{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:30:06Z","timestamp":1794483006081,"version":"4.9.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI22\/01009"],"award-info":[{"award-number":["PI22\/01009"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["FI23\/00070"],"award-info":[{"award-number":["FI23\/00070"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CB06\/04\/0071"],"award-info":[{"award-number":["CB06\/04\/0071"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["FI23\/00141"],"award-info":[{"award-number":["FI23\/00141"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI22\/00424"],"award-info":[{"award-number":["PI22\/00424"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CD23\/0006"],"award-info":[{"award-number":["CD23\/0006"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011597","name":"Generalitat Valenciana Conselleria de Sanitat","doi-asserted-by":"publisher","award":["CIPROM\/2022\/32"],"award-info":[{"award-number":["CIPROM\/2022\/32"]}],"id":[{"id":"10.13039\/501100011597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011597","name":"Generalitat Valenciana Conselleria de Sanitat","doi-asserted-by":"publisher","award":["CIGRIS\/2022\/172"],"award-info":[{"award-number":["CIGRIS\/2022\/172"]}],"id":[{"id":"10.13039\/501100011597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011597","name":"Generalitat Valenciana Conselleria de Sanitat","doi-asserted-by":"publisher","award":["CIGRIS\/2021\/112"],"award-info":[{"award-number":["CIGRIS\/2021\/112"]}],"id":[{"id":"10.13039\/501100011597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011597","name":"Generalitat Valenciana Conselleria de Sanitat","doi-asserted-by":"publisher","award":["CIGE\/2024\/82"],"award-info":[{"award-number":["CIGE\/2024\/82"]}],"id":[{"id":"10.13039\/501100011597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101136516"],"award-info":[{"award-number":["101136516"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["FI23\/00141"],"award-info":[{"award-number":["FI23\/00141"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["FI23\/00070"],"award-info":[{"award-number":["FI23\/00070"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/01009"],"award-info":[{"award-number":["PI22\/01009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/00424"],"award-info":[{"award-number":["PI22\/00424"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.isci.2026.117743","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:53:37Z","timestamp":1791212017000},"page":"117743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caloric restriction attenuates NLRP3 inflammasome activation and oxidative stress in leukocytes of patients with obesity"],"prefix":"10.1016","volume":"29","author":[{"given":"Sandra","family":"L\u00f3pez-Dom\u00e8nech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perea-Galera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Pelech\u00e1-Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Abad-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hermenejildo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meylin","family":"Fern\u00e1ndez-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Luna-Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Cacace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Veses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Morillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3027-3945","authenticated-orcid":false,"given":"V\u00edctor M.","family":"V\u00edctor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2923-6546","authenticated-orcid":false,"given":"Milagros","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117743_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13956","article-title":"Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?","volume":"26","author":"Turner","year":"2025","journal-title":"Obes. Rev."},{"key":"10.1016\/j.isci.2026.117743_bib2","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.immuni.2025.09.011","article-title":"Obesity, diabetes, and inflammation: Pathophysiology and clinical implications","volume":"58","author":"Donath","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.117743_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.117743_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.117743_bib5","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ijo.2016.26","article-title":"Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents","volume":"40","author":"Rainone","year":"2016","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.isci.2026.117743_bib6","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/s41423-019-0296-z","article-title":"NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling","volume":"18","author":"Unamuno","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.isci.2026.117743_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-024-06306-1","article-title":"Targeting the NLRP3 inflammasome\u2013IL-1\u03b2 pathway in type 2 diabetes and obesity","volume":"68","author":"Meier","year":"2025","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2026.117743_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/annrheumdis-2016-209707","article-title":"2016 updated EULAR evidence-based recommendations for the management of gout","volume":"76","author":"Richette","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.isci.2026.117743_bib9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cmet.2016.02.005","article-title":"Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity","volume":"23","author":"Magkos","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.117743_bib10","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2337\/dc10-2415","article-title":"Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes","volume":"34","author":"Wing","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.isci.2026.117743_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clnesp.2018.08.007","article-title":"Weight loss is a critical factor to reduce inflammation","volume":"28","author":"Bianchi","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.isci.2026.117743_bib12","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/advances\/nmaa179","article-title":"Calorie Restriction as a New Treatment of Inflammatory Diseases","volume":"12","author":"K\u00f6kten","year":"2021","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.isci.2026.117743_bib13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00125-017-4462-5","article-title":"Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes","volume":"61","author":"Szpigel","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2026.117743_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155527","article-title":"TNF\u03b1-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2","volume":"142","author":"Javaid","year":"2023","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.117743_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207882","article-title":"One-year weight management lowers lipopolysaccharide-binding protein and its implication in metainflammation and liver fibrosis","volume":"13","author":"Nien","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.117743_bib16","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3390\/nu17142360","article-title":"Gut Microbiota Shifts After a Weight Loss Program in Adults with Obesity: The WLM3P Study","volume":"17","author":"Pereira","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2026.117743_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.clicom.2022.03.003","article-title":"Potential role of uric acid to activate NLRP3 inflammasome triggering endothelial dysfunction in preeclampsia","volume":"2","author":"Nunes","year":"2022","journal-title":"Clin. Immunol. Commun."},{"key":"10.1016\/j.isci.2026.117743_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep39884","article-title":"Soluble Uric Acid Activates the NLRP3 Inflammasome","volume":"7","author":"Braga","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117743_bib19","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1136\/annrheumdis-2017-211472","article-title":"Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies","volume":"76","author":"Nielsen","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.isci.2026.117743_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1109","article-title":"The rOX-stars of inflammation: links between the inflammasome and mitochondrial meltdown","volume":"9","author":"Holley","year":"2020","journal-title":"Clin & Trans Imm"},{"key":"10.1016\/j.isci.2026.117743_bib21","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1159\/000479972","article-title":"Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review","volume":"10","author":"Himbert","year":"2017","journal-title":"Obes. Facts"},{"key":"10.1016\/j.isci.2026.117743_bib22","first-page":"355","article-title":"The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation","volume":"86","author":"Dandona","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.117743_bib23","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3390\/antiox9080734","article-title":"Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study","volume":"9","author":"Abad-Jim\u00e9nez","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.isci.2026.117743_bib24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s42003-023-04817-y","article-title":"Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation","volume":"6","author":"Cabral","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.isci.2026.117743_bib25","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1038\/s41598-019-41593-4","article-title":"Quantifying circulating cell-free DNA in humans","volume":"9","author":"Meddeb","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117743_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molmet.2018.10.005","article-title":"Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity","volume":"19","author":"L\u00f3pez-Dom\u00e8nech","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2026.117743_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/729515","article-title":"The Impact of Rapid Weight Loss on Oxidative Stress Markers and the Expression of the Metabolic Syndrome in Obese Individuals","volume":"2013","author":"Tumova","year":"2013","journal-title":"J. Obes."},{"key":"10.1016\/j.isci.2026.117743_bib28","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s00018-016-2431-7","article-title":"The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome","volume":"74","author":"Traba","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.isci.2026.117743_bib29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.freeradbiomed.2024.10.295","article-title":"Calorie restriction modulates mitochondrial dynamics and autophagy in leukocytes of patients with obesity","volume":"225","author":"Abad-Jim\u00e9nez","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2026.117743_bib30","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2119\/molmed.2015.00104","article-title":"Targeting the NLRP3 inflammasome to Reduce Diet-induced Metabolic Abnormalities in Mice","volume":"21","author":"Chiazza","year":"2016","journal-title":"Mol. Med."},{"key":"10.1016\/j.isci.2026.117743_bib31","first-page":"e4917","article-title":"Dysregulation of Components of the Inflammasome Machinery After Bariatric Surgery: Novel Targets for a Chronic Disease","volume":"106","author":"Herrero-Aguayo","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2026.117743_bib32","doi-asserted-by":"crossref","DOI":"10.1172\/JCI169173","article-title":"Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity","volume":"133","author":"Ryu","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.117743_bib33","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.18632\/aging.100994","article-title":"Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans","volume":"8","author":"Meydani","year":"2016","journal-title":"Aging"},{"key":"10.1016\/j.isci.2026.117743_bib34","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1093\/jn\/nxaa085","article-title":"Nutrients and Immunometabolism: Role of Macrophage NLRP3","volume":"150","author":"Claycombe-Larson","year":"2020","journal-title":"J. Nutr."},{"key":"10.1016\/j.isci.2026.117743_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2026.117743_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96981-6","article-title":"Use of human PBMC to analyse the impact of obesity on lipid metabolism and metabolic status: a proof-of-concept pilot study","volume":"11","author":"Costa","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2026.117743_bib37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1080\/13813455.2020.1752257","article-title":"PBMCs: a new source of diagnostic and prognostic biomarkers","volume":"128","author":"Mosallaei","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.isci.2026.117743_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2017.06.002","article-title":"Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review","volume":"74","author":"Rheinheimer","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.117743_bib39","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3945\/ajcn.113.058099","article-title":"Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach","volume":"98","author":"Kong","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2026.117743_bib40","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.metabol.2016.07.008","article-title":"Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status","volume":"65","author":"Rock","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2026.117743_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12974-020-01998-9","article-title":"The peri-menopause in a woman\u2019s life: a systemic inflammatory phase that enables later neurodegenerative disease","volume":"17","author":"McCarthy","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.isci.2026.117743_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115554","article-title":"Estrogen plays an important role by influencing the NLRP3 inflammasome","volume":"167","author":"Dong","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422603124X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422603124X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:21:36Z","timestamp":1794478896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422603124X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S258900422603124X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117743","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caloric restriction attenuates NLRP3 inflammasome activation and oxidative stress in leukocytes of patients with obesity","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117743"}}