics of ribosome scanning and recycling revealed by translation complex profiling","volume":"535","author":"Archer","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117515_bib52","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.molcel.2020.06.004","article-title":"Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes","volume":"79","author":"Wagner","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.117515_bib53","doi-asserted-by":"crossref","first-page":"8704","DOI":"10.1093\/nar\/gkw559","article-title":"Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation","volume":"44","author":"Kozel","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib54","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/bioinformatics\/btr146","article-title":"anota: analysis of differential translation in genome-wide studies","volume":"27","author":"Larsson","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117515_bib55","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz223","article-title":"Generally applicable transcriptome-wide analysis of translation using anota2seq","volume":"47","author":"Oertlin","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib56","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00294-001-0269-4","article-title":"Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis","volume":"40","author":"Eschrich","year":"2002","journal-title":"Curr. Genet."},{"key":"10.1016\/j.isci.2026.117515_bib57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-213X-10-99","article-title":"EMG1 is essential for mouse pre-implantation embryo development","volume":"10","author":"Wu","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.isci.2026.117515_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2025.102330","article-title":"Modification of the RNA methylome in neurodevelopmental disorders","volume":"92","author":"PerezGrovas-Saltijeral","year":"2025","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.isci.2026.117515_bib59","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1091\/mbc.12.11.3644","article-title":"Novel Stress-responsive Genes EMG1 and NOP14 Encode Conserved, Interacting Proteins Required for 40S Ribosome Biogenesis","volume":"12","author":"Liu","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.isci.2026.117515_bib60","doi-asserted-by":"crossref","first-page":"38177","DOI":"10.1074\/jbc.M506916200","article-title":"Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis","volume":"280","author":"L\u00e9ger-Silvestre","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.117515_bib61","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nmeth.4577","article-title":"Highly parallel direct RNA sequencing on an array of nanopores","volume":"15","author":"Garalde","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2026.117515_bib62","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00438-006-0132-x","article-title":"Genetic evidence for 18S rRNA binding and an Rps19p assembly function of yeast nucleolar protein Nep1p","volume":"276","author":"Buchhaupt","year":"2006","journal-title":"Mol. Genet. Genomics."},{"key":"10.1016\/j.isci.2026.117515_bib63","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200114","article-title":"Ribosomal proteins: mutant phenotypes by the numbers and associated gene expression changes","volume":"10","author":"Polymenis","year":"2020","journal-title":"Open Biol."},{"key":"10.1016\/j.isci.2026.117515_bib64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood.V30.2.251.251","article-title":"Riddle: What Do Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria (PNH) and \u201cHypoplastic\u201d Leukemia Have in Common?","volume":"30","author":"Dameshek","year":"1967","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib65","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molcel.2005.09.005","article-title":"Roles of Eukaryotic Ribosomal Proteins in Maturation and Transport of Pre-18S rRNA and Ribosome Function","volume":"20","author":"Ferreira-Cerca","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.117515_bib66","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.molcel.2007.09.029","article-title":"Analysis of the In Vivo Assembly Pathway of Eukaryotic 40S Ribosomal Proteins","volume":"28","author":"Ferreira-Cerca","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.117515_bib67","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nsmb.3442","article-title":"Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements","volume":"24","author":"Ferretti","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.isci.2026.117515_bib68","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2014.10.001","article-title":"Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex","volume":"159","author":"Hussain","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117515_bib69","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molcel.2009.03.006","article-title":"How Common Are Extraribosomal Functions of Ribosomal Proteins?","volume":"34","author":"Warner","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.117515_bib70","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.117515_bib71","doi-asserted-by":"crossref","first-page":"35205","DOI":"10.18632\/oncotarget.26231","article-title":"Rise of the specialized onco-ribosomes","volume":"9","author":"Kampen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2026.117515_bib72","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41392-021-00728-8","article-title":"Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy","volume":"6","author":"Kang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2026.117515_bib73","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1016\/S0021-9258(18)32356-1","article-title":"Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis","volume":"258","author":"Duncan","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.117515_bib74","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1365-2958.2002.03172.x","article-title":"Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function","volume":"46","author":"von der Haar","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.isci.2026.117515_bib75","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1017\/S135583820100108X","article-title":"The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5\u2032 secondary structure","volume":"7","author":"Svitkin","year":"2001","journal-title":"RNA"},{"key":"10.1016\/j.isci.2026.117515_bib76","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrm2838","article-title":"The mechanism of eukaryotic translation initiation and principles of its regulation","volume":"11","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.117515_bib77","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tibs.2017.03.004","article-title":"Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation","volume":"42","author":"Hinnebusch","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2026.117515_bib78","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/35002118","article-title":"The joining of ribosomal subunits in eukaryotes requires eIF5B","volume":"403","author":"Pestova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117515_bib79","doi-asserted-by":"crossref","first-page":"12052","DOI":"10.1093\/nar\/gku877","article-title":"eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning","volume":"42","author":"Pisareva","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib80","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2018.02.036","article-title":"Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis","volume":"173","author":"Khajuria","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117515_bib81","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1126\/science.aad9868","article-title":"Translational control by 5\u2032-untranslated regions of eukaryotic mRNAs","volume":"352","author":"Hinnebusch","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117515_bib82","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tibs.2021.07.001","article-title":"Translational control through ribosome heterogeneity and functional specialization","volume":"47","author":"Gay","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2026.117515_bib83","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1212642","article-title":"The Structure of the Eukaryotic Ribosome at 3.0 \u00c5 Resolution","volume":"334","author":"Ben-Shem","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117515_bib84","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nsmb.3111","article-title":"Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis","volume":"22","author":"Chaker-Margot","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.isci.2026.117515_bib85","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1093\/nar\/gkw244","article-title":"Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans","volume":"44","author":"Meyer","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107611","article-title":"Loss of m1acp3\u03a8 Ribosomal RNA Modification Is a Major Feature of Cancer","volume":"31","author":"Babaian","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.117515_bib87","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1182\/blood-2006-07-038232","article-title":"Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits","volume":"109","author":"Flygare","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117515_bib88","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bcmd.2007.02.001","article-title":"Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production","volume":"39","author":"Idol","year":"2007","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.isci.2026.117515_bib89","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nature12104","article-title":"Structures of the human and Drosophila 80S ribosome","volume":"497","author":"Anger","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117515_bib90","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/bs.mcb.2017.03.011","article-title":"A new method for cryo-sectioning cell monolayers using a correlative workflow","volume":"140","author":"Kolovou","year":"2017","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.isci.2026.117515_bib91","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11103-012-9885-2","article-title":"miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs","volume":"80","author":"Xie","year":"2012","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.isci.2026.117515_bib92","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.4049\/jimmunol.1502062","article-title":"Characterization of the Antigen Processing Machinery and Endogenous Peptide Presentation of a Bat MHC Class I Molecule","volume":"196","author":"Wynne","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.isci.2026.117515_bib93","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1101\/pdb.prot074351","article-title":"Inducing RNAi in Drosophila Cells by Transfection with dsRNA","volume":"2013","author":"Zhou","year":"2013","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.isci.2026.117515_bib94","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaa620","article-title":"Decoding the epitranscriptional landscape from native RNA sequences","volume":"49","author":"Jenjaroenpun","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117515_bib95","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117515_bib96","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2026.117515_bib97","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226028944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226028944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:38:33Z","timestamp":1794346713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226028944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":97,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2589004226028944"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117515","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RpS19a depletion alters the hematopoietic translatome to drive tissue overgrowth","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117515"}}