{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:24:24Z","timestamp":1794349464355,"version":"4.9.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS099586"],"award-info":[{"award-number":["R01NS099586"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.isci.2026.117673","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:48:50Z","timestamp":1790797730000},"page":"117673","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Midline thalamic neurons show early hypersynchrony during absence seizures in mouse models"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-0509","authenticated-orcid":false,"given":"Elzbieta","family":"Dulko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Kilianski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Grace","family":"Carns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Lesmana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Pikus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Beenhakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117673_bib1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrn2774","article-title":"Abnormal neural oscillations and synchrony in schizophrenia","volume":"11","author":"Uhlhaas","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.neubiorev.2006.11.005","article-title":"From symphony to cacophony: Pathophysiology of the human basal ganglia in Parkinson disease","volume":"32","author":"Gale","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.isci.2026.117673_bib3","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/WNR.0b013e32833ed111","article-title":"Epileptic hypersynchrony revisited","volume":"21","author":"Margineanu","year":"2010","journal-title":"Neuroreport"},{"key":"10.1016\/j.isci.2026.117673_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1528-1157.1989.tb05316.x","article-title":"Proposal for Revised Classification of Epilepsies and Epileptic Syndromes: Commission on Classification and Terminology of the International League Against Epilepsy","volume":"30","year":"1989","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2026.117673_bib5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrn811","article-title":"Childhood absence epilepsy: Genes, channels, neurons and networks","volume":"3","author":"Crunelli","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib6","first-page":"305","article-title":"Effects of thalamic stimulation in unanaesthetised animals: The arrest reaction and petit Mal-like seizures, activation patterns and generalized convulsions","volume":"1","author":"Hunter","year":"1949","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.isci.2026.117673_bib7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.8392750","article-title":"Cellular mechanisms of a synchronized oscillation in the thalamus","volume":"261","author":"Krosigk von","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117673_bib8","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1146\/annurev.physiol.63.1.815","article-title":"On The Cellular and Network Bases of Epileptic Seizures","volume":"63","author":"McCormick","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.isci.2026.117673_bib9","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.neuron.2017.01.031","article-title":"Regulation of Thalamic and Cortical Network Synchrony by Scn8a","volume":"93","author":"Makinson","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2026.117673_bib10","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1523\/JNEUROSCI.22-04-01480.2002","article-title":"Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats","volume":"22","author":"Meeren","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib11","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.0753-07.2007","article-title":"Deep Layer Somatosensory Cortical Neurons Initiate Spike-and-Wave Discharges in a Genetic Model of Absence Seizures","volume":"27","author":"Polack","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/archneur.62.3.371","article-title":"Evolving concepts on the pathophysiology of absence seizures: The cortical focus theory","volume":"62","author":"Meeren","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.isci.2026.117673_bib13","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1111\/j.1528-1167.2009.02162.x","article-title":"Onset and propagation of spike and slow wave discharges in human absence epilepsy: A MEG study","volume":"50","author":"Westmijse","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2026.117673_bib14","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1212\/WNL.0b013e3181c55d02","article-title":"Thalamic nuclei activity in idiopathic generalized epilepsy: An EEG-fMRI study","volume":"73","author":"Tyvaert","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2026.117673_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2004.03.041","article-title":"Cortical control of generalized absence seizures: effect of lidocaine applied to the somatosensory cortex in WAG\/Rij rats","volume":"1012","author":"Sitnikova","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2026.117673_bib16","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/cercor\/bhn237","article-title":"Inactivation of the Somatosensory Cortex Prevents Paroxysmal Oscillations in Cortical and Related Thalamic Neurons in a Genetic Model of Absence Epilepsy","volume":"19","author":"Polack","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.isci.2026.117673_bib17","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41593-018-0130-4","article-title":"Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures","volume":"21","author":"McCafferty","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41467-022-35535-4","article-title":"Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures","volume":"14","author":"McCafferty","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117673_bib19","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1523\/JNEUROSCI.0231-05.2005","article-title":"Development of a New Genetic Model for Absence Epilepsy: Spike-Wave Seizures in C3H\/He and Backcross Mice","volume":"25","author":"Frankel","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004454","article-title":"Unraveling Genetic Modifiers in the Gria4 Mouse Model of Absence Epilepsy","volume":"10","author":"Frankel","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.isci.2026.117673_bib21","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/hmg\/ddn064","article-title":"Absence seizures in C3H\/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4","volume":"17","author":"Beyer","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2026.117673_bib22","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/1228","article-title":"The mouse stargazer gene encodes a neuronal Ca2+-channel \u03b3 subunit","volume":"19","author":"Letts","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.117673_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1535-7511.2005.00051.x","article-title":"Stargazer\u2014A Mouse to Seize","volume":"5","author":"Letts","year":"2005","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.isci.2026.117673_bib24","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1038\/s41467-018-04349-8","article-title":"Asynchronous suppression of visual cortex during absence seizures in stargazer mice","volume":"9","author":"Meyer","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117673_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.expneurol.2009.01.009","article-title":"Thalamic lesions in a genetic rat model of absence epilepsy: Dissociation between spike-wave discharges and sleep spindles","volume":"217","author":"Meeren","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.isci.2026.117673_bib26","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/jn.1992.68.4.1373","article-title":"Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons","volume":"68","author":"Huguenard","year":"1992","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.isci.2026.117673_bib27","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1113\/jphysiol.2003.046573","article-title":"Cellular interactions in the rat somatosensory thalamocortical system during normal and epileptic 5\u20139 Hz oscillations","volume":"552","author":"Pinault","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.117673_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106025","article-title":"Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges of absence seizures","volume":"178","author":"Atherton","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2026.117673_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.nbd.2012.03.023","article-title":"The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy","volume":"47","author":"L\u00fcttjohann","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2026.117673_bib30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.eplepsyres.2013.03.009","article-title":"Thalamic stimulation in absence epilepsy","volume":"106","author":"L\u00fcttjohann","year":"2013","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.isci.2026.117673_bib31","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1113\/JP279483","article-title":"Spike-wave discharges in absence epilepsy: segregation of electrographic components reveals distinct pathways of seizure activity","volume":"598","author":"Terlau","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.117673_bib32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.nbd.2011.03.019","article-title":"Seizure-related activity of intralaminar thalamic neurons in a genetic model of absence epilepsy","volume":"43","author":"Gorji","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2026.117673_bib33","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1046\/j.0953-816x.2001.01537.x","article-title":"Contribution of intralaminar thalamic nuclei to spike-and-wave-discharges during spontaneous seizures in a genetic rat model of absence epilepsy","volume":"13","author":"Seidenbecher","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72898","article-title":"Respiratory alkalosis provokes spike-wave discharges in seizure-prone rats","volume":"11","author":"Salvati","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.isci.2026.117673_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.eplepsyres.2015.12.007","article-title":"The hippocampus participates in a pharmacological rat model of absence seizures","volume":"120","author":"Arcaro","year":"2016","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.isci.2026.117673_bib36","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.3390\/diagnostics12112798","article-title":"Reduction of Hippocampal High-Frequency Activity in Wag\/Rij Rats with a Genetic Predisposition to Absence Epilepsy","volume":"12","author":"Sitnikova","year":"2022","journal-title":"Diagnostics"},{"key":"10.1016\/j.isci.2026.117673_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2007.01.038","article-title":"Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG\/Rij rats","volume":"416","author":"Tolmacheva","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2026.117673_bib38","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pbb.2009.07.017","article-title":"The circuitry of atypical absence seizures in GABABR1a transgenic mice","volume":"94","author":"Wang","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.isci.2026.117673_bib39","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.cell.2020.04.007","article-title":"The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117673_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnins.2019.00083","article-title":"Optimizing the Yield of Multi-Unit Activity by Including the Entire Spiking Activity","volume":"13","author":"Drebitz","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib41","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/brain\/awq112","article-title":"Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex","volume":"133","author":"Keller","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.isci.2026.117673_bib42","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1152\/jn.01170.2003","article-title":"Characterization of Neocortical Principal Cells and Interneurons by Network Interactions and Extracellular Features","volume":"92","author":"Barth\u00f3","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.isci.2026.117673_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1113\/jphysiol.1984.sp015153","article-title":"Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study","volume":"349","author":"Jahnsen","year":"1984","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.117673_bib44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/cercor\/7.6.583","article-title":"Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance","volume":"7","author":"Steriade","year":"1997","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.isci.2026.117673_bib45","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1126\/science.283.5401.541","article-title":"Reciprocal inhibitory connections and network synchrony in the mammalian thalamus","volume":"283","author":"Huntsman","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117673_bib46","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1162\/089976601300014312","article-title":"Sampling Properties of the Spectrum and Coherency of Sequences of Action Potentials","volume":"13","author":"Jarvis","year":"2001","journal-title":"Neural Comput."},{"key":"10.1016\/j.isci.2026.117673_bib47","series-title":"Case Studies inNeural Data Analysis","author":"Kramer","year":"2016"},{"key":"10.1016\/j.isci.2026.117673_bib48","doi-asserted-by":"crossref","first-page":"R685","DOI":"10.1016\/j.cub.2005.08.022","article-title":"Invertebrate Central Pattern Generation Moves along","volume":"15","author":"Marder","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2026.117673_bib49","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1523\/JNEUROSCI.08-11-04007.1988","article-title":"Nucleus basalis and thalamic control of neocortical activity in the freely moving rat","volume":"8","author":"Buzsaki","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib50","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nrn3241","article-title":"The origin of extracellular fields and currents \u2014 EEG, ECoG, LFP and spikes","volume":"13","author":"Buzs\u00e1ki","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib52","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nn.2842","article-title":"Measuring and interpreting neuronal correlations","volume":"14","author":"Cohen","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib53","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature14273","article-title":"Diverse coupling of neurons to populations in sensory cortex","volume":"521","author":"Okun","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.isci.2026.117673_bib54","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12021-008-9039-5","article-title":"Matching Spatial with Ontological Brain Regions using Java Tools for Visualization, Database Access, and Integrated Data Analysis","volume":"7","author":"Bezgin","year":"2009","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.isci.2026.117673_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09215","article-title":"Frequency-selective control of cortical and subcortical networks by central thalamus","volume":"4","author":"Liu","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.isci.2026.117673_bib57","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1113\/jphysiol.1995.sp020613","article-title":"Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro","volume":"483","author":"Bal","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.isci.2026.117673_bib58","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1523\/JNEUROSCI.14-09-05485.1994","article-title":"Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects","volume":"14","author":"Huguenard","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59548","article-title":"Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations","volume":"9","author":"Lu","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.isci.2026.117673_bib60","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1523\/JNEUROSCI.12-10-03804.1992","article-title":"A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus","volume":"12","author":"Huguenard","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib61","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ana.410250610","article-title":"Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons","volume":"25","author":"Coulter","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.isci.2026.117673_bib62","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0304-3940(89)90376-5","article-title":"Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons","volume":"98","author":"Coulter","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2026.117673_bib63","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.neuroimage.2007.10.058","article-title":"Changes in activity of striato-thalamo-cortical network precede generalized spike wave discharges","volume":"39","author":"Moeller","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.isci.2026.117673_bib64","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0920-1211(94)90050-7","article-title":"Thalamic mediodorsal and intralaminar nuclear lesions disrupt the generation of experimentally induced generalized absence-like seizures in rats","volume":"17","author":"Banerjee","year":"1994","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.isci.2026.117673_bib65","doi-asserted-by":"crossref","first-page":"11441","DOI":"10.1523\/JNEUROSCI.1011-17.2017","article-title":"Seizures and Sleep in the Thalamus: Focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic Nuclei","volume":"37","author":"Feng","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib66","doi-asserted-by":"crossref","first-page":"13763","DOI":"10.1073\/pnas.231499798","article-title":"Degeneracy and complexity in biological systems","volume":"98","author":"Edelman","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.isci.2026.117673_bib67","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/nn1352","article-title":"Similar network activity from disparate circuit parameters","volume":"7","author":"Prinz","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib68","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1339-24.2024","article-title":"The Brain\u2019s Best Kept Secret Is Its Degenerate Structure","volume":"44","author":"Albantakis","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.isci.2026.117673_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-023-04823-0","article-title":"Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair","volume":"6","author":"St\u00f6ber","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.isci.2026.117673_bib70","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14226","article-title":"Divergent paths to seizure -like events","volume":"7","author":"Codadu","year":"2019","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.isci.2026.117673_bib71","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0485-18.2019","article-title":"The Epileptor Model: A Systematic Mathematical Analysis Linked to the Dynamics of Seizures, Refractory Status Epilepticus, and Depolarization Block","volume":"7","author":"El Houssaini","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.isci.2026.117673_bib72","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/brain\/awu133","article-title":"On the nature of seizure dynamics","volume":"137","author":"Jirsa","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.isci.2026.117673_bib73","series-title":"Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects","author":"Malafosse","year":"1994"},{"key":"10.1016\/j.isci.2026.117673_bib74","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2011.04.038","article-title":"Electrical stimulation of the epileptic focus in absence epileptic WAG\/Rij rats: assessment of local and network excitability","volume":"188","author":"L\u00fcttjohann","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2026.117673_bib75","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0920-1211(98)00011-4","article-title":"High-frequency stimulation of the sub-thalamic nucleus suppresses absence seizures in the rat: comparison with neurotoxic lesions","volume":"31","author":"Vercueil","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.isci.2026.117673_bib76","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.eplepsyres.2014.10.019","article-title":"Electric stimulation of the tuberomamillary nucleus affects epileptic activity and sleep\u2013wake cycle in a genetic absence epilepsy model","volume":"109","author":"Blik","year":"2015","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.isci.2026.117673_bib77","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/s41588-023-01485-w","article-title":"GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture","volume":"55","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.117673_bib78","article-title":"Mouse running [Illustration]. CC-BY 4.0","author":"Branco","year":"2026","journal-title":"SciDraw.io"},{"key":"10.1016\/j.isci.2026.117673_bib85","author":"Thompson"},{"key":"10.1016\/j.isci.2026.117673_bib79","article-title":"Solving the Spike Sorting Problem with Kilosort","author":"Pachitariu","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2026.117673_bib80","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1038\/s41598-019-39724-y","article-title":"pyPhotometry: Open source Python based hardware and software for fiber photometry data acquisition","volume":"9","author":"Akam","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117673_bib81","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.isci.2026.117673_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111487","article-title":"Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex","volume":"41","author":"Peters","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.117673_bib84","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/ab581a","article-title":"Open source silicon microprobes for high throughput neural recording","volume":"17","author":"Yang","year":"2020","journal-title":"J. Neural. Eng."},{"key":"10.1016\/j.isci.2026.117673_bib83","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41598-018-36816-z","article-title":"Slow insertion of silicon probes improves the quality of acute neuronal recordings","volume":"9","author":"Fi\u00e1th","year":"2019","journal-title":"Sci. Rep."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226030543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226030543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:36:46Z","timestamp":1794346606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226030543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":84,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2589004226030543"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117673","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Midline thalamic neurons show early hypersynchrony during absence seizures in mouse models","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117673","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117673"}}