{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:24:37Z","timestamp":1794349477677,"version":"4.9.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.isci.2026.117646","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:24:33Z","timestamp":1790781873000},"page":"117646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity"],"prefix":"10.1016","volume":"29","author":[{"given":"Davide","family":"D\u2019Amico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Faitg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Ballihaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ane M.","family":"Fouassier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Tissot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Laboureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Hennighausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Kron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Marat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Jouy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie F.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayan\u00e9","family":"Azadiguian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Guillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Thierry","family":"Simonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Rinsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5717-4560","authenticated-orcid":false,"given":"Anurag","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117646_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/930164","article-title":"Skin photoaging and the role of antioxidants in its prevention","volume":"2013","author":"Pandel","year":"2013","journal-title":"ISRN Dermatol."},{"key":"10.1016\/j.isci.2026.117646_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/15569520701622951","article-title":"Structural characteristics of the aging skin: a review","volume":"26","author":"Farage","year":"2007","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.isci.2026.117646_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/path.2098","article-title":"Skin ageing and its treatment","volume":"211","author":"Baumann","year":"2007","journal-title":"J. Pathol."},{"key":"10.1016\/j.isci.2026.117646_bib4","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jid.2020.11.006","article-title":"Inflammaging and the Skin","volume":"141","author":"Pilkington","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.isci.2026.117646_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1297637","article-title":"The role of cellular senescence in skin aging and age-related skin pathologies","volume":"14","author":"Chin","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2026.117646_bib6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/archderm.143.5.606","article-title":"Improvement of naturally aged skin with vitamin A (retinol)","volume":"143","author":"Kafi","year":"2007","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.isci.2026.117646_bib7","first-page":"s3","article-title":"SUPPLEMENT ARTICLE: Effectiveness of Retinol for Skin Health","volume":"21","author":"Mariwalla","year":"2022","journal-title":"J. Drugs Dermatol. JDD"},{"key":"10.1016\/j.isci.2026.117646_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.molmed.2021.04.009","article-title":"Impact of the Natural Compound Urolithin A on Health, Disease, and Aging","volume":"27","author":"D\u2019Amico","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.isci.2026.117646_bib9","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.44279","article-title":"Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial","volume":"5","author":"Liu","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.isci.2026.117646_bib10","article-title":"Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults","volume":"3","author":"Singh","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.isci.2026.117646_bib11","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1038\/s43587-025-00996-x","article-title":"Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial","volume":"5","author":"Denk","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.isci.2026.117646_bib20","article-title":"Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers","volume":"28","author":"Liu","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.isci.2026.117646_bib21","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1186\/gb-2013-14-7-r75","article-title":"Gene expression changes with age in skin, adipose tissue, blood and brain","volume":"14","author":"Glass","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2026.117646_bib22","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.2353\/ajpath.2006.051302","article-title":"Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation","volume":"168","author":"Varani","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2026.117646_bib23","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1046\/j.1365-2133.2002.04694.x","article-title":"Smoking affects collagen synthesis and extracellular matrix turnover in human skin","volume":"146","author":"Knuutinen","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.isci.2026.117646_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/ics.12524","article-title":"Localization, fate and interactions of Emilin-1 in human skin","volume":"41","author":"Fitoussi","year":"2019","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.isci.2026.117646_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ajhg.2018.02.018","article-title":"Bi-allelic Alterations in AEBP1 Lead to Defective Collagen Assembly and Connective Tissue Structure Resulting in a Variant of Ehlers-Danlos Syndrome","volume":"102","author":"Blackburn","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.isci.2026.117646_bib26","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117646_bib29","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.cell.2025.03.011","article-title":"From geroscience to precision geromedicine: Understanding and managing aging","volume":"188","author":"Kroemer","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117646_bib30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2133.1975.tb05113.x","article-title":"The influence of age and sex on skin thickness, skin collagen and density","volume":"93","author":"Shuster","year":"1975","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.isci.2026.117646_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2022.112462","article-title":"Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy","volume":"232","author":"Liu","year":"2022","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.isci.2026.117646_bib18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.isci.2026.117646_bib16","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/00006534-200111000-00049","article-title":"A classification of facial wrinkles","volume":"108","author":"Lemperle","year":"2001","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.isci.2026.117646_bib12","article-title":"Induction and Validation of Cellular Senescence in Primary Human Cells","volume":"21","author":"Hernandez-Segura","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.isci.2026.117646_bib13","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.mex.2015.11.001","article-title":"Sequential fractionation and isolation of subcellular proteins from tissue or cultured cells","volume":"2","author":"Baghirova","year":"2015","journal-title":"MethodsX"},{"key":"10.1016\/j.isci.2026.117646_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.freeradbiomed.2022.01.029","article-title":"Oxidative damage prevention in human skin and sensory neurons by a salicylic acid derivative","volume":"181","author":"Lavigne","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2026.117646_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jprot.2013.05.008","article-title":"Proteomic quantification and identification of carbonylated proteins upon oxidative stress and during cellular aging","volume":"92","author":"Baraibar","year":"2013","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.isci.2026.117646_bib17","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117646_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226030270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226030270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:47:27Z","timestamp":1794347247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226030270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2589004226030270"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117646","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117646","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117646"}}