{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:30:37Z","timestamp":1794483037025,"version":"4.9.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004572","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["2023ZD0501500"],"award-info":[{"award-number":["2023ZD0501500"]}],"id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["2025ZD0545200"],"award-info":[{"award-number":["2025ZD0545200"]}],"id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82125033"],"award-info":[{"award-number":["82125033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230110"],"award-info":[{"award-number":["82230110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82388102"],"award-info":[{"award-number":["82388102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574185"],"award-info":[{"award-number":["82574185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.isci.2026.117742","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:45:37Z","timestamp":1791085537000},"page":"117742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["PTTG1 drives intestinal-type gastric cancer progression via G2\/M checkpoint-mediated cell-cycle reprogramming"],"prefix":"10.1016","volume":"29","author":[{"given":"Caihong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8055-546X","authenticated-orcid":false,"given":"Lin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-5337","authenticated-orcid":false,"given":"Guangfu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117742_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.isci.2026.117742_bib2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrclinonc.2016.15","article-title":"Clinical impact of tumour biology in the management of gastroesophageal cancer","volume":"13","author":"Lordick","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.isci.2026.117742_bib3","doi-asserted-by":"crossref","first-page":"10510","DOI":"10.3748\/wjg.v21.i37.10510","article-title":"Challenges of deciphering gastric cancer heterogeneity","volume":"21","author":"Hudler","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2026.117742_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma","volume":"64","author":"Laur\u00c9N","year":"1965","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.isci.2026.117742_bib5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10147-019-01443-9","article-title":"Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells","volume":"24","author":"Oue","year":"2019","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.isci.2026.117742_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13235930","article-title":"Proteomic Signatures of Diffuse and Intestinal Subtypes of Gastric Cancer","volume":"13","author":"Singh","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.isci.2026.117742_bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"Correa","year":"2011","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.isci.2026.117742_bib8","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2026.117742_bib9","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2026.117742_bib10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ccell.2023.03.001","article-title":"Epithelial cells activate fibroblasts to promote esophageal cancer development","volume":"41","author":"Chen","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2026.117742_bib11","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1038\/s41467-022-34395-2","article-title":"Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment","volume":"13","author":"Luo","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117742_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41467-021-27322-4","article-title":"Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states","volume":"13","author":"Song","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117742_bib13","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1038\/s41467-023-40895-6","article-title":"Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtype","volume":"14","author":"Oh","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117742_bib14","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1038\/s41467-024-47737-z","article-title":"A patient-specific lung cancer assembloid model with heterogeneous tumor microenvironments","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117742_bib15","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1038\/s41467-023-38426-4","article-title":"Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117742_bib16","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1038\/s41467-022-32627-z","article-title":"scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory","volume":"13","author":"Sun","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117742_bib17","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41467-023-36310-9","article-title":"Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117742_bib18","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1126\/science.285.5426.418","article-title":"Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis","volume":"285","author":"Zou","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.isci.2026.117742_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1098\/rstb.2004.1615","article-title":"Basic mechanism of eukaryotic chromosome segregation","volume":"360","author":"Yanagida","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.isci.2026.117742_bib20","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1073\/pnas.1318124111","article-title":"Pttg1\/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis","volume":"111","author":"Hatcher","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117742_bib21","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1158\/0008-5472.CAN-22-3561","article-title":"PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression","volume":"83","author":"Zhou","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2026.117742_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1677\/JME-08-0076","article-title":"Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer","volume":"42","author":"Ghayad","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.isci.2026.117742_bib23","doi-asserted-by":"crossref","first-page":"113472","DOI":"10.18632\/oncotarget.23052","article-title":"Targeting the PTTG1 oncogene impairs proliferation and invasiveness of melanoma cells sensitive or with acquired resistance to the BRAF inhibitor dabrafenib","volume":"8","author":"Caporali","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2026.117742_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3507436","article-title":"Prognostic Significance of PTTG1 and Its Methylation in Lung Adenocarcinoma","volume":"2022","author":"Bai","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.isci.2026.117742_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119594","article-title":"PTTG1 knockdown enhances radiation-induced antitumour immunity in lung adenocarcinoma","volume":"277","author":"Chen","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.isci.2026.117742_bib26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0140-6736(99)10238-1","article-title":"Expression of pituitary-tumour transforming gene in colorectal tumours","volume":"355","author":"Heaney","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.117742_bib27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/and.12283","article-title":"Pituitary-tumour-transforming-gene 1 expression in testicular cancer","volume":"47","author":"Pierconti","year":"2015","journal-title":"Andrologia"},{"key":"10.1016\/j.isci.2026.117742_bib28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1757-2215-1-6","article-title":"PTTG: an important target gene for ovarian cancer therapy","volume":"1","author":"Panguluri","year":"2008","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.isci.2026.117742_bib29","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.1007\/s13277-014-2143-2","article-title":"Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.isci.2026.117742_bib30","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.3892\/ol.2015.3074","article-title":"Securin promotes migration and invasion via matrix metalloproteinases in glioma cells","volume":"9","author":"Yan","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.isci.2026.117742_bib31","doi-asserted-by":"crossref","first-page":"15495","DOI":"10.1007\/s13277-015-3796-1","article-title":"Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13","volume":"37","author":"Lin","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.isci.2026.117742_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s10020-020-00161-7","article-title":"Estrogen-regulated PTTG1 promotes breast cancer progression by regulating cyclin kinase expression","volume":"26","author":"Meng","year":"2020","journal-title":"Mol. Med."},{"key":"10.1016\/j.isci.2026.117742_bib33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10120-015-0459-2","article-title":"Pituitary tumor-transforming gene-1 serves as an independent prognostic biomarker for gastric cancer","volume":"19","author":"Xu","year":"2016","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.isci.2026.117742_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/gutjnl-2025-335793","article-title":"Hybrid identity and distinct methylation profiles of incomplete intestinal metaplasia in the stomach","volume":"75","author":"Kim","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.isci.2026.117742_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27959","article-title":"AURKA promotes renal cell carcinoma progression via regulation of CCNB1 transcription","volume":"10","author":"Wen","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.isci.2026.117742_bib36","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/MCB.06663-11","article-title":"Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching","volume":"32","author":"Li","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.117742_bib37","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/gutjnl-2019-320368","article-title":"Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.isci.2026.117742_bib38","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1053\/j.gastro.2024.07.038","article-title":"Atlas of Metastatic Gastric Cancer Links Ferroptosis to Disease Progression and Immunotherapy Response","volume":"167","author":"Cheng","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2026.117742_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0140-6736(75)90498-5","article-title":"A model for gastric cancer epidemiology","volume":"2","author":"Correa","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.117742_bib40","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/S1470-2045(14)71016-2","article-title":"Familial gastric cancer: genetic susceptibility, pathology, and implications for management","volume":"16","author":"Oliveira","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.isci.2026.117742_bib41","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.celrep.2019.04.052","article-title":"Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric Cancer","volume":"27","author":"Zhang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2026.117742_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166849","article-title":"Integrated analysis of single-cell RNA-seq and bulk RNA-seq to unravel the molecular mechanisms underlying the immune microenvironment in the development of intestinal-type gastric cancer","volume":"1870","author":"Su","year":"2024","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"10.1016\/j.isci.2026.117742_bib43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1210\/mend.11.4.9911","article-title":"Isolation and characterization of a pituitary tumor-transforming gene (PTTG)","volume":"11","author":"Pei","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.isci.2026.117742_bib44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000015261","article-title":"Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis","volume":"84","author":"Kakar","year":"1999","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.isci.2026.117742_bib45","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1158\/0008-5472.CAN-08-0367","article-title":"PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma","volume":"69","author":"Yan","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2026.117742_bib46","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.breast.2003.09.008","article-title":"PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence","volume":"13","author":"Solbach","year":"2004","journal-title":"Breast"},{"key":"10.1016\/j.isci.2026.117742_bib47","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.1007\/s13277-015-3420-4","volume":"36","author":"Liang","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.isci.2026.117742_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12032-020-01398-2","article-title":"Suppression of PTTG1 inhibits cell angiogenesis, migration and invasion in glioma cells","volume":"37","author":"Cui","year":"2020","journal-title":"Med. Oncol."},{"key":"10.1016\/j.isci.2026.117742_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114654","article-title":"PTTG1 promotes CD34(+)CD45(+) cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF\/PI3K\/AKT\/eNOS signaling pathway in rats with phosgene-induced acute lung injury","volume":"162","author":"Dun","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.isci.2026.117742_bib50","doi-asserted-by":"crossref","first-page":"92388","DOI":"10.18632\/oncotarget.21343","article-title":"PTTG1 cooperated with GLI1 leads to epithelial-mesenchymal transition in esophageal squamous cell cancer","volume":"8","author":"Feng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2026.117742_bib51","first-page":"811","article-title":"[On-Orbit Multispectral Sensor Characterization Based on Spectral Tarps]","volume":"36","author":"Li","year":"2016","journal-title":"Guang Pu Xue Yu Guang Pu Fen Xi"},{"key":"10.1016\/j.isci.2026.117742_bib52","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s12672-025-02512-4","article-title":"PTTG1 promotes M2 macrophage polarization via the cGMP-PKG signaling pathway and facilitates EMT progression in human epithelial ovarian cancer cells","volume":"16","author":"Tian","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.isci.2026.117742_bib53","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3121\/cmr.4.2.130","article-title":"The emerging role of pituitary tumor transforming gene in tumorigenesis","volume":"4","author":"Tfelt-Hansen","year":"2006","journal-title":"Clin. Med. Res."},{"key":"10.1016\/j.isci.2026.117742_bib54","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1158\/2159-8290.CD-20-1109","article-title":"A CRISPR\/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation","volume":"11","author":"Lo","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.isci.2026.117742_bib55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-4598-5-10","article-title":"Expression profile of mucins (MUC2, MUC5AC and MUC6) in Helicobacter pylori infected pre-neoplastic and neoplastic human gastric epithelium","volume":"5","author":"Babu","year":"2006","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.isci.2026.117742_bib56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.isci.2026.117742_bib57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117742_bib58","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117742_bib59","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2026.117742_bib60","author":"Tickle"},{"key":"10.1016\/j.isci.2026.117742_bib61","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2026.117742_bib62","article-title":"hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data","volume":"3","author":"Morabito","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.isci.2026.117742_bib63","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.isci.2026.117742_bib64","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/s41588-021-00972-2","article-title":"Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro","volume":"53","author":"Garcia-Alonso","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.117742_bib65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.isci.2026.117742_bib66","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/gutjnl-2022-327121","article-title":"Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models","volume":"72","author":"Tong","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.isci.2026.117742_bib67","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1093\/nar\/gky1173","article-title":"scFTD-seq: freeze-thaw lysis based, portable approach toward highly distributed single-cell 3' mRNA profiling","volume":"47","author":"Dura","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117742_bib68","article-title":"Single-cell eQTL mapping reveals cell-type-specific genes associated with the risk of gastric cancer","volume":"5","author":"Bian","year":"2025","journal-title":"Cell Genom."},{"key":"10.1016\/j.isci.2026.117742_bib69","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nm.3850","article-title":"Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes","volume":"21","author":"Cristescu","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.117742_bib70","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1158\/0008-5472.CAN-24-4065","article-title":"Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer","volume":"85","author":"Xu","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2026.117742_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114099","article-title":"MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells","volume":"439","author":"Dai","year":"2024","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2026.117742_bib72","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13059-025-03526-5","article-title":"ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma","volume":"26","author":"Jiang","year":"2025","journal-title":"Genome Biol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226031238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226031238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:27:21Z","timestamp":1794479241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226031238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":72,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2589004226031238"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117742","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PTTG1 drives intestinal-type gastric cancer progression via G2\/M checkpoint-mediated cell-cycle reprogramming","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117742"}}